Nancy P Keller

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Fungal secondary metabolism - from biochemistry to genomics
    Nancy P Keller
    University of Wisconsin Madison, Department of Plant Pathology, 882 Russell Labs, 1630 Linden Drive, Madison, Wisconsin 53706, USA
    Nat Rev Microbiol 3:937-47. 2005
  2. pmc Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus
    S Horowitz Brown
    Department of Medical Microbiology and Immunology and Department of Plant Pathology, UW Madison, 1550 Linden Dr, Madison, WI 53706, USA
    Appl Environ Microbiol 74:5674-85. 2008
  3. pmc Endogenous lipogenic regulators of spore balance in Aspergillus nidulans
    Dimitrios I Tsitsigiannis
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Eukaryot Cell 3:1398-411. 2004
  4. pmc GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, 882 Russell Labs, 1630 Linden Drive, Madison, WI 53706, USA
    Infect Immun 74:6761-8. 2006
  5. doi request reprint Reciprocal oxylipin-mediated cross-talk in the Aspergillus-seed pathosystem
    Marion Brodhagen
    Department of Plant Pathology, University of Wisconsin Madison, 1630 Linden Dr, Madison, WI 53706 1598, USA
    Mol Microbiol 67:378-91. 2008
  6. ncbi request reprint Three putative oxylipin biosynthetic genes integrate sexual and asexual development in Aspergillus nidulans
    Dimitrios I Tsitsigiannis
    Department of Plant Pathology, University of Wisconsin Madison, WI 53706, USA
    Microbiology 151:1809-21. 2005
  7. ncbi request reprint Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters
    D Ryan Georgianna
    Department of Plant Pathology, Center for Integrated Fungal Research, North Carolina State University, Raleigh, NC 27695, USA
    Mol Plant Pathol 11:213-26. 2010
  8. pmc Chromatin-level regulation of biosynthetic gene clusters
    Jin Woo Bok
    Department of Medical Microbiology and Immunology formerly Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Chem Biol 5:462-4. 2009
  9. pmc A single acyl-CoA dehydrogenase is required for catabolism of isoleucine, valine and short-chain fatty acids in Aspergillus nidulans
    Lori A Maggio-Hall
    Department of Plant Pathology, University of Wisconsin Madison, 882 Russell Labs, 1630 Linden Drive, Madison, WI 53706, USA
    Fungal Genet Biol 45:180-9. 2008
  10. ncbi request reprint Fundamental contribution of beta-oxidation to polyketide mycotoxin production in planta
    Lori A Maggio-Hall
    Department of Plant Pathology, University of Wisconsin Madison, 1630 Linden Drive, Madison, WI 53706, USA
    Mol Plant Microbe Interact 18:783-93. 2005

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Fungal secondary metabolism - from biochemistry to genomics
    Nancy P Keller
    University of Wisconsin Madison, Department of Plant Pathology, 882 Russell Labs, 1630 Linden Drive, Madison, Wisconsin 53706, USA
    Nat Rev Microbiol 3:937-47. 2005
    ....
  2. pmc Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus
    S Horowitz Brown
    Department of Medical Microbiology and Immunology and Department of Plant Pathology, UW Madison, 1550 Linden Dr, Madison, WI 53706, USA
    Appl Environ Microbiol 74:5674-85. 2008
    ....
  3. pmc Endogenous lipogenic regulators of spore balance in Aspergillus nidulans
    Dimitrios I Tsitsigiannis
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Eukaryot Cell 3:1398-411. 2004
    ..The second loop suggests Ppo oxylipin products antagonistically signal the generation of Ppo substrates. These data support a case for a fungal "oxylipin signature-profile" indicative of relative sexual and asexual spore differentiation...
  4. pmc GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, 882 Russell Labs, 1630 Linden Drive, Madison, WI 53706, USA
    Infect Immun 74:6761-8. 2006
    ..This may indicate that several secondary metabolites are involved in A. fumigatus virulence...
