D E Kelley

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 277:E1130-41. 1999
  2. ncbi request reprint Effect of exercise intensity on glucose and insulin metabolism in obese individuals and obese NIDDM patients
    J Kang
    Department of Health and Physical Education, University of Pittsburgh, Pennsylvania, USA
    Diabetes Care 19:341-9. 1996
  3. pmc The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    J Clin Invest 97:2705-13. 1996
  4. ncbi request reprint Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
    B H Goodpaster
    Departments of Endocrinology and Metabolism and Radiology, University of Pittsburgh, PA 15261, USA
    Am J Clin Nutr 71:885-92. 2000
  5. ncbi request reprint Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance
    D E Kelley
    Division of Endocrinology and Metabolism, Department of Medicine, and Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Endocrinol Metab 278:E941-8. 2000
  6. ncbi request reprint Interactions of impaired glucose transport and phosphorylation in skeletal muscle insulin resistance: a dose-response assessment using positron emission tomography
    K V Williams
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Diabetes 50:2069-79. 2001
  7. ncbi request reprint The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes
    K V Williams
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Diabetes Care 21:2-8. 1998
  8. ncbi request reprint Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 277:E361-9. 1999
  9. ncbi request reprint Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content
    B H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Appl Physiol 89:104-10. 2000
  10. ncbi request reprint Assessing skeletal muscle glucose metabolism with positron emission tomography
    D E Kelley
    Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pennsylvania 15213, USA
    IUBMB Life 52:279-84. 2001

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 277:E1130-41. 1999
    ....
  2. ncbi request reprint Effect of exercise intensity on glucose and insulin metabolism in obese individuals and obese NIDDM patients
    J Kang
    Department of Health and Physical Education, University of Pittsburgh, Pennsylvania, USA
    Diabetes Care 19:341-9. 1996
    ..The primary purpose of this study was to evaluate the acute effect of exercise of differing intensity on plasma glucose and insulin responses to an oral glucose challenge...
  3. pmc The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    J Clin Invest 97:2705-13. 1996
    ....
  4. ncbi request reprint Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
    B H Goodpaster
    Departments of Endocrinology and Metabolism and Radiology, University of Pittsburgh, PA 15261, USA
    Am J Clin Nutr 71:885-92. 2000
    ..Adipose tissue (AT) content of the thigh is generally not considered to be associated with insulin resistance (IR), but it is unclear whether the distribution of AT in the thigh is a determinant of IR...
  5. ncbi request reprint Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance
    D E Kelley
    Division of Endocrinology and Metabolism, Department of Medicine, and Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Endocrinol Metab 278:E941-8. 2000
    ..We conclude that there are two functionally distinct compartments of adipose tissue within abdominal subcutaneous fat and that the deep SAT has a strong relation to insulin resistance...
  6. ncbi request reprint Interactions of impaired glucose transport and phosphorylation in skeletal muscle insulin resistance: a dose-response assessment using positron emission tomography
    K V Williams
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Diabetes 50:2069-79. 2001
    ..05). These findings indicate an important interaction between transport and phosphorylation in the insulin resistance of obesity and type 2 diabetes...
  7. ncbi request reprint The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes
    K V Williams
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Diabetes Care 21:2-8. 1998
    ..To determine whether an intermittent very-low-calorie diet (VLCD) improves weight loss and glycemic control more than moderate caloric restriction alone...
  8. ncbi request reprint Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 277:E361-9. 1999
    ..91, P < 0.001). These findings indicate an important interaction between transport and phosphorylation in the control of insulin-stimulated glucose metabolism in skeletal muscle...
  9. ncbi request reprint Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content
    B H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Appl Physiol 89:104-10. 2000
    ....
  10. ncbi request reprint Assessing skeletal muscle glucose metabolism with positron emission tomography
    D E Kelley
    Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pennsylvania 15213, USA
    IUBMB Life 52:279-84. 2001
    ....
  11. ncbi request reprint Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance
    D E Kelley
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Diabetes Care 24:933-41. 2001
    ....
