Research Topics
Species | Ann E KelleySummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and rewardAnn E Kelley
Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
Physiol Behav 86:773-95. 2005....- Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learningAnn E Kelley
Department of Psychiatry and Neuroscience Program, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
Neurosci Biobehav Rev 27:765-76. 2004..g. lever pressing and delivery of reward) become associated. Such basic mechanisms of plasticity within this reinforcement learning network also appear to be profoundly affected in addiction... 
Acute stress and nicotine cues interact to unveil locomotor arousal and activity-dependent gene expression in the prefrontal cortexCraig A Schiltz
Neuroscience Training Program, University of Wisconsin Madison Medical School, Madison, Wisconsin 53719, USA
Biol Psychiatry 61:127-35. 2007..This study examines the interactive effects of acute stress and nicotine-associated contextual cues on locomotor activity and activity-dependent gene expression in subregions of the prefrontal cortex...- Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feedingBrian A Baldo
Department of Psychiatry, University of Wisconsin Madison School of Medicine and Public Health, 6001 Research Park Blvd, Madison, WI, 53719, USA
Psychopharmacology (Berl) 191:439-59. 2007.... - Dynamic shifts in corticostriatal expression patterns of the immediate early genes Homer 1a and Zif268 during early and late phases of instrumental trainingPepe J Hernandez
University of Wisconsin School of Medicine, Department of Psychiatry, Madison, Wisconsin 53719, USA
Learn Mem 13:599-608. 2006.... - AMPA/kainate, NMDA, and dopamine D1 receptor function in the nucleus accumbens core: a context-limited role in the encoding and consolidation of instrumental memoryPepe J Hernandez
Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
Learn Mem 12:285-95. 2005..Thus, glutamate and dopamine receptors are activated in a time-limited fashion-only being required while the animals are actively engaged in the learning context... - Dissociating ventral and dorsal subicular dopamine D1 receptor involvement in instrumental learning, spontaneous motor behavior, and motivationMatthew E Andrzejewski
Department of Psychiatry, University of Wisconsin Madison, WI 53719, USA
Behav Neurosci 120:542-53. 2006..Further, D1 activation in the vSUB may be a critical component of motivational arousal associated with learned contextual cues... - Hyperphagia induced by GABAA receptor-mediated inhibition of the nucleus accumbens shell: dependence on intact neural output from the central amygdaloid regionBrian A Baldo
Department of Psychiatry, School of Medicine, University of Wisconsin Madison, 6001 Research Park Boulevard, WI 53719, USA
Behav Neurosci 119:1195-206. 2005..Intra-CeA tetrodotoxin infusions also blocked intra-Acb shell muscimol-induced hyperphagia. Hence, feeding elicited by intra-Acb shell GABA(A) receptor stimulation requires intact neural output from the CeA but not the BLA... - Glutamate-mediated plasticity in corticostriatal networks: role in adaptive motor learningAnn E Kelley
Department of Psychiatry and Neuroscience Training Program, University of Wisconsin-Madison Medical School, 6001 Research Park Boulevard, Madison, Wisconsin 53719, USA
Ann N Y Acad Sci 1003:159-68. 2003..g., lever pressing and delivery of reward) become associated. Such basic mechanisms of plasticity within this reinforcement learning network also appear to be profoundly affected in addiction... - Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expressionCraig A Schiltz
Medical Scientist and Neuroscience Training Programs, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI 53705, USA
BMC Biol 5:16. 2007..We used immediate early gene and proenkephalin expression as a means of assessing food cue-elicited regional activation and alterations in functional connectivity within the forebrain... 
