Evan Keller

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Activation of the Wnt pathway through AR79, a GSK3β inhibitor, promotes prostate cancer growth in soft tissue and bone
    Yuan Jiang
    Department of Urology, University of Michigan, 5308 CCGC, 1500 E Medical Center Drive, Ann Arbor, MI 48109 8940
    Mol Cancer Res 11:1597-610. 2013
  2. pmc Understanding and targeting osteoclastic activity in prostate cancer bone metastases
    J L Sottnik
    Department of Urology, University of Michigan, Ann Arbor, MI 48109 8940, USA
    Curr Mol Med 13:626-39. 2013
  3. ncbi request reprint Ovariectomy does not induce osteopenia through interleukin-6 in rhesus monkeys (Macaca mulatta)
    E T Keller
    Department of Pathology, School of Medicine and Institute of Gerontology, University of Michigan, Ann Arbor, USA
    Bone 26:55-62. 2000
  4. ncbi request reprint The use of mature zebrafish (Danio rerio) as a model for human aging and disease
    Evan T Keller
    Department of Urology, University of Michigan School of Medicine, 1500 E Medical Ctr Dr, Ann Arbor, MI 48109 0940, USA
    Comp Biochem Physiol C Toxicol Pharmacol 138:335-41. 2004
  5. ncbi request reprint The role of Raf kinase inhibitor protein (RKIP) in health and disease
    Evan T Keller
    Department of Urology, University of Michigan, Ann Arbor 48109, USA
    Biochem Pharmacol 68:1049-53. 2004
  6. ncbi request reprint Prostate cancer bone metastases promote both osteolytic and osteoblastic activity
    Evan T Keller
    Unit for Laboratory Animal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Cell Biochem 91:718-29. 2004
  7. ncbi request reprint Signal Transduction Pathways as Therapeutic Targets. 25-28 January 2004, Luxembourg
    Evan T Keller
    University of Michigan, Room 5304 CCGCB, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0940, USA
    IDrugs 7:217-22. 2004
  8. ncbi request reprint Metastasis suppressor genes: a role for raf kinase inhibitor protein (RKIP)
    Evan T Keller
    Department of Urology, University of Michigan, Ann Arbor 48109 0940, USA
    Anticancer Drugs 15:663-9. 2004
  9. ncbi request reprint Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene
    Evan T Keller
    Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Lett 207:131-7. 2004
  10. ncbi request reprint The biology of a prostate cancer metastasis suppressor protein: Raf kinase inhibitor protein
    Evan T Keller
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 0940, USA
    J Cell Biochem 94:273-8. 2005