  5. doi request reprint Reciprocal oxylipin-mediated cross-talk in the Aspergillus-seed pathosystem
    Marion Brodhagen
    Department of Plant Pathology, University of Wisconsin Madison, 1630 Linden Dr, Madison, WI 53706 1598, USA
    Mol Microbiol 67:378-91. 2008
    ..This report provides the first genetic evidence for reciprocal oxylipin cross-talk in the Aspergillus-seed pathosystem...
  6. ncbi request reprint Three putative oxylipin biosynthetic genes integrate sexual and asexual development in Aspergillus nidulans
    Dimitrios I Tsitsigiannis
    Department of Plant Pathology, University of Wisconsin Madison, WI 53706, USA
    Microbiology 151:1809-21. 2005
    ..Phylogenetic analyses showed that ppo genes are present in both saprophytic and pathogenic Ascomycetes and Basidiomycetes, suggesting a conserved role for Ppo enzymes in the life cycle of fungi...
  7. ncbi request reprint Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters
    D Ryan Georgianna
    Department of Plant Pathology, Center for Integrated Fungal Research, North Carolina State University, Raleigh, NC 27695, USA
    Mol Plant Pathol 11:213-26. 2010
    ..Aflatoxin and CPA were found to have unique regulation, but are sufficiently similar that they would be expected to co-occur in substrates colonized with A. flavus...
  8. pmc Chromatin-level regulation of biosynthetic gene clusters
    Jin Woo Bok
    Department of Medical Microbiology and Immunology formerly Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Chem Biol 5:462-4. 2009
    ..Modification of the chromatin landscape in fungal secondary metabolite clusters allows for a simple technological means to express silent fungal secondary metabolite gene clusters...
  9. pmc A single acyl-CoA dehydrogenase is required for catabolism of isoleucine, valine and short-chain fatty acids in Aspergillus nidulans
    Lori A Maggio-Hall
    Department of Plant Pathology, University of Wisconsin Madison, 882 Russell Labs, 1630 Linden Drive, Madison, WI 53706, USA
    Fungal Genet Biol 45:180-9. 2008
    ....
  10. ncbi request reprint Fundamental contribution of beta-oxidation to polyketide mycotoxin production in planta
    Lori A Maggio-Hall
    Department of Plant Pathology, University of Wisconsin Madison, 1630 Linden Drive, Madison, WI 53706, USA
    Mol Plant Microbe Interact 18:783-93. 2005
    ....
  11. doi request reprint Real-time and semiquantitative RT-PCR methods to analyze gene expression patterns during Aspergillus-host interactions
    Jin Woo Bok
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USA
    Methods Mol Biol 470:151-67. 2009
    ..Moreover, these techniques can be employed for routine screening of large numbers of aspergilli to improve diagnosis, disease monitoring, and therapy of fungal disease...
  12. pmc VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation
    Jin Woo Bok
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA
    Mol Microbiol 89:963-74. 2013
    ..Finally, deletion of gcnE in the ΔveA background abolishes ors cluster activation and F9775 production. Together, this work supports a role for VeA and MvlA in modifying SAGA/ADA complex activity. ..
  13. pmc Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production
    Alexandra A Soukup
    Department of Genetics, University of Wisconsin Madison, 1550 Linden Drive, Madison, WI 53706, USA
    Mol Microbiol 86:314-30. 2012
    ..H4K12 levels may thus represent a unique indicator of relative production potential, notably of SMs...
  14. pmc Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA
    Robyn M Perrin
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 3:e50. 2007
    ..Our findings suggest that LaeA is a novel target for comprehensive modification of chemical diversity and pathogenicity...
  15. ncbi request reprint Characterization of the Aspergillus parasiticus delta12-desaturase gene: a role for lipid metabolism in the Aspergillus-seed interaction
    Richard A Wilson
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Microbiology 150:2881-8. 2004
    ....
  16. pmc LaeA, a regulator of secondary metabolism in Aspergillus spp
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Eukaryot Cell 3:527-35. 2004
    ....
  17. pmc Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites
    Erwin Berthier
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 9:e1003289. 2013
    ..The tools developed here will open new "function-omic" avenues downstream of the metabolomics, identification, and purification phases...
