David E Kelley

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Effects of physical activity on insulin action and glucose tolerance in obesity
    D E Kelley
    Department of Medicine, University of Pittsburgh School of Medicine, PA 15261, USA
    Med Sci Sports Exerc 31:S619-23. 1999
  2. ncbi Assessing skeletal muscle glucose metabolism with positron emission tomography
    D E Kelley
    Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pennsylvania 15213, USA
    IUBMB Life 52:279-84. 2001
  3. ncbi Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: A 1-year randomized controlled trial
    David E Kelley
    Montifiore Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 25:1033-41. 2002
  4. ncbi Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance
    David E Kelley
    Department of Medicine, University of Pittsburgh, 810N Montefiore University Hospital, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 285:E906-16. 2003
  5. ncbi Effects of exercise on glucose homeostasis in Type 2 diabetes mellitus
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Med Sci Sports Exerc 33:S495-501; discussion S528-9. 2001
  6. ncbi Muscle triglyceride and insulin resistance
    David E Kelley
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Annu Rev Nutr 22:325-46. 2002
  7. ncbi Skeletal muscle triglycerides: an aspect of regional adiposity and insulin resistance
    David E Kelley
    Department of Medicine, Montefiore University Hospital, University of Pittsburgh, Pennsylvania 15213, USA
    Ann N Y Acad Sci 967:135-45. 2002
  8. ncbi Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    David E Kelley
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Diabetes 51:2944-50. 2002
  9. ncbi Action for health in diabetes: the look AHEAD clinical trial
    David E Kelley
    810N Montefiore University Hospital, 3459 Fifth Avenue, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Curr Diab Rep 2:207-9. 2002
  10. ncbi Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance
    D E Kelley
    Division of Endocrinology and Metabolism, Department of Medicine, and Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Endocrinol Metab 278:E941-8. 2000

Detail Information

Publications96

  1. ncbi Effects of physical activity on insulin action and glucose tolerance in obesity
    D E Kelley
    Department of Medicine, University of Pittsburgh School of Medicine, PA 15261, USA
    Med Sci Sports Exerc 31:S619-23. 1999
    ..The purpose of this paper is to examine the effect of physical activity on glucose tolerance in relation to obesity...
  2. ncbi Assessing skeletal muscle glucose metabolism with positron emission tomography
    D E Kelley
    Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pennsylvania 15213, USA
    IUBMB Life 52:279-84. 2001
    ....
  3. ncbi Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: A 1-year randomized controlled trial
    David E Kelley
    Montifiore Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 25:1033-41. 2002
    ..The aim of this study was to assess the effect of orlistat, a gastrointestinal lipase inhibitor, on weight loss, glycemic control, and cardiovascular risk factors in overweight or obese insulin-treated type 2 diabetic patients...
  4. ncbi Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance
    David E Kelley
    Department of Medicine, University of Pittsburgh, 810N Montefiore University Hospital, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 285:E906-16. 2003
    ..34; P < 0.01). In summary, fatty liver is relatively common in overweight and obese volunteers with type 2 DM and is an aspect of body composition related to severity of insulin resistance, dyslipidemia, and inflammatory markers...
  5. ncbi Effects of exercise on glucose homeostasis in Type 2 diabetes mellitus
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Med Sci Sports Exerc 33:S495-501; discussion S528-9. 2001
    ..This review has evaluated the effectiveness of physical activity in the treatment and prevention of Type 2 diabetes mellitus (DM)...
  6. ncbi Muscle triglyceride and insulin resistance
    David E Kelley
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Annu Rev Nutr 22:325-46. 2002
    ..This inflexibility in fuel selection by skeletal muscle appears to be related to the accumulation of imTG and is an important aspect of IR of skeletal muscle in obesity and type 2 DM...