  12. ncbi request reprint Composition of skeletal muscle evaluated with computed tomography
    B H Goodpaster
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Ann N Y Acad Sci 904:18-24. 2000
    ....
  13. ncbi request reprint Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study
    B H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Appl Physiol 90:2157-65. 2001
    ..These results demonstrate that the attenuation values of muscle on computed tomography in older persons can account for differences in muscle strength not attributed to muscle quantity...
  14. ncbi request reprint Effects of physical activity on insulin action and glucose tolerance in obesity
    D E Kelley
    Department of Medicine, University of Pittsburgh School of Medicine, PA 15261, USA
    Med Sci Sports Exerc 31:S619-23. 1999
    ..The purpose of this paper is to examine the effect of physical activity on glucose tolerance in relation to obesity...
  15. ncbi request reprint Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes
    B H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 86:5755-61. 2001
    ..In conclusion, the capacity for lipid oxidation may be an important mediator of the association between excess muscle lipid accumulation and insulin resistance...
  16. ncbi request reprint Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity
    J He
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Diabetes 50:817-23. 2001
    ..01). In summary, based on single-fiber analysis, skeletal muscle in obese and type 2 diabetic subjects mani-fests disturbances of oxidative enzyme activity and increased lipid content that are independent of the effect of fiber type...
  17. ncbi request reprint Effects of exercise on glucose homeostasis in Type 2 diabetes mellitus
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Med Sci Sports Exerc 33:S495-501; discussion S528-9. 2001
    ..This review has evaluated the effectiveness of physical activity in the treatment and prevention of Type 2 diabetes mellitus (DM)...
  18. ncbi request reprint The analog free testosterone assay: are the results in men clinically useful?
    S J Winters
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, PA 15213, USA
    Clin Chem 44:2178-82. 1998
    ..Moreover, the previous findings of reduced free testosterone concentrations with hypertension or hyperinsulinemia or as a risk factor for developing type 2 diabetes, conditions in which SHBG is reduced, may have been methodology-related...
  19. ncbi request reprint Plasma fatty acids, adiposity, and variance of skeletal muscle insulin resistance in type 2 diabetes mellitus
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 86:5412-9. 2001
    ....
  20. ncbi request reprint Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat
    A E Tsirka
    Department of Pediatrics, Division of Neonatology and Developmental Biology, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Endocrinol 169:373-80. 2001
    ..We speculate that this reduced GLUT gene expression and glucose uptake contribute towards mortality from ischemic heart disease seen in adults born with IUGR...
  21. doi request reprint High energy expenditure masks low physical activity in obesity
    J P DeLany
    Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, Pittsburgh, PA 15213, USA
    Int J Obes (Lond) 37:1006-11. 2013
    ..To investigate energy expenditure in lean and obese individuals, focusing particularly on physical activity and severely obese individuals...
  22. ncbi request reprint Hexokinase isozyme distribution in human skeletal muscle
    V B Ritov
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Diabetes 50:1253-62. 2001
    ..Thus, within the particulate fraction, the relative contributions of hexokinase I and hexokinase II were 81 and 19%, whereas within the cytosolic fraction, the relative contributions for hexokinase I and hexokinase II were 37 and 63%...
  23. ncbi request reprint Approaches to preventing mealtime hyperglycaemic excursions
    D E Kelley
    Division of Endocrinology and Metabolism, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Diabetes Obes Metab 4:11-8. 2002
  24. ncbi request reprint Is type 2 diabetes a chronic inflammatory/autoimmune disease?
    M A Syed
    Diabetes Nutr Metab 15:68-83. 2002
    ....
  25. ncbi request reprint Hypoglycemic potential of nateglinide versus glyburide in patients with type 2 diabetes mellitus
    V A Fonseca
    Tulane University Medical Center, Endocrinology Department, New Orleans, LA 70112, USA
    Metabolism 53:1331-5. 2004
    ....
  26. doi request reprint Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes
    J E Foley
    Novartis Pharmaceutical Corporation, One Health Plaza, East Hanover, NJ 07936, USA
    Horm Metab Res 40:727-30. 2008