  18. ncbi request reprint Oxylipins act as determinants of natural product biosynthesis and seed colonization in Aspergillus nidulans
    Dimitrios I Tsitsigiannis
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Microbiol 59:882-92. 2006
    ..These results indicate that oxylipin production is important for host colonization and mycotoxin production and may provide a promising target for future control strategies...
  19. pmc Defects in conidiophore development and conidium-macrophage interactions in a dioxygenase mutant of Aspergillus fumigatus
    Taylor R T Dagenais
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Infect Immun 76:3214-20. 2008
    ..These experiments implicate oxylipins in pathogen development and suggest that Delta ppoC represents a useful model for studying the A. fumigatus-host interaction...
  20. doi request reprint Oxygenase coordination is required for morphological transition and the host-fungus interaction of Aspergillus flavus
    Sigal Horowitz Brown
    Department of Plant Pathology, University of Wisconsin Madison, Madison 53706 1598, USA
    Mol Plant Microbe Interact 22:882-94. 2009
    ..These studies provide substantial evidence for oxylipin-based mechanisms in governing fungus-seed interactions and in regulating a coordinated quorum-sensing mechanism in A. flavus...
  21. pmc RsmA regulates Aspergillus fumigatus gliotoxin cluster metabolites including cyclo(L-Phe-L-Ser), a potential new diagnostic marker for invasive aspergillosis
    Relebohile Sekonyela
    Department of Bacteriology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 8:e62591. 2013
    ..2 fold higher in OErsmA treatment). The data here presents a conserved role for RsmA in secondary metabolite cluster activation and suggests cyclo(L-Phe-L-Ser) may serve as an alternative marker for diagnosis of invasive aspergillosis...
  22. pmc Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi
    Fang Yun Lim
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USA
    Methods Enzymol 517:303-24. 2012
    ..Capitalizing on the current knowledge on how secondary metabolite gene clusters are regulated has allowed the research community to unlock many hidden fungal treasures, as described in this chapter...
  23. ncbi request reprint Aspergillus flavus
    Saori Amaike
    Department of Plant Pathology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Annu Rev Phytopathol 49:107-33. 2011
    ..flavus in competitive exclusion studies. In this review, we discuss A. flavus as an agricultural and medical threat and summarize recent research advances in genomics, elucidation of parameters of pathogenicity, and control measures...
  24. pmc Secondary metabolism in fungi: does chromosomal location matter?
    Jonathan M Palmer
    Plant Pathology Department, University of Wisconsin, Madison, WI 53706, USA
    Curr Opin Microbiol 13:431-6. 2010
    ..Secondary metabolite gene clusters are often located subtelomerically and recently it has been shown that proteins involved in chromatin remodeling, such as LaeA, ClrD, CclA, and HepA mediate cluster regulation...
  25. ncbi request reprint Secondary metabolic gene cluster silencing in Aspergillus nidulans
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, 1630 Linden Drive, WI 53706, USA
    Mol Microbiol 61:1636-45. 2006
    ..Site-specific mutation of an s-adenosyl methionine (AdoMet) binding site in LaeA generated a DeltalaeA phenotype suggesting the protein to be a methyltransferase...
  26. pmc The bZIP protein MeaB mediates virulence attributes in Aspergillus flavus
    Saori Amaike
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 8:e74030. 2013
    ..MeaB and LaeA appear to be part of regulatory networks that allow them to have both shared and distinct roles in fungal biology. ..
  27. pmc Cryptic Aspergillus nidulans antimicrobials
    Steve S Giles
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, WI 53706, USA
    Appl Environ Microbiol 77:3669-75. 2011
    ..The ability of catalase to diminish this antimicrobial activity implicates reactive oxygen species generation, specifically, the generation of hydrogen peroxide, as the mechanism of emodin hydroxyl activity...
  28. pmc An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR
    Wen Bing Yin
    Departments of Medical Microbiology and Immunology Plant Pathology Genetics Bacteriology, University of Wisconsin Madison, WI, USA
    Mol Microbiol 83:1024-34. 2012
    ..RsmA may thus have a critical function in mediating direct chemical resistance against predation. Taken together, these results suggest RsmA represents a bZIP pathway hardwired for defensive SM production...