  7. ncbi Skeletal muscle triglycerides: an aspect of regional adiposity and insulin resistance
    David E Kelley
    Department of Medicine, Montefiore University Hospital, University of Pittsburgh, Pennsylvania 15213, USA
    Ann N Y Acad Sci 967:135-45. 2002
    ..An effort to modify skeletal muscle in individuals with obesity and type 2 DM so that the capacity for fat oxidation and metabolic flexibility is improved should be among the goals of treatment for these disorders...
  8. ncbi Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    David E Kelley
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Diabetes 51:2944-50. 2002
    ..01). We conclude that there is an impaired bioenergetic capacity of skeletal muscle mitochondria in type 2 diabetes, with some impairment also present in obesity...
  9. ncbi Action for health in diabetes: the look AHEAD clinical trial
    David E Kelley
    810N Montefiore University Hospital, 3459 Fifth Avenue, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Curr Diab Rep 2:207-9. 2002
  10. ncbi Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance
    D E Kelley
    Division of Endocrinology and Metabolism, Department of Medicine, and Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Endocrinol Metab 278:E941-8. 2000
    ..We conclude that there are two functionally distinct compartments of adipose tissue within abdominal subcutaneous fat and that the deep SAT has a strong relation to insulin resistance...
  11. ncbi Approaches to preventing mealtime hyperglycaemic excursions
    D E Kelley
    Division of Endocrinology and Metabolism, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Diabetes Obes Metab 4:11-8. 2002
  12. ncbi Influence of weight loss and physical activity interventions upon muscle lipid content in relation to insulin resistance
    David E Kelley
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, 807N Montefiore University Hospital, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Curr Diab Rep 4:165-8. 2004
    ..Potential explanations for this difference between weight loss and physical activity are discussed in this article...
  13. ncbi Effects of moderate weight loss and orlistat on insulin resistance, regional adiposity, and fatty acids in type 2 diabetes
    David E Kelley
    Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 27:33-40. 2004
    ....
  14. ncbi Sugars and starch in the nutritional management of diabetes mellitus
    David E Kelley
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, PA, USA
    Am J Clin Nutr 78:858S-864S. 2003
    ..This new emphasis reflects greater awareness of the importance of responding to individual and cultural dietary preferences and the need to address treatment of both hyperglycemia and dyslipidemia in diabetes mellitus...
  15. pmc Metabolic changes following a 1-year diet and exercise intervention in patients with type 2 diabetes
    Jeanine B Albu
    Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University, New York, New York, USA
    Diabetes 59:627-33. 2010
    ....
  16. ncbi Weight loss-induced plasticity of glucose transport and phosphorylation in the insulin resistance of obesity and type 2 diabetes
    Katherine V Williams
    Department of Medicine, University of Pittsburgh, Pittsburgh, Montefiore University Hospital, Pennsylvania 15213, USA
    Diabetes 52:1619-26. 2003
    ..In particular, clinically significant weight loss fully corrected insulin resistance in type 2 diabetes at the step of glucose phosphorylation and largely, but incompletely, corrected insulin resistance at the glucose transport step...
  17. doi Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content
    Frederico G S Toledo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes 57:987-94. 2008
    ..Both are known to improve insulin resistance, and we tested the hypothesis that physical activity, rather than improved insulin resistance, is required to increase mitochondrial capacity of muscle...
  18. ncbi Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
    Vladimir B Ritov
    Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Diabetes 54:8-14. 2005
    ..Because of the potential importance of subsarcolemmal mitochondria for signal transduction and substrate transport, this deficit may contribute to the pathogenesis of muscle insulin resistance in type 2 diabetes...
  19. pmc Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity
    Vladimir B Ritov
    Univ of Pittsburgh, School of Medicine, Div of Endocrinology and Metabolism, 810N MUH, 3459 5th Ave, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 298:E49-58. 2010
    ..The specific activity of NADH oxidase (per mg cardiolipin) and NADH oxidase/citrate synthase and NADH oxidase/beta-HAD ratios are reduced two- to threefold in both T2DM and obesity...
