Ann E Kelley

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward
    Ann E Kelley
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
    Physiol Behav 86:773-95. 2005
  2. ncbi Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning
    Ann E Kelley
    Department of Psychiatry and Neuroscience Program, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Neurosci Biobehav Rev 27:765-76. 2004
  3. pmc Acute stress and nicotine cues interact to unveil locomotor arousal and activity-dependent gene expression in the prefrontal cortex
    Craig A Schiltz
    Neuroscience Training Program, University of Wisconsin Madison Medical School, Madison, Wisconsin 53719, USA
    Biol Psychiatry 61:127-35. 2007
  4. ncbi Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding
    Brian A Baldo
    Department of Psychiatry, University of Wisconsin Madison School of Medicine and Public Health, 6001 Research Park Blvd, Madison, WI, 53719, USA
    Psychopharmacology (Berl) 191:439-59. 2007
  5. pmc Dynamic shifts in corticostriatal expression patterns of the immediate early genes Homer 1a and Zif268 during early and late phases of instrumental training
    Pepe J Hernandez
    University of Wisconsin School of Medicine, Department of Psychiatry, Madison, Wisconsin 53719, USA
    Learn Mem 13:599-608. 2006
  6. pmc AMPA/kainate, NMDA, and dopamine D1 receptor function in the nucleus accumbens core: a context-limited role in the encoding and consolidation of instrumental memory
    Pepe J Hernandez
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    Learn Mem 12:285-95. 2005
  7. pmc Dissociating ventral and dorsal subicular dopamine D1 receptor involvement in instrumental learning, spontaneous motor behavior, and motivation
    Matthew E Andrzejewski
    Department of Psychiatry, University of Wisconsin Madison, WI 53719, USA
    Behav Neurosci 120:542-53. 2006
  8. ncbi Hyperphagia induced by GABAA receptor-mediated inhibition of the nucleus accumbens shell: dependence on intact neural output from the central amygdaloid region
    Brian A Baldo
    Department of Psychiatry, School of Medicine, University of Wisconsin Madison, 6001 Research Park Boulevard, WI 53719, USA
    Behav Neurosci 119:1195-206. 2005
  9. ncbi Glutamate-mediated plasticity in corticostriatal networks: role in adaptive motor learning
    Ann E Kelley
    Department of Psychiatry and Neuroscience Training Program, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, Wisconsin 53719, USA
    Ann N Y Acad Sci 1003:159-68. 2003
  10. pmc Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression
    Craig A Schiltz
    Medical Scientist and Neuroscience Training Programs, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI 53705, USA
    BMC Biol 5:16. 2007

Detail Information

Publications50

  1. ncbi Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward
    Ann E Kelley
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
    Physiol Behav 86:773-95. 2005
    ....
  2. ncbi Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning
    Ann E Kelley
    Department of Psychiatry and Neuroscience Program, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Neurosci Biobehav Rev 27:765-76. 2004
    ..g. lever pressing and delivery of reward) become associated. Such basic mechanisms of plasticity within this reinforcement learning network also appear to be profoundly affected in addiction...
  3. pmc Acute stress and nicotine cues interact to unveil locomotor arousal and activity-dependent gene expression in the prefrontal cortex
    Craig A Schiltz
    Neuroscience Training Program, University of Wisconsin Madison Medical School, Madison, Wisconsin 53719, USA
    Biol Psychiatry 61:127-35. 2007
    ..This study examines the interactive effects of acute stress and nicotine-associated contextual cues on locomotor activity and activity-dependent gene expression in subregions of the prefrontal cortex...
  4. ncbi Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding
    Brian A Baldo
    Department of Psychiatry, University of Wisconsin Madison School of Medicine and Public Health, 6001 Research Park Blvd, Madison, WI, 53719, USA
    Psychopharmacology (Berl) 191:439-59. 2007
    ....