  29. pmc Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer
    Taylor R T Dagenais
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, 3467 Microbial Sciences, 1550 Linden Drive, Madison, WI 53706, USA
    Infect Immun 78:823-9. 2010
    ..We theorize that RodAp acts as an antiphagocytic molecule, possibly via physicochemical means and/or by impeding MAMP recognition by macrophage receptors...
  30. ncbi request reprint Blockage of methylcitrate cycle inhibits polyketide production in Aspergillus nidulans
    Yong Qiang Zhang
    Department of Plant Pathology, University of Wisconsin, 1630 Linden Drive, Madison, WI 53706, USA
    Mol Microbiol 52:541-50. 2004
    ..We hypothesize that excess buildup of propionyl-CoA in mcsA mutants interferes with polyketide synthase activity...
  31. pmc LaeA, a regulator of morphogenetic fungal virulence factors
    Jin Woo Bok
    University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Eukaryot Cell 4:1574-82. 2005
    ..LaeA, a conserved protein in filamentous fungi, is a developmental regulator of virulence genes and, possibly, the first antimicrobial target specific to filamentous fungi that are pathogenic to plants and animals...
  32. pmc NosA, a transcription factor important in Aspergillus fumigatus stress and developmental response, rescues the germination defect of a laeA deletion
    Alexandra A Soukup
    Department of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Fungal Genet Biol 49:857-65. 2012
    ..nidulans ΔnosA background. Likewise, the A. nidulans nosA allele was able to restore the menadione sensitivity defect of the A. fumigatus ΔnosA strain, suggesting conservation of function of the NosA protein in these two species...
  33. pmc H3K9 methylation regulates growth and development in Aspergillus fumigatus
    Jonathan M Palmer
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin, USA
    Eukaryot Cell 7:2052-60. 2008
    ..Sensitivity of DeltaAfclrD to 6-azauracil suggests that ClrD influences transcriptional processing in A. fumigatus. Despite growth abnormalities, macrophage assays suggest ClrD may be dispensable for host interactions...
  34. ncbi request reprint Two Delta9-stearic acid desaturases are required for Aspergillus nidulans growth and development
    Richard A Wilson
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Fungal Genet Biol 41:501-9. 2004
    ..Taken together, our results suggest a role for sdeA in growth and development at all temperatures, while sdeB is involved in growth and development at lower temperatures...
  35. pmc Connection of propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans
    Yong Qiang Zhang
    Department of Plant Pathology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 168:785-94. 2004
    ..These results demonstrate that excessive propionyl-CoA levels in the cell can inhibit polyketide synthesis...
  36. pmc Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans
    Steven S Giles
    Department of Biomolecular Chemistry, University of Wisconsin Madison, USA
    Infect Immun 77:3491-500. 2009
    ..We anticipate these results will serve as the basis for a model to further investigate the pathogenic implications of infections caused by fungal spores...
  37. pmc Distinct roles for VeA and LaeA in development and pathogenesis of Aspergillus flavus
    Saori Amaike
    Department of Plant Patholog, University of Wisconsin Madison, Wisconsin 53706 1598, USA
    Eukaryot Cell 8:1051-60. 2009
    ..This study revealed unique roles of VeA and LaeA in seed pathogenesis and fungal biology, distinct from their cooperative regulatory functions in aflatoxin and sclerotial development...
  38. ncbi request reprint Mitochondrial beta-oxidation in Aspergillus nidulans
    Lori A Maggio-Hall
    Department of Plant Pathology, University of Wisconsin Madison, 882 Russell Labs, 1630 Linden Drive, Madison, WI 53706, USA
    Mol Microbiol 54:1173-85. 2004
    ..EchA was also required for growth on isoleucine and valine. The subcellular localization of the FoxA and EchA proteins was confirmed through the use of red and green fluorescent protein fusions...
  39. ncbi request reprint Genomic mining for Aspergillus natural products
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin, Madison, 53706, USA
    Chem Biol 13:31-7. 2006
    ..nidulans. In this paper, we highlight that LaeA-based genome mining helps decipher the secondary metabolome of Aspergilli and provides an unparalleled view to assess secondary metabolism gene regulation...