  20. pmc Ethnic difference in liver fat content: a cross-sectional observation among Japanese American in Hawaii, Japanese in Japan, and non-Hispanic whites in United States
    Koichiro Azuma
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Obes Res Clin Pract 7:e198-205. 2013
    ..Objective: We hypothesize that ethnic difference in fat storage capacity contributes to this ethnic difference in liver fat...
  21. pmc PET imaging reveals distinctive roles for different regional adipose tissue depots in systemic glucose metabolism in nonobese humans
    Jason M Ng
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Physiol Endocrinol Metab 303:E1134-41. 2012
    ..These dynamic PET imaging studies indicate that both quantity and quality of specific AT depots have distinct roles in systemic insulin resistance and may help explain the metabolically obese but normal-weight phenotype...
  22. pmc Effects of exercise on mitochondrial content and function in aging human skeletal muscle
    Elizabeth V Menshikova
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 61:534-40. 2006
    ..01). In conclusion, exercise enhances mitochondria ETC activity in older human skeletal muscle, particularly in subsarcolemmal mitochondria, which is likely related to the concomitant increases in mitochondrial biogenesis...
  23. ncbi Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesity
    Elizabeth V Menshikova
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Appl Physiol 103:21-7. 2007
    ....
  24. ncbi Relationship of adiposity to subclinical atherosclerosis in obese patients with type 2 diabetes
    Refaat A F Hegazi
    Department of Medicine, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    Obes Res 11:1597-605. 2003
    ..This study was designed to examine the relationship between obesity and regional patterns of adiposity, insulin resistance, and five independent measures of subclinical atherosclerosis...
  25. ncbi Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 52:2191-7. 2003
    ..In conclusion, exercise combined with weight loss enhances postabsorptive fat oxidation, which appears to be a key aspect of the improvement in insulin sensitivity in obesity...
  26. ncbi Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women: a report from the Women's Ischemia Syndrome Evaluation
    Oscar C Marroquin
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 109:714-21. 2004
    ..The interrelationship between metabolic status and CAD on cardiovascular risk in women is not known...
  27. ncbi Dose-responsive insulin regulation of glucose transport in human skeletal muscle
    R Richard Pencek
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 290:E1124-30. 2006
    ..In summary, in healthy volunteers there is robust dose-responsive insulin stimulation of glucose transport in skeletal muscle...
  28. ncbi Effect of weight loss and nutritional intervention on arterial stiffness in type 2 diabetes
    Emma Barinas-Mitchell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 29:2218-22. 2006
    ..However, the effect of intentional weight loss on arterial stiffness is uncertain, and the purpose of the current study was to assess this effect...
  29. ncbi Exercise training increases intramyocellular lipid and oxidative capacity in older adults
    Ryan Pruchnic
    Dept of Medicine, University of Pittsburgh Medical Center, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 287:E857-62. 2004
    ..6 AU. The percentage of type I fibers significantly increased (P < 0.05) from 35.4 +/- 2.1 to 40.1 +/- 2.3%. In conclusion, exercise training increases IMCL in older persons in parallel with an enhanced capacity for fat oxidation...
  30. ncbi Interactions of impaired glucose transport and phosphorylation in skeletal muscle insulin resistance: a dose-response assessment using positron emission tomography
    K V Williams
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Diabetes 50:2069-79. 2001
    ..05). These findings indicate an important interaction between transport and phosphorylation in the insulin resistance of obesity and type 2 diabetes...
  31. ncbi Muscle glycogen content in type 2 diabetes mellitus
    Jing He
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 287:E1002-7. 2004
    ..This ratio tended to be higher in Ob and T2DM. In summary, there is decreased muscle Glyc in T2DM yet a disproportional Glyc-to-OX-Enz relationship that is related to IR, although not as robustly as the IMCL-to-OX-Enz ratio...
  32. ncbi Effects of weight loss and physical activity on muscle lipid content and droplet size
    Jing He
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pennsyvania, USA
    Obes Res 12:761-9. 2004
    ..To address the potential effects of weight loss and physical activity (WL + Ex) on intramyocellular lipid (IMCL) and lipid droplet size in overweight and obese previously sedentary individuals...