The dendritically targeted protein Dendrin is induced by acute nicotine in cortical regions of adolescent rat brainTerri L Schochet
Neuroscience Training Program, University of Wisconsin Madison, Madison, WI 53706, USA
Eur J Neurosci 28:1967-79. 2008..As Dendrin is an important component of cytoskeletal modifications at the synapse, these results suggest that nicotine influences unique plasticity-related changes in the adolescent forebrain that differ from the adult...- A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food rewardAnn E Kelley
Department of Psychiatry, University of Wisconsin Madison Medical School, Madison, Wisconsin 53719, USA
J Comp Neurol 493:72-85. 2005.... - Striatal muscarinic receptor antagonism reduces 24-h food intake in association with decreased preproenkephalin gene expressionWayne E Pratt
Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
Eur J Neurosci 22:3229-40. 2005.... - Operant learning requires NMDA-receptor activation in the anterior cingulate cortex and dorsomedial striatum, but not in the orbitofrontal cortexBrenda L McKee
Department of Psychiatry, University of Wisconsin, Madison, 53705, USA
Behav Neurosci 124:500-9. 2010..These data extend our understanding of the role of NMDA receptors in operant learning and behavior throughout an extended corticostriatal network... - Muscarinic receptor antagonism causes a functional alteration in nucleus accumbens mu-opiate-mediated feeding behaviorMichelle L Perry
Molecular and Cellular Pharmacology, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
Behav Brain Res 197:225-9. 2009..Hence, Acb muscarinic manipulations exhibit some specificity for feeding, perhaps via interactions with the striatal opioid system... - Central amygdalar and dorsal striatal NMDA receptor involvement in instrumental learning and spontaneous behaviorMatthew E Andrzejewski
Department of Psychiatry, University of Wisconsin Madison Medical School, Madison, WI 53719, USA
Behav Neurosci 118:715-29. 2004..The present findings extend knowledge of the dynamic neurophysiological processes, instantiated in a complex neural network, required for instrumental learning in the mammalian brain... - Striatal opioid peptide gene expression differentially tracks short-term satiety but does not vary with negative energy balance in a manner opposite to hypothalamic NPYMatthew J Will
Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
Am J Physiol Regul Integr Comp Physiol 292:R217-26. 2007..This double dissociation between striatal and hypothalamic peptide systems suggests a specific role for striatal PPE in relatively short-term food motivational states, but not in long-term metabolic responses to diet restriction... - Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptorsWayne E Pratt
Wisconsin Psychiatric Institute and Clinics, Department of Psychiatry, University of Wisconsin Madison Medical School, Madison, WI 53719, USA
Behav Neurosci 118:730-9. 2004..These novel results implicate nucleus accumbens muscarinic receptors in the modulation of appetitive learning, performance, and motivation for food... - Neural systems recruited by drug- and food-related cues: studies of gene activation in corticolimbic regionsAnn E Kelley
Department of Psychiatry, University of Wisconsin Madison Medical School, 53719, USA
Physiol Behav 86:11-4. 2005..These considerations may have important implications for the pharmacological and cognitive-behavioral treatments of substance use disorders, addiction, eating disorders, and obesity... - The amygdala is critical for opioid-mediated binge eating of fatMatthew J Will
Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
Neuroreport 15:1857-60. 2004..In summary, we demonstrate that amygdala inactivation prevents the intra-accumbens opioid induced "binge" eating of fat, possibly through reducing the hedonic properties of high-fat palatable food... - Activation of a subpopulation of orexin/hypocretin-containing hypothalamic neurons by GABAA receptor-mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environmentBrian A Baldo
Department of Psychiatry, University of Madison Wisconsin, School of Medicine, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
Eur J Neurosci 19:376-86. 2004.... - Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive functionCraig W Berridge
Psychology Department, University of Wisconsin, Madison, WI 53706, USA
Biol Psychiatry 60:1111-20. 2006..Moreover, dopamine (DA) and norepinephrine (NE) are important modulators of PFC-dependent cognition. To date, the actions of low-dose psychostimulants on PFC DA and NE neurotransmission are unknown... - Contextual cues associated with nicotine administration increase arc mRNA expression in corticolimbic areas of the rat brainCraig A Schiltz