  40. pmc Prototype of an intertwined secondary-metabolite supercluster
    Philipp Wiemann
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI 53706
    Proc Natl Acad Sci U S A 110:17065-70. 2013
    ..This blended design confounds predictions from established secondary-metabolite cluster search algorithms and provides an expanded view of natural product evolution. ..
  41. pmc Secondary metabolism and development is mediated by LlmF control of VeA subcellular localization in Aspergillus nidulans
    Jonathan M Palmer
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Genet 9:e1003193. 2013
    ..This study identifies a new interaction partner for VeA and highlights the importance of cellular compartmentalization of VeA for regulation of development and secondary metabolism...
  42. pmc Histone deacetylase activity regulates chemical diversity in Aspergillus
    E Keats Shwab
    Plant Pathology Department, Russell Laboratories, University of Wisconsin Madison, 1630 Linden Drive, Madison, WI 53706, USA
    Eukaryot Cell 6:1656-64. 2007
    ..Chromatin regulation of small-molecule gene clusters may enable filamentous fungi to successfully exploit environmental resources by modifying chemical diversity...
  43. ncbi request reprint Aspergillus infection inhibits the expression of peanut 13S-HPODE-forming seed lipoxygenases
    Dimitrios I Tsitsigiannis
    Department of Plant Pathology, University of Wisconsin Madison, Madison 53706, USA
    Mol Plant Microbe Interact 18:1081-9. 2005
    ..flavus infection. The results of these studies suggest that 9S-HPODE and 13S-HPODE molecules act as putative susceptibility and resistance factors respectively, in Aspergillus seed-aflatoxin interactions...
  44. pmc A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus
    Wen Bing Yin
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Wisconsin 53706, USA
    J Am Chem Soc 135:2064-7. 2013
    ..Comparative metabolomics of different mutant strains allowed to propose a pathway for HAS biosynthesis and further revealed cross-talk with another NRPS pathway producing the anticancer fumitremorgins...
  45. pmc Fast and easy method for construction of plasmid vectors using modified quick-change mutagenesis
    Jin Woo Bok
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, WI, USA
    Methods Mol Biol 944:163-74. 2012
    ..Here we introduce a modified Quick-change site-directed mutagenesis method that allows for rapid and accurate construction of fungal transformation vectors...
  46. doi request reprint Regulation of secondary metabolite production in filamentous ascomycetes
    E Keats Shwab
    Plant Pathology Department, University of Wisconsin Madison, Russell Laboratories, 1630 Linden Drive, Madison, WI 53706, USA
    Mycol Res 112:225-30. 2008
    ..This review covers the latest insights into the processes regulating secondary metabolite production in filamentous fungi...
  47. pmc Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans
    Jonathan M Palmer
    Department of Plant Pathology, University of Wisconsin, Madison, WI 53706, USA
    Microbiology 156:3522-31. 2010
    ..This study indicates that TPE extends at least 30 kb on chromosome III, suggesting that this phenomenon may be important for gene regulation in subtelomeric regions of A. nidulans...
  48. pmc Suppressor mutagenesis identifies a velvet complex remediator of Aspergillus nidulans secondary metabolism
    Mona I Shaaban
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, WI 53706, USA
    Eukaryot Cell 9:1816-24. 2010
    ..An intact Velvet complex coupled with an OE::rsmA allele increases SM many fold over the wild-type level, but loss of rsmA does not decrease SM. RsmA encodes a putative bZIP basic leucine zipper-type transcription factor...
  49. pmc Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence
    Dimitrios I Tsitsigiannis
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Infect Immun 73:4548-59. 2005
    ....
  50. pmc bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans
    Wen Bing Yin
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, WI, USA
    Microbiology 159:77-88. 2013
    ..Quantification of bZIP homodimer and heterodimer formation using fluorescence resonance energy transfer (FRET) suggested that these proteins preferentially self-associate...
  51. pmc Aspergillus oxylipin signaling and quorum sensing pathways depend on g protein-coupled receptors
    Katharyn J Affeldt
    Department of Bacteriology and Department of Medical Microbiology and Immunology, 1550 Linden Drive, Madison, WI 53706, USA
    Toxins (Basel) 4:695-717. 2012
    ..The finding of GPCRs that regulate production of survival structures (sclerotia), inoculum (spores) and aflatoxin holds promise for future development of anti-fungal therapeutics...