  33. ncbi Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity
    Elizabeth V Menshikova
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, School of Medicine, Pennsylvania, USA
    Am J Physiol Endocrinol Metab 288:E818-25. 2005
    ..We conclude that improved skeletal muscle ETC activity following moderate WL and improved aerobic capacity contributes to associated alleviation of insulin resistance...
  34. ncbi Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes
    Frederico G S Toledo
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes 56:2142-7. 2007
    ....
  35. ncbi Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes
    Koichiro Azuma
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 93:459-64. 2008
    ..We undertook a double-blinded, randomized-order, crossover study to examine the vildagliptin mechanisms of action on islet function and glucose utilization. Research..
  36. ncbi Effect of exercise intensity on glucose and insulin metabolism in obese individuals and obese NIDDM patients
    J Kang
    Department of Health and Physical Education, University of Pittsburgh, Pennsylvania, USA
    Diabetes Care 19:341-9. 1996
    ..The primary purpose of this study was to evaluate the acute effect of exercise of differing intensity on plasma glucose and insulin responses to an oral glucose challenge...
  37. doi Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity
    Stephanie J Mihalik
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 18:1695-700. 2010
    ..Plasma long-chain AcylCN species are increased in obesity and T2DM, suggesting that more fatty acids can enter mitochondria. In T2DM, many shorter species accumulate, suggesting that they have a generalized complex oxidation defect...
  38. pmc Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States
    Koichiro Azuma
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Metabolism 58:1200-7. 2009
    ....
  39. ncbi Thermodynamics, liposuction, and metabolism
    David E Kelley
    Obesity and Nutrition Research Center, University of Pittsburgh Medical Center, Pittsburgh, USA
    N Engl J Med 350:2542-4. 2004
  40. ncbi Effects of obesity on substrate utilization during exercise
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Obes Res 10:575-84. 2002
    ..The capacity for lipid and carbohydrate (CHO) oxidation during exercise is important for energy partitioning and storage. This study examined the effects of obesity on lipid and CHO oxidation during exercise...
  41. ncbi Plasma fatty acids, adiposity, and variance of skeletal muscle insulin resistance in type 2 diabetes mellitus
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 86:5412-9. 2001
    ....
  42. ncbi Glucose transport and phosphorylation in skeletal muscle in obesity: insight from a muscle-specific positron emission tomography model
    Katherine V Williams
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 88:1271-9. 2003
    ....
  43. doi Mechanisms of insulin resistance assessed by dynamic in-vivo positron emission tomography imaging
    Jason M Ng
    Department of Medicine, University of Pittsburgh, Montefiore Hospital, Pittsburgh, PA 15213, USA
    Curr Opin Clin Nutr Metab Care 12:508-12. 2009
    ..In this review, we examine recent studies utilizing dynamic in-vivo PET imaging in assessing insulin resistance in humans...
  44. ncbi Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Diabetes Care 26:372-9. 2003
    ....
  45. ncbi Pulling in more fat
    David E Kelley
    Department of Medicine, University of Pittsburgh Medical Center, Montefiore Hospital, Pittsburgh, Pennsylvania 15213, USA
    Cell Metab 2:275-6. 2005
    ..In obesity, skeletal muscle accumulates triglyceride. Recent work from Hulver and colleagues (2005) in the October issue of Cell Metabolism implicates stearoyl-CoA desaturase as part of the underlying molecular mechanism...
  46. ncbi Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women
    Frederico G S Toledo
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, 807N Montefiore Hospital, 3459 5th Avenue, Pittsburgh, PA 15213, USA
    J Clin Endocrinol Metab 91:3224-7. 2006
    ..In obesity, skeletal muscle insulin resistance may be associated with smaller mitochondria...