Neuroscience Training Program and Medical Scientist Training Program, Department of Psychiatry, University of Wisconsin-Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
Eur J Neurosci 21:1703-11. 2005..Further work will be needed in order to assess the role of arc expression in the extinction of conditioned responses to drug-paired cues... - A comparison of adult and adolescent rat behavior in operant learning, extinction, and behavioral inhibition paradigmsMatthew E Andrzejewski
University of Wisconsin Madison, Waisman Center, 1500 Highland Avenue, Madison, WI 53719, USA
Behav Neurosci 125:93-105. 2011.... - Long-term memory for instrumental responses does not undergo protein synthesis-dependent reconsolidation upon retrievalPepe J Hernandez
Department of Psychiatry and Neuroscience Training Program, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
Learn Mem 11:748-54. 2004..Thus, these data suggest that memory for a well-learned instrumental response does not require protein synthesis-dependent reconsolidation as a means of long-term maintenance... - Increases in food intake or food-seeking behavior induced by GABAergic, opioid, or dopaminergic stimulation of the nucleus accumbens: is it hunger?Erin C Hanlon
Neuroscience Training Program, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
Psychopharmacology (Berl) 172:241-7. 2004..However, it is not known whether such stimulation mimics a motivational state of food deprivation that commonly enables animals to learn a new operant response to obtain food... - Vertebrate GLD2 poly(A) polymerases in the germline and the brainLabib Rouhana
Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
RNA 11:1117-30. 2005..We suggest that mammalian GLD2 poly(A) polymerases are important in synaptic translation, and in polyadenylation throughout the soma... - Worms clear the smoke surrounding nicotine addictionAnn E Kelley
Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53705, USA
Cell 127:460-2. 2006..These authors show a critical link between nicotinic receptors and TRP channels, which may represent a new therapeutic target for treating nicotine addiction... - Is extinction the hallmark of operant discrimination? Reinforcement and S(Delta) effectsMatthew E Andrzejewski
University of Wisconsin Madison, Madison, WI 53719, USA
Behav Processes 74:49-63. 2007..In sum, it appears that higher reinforcement rates and longer S(Delta) exposure facilitate the acquisition of discriminated operant responding... - Effects of selective dopamine D1 or D2 receptor blockade within nucleus accumbens subregions on ingestive behavior and associated motor activityBrian A Baldo
Department of Psychiatry, University of Wisconsin-Madison Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
Behav Brain Res 137:165-77. 2002..These results are discussed with regard to current theories of dopaminergic control of feeding behavior, and with reference to the functional heterogeneity of Acb subregions... - Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stressBrian A Baldo
Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
J Comp Neurol 464:220-37. 2003.... - Differential behavioral effects of nicotine exposure in adolescent and adult ratsTerri L Schochet
Neuroscience Training Program, University of Wisconsin Madison, Madison, WI 53719, USA
Psychopharmacology (Berl) 175:265-73. 2004..An important question is whether adolescents and adults differ in the development of nicotine sensitization and drug-cue conditioning... - REM sleep deprivation produces a motivational deficit for food reward that is reversed by intra-accumbens amphetamine in ratsErin C Hanlon
University of Wisconsin Madison, 53719, USA
Brain Res Bull 83:245-54. 2010..These data suggest that decreased motivation for food reward caused by REMSD may result from a suppression of dopamine function in the Acb... - Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbensPepe J Hernandez
Neuroscience Training Program, University of Wisconsin Madison, 7226 Medical Sciences Center, 1300 University Avenue, Madison, Wisconsin 53706, USA
Nat Neurosci 5:1327-31. 2002..These results show that de novo protein synthesis within the NAc is necessary for the consolidation, but not reconsolidation, of appetitive instrumental memories... - Appetitive instrumental learning is impaired by inhibition of cAMP-dependent protein kinase within the nucleus accumbensAnne E Baldwin
Neuroscience Training Program, University of Wisconsin Madison Medical School, 53719 1176, USA