  5. pmc Dynamic shifts in corticostriatal expression patterns of the immediate early genes Homer 1a and Zif268 during early and late phases of instrumental training
    Pepe J Hernandez
    University of Wisconsin School of Medicine, Department of Psychiatry, Madison, Wisconsin 53719, USA
    Learn Mem 13:599-608. 2006
    ....
  6. pmc AMPA/kainate, NMDA, and dopamine D1 receptor function in the nucleus accumbens core: a context-limited role in the encoding and consolidation of instrumental memory
    Pepe J Hernandez
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    Learn Mem 12:285-95. 2005
    ..Thus, glutamate and dopamine receptors are activated in a time-limited fashion-only being required while the animals are actively engaged in the learning context...
  7. pmc Dissociating ventral and dorsal subicular dopamine D1 receptor involvement in instrumental learning, spontaneous motor behavior, and motivation
    Matthew E Andrzejewski
    Department of Psychiatry, University of Wisconsin Madison, WI 53719, USA
    Behav Neurosci 120:542-53. 2006
    ..Further, D1 activation in the vSUB may be a critical component of motivational arousal associated with learned contextual cues...
  8. ncbi Hyperphagia induced by GABAA receptor-mediated inhibition of the nucleus accumbens shell: dependence on intact neural output from the central amygdaloid region
    Brian A Baldo
    Department of Psychiatry, School of Medicine, University of Wisconsin Madison, 6001 Research Park Boulevard, WI 53719, USA
    Behav Neurosci 119:1195-206. 2005
    ..Intra-CeA tetrodotoxin infusions also blocked intra-Acb shell muscimol-induced hyperphagia. Hence, feeding elicited by intra-Acb shell GABA(A) receptor stimulation requires intact neural output from the CeA but not the BLA...
  9. ncbi Glutamate-mediated plasticity in corticostriatal networks: role in adaptive motor learning
    Ann E Kelley
    Department of Psychiatry and Neuroscience Training Program, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, Wisconsin 53719, USA
    Ann N Y Acad Sci 1003:159-68. 2003
    ..g., lever pressing and delivery of reward) become associated. Such basic mechanisms of plasticity within this reinforcement learning network also appear to be profoundly affected in addiction...
  10. pmc Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression
    Craig A Schiltz
    Medical Scientist and Neuroscience Training Programs, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI 53705, USA
    BMC Biol 5:16. 2007
    ..We used immediate early gene and proenkephalin expression as a means of assessing food cue-elicited regional activation and alterations in functional connectivity within the forebrain...
  11. doi The dendritically targeted protein Dendrin is induced by acute nicotine in cortical regions of adolescent rat brain
    Terri L Schochet
    Neuroscience Training Program, University of Wisconsin Madison, Madison, WI 53706, USA
    Eur J Neurosci 28:1967-79. 2008
    ..As Dendrin is an important component of cytoskeletal modifications at the synapse, these results suggest that nicotine influences unique plasticity-related changes in the adolescent forebrain that differ from the adult...
  12. ncbi A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward
    Ann E Kelley
    Department of Psychiatry, University of Wisconsin Madison Medical School, Madison, Wisconsin 53719, USA
    J Comp Neurol 493:72-85. 2005
    ....
  13. ncbi Striatal muscarinic receptor antagonism reduces 24-h food intake in association with decreased preproenkephalin gene expression
    Wayne E Pratt
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Eur J Neurosci 22:3229-40. 2005
    ....
  14. doi Operant learning requires NMDA-receptor activation in the anterior cingulate cortex and dorsomedial striatum, but not in the orbitofrontal cortex
    Brenda L McKee
    Department of Psychiatry, University of Wisconsin, Madison, 53705, USA
    Behav Neurosci 124:500-9. 2010
    ..These data extend our understanding of the role of NMDA receptors in operant learning and behavior throughout an extended corticostriatal network...
  15. pmc Muscarinic receptor antagonism causes a functional alteration in nucleus accumbens mu-opiate-mediated feeding behavior
    Michelle L Perry
    Molecular and Cellular Pharmacology, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Behav Brain Res 197:225-9. 2009
    ..Hence, Acb muscarinic manipulations exhibit some specificity for feeding, perhaps via interactions with the striatal opioid system...