  47. ncbi High-performance liquid chromatography-based methods of enzymatic analysis: electron transport chain activity in mitochondria from human skeletal muscle
    Vladimir B Ritov
    Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Anal Biochem 333:27-38. 2004
    ..NADH is quantitatively analyzed with a detection limit of 3-5 pmol by HPLC using a reverse-phase Hypersil ODS column connected to a fluorescence detector...
  48. ncbi Analysis of cardiolipin in human muscle biopsy
    Vladimir B Ritov
    Department of Medicine, Division of Endocrinology and Metabolism, School of Medicine, University of Pittsburgh, 3459 Fifth Avenue, MUH N809 Pittsburgh, PA 15213 3236, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 831:63-71. 2006
    ..The assay is linear over the range between 0.3 and 3.0mg of tissue (R(2)=0.998). The assay provides good reproducibility and accuracy (within 5-10%)...
  49. ncbi Influence of hepatic steatosis (fatty liver) on severity and composition of dyslipidemia in type 2 diabetes
    Frederico G S Toledo
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, School of Medicine, Pennsylvania, USA
    Diabetes Care 29:1845-50. 2006
    ....
  50. ncbi The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss
    Daniel R Cottam
    Department of Surgery, The University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Obes Surg 14:589-600. 2004
    ..Recently, there has been intense interest in the role of inflammation in obesity. Using the inflammatory hypothesis, many of the mechanisms by which co-morbid conditions are associated with obesity are being elucidated...
  51. ncbi Orlistat in the treatment of Type 2 diabetes mellitus
    David E Kelley
    810N Montefiore University Hospital, University of Pittsburgh, 3459 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Expert Opin Pharmacother 3:599-605. 2002
    ..Data on > 2500 orlistat-treated patients with DM-2 are reviewed and summarised. Orlistat therapy led to greater weight loss and improved metabolic control in overweight and obese patients with DM-2...
  52. ncbi Skeletal muscle triglyceride: marker or mediator of obesity-induced insulin resistance in type 2 diabetes mellitus?
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, 3459 Fifth Avenue, 810N MUH, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Curr Diab Rep 2:216-22. 2002
    ..Defining mechanisms by which dysregulation of fatty acid metabolism and persistent lipid oversupply alter insulin action may help to target more effective strategies to prevent or treat type 2 diabetes...
  53. ncbi Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance
    D E Kelley
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Diabetes Care 24:933-41. 2001
    ....
  54. pmc Dynamic PET Imaging Reveals Heterogeneity of Skeletal Muscle Insulin Resistance
    Jason M Ng
    Division of Endocrinology and Metabolism Department of Medicine J M N, N L H, B H G and Departments of Radiology D S M, J C P and Health and Physical Activity P M C, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15231 Department of Information Engineering A B, C C, University of Padova, Padova, Italy and Merck, Sharp, and Dohme Corporation D E K, Rahway, New Jersey 07065
    J Clin Endocrinol Metab 99:E102-6. 2014
    ..Conclusion: Lower glucose transport rates are the major feature underlying IR preceding type 2 diabetes, although substantial heterogeneity in insulin action across muscle types highlight the complexity of skeletal muscle IR. ..
  55. ncbi Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus
    Koichiro Azuma
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Endocrinol Metab 293:E435-42. 2007
    ..In summary, T2DM, compared with similarly obese nondiabetic men and women, is associated with less leg FM and greater trunk FM and hepatic fat...
  56. pmc Skeletal muscle fat oxidation: timing and flexibility are everything
    David E Kelley
    Obesity and Nutrition Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Invest 115:1699-702. 2005
    ..These findings support the concept that the capacity of skeletal muscle to oxidize fat under appropriate physiological conditions is related to leanness, aerobic fitness, and insulin sensitivity...
  57. ncbi Skeletal muscle lipid concentration quantified by magnetic resonance imaging
    Bret H Goodpaster
    Department of Medicine, 809 North MUH, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 79:748-54. 2004
    ..Skeletal muscle lipid is associated with obesity and type 2 diabetes and may be altered by diet, physical activity, and weight loss...