  52. pmc Loss of CclA, required for histone 3 lysine 4 methylation, decreases growth but increases secondary metabolite production in Aspergillus fumigatus
    Jonathan M Palmer
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, WI, USA
    Peerj 1:e4. 2013
    ..These data indicate that tri- and di-methylation of H3K4 is involved in the regulation of several secondary metabolites in A. fumigatus, however does not contribute to pathogenicity under the conditions tested...
  53. pmc Transcriptional regulatory elements in fungal secondary metabolism
    Wenbing Yin
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, WI 53706, USA
    J Microbiol 49:329-39. 2011
    ..This review summarizes regulation of secondary metabolism associated with transcriptional regulatory elements from a broad view as well as the tremendous advances in discovery of cryptic or novel secondary metabolites by genomic mining...
  54. pmc Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis
    Taylor R T Dagenais
    Medical Microbiology and Immunology, University of Wisconsin Madison, 3467 Microbial Sciences Building, 1550 Linden Drive, Madison, WI 53706, USA
    Clin Microbiol Rev 22:447-65. 2009
    ..fumigatus. Here, we provide an overview of the significant findings regarding A. fumigatus pathogenesis as it pertains to invasive disease...
  55. ncbi request reprint The lipid body protein, PpoA, coordinates sexual and asexual sporulation in Aspergillus nidulans
    Dimitrios I Tsitsigiannis
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 279:11344-53. 2004
    ..PpoA localizes in lipid bodies in these tissues. These data support an important role for oxylipins in integrating mitotic and meiotic spore development...
  56. ncbi request reprint Crossover fungal pathogens: the biology and pathogenesis of fungi capable of crossing kingdoms to infect plants and humans
    Gregory M Gauthier
    University of Wisconsin Madison, Madison, WI, USA Electronic address
    Fungal Genet Biol 61:146-57. 2013
    ..Several genes including veA, laeA, and hapX are important in regulating biological processes in fungi important for both invasive plant and animal infections. ..
  57. ncbi request reprint Strategies for mining fungal natural products
    Philipp Wiemann
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, 3476 Microbial Sciences Building, 1550 Linden Drive, Madison, WI, 53706, USA
    J Ind Microbiol Biotechnol 41:301-13. 2014
    ..This review will cover the latest advances in fungal genome mining undertaken to unlock novel products. ..
  58. pmc Suspended microfluidics
    Benjamin P Casavant
    Carbone Cancer Center, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 110:10111-6. 2013
    ..Suspended microfluidics brings the high degree of fluidic control and unique functionality of closed microfluidics into the highly accessible and robust platform of open microfluidics...
  59. pmc Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus
    Fang Yun Lim
    Department of Bacteriology, University of Wisconsin Madison, Madison, Wisconsin, USA
    Appl Environ Microbiol 78:4117-25. 2012
    ..We discuss a model of the enc cluster as one evolutionary origin of fungal anthraquinones derived from a nonreducing polyketide synthase and a discrete metallo-β-lactamase-type thioesterase...
  60. ncbi request reprint RNA silencing of mycotoxin production in Aspergillus and Fusarium species
    Tami McDonald
    Department of Plant Pathology, University of Wisconsin, Madison, USA
    Mol Plant Microbe Interact 18:539-45. 2005
    ..These results indicate that RNA silencing exists in Aspergillus and Fusarium plant pathogens and suggest that RNA silencing technology may be a useful tool for eliminating mycotoxin contamination of agricultural products...
  61. pmc RNA silencing in Aspergillus nidulans is independent of RNA-dependent RNA polymerases
    T M Hammond
    Department of Plant Pathology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 169:607-17. 2005
    ..nidulans IRT-RNA silencing. These results indicate a lack of conserved kingdom-wide requirements for RDRPs in fungal RNA silencing...
  62. pmc RNA silencing gene truncation in the filamentous fungus Aspergillus nidulans
    T M Hammond
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin 537061, USA
    Eukaryot Cell 7:339-49. 2008
    ..Thus, our results suggest that the remaining A. nidulans RNA silencing genes have a "nonhousekeeping" function, such as defense against viruses and transposons...