Neurobiol Learn Mem 77:44-62. 2002.... - Memory and addiction: shared neural circuitry and molecular mechanismsAnn E Kelley
Department of Psychiatry and Neuroscience Training Program, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
Neuron 44:161-79. 2004.... - Risk taking and novelty seeking in adolescence: introduction to part IAnn E Kelley
Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
Ann N Y Acad Sci 1021:27-32. 2004..Moreover, the investigation of mammalian animal models of adolescence-such as those examining impulsivity, reward sensitivity, and decision making-may also provide new opportunities for addressing the problem of adolescent vulnerability... - Cracking addiction the second time around: reconsolidation of drug-related memoriesPepe J Hernandez
Department of Psychiatry and Neuroscience Training Program, University of Wisconsin-Madison Medical School, 6001 Research Park Boulevard, Madison, Wisconsin 53719, USA
Neuron 47:772-5. 2005..reported in this issue of Neuron demonstrate that retrieved drug-related memories undergo reconsolidation and thus suggest that these maladaptive associations may be more labile than previously thought... - The neuroscience of natural rewards: relevance to addictive drugsAnn E Kelley
Department of Psychiatry, University of Wisconsin-Madison Medical School, Madison, Wisconsin 53719, USA
J Neurosci 22:3306-11. 2002 - Accessories to addiction: G protein regulators play a key role in cocaine seeking and neuroplasticityAnn E Kelley
Department of Psychiatry, Neuroscience Training Program and Medical Scientist Training Program, University of Wisconsin-Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53705, USA
Neuron 42:181-3. 2004..Furthermore, they find that AGS3 is responsible for altered behavior, such as enhanced drug seeking, and altered neurotransmission in cocaine-treated rats, representing a novel therapeutic target... - Appetitive instrumental learning requires coincident activation of NMDA and dopamine D1 receptors within the medial prefrontal cortexAnne E Baldwin
Neuroscience Training Program and Department of Psychiatry, University of Wisconsin-Madison Medical School, Madison Wisconsin 53719-1176, USA
J Neurosci 22:1063-71. 2002.... - Intake of saccharin, salt, and ethanol solutions is increased by infusion of a mu opioid agonist into the nucleus accumbensMin Zhang
Department of Psychiatry, University of Wisconsin-Madison, 53719, USA
Psychopharmacology (Berl) 159:415-23. 2002..In addition, the nucleus accumbens may be a key brain area where ethanol interacts with endogenous opioid systems, and thus may be a common neural substrate for both food palatability and alcohol drinking... - Neural activation profile elicited by cues associated with the anxiogenic drug yohimbine differs from that observed for reward-paired cuesBrock E Schroeder
Department of Psychology, Arizona State University, Tempe, AZ, USA
Neuropsychopharmacology 28:14-21. 2003..These observations show a neural activation profile elicited by cues associated with the anxiogenic drug yohimbine and further support the hypothesis that prefrontal cortex has a specific role in reward expectancy... - Pharmacological characterization of high-fat feeding induced by opioid stimulation of the ventral striatumMatthew J Will
Department of Psychological Sciences, University of Missouri, Columbia, Christopher Bond Life Sciences Center, 1201 Rollins St, Columbia, MO 65211, United States
Physiol Behav 89:226-34. 2006.... - Nucleus accumbens opioid, GABaergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the ratMin Zhang
Department of Psychiatry, University of Wisconsin-Madison Medical School, 53715, USA
Behav Neurosci 117:202-11. 2003.... - The effect of REM sleep deprivation on motivation for food rewardErin C Hanlon
Neuroscience Training Program, University of Wisconsin-Madison, WI, USA
Behav Brain Res 163:58-69. 2005..Rather, REM sleep deprivation appears to alter systems involved in motivational processes, reward, and/or attention... - Muscarinic receptor antagonism of the nucleus accumbens core causes avoidance to flavor and spatial cuesWayne E Pratt
Department of Psychology, Wake Forest University, Winston Salem, NC 27109, USA
Behav Neurosci 121:1215-23. 2007.... - Nicotinic receptors: addiction's smoking gun?Ann E Kelley
Nat Med 8:447-9. 2002 - Conditioned Fos expression following morphine-paired contextual cue exposure is environment specificBrock E Schroeder
Department of Psychology, Arizona State University, USA
Behav Neurosci 116:727-32. 2002.... - Obituary: Dr Ann E. Kelley (1954-2007)T W Robbins
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
Psychopharmacology (Berl) 196:341-2. 2008