  58. ncbi Quantitative assessment of glucose transport in human skeletal muscle: dynamic positron emission tomography imaging of [O-methyl-11C]3-O-methyl-D-glucose
    Alessandra Bertoldo
    Montefiore University Hospital, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 90:1752-9. 2005
    ..We conclude that dynamic PET imaging of [(11)C]3-OMG offers a novel quantitative approach that is both chemically specific and tissue specific for in vivo assessment of glucose transport in human skeletal muscle...
  59. ncbi Clinical importance of obesity versus the metabolic syndrome in cardiovascular risk in women: a report from the Women's Ischemia Syndrome Evaluation (WISE) study
    Kevin E Kip
    Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Circulation 109:706-13. 2004
    ..Both are associated with cardiovascular disease (CVD). However, the contribution of obesity to cardiovascular risk, independent of the presence of the metabolic syndrome, remains controversial...
  60. pmc A role of apolipoprotein D in triglyceride metabolism
    German Perdomo
    Rangos Research Center, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    J Lipid Res 51:1298-311. 2010
    ..These data provide important clues to clinical observations that genetic variants of apoD are associated with abnormal lipid metabolism and increased risk of metabolic syndrome...
  61. ncbi Induction of leptin resistance through direct interaction of C-reactive protein with leptin
    Ke Chen
    Department of Cell Biology and Physiology, University of Pittsburgh, 3500 Terrace Street, BST S 326, Pittsburgh, Pennsylvania 15261, USA
    Nat Med 12:425-32. 2006
    ..Thus, our results suggest a potential mechanism contributing to leptin resistance, by which circulating CRP binds to leptin and attenuates its physiological functions...
  62. ncbi Synthesis and mass spectrometry of benzoxazoline, dimethyloxazoline and 4-phenyloxazoline derivatives of polyunsaturated fatty acids
    Cyrous O Kangani
    Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Rapid Commun Mass Spectrom 21:2129-36. 2007
    ..A comparison of the mass spectral properties of the three derivatives of these saturated and unsaturated fatty acids is described...
  63. ncbi The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes
    K V Williams
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Diabetes Care 21:2-8. 1998
    ..To determine whether an intermittent very-low-calorie diet (VLCD) improves weight loss and glycemic control more than moderate caloric restriction alone...
  64. ncbi Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study
    B H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Appl Physiol (1985) 90:2157-65. 2001
    ..These results demonstrate that the attenuation values of muscle on computed tomography in older persons can account for differences in muscle strength not attributed to muscle quantity...
  65. ncbi Acute effects of intraperitoneal versus subcutaneous insulin delivery on glucose homeostasis in patients with NIDDM. Veterans Affairs Implantable Insulin Pump Study Group
    D E Kelley
    Pittsburgh Veterans Affairs Medical Center, Pennsylvania, USA
    Diabetes Care 19:1237-42. 1996
    ..The objective of this study is to compare the effect of intraperitoneal versus subcutaneous insulin injection on hepatic glucose production (HGP) and systemic glucose utilization (Rd) in patients with NIDDM...
  66. ncbi Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content
    B H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Appl Physiol (1985) 89:104-10. 2000
    ....
  67. ncbi Composition of skeletal muscle evaluated with computed tomography
    B H Goodpaster
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Ann N Y Acad Sci 904:18-24. 2000
    ....
  68. ncbi Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
    B H Goodpaster
    Departments of Endocrinology and Metabolism and Radiology, University of Pittsburgh, PA 15261, USA
    Am J Clin Nutr 71:885-92. 2000
    ..Adipose tissue (AT) content of the thigh is generally not considered to be associated with insulin resistance (IR), but it is unclear whether the distribution of AT in the thigh is a determinant of IR...
  69. ncbi Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 277:E1130-41. 1999
    ....
  70. ncbi Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 277:E361-9. 1999
    ..91, P < 0.001). These findings indicate an important interaction between transport and phosphorylation in the control of insulin-stimulated glucose metabolism in skeletal muscle...