  63. pmc Kit-On-A-Lid-Assays for accessible self-contained cell assays
    Erwin Berthier
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, WI, USA
    Lab Chip 13:424-31. 2013
    ..We demonstrate that the KOALA cell-based assays can be simply operated from start to finish without any external laboratory equipment...
  64. ncbi request reprint Requirement of spermidine for developmental transitions in Aspergillus nidulans
    Yuan Jin
    Department of Plant Pathology, Texas A and M University, College Station, TX 77843 2132, USA
    Mol Microbiol 46:801-12. 2002
    ..Suppression of G protein signalling can over-ride the spermidine requirement for the latter but not the former transition...
  65. pmc Pka, Ras and RGS protein interactions regulate activity of AflR, a Zn(II)2Cys6 transcription factor in Aspergillus nidulans
    Kiminori Shimizu
    Department of Plant Pathology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 165:1095-104. 2003
    ..aflR is also transcriptionally and post-transcriptionally regulated by RasA. RasA transcriptional control of aflR is PkaA independent but RasA post-transcriptional control of AflR is partially mediated by PkaA...
  66. pmc Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans
    D W Brown
    Department of Plant Pathology, Texas A and M University, College Station 77843, USA
    Proc Natl Acad Sci U S A 93:1418-22. 1996
    ..A revised system for naming the genes of the ST pathway is presented...
  67. pmc A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans
    Ellen M Fox
    School of Botany, The University of Melbourne, VIC 3010, Australia
    Fungal Genet Biol 45:671-82. 2008
    ..These sites are similar to those commonly bound by other proteins with Zn(II)(2)Cys(6) DNA binding domains...
  68. doi request reprint Paradigm shifts in fungal secondary metabolite research
    Marc Stadler
    InterMed Discovery GmbH, Otto Hahn Strasse 15, D 44227 Dortmund, Germany
    Mycol Res 112:127-30. 2008
    ..Eumycota); and (2) the genetic processes regulating secondary metabolite biosynthesis. The history of fungal chemotaxonomy and some important classes of secondary metabolites are reviewed...
  69. pmc Relationship between secondary metabolism and fungal development
    Ana M Calvo
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    Microbiol Mol Biol Rev 66:447-59, table of contents. 2002
    ....
  70. ncbi request reprint Regulation of aflatoxin synthesis by FadA/cAMP/protein kinase A signaling in Aspergillus parasiticus
    Ludmila V Roze
    Department of Food Science and Human Nutrition, Michigan State University MSU, USA
    Mycopathologia 158:219-32. 2004
    ..and (2) intracellular cAMP levels, at least in part, mediate a PKA-dependent regulatory influence on conidiation and AF synthesis...
  71. pmc veA is required for toxin and sclerotial production in Aspergillus parasiticus
    Ana M Calvo
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    Appl Environ Microbiol 70:4733-9. 2004
    ....
  72. ncbi request reprint Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA
    Sarah Bouhired
    Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Stefan Meier Strasse 19, 79104 Freiburg, Germany
    Fungal Genet Biol 44:1134-45. 2007
    ..Further, this study identifies TdiE as a protein of unknown yet essential function for terrequinone A biosynthesis...
  73. ncbi request reprint VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
    Özgür Bayram
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    Science 320:1504-6. 2008
    ..VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites...
  74. ncbi request reprint Oxylipins as developmental and host-fungal communication signals
    Dimitrios I Tsitsigiannis
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney Lane, Norwich, NR4 7UH, UK
    Trends Microbiol 15:109-18. 2007
    ..these results suggest that host and microbial oxylipins might interfere with the metabolism, perception or signalling processes of each other...
  75. ncbi request reprint Natural products of filamentous fungi: enzymes, genes, and their regulation
    Dirk Hoffmeister
    Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Stefan Meier Strasse 19, 79104 Freiburg, Germany
    Nat Prod Rep 24:393-416. 2007
    ..We have included literature references from 1958, yet the majority of citations are between 1995 and the present. A total of 295 references are cited...