  16. pmc Central amygdalar and dorsal striatal NMDA receptor involvement in instrumental learning and spontaneous behavior
    Matthew E Andrzejewski
    Department of Psychiatry, University of Wisconsin Madison Medical School, Madison, WI 53719, USA
    Behav Neurosci 118:715-29. 2004
    ..The present findings extend knowledge of the dynamic neurophysiological processes, instantiated in a complex neural network, required for instrumental learning in the mammalian brain...
  17. ncbi Striatal opioid peptide gene expression differentially tracks short-term satiety but does not vary with negative energy balance in a manner opposite to hypothalamic NPY
    Matthew J Will
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
    Am J Physiol Regul Integr Comp Physiol 292:R217-26. 2007
    ..This double dissociation between striatal and hypothalamic peptide systems suggests a specific role for striatal PPE in relatively short-term food motivational states, but not in long-term metabolic responses to diet restriction...
  18. ncbi Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors
    Wayne E Pratt
    Wisconsin Psychiatric Institute and Clinics, Department of Psychiatry, University of Wisconsin Madison Medical School, Madison, WI 53719, USA
    Behav Neurosci 118:730-9. 2004
    ..These novel results implicate nucleus accumbens muscarinic receptors in the modulation of appetitive learning, performance, and motivation for food...
  19. ncbi Neural systems recruited by drug- and food-related cues: studies of gene activation in corticolimbic regions
    Ann E Kelley
    Department of Psychiatry, University of Wisconsin Madison Medical School, 53719, USA
    Physiol Behav 86:11-4. 2005
    ..These considerations may have important implications for the pharmacological and cognitive-behavioral treatments of substance use disorders, addiction, eating disorders, and obesity...
  20. ncbi The amygdala is critical for opioid-mediated binge eating of fat
    Matthew J Will
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
    Neuroreport 15:1857-60. 2004
    ..In summary, we demonstrate that amygdala inactivation prevents the intra-accumbens opioid induced "binge" eating of fat, possibly through reducing the hedonic properties of high-fat palatable food...
  21. ncbi Activation of a subpopulation of orexin/hypocretin-containing hypothalamic neurons by GABAA receptor-mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment
    Brian A Baldo
    Department of Psychiatry, University of Madison Wisconsin, School of Medicine, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
    Eur J Neurosci 19:376-86. 2004
    ....
  22. ncbi Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function
    Craig W Berridge
    Psychology Department, University of Wisconsin, Madison, WI 53706, USA
    Biol Psychiatry 60:1111-20. 2006
    ..Moreover, dopamine (DA) and norepinephrine (NE) are important modulators of PFC-dependent cognition. To date, the actions of low-dose psychostimulants on PFC DA and NE neurotransmission are unknown...
  23. pmc Contextual cues associated with nicotine administration increase arc mRNA expression in corticolimbic areas of the rat brain
    Craig A Schiltz
    Neuroscience Training Program and Medical Scientist Training Program, Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Eur J Neurosci 21:1703-11. 2005
    ..Further work will be needed in order to assess the role of arc expression in the extinction of conditioned responses to drug-paired cues...
  24. doi A comparison of adult and adolescent rat behavior in operant learning, extinction, and behavioral inhibition paradigms
    Matthew E Andrzejewski
    University of Wisconsin Madison, Waisman Center, 1500 Highland Avenue, Madison, WI 53719, USA
    Behav Neurosci 125:93-105. 2011
    ....
  25. pmc Long-term memory for instrumental responses does not undergo protein synthesis-dependent reconsolidation upon retrieval
    Pepe J Hernandez
    Department of Psychiatry and Neuroscience Training Program, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    Learn Mem 11:748-54. 2004
    ..Thus, these data suggest that memory for a well-learned instrumental response does not require protein synthesis-dependent reconsolidation as a means of long-term maintenance...