  71. ncbi The analog free testosterone assay: are the results in men clinically useful?
    S J Winters
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, PA 15213, USA
    Clin Chem 44:2178-82. 1998
    ..Moreover, the previous findings of reduced free testosterone concentrations with hypertension or hyperinsulinemia or as a risk factor for developing type 2 diabetes, conditions in which SHBG is reduced, may have been methodology-related...
  72. ncbi Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes
    B H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 86:5755-61. 2001
    ..In conclusion, the capacity for lipid oxidation may be an important mediator of the association between excess muscle lipid accumulation and insulin resistance...
  73. pmc The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    J Clin Invest 97:2705-13. 1996
    ....
  74. doi Lower thigh subcutaneous and higher visceral abdominal adipose tissue content both contribute to insulin resistance
    Francesca Amati
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Obesity (Silver Spring) 20:1115-7. 2012
    ..This strongly suggests that these two distinct fat distribution phenotypes should both be considered in IR as important determinants of cardiometabolic risk...
  75. pmc Activity patterns of obese adults with type 2 diabetes in the look AHEAD study
    John M Jakicic
    Department of Health and Physical Activity, Physical Activity and Weight Management Research Center, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Med Sci Sports Exerc 42:1995-2005. 2010
    ..This study describes baseline physical activity (PA) patterns of individuals with type 2 diabetes mellitus (T2DM) enrolled in the multicenter Look AHEAD Study using an objective measure of PA (accelerometry)...
  76. ncbi Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat
    A E Tsirka
    Department of Pediatrics, Division of Neonatology and Developmental Biology, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Endocrinol 169:373-80. 2001
    ..We speculate that this reduced GLUT gene expression and glucose uptake contribute towards mortality from ischemic heart disease seen in adults born with IUGR...
  77. pmc New method for GC/FID and GC-C-IRMS analysis of plasma free fatty acid concentration and isotopic enrichment
    Cyrous O Kangani
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 873:95-101. 2008
    ..The present method provided accurate and precise measures of concentration as well as enrichment when analyzed with gas chromatography combustion-isotope ratio-mass spectrometry...
  78. ncbi Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity
    J He
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Diabetes 50:817-23. 2001
    ..01). In summary, based on single-fiber analysis, skeletal muscle in obese and type 2 diabetic subjects mani-fests disturbances of oxidative enzyme activity and increased lipid content that are independent of the effect of fiber type...
  79. ncbi Derivatization of F2-isoprostanes with 1-pyrenyldiazomethane and their subsequent determination by fluorescence high-performance liquid chromatography
    Vladimir B Ritov
    Department of Medicine, School of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, 3459 Fifth Avenue, MUH N809, Pittsburgh, PA 15213 3236, USA
    Anal Biochem 311:10-8. 2002
    ..The purified 1-pyrenylmethyl esters of PGF(2alpha) were quantitatively analyzed by reverse-phase HPLC with fluorescent detection, with a detection limit of 5-10 pg...
  80. ncbi Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study
    Julie C Price
    PET Facility, Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop St, Rm B938, Pittsburgh, PA 15213, USA
    Brain Res 927:97-103. 2002
    ..02). These findings support previous studies that suggest serotonergic underpinnings to the neurobiology of diabetes and have shown diabetes-induced neurological changes in hippocampus...
  81. ncbi Hexokinase isozyme distribution in human skeletal muscle
    V B Ritov
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Diabetes 50:1253-62. 2001
    ..Thus, within the particulate fraction, the relative contributions of hexokinase I and hexokinase II were 81 and 19%, whereas within the cytosolic fraction, the relative contributions for hexokinase I and hexokinase II were 37 and 63%...
  82. pmc Decreased expression of adipogenic genes in obese subjects with type 2 diabetes
    Severine G Dubois
    Health and Performance Enhancement Division, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:1543-52. 2006
    ..The inability of the adipose tissue to recruit new fat cells may cause ectopic fat deposition and insulin resistance...
  83. pmc The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it
    Thomas A Wadden
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA corrected
    Obesity (Silver Spring) 14:737-52. 2006
    ..After Year 4, participants are offered monthly individual visits. The intervention is delivered by a multidisciplinary team that includes medical staff who monitor participants at risk of hypoglycemic episodes...
  84. ncbi Metabolic flexibility
    Len Storlien
    AstraZeneca R and D, Pepparedsleden 3, Mölndal 431 83, Sweden
    Proc Nutr Soc 63:363-8. 2004
    ..Key questions that remain are how metabolic flexibility is lost in obese and diabetic individuals and by what means it may be regained...
  85. pmc Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial
    Xavier Pi-Sunyer
    St Luke s Roosevelt Hospital Center, USA
    Diabetes Care 30:1374-83. 2007
    ..This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events...
  86. ncbi Interactions between delivery, transport, and phosphorylation of glucose in governing uptake into human skeletal muscle
    Alessandra Bertoldo
    Department of Information Engineering, University of Padova, Italy
    Diabetes 55:3028-37. 2006
    ..This redistribution of control is triggered by the robust stimulation of glucose transport, which in turn unmasks a greater dependence upon delivery and glucose phosphorylation...
  87. pmc Relationship of body mass index with demographic and clinical characteristics in the Longitudinal Assessment of Bariatric Surgery (LABS)
    Steven H Belle
    Surg Obes Relat Dis 4:474-80. 2008
    ..BMI is often used to characterize patient risk in bariatric surgery. However, its relationship with other risk factors has not been well characterized...
  88. pmc Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate
    Jose E Galgani
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 57:841-5. 2008
    ....
  89. pmc Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans
    Satish C Kalhan
    Schwartz Center for Nutrition and Metabolism, MetroHealth Center, Cleveland, OH 44109, USA
    Metabolism 57:305-12. 2008
    ..The contribution of glyceroneogenesis to triglyceride-glycerol is not affected by short (4 hours) infusion of insulin in type 2 diabetes mellitus...
  90. ncbi Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome
    Neil B Ruderman
    Section of Endocrinology, Diabetes Unit, Boston Medical Center, 650 Albany St, X 820, Boston, MA 02118, USA
    Diabetes 55:S48-54. 2006
    ....
  91. ncbi Effect of creatine supplementation and a lacto-ovo-vegetarian diet on muscle creatine concentration
    Judith M Lukaszuk
    Department of Nutrition Dietetics and Hospitality Administration at Northern Illinois University, DeKalb, IL 60115, USA
    Int J Sport Nutr Exerc Metab 12:336-48. 2002
    ..However, muscle total creatine (TCr) following creatine supplementation did not differ statistically between LOV and Omni diet groups (148.6 4.5 vs. 141.7 4.5 mmol kg-1 d.m.)...
  92. ncbi Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, Saint Louis, Missouri 63110, USA
    Obesity (Silver Spring) 15:1061-7. 2007
  93. ncbi Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Center for Human Nutrition and the Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 85:1197-202. 2007
  94. pmc Muscle-associated triglyceride measured by computed tomography and magnetic resonance spectroscopy
    D Enette Larson-Meyer
    Department of Family and Consumer Sciences Human Nutrition, Department 3354, College of Agriculture, 1000 East University Avenue, Laramie, WY 82071, USA
    Obesity (Silver Spring) 14:73-87. 2006
    ..Little is known, however, about the cross-correlation between these techniques and their test-retest reliability...
  95. pmc Potential role of increased matrix metalloproteinase-2 (MMP2) transcription in impaired adipogenesis in type 2 diabetes mellitus
    Severine G Dubois
    Health and Performance Enhancement Division, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 367:725-8. 2008
    ..32, p=0.03). We conclude that early steps of adipogenesis may be impaired in T2DM independently of obesity due, in part, to an upregulation of the MMP2 transcription...
  96. ncbi Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes Care 30:1647-52. 2007