  26. ncbi Increases in food intake or food-seeking behavior induced by GABAergic, opioid, or dopaminergic stimulation of the nucleus accumbens: is it hunger?
    Erin C Hanlon
    Neuroscience Training Program, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Psychopharmacology (Berl) 172:241-7. 2004
    ..However, it is not known whether such stimulation mimics a motivational state of food deprivation that commonly enables animals to learn a new operant response to obtain food...
  27. pmc Vertebrate GLD2 poly(A) polymerases in the germline and the brain
    Labib Rouhana
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    RNA 11:1117-30. 2005
    ..We suggest that mammalian GLD2 poly(A) polymerases are important in synaptic translation, and in polyadenylation throughout the soma...
  28. ncbi Worms clear the smoke surrounding nicotine addiction
    Ann E Kelley
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53705, USA
    Cell 127:460-2. 2006
    ..These authors show a critical link between nicotinic receptors and TRP channels, which may represent a new therapeutic target for treating nicotine addiction...
  29. pmc Is extinction the hallmark of operant discrimination? Reinforcement and S(Delta) effects
    Matthew E Andrzejewski
    University of Wisconsin Madison, Madison, WI 53719, USA
    Behav Processes 74:49-63. 2007
    ..In sum, it appears that higher reinforcement rates and longer S(Delta) exposure facilitate the acquisition of discriminated operant responding...
  30. ncbi Effects of selective dopamine D1 or D2 receptor blockade within nucleus accumbens subregions on ingestive behavior and associated motor activity
    Brian A Baldo
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
    Behav Brain Res 137:165-77. 2002
    ..These results are discussed with regard to current theories of dopaminergic control of feeding behavior, and with reference to the functional heterogeneity of Acb subregions...
  31. ncbi Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress
    Brian A Baldo
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
    J Comp Neurol 464:220-37. 2003
    ....
  32. ncbi Differential behavioral effects of nicotine exposure in adolescent and adult rats
    Terri L Schochet
    Neuroscience Training Program, University of Wisconsin Madison, Madison, WI 53719, USA
    Psychopharmacology (Berl) 175:265-73. 2004
    ..An important question is whether adolescents and adults differ in the development of nicotine sensitization and drug-cue conditioning...
  33. pmc REM sleep deprivation produces a motivational deficit for food reward that is reversed by intra-accumbens amphetamine in rats
    Erin C Hanlon
    University of Wisconsin Madison, 53719, USA
    Brain Res Bull 83:245-54. 2010
    ..These data suggest that decreased motivation for food reward caused by REMSD may result from a suppression of dopamine function in the Acb...
  34. ncbi Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens
    Pepe J Hernandez
    Neuroscience Training Program, University of Wisconsin Madison, 7226 Medical Sciences Center, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Neurosci 5:1327-31. 2002
    ..These results show that de novo protein synthesis within the NAc is necessary for the consolidation, but not reconsolidation, of appetitive instrumental memories...
  35. ncbi Appetitive instrumental learning is impaired by inhibition of cAMP-dependent protein kinase within the nucleus accumbens
    Anne E Baldwin
    Neuroscience Training Program, University of Wisconsin Madison Medical School, 53719 1176, USA
    Neurobiol Learn Mem 77:44-62. 2002
    ....
  36. ncbi Memory and addiction: shared neural circuitry and molecular mechanisms
    Ann E Kelley
    Department of Psychiatry and Neuroscience Training Program, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Neuron 44:161-79. 2004
    ....
  37. ncbi Risk taking and novelty seeking in adolescence: introduction to part I
    Ann E Kelley
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Ann N Y Acad Sci 1021:27-32. 2004
    ..Moreover, the investigation of mammalian animal models of adolescence-such as those examining impulsivity, reward sensitivity, and decision making-may also provide new opportunities for addressing the problem of adolescent vulnerability...
  38. ncbi Cracking addiction the second time around: reconsolidation of drug-related memories
    Pepe J Hernandez
    Department of Psychiatry and Neuroscience Training Program, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, Wisconsin 53719, USA
    Neuron 47:772-5. 2005
    ..reported in this issue of Neuron demonstrate that retrieved drug-related memories undergo reconsolidation and thus suggest that these maladaptive associations may be more labile than previously thought...
  39. ncbi The neuroscience of natural rewards: relevance to addictive drugs
    Ann E Kelley
    Department of Psychiatry, University of Wisconsin Madison Medical School, Madison, Wisconsin 53719, USA
    J Neurosci 22:3306-11. 2002
  40. ncbi Accessories to addiction: G protein regulators play a key role in cocaine seeking and neuroplasticity
    Ann E Kelley
    Department of Psychiatry, Neuroscience Training Program and Medical Scientist Training Program, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53705, USA
    Neuron 42:181-3. 2004
    ..Furthermore, they find that AGS3 is responsible for altered behavior, such as enhanced drug seeking, and altered neurotransmission in cocaine-treated rats, representing a novel therapeutic target...
  41. ncbi Appetitive instrumental learning requires coincident activation of NMDA and dopamine D1 receptors within the medial prefrontal cortex
    Anne E Baldwin
    Neuroscience Training Program and Department of Psychiatry, University of Wisconsin Madison Medical School, Madison Wisconsin 53719 1176, USA
    J Neurosci 22:1063-71. 2002
    ....
  42. ncbi Intake of saccharin, salt, and ethanol solutions is increased by infusion of a mu opioid agonist into the nucleus accumbens
    Min Zhang
    Department of Psychiatry, University of Wisconsin Madison, 53719, USA
    Psychopharmacology (Berl) 159:415-23. 2002
    ..Our previous studies have shown that mu opioid stimulation of the nucleus accumbens preferentially augments intake of palatable food containing sucrose and fat...
  43. ncbi Neural activation profile elicited by cues associated with the anxiogenic drug yohimbine differs from that observed for reward-paired cues
    Brock E Schroeder
    Department of Psychology, Arizona State University, Tempe, AZ, USA
    Neuropsychopharmacology 28:14-21. 2003
    ..These observations show a neural activation profile elicited by cues associated with the anxiogenic drug yohimbine and further support the hypothesis that prefrontal cortex has a specific role in reward expectancy...
  44. ncbi Pharmacological characterization of high-fat feeding induced by opioid stimulation of the ventral striatum
    Matthew J Will
    Department of Psychological Sciences, University of Missouri, Columbia, Christopher Bond Life Sciences Center, 1201 Rollins St, Columbia, MO 65211, United States
    Physiol Behav 89:226-34. 2006
    ....
  45. ncbi Nucleus accumbens opioid, GABaergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the rat
    Min Zhang
    Department of Psychiatry, University of Wisconsin Madison Medical School, 53715, USA
    Behav Neurosci 117:202-11. 2003
    ....
  46. ncbi The effect of REM sleep deprivation on motivation for food reward
    Erin C Hanlon
    Neuroscience Training Program, University of Wisconsin Madison, WI, USA
    Behav Brain Res 163:58-69. 2005
    ..Rather, REM sleep deprivation appears to alter systems involved in motivational processes, reward, and/or attention...
  47. ncbi Muscarinic receptor antagonism of the nucleus accumbens core causes avoidance to flavor and spatial cues
    Wayne E Pratt
    Department of Psychology, Wake Forest University, Winston Salem, NC 27109, USA
    Behav Neurosci 121:1215-23. 2007
    ....
  48. ncbi Nicotinic receptors: addiction's smoking gun?
    Ann E Kelley
    Nat Med 8:447-9. 2002
  49. ncbi Conditioned Fos expression following morphine-paired contextual cue exposure is environment specific
    Brock E Schroeder
    Department of Psychology, Arizona State University, USA
    Behav Neurosci 116:727-32. 2002
    ....
  50. ncbi Obituary: Dr Ann E. Kelley (1954-2007)
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 196:341-2. 2008