Detail Information

Publications81

  1. pmc Activation of the Wnt pathway through AR79, a GSK3β inhibitor, promotes prostate cancer growth in soft tissue and bone
    Yuan Jiang
    Department of Urology, University of Michigan, 5308 CCGC, 1500 E Medical Center Drive, Ann Arbor, MI 48109 8940
    Mol Cancer Res 11:1597-610. 2013
    ..Furthermore, AR79 increased the ALDH(+)CD133(+) cancer stem cell-like proportion of the prostate cancer cell lines. In conclusion, AR79, while being bone anabolic, promotes prostate cancer cell growth through Wnt pathway activation...
  2. pmc Understanding and targeting osteoclastic activity in prostate cancer bone metastases
    J L Sottnik
    Department of Urology, University of Michigan, Ann Arbor, MI 48109 8940, USA
    Curr Mol Med 13:626-39. 2013
    ..In this review, we describe the processes involved in osteolysis of the prostate cancer bone microenvironment, and introduce therapeutics that may play a role in inhibiting tumor growth leading to increased survival and quality of life...
  3. ncbi request reprint Ovariectomy does not induce osteopenia through interleukin-6 in rhesus monkeys (Macaca mulatta)
    E T Keller
    Department of Pathology, School of Medicine and Institute of Gerontology, University of Michigan, Ann Arbor, USA
    Bone 26:55-62. 2000
    ..These data suggest that modulation of IL-6 is not the key mechanism through which estrogen deprivation mediates bone loss in rhesus monkeys...
  4. ncbi request reprint The use of mature zebrafish (Danio rerio) as a model for human aging and disease
    Evan T Keller
    Department of Urology, University of Michigan School of Medicine, 1500 E Medical Ctr Dr, Ann Arbor, MI 48109 0940, USA
    Comp Biochem Physiol C Toxicol Pharmacol 138:335-41. 2004
    ..These highlights demonstrate the utility of zebrafish as a model for disease and aging...
  5. ncbi request reprint The role of Raf kinase inhibitor protein (RKIP) in health and disease
    Evan T Keller
    Department of Urology, University of Michigan, Ann Arbor 48109, USA
    Biochem Pharmacol 68:1049-53. 2004
    ..Clearly, RKIP has multiple molecular and cellular functions. In this review, RKIP's molecular roles in intracellular signaling, its physiological functions and its role in disease are described...
  6. ncbi request reprint Prostate cancer bone metastases promote both osteolytic and osteoblastic activity
    Evan T Keller
    Unit for Laboratory Animal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Cell Biochem 91:718-29. 2004
    ..Accordingly, the determination of how the prostate cancer cells and bone microenvironment crosstalk are important to elucidate how prostate cancer cells modulate bone remodeling...
  7. ncbi request reprint Signal Transduction Pathways as Therapeutic Targets. 25-28 January 2004, Luxembourg
    Evan T Keller
    University of Michigan, Room 5304 CCGCB, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0940, USA
    IDrugs 7:217-22. 2004
    ..This report also describes various compounds as potential anti-inflammatory or anticancer agents...
  8. ncbi request reprint Metastasis suppressor genes: a role for raf kinase inhibitor protein (RKIP)
    Evan T Keller
    Department of Urology, University of Michigan, Ann Arbor 48109 0940, USA
    Anticancer Drugs 15:663-9. 2004
    ..Restoration of RKIP expression in all cancer cells in vivo is challenging. A plausible strategy is to use small molecules that target proteins in signaling pathways that are dysregulated due to loss of RKIP...
  9. ncbi request reprint Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene
    Evan T Keller
    Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Lett 207:131-7. 2004
    ..In this review, RKIP biology and its role in cancer will be described...
  10. ncbi request reprint The biology of a prostate cancer metastasis suppressor protein: Raf kinase inhibitor protein
    Evan T Keller
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 0940, USA
    J Cell Biochem 94:273-8. 2005
    ..These parameters identify RKIP as a metastasis suppressor gene. In this review, the biology and pathophysiology of RKIP is described...
  11. ncbi request reprint New trends in the treatment of bone metastasis
    Evan T Keller
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Cell Biochem 102:1095-102. 2007
    ..Additionally, gains in promising clinical strategies to target bone metastases have been developed. In this prospectus, we will discuss some of these advances...
  12. ncbi request reprint The impact of chronic estrogen deprivation on immunologic parameters in the ovariectomized rhesus monkey (Macaca mulatta) model of menopause
    E T Keller
    Unit for Laboratory Animal Medicine, RM 5304 CCGCB, 1500 E Medical Center Drive, University of Michigan, Ann Arbor, MI 48109 0940, USA
    J Reprod Immunol 50:41-55. 2001
    ..These data demonstrate that E(2)-deprivation affects several aspects of immune function. These findings may have implications for menopause-associated changes of immune function that occur in women...
  13. ncbi request reprint Prostate carcinoma skeletal metastases: cross-talk between tumor and bone
    E T Keller
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, USA
    Cancer Metastasis Rev 20:333-49. 2001
    ..This review focuses on the interaction between the bone and the prostate carcinoma cells that allow for development and progression of prostate carcinoma skeletal metastases...
  14. ncbi request reprint The role of osteoclastic activity in prostate cancer skeletal metastases
    Evan T Keller
    Unit for Laboratory Animal Medicine and Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0940, USA
    Drugs Today (Barc) 38:91-102. 2002
    ..In addition to bisphosphonates, other novel therapies based on studies that delineate mechanisms of skeletal metastases establishment and progression will be developed in the near future...
  15. pmc The first Tianjin, China forum on tumor microenvironment
    Evan T Keller
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 71:310-3. 2011
    ....
  16. ncbi request reprint ALDH activity indicates increased tumorigenic cells, but not cancer stem cells, in prostate cancer cell lines
    Chunyan Yu
    Department of Urology, University of Michigan Medical School, 5111 CCGC, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0940, USA
    In Vivo 25:69-76. 2011
    ..The enzyme aldehyde dehydrogenase (ALDH) has been found to identify hematopoietic stem cells and our aim was to determine the utility of ALDH activity and CD44 in identifying PCa stem cell-like cells in PCa cell lines...
  17. ncbi request reprint A bioluminescent orthotopic mouse model of human osteosarcoma that allows sensitive and rapid evaluation of new therapeutic agents In vivo
    Kenine E Comstock
    Department of Urology Surgery, University of Michigan, Ann Arbor, MI, USA
    In Vivo 23:661-8. 2009
    ..This model allows real-time detection of tumors and can be used to study mechanisms of OSA metastasis and test new therapeutic agents...
  18. ncbi request reprint Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo
    Yan Xi Sun
    Department of Periodontics, Prevention, Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    J Bone Miner Res 20:318-29. 2005
    ..Neutralization of CXCR4 limited the number and the growth of intraosseous metastasis in vivo. Together, these in vivo metastasis data provide critical support that SDF-1/CXCR4 plays a role in skeletal metastasis...
  19. pmc Expression of PGK1 by prostate cancer cells induces bone formation
    Younghun Jung
    Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    Mol Cancer Res 7:1595-604. 2009
    ..Together, these data suggest that PGK1 secreted by PCa regulates bone formation at the metastatic site by increasing osteoblastic activity, decreasing osteoclastic function, and expressing an osteoblastic phenotype by PCa cells...
  20. pmc Prostate cancer and parasitism of the bone hematopoietic stem cell niche
    Chunyan Yu
    Department of Urology, School of Medicine, University of Michigan, Ann Arbor, MI 48109 0940, USA
    Crit Rev Eukaryot Gene Expr 22:131-48. 2012
    ..Understanding the concepts of how PCa successfully parasitizes the bone microenvironment is paramount toward identifying therapeutic candidates to prevent or diminish PCa bone metastases...
  21. pmc Reversal of chemotherapy-induced leukopenia using granulocyte macrophage colony-stimulating factor promotes bone metastasis that can be blocked with osteoclast inhibitors
    Jinlu Dai
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 8940, USA
    Cancer Res 70:5014-23. 2010
    ..Our findings indicate that it is possible to dissociate the bone-resorptive effects of GM-CSF, to reduce metastatic risk, from the benefits of this growth factor in reversing leukopenia caused by treatment with chemotherapy...
  22. ncbi request reprint Soluble receptor activator of nuclear factor kappaB Fc diminishes prostate cancer progression in bone
    Jian Zhang
    Department of Pathology, School of Medicine, Comprehensive Cancer Center, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0940, USA
    Cancer Res 63:7883-90. 2003
    ..In contrast, sRANK-Fc had no effect on s.c. implanted LuCaP cells. We conclude that sRANK-Fc is an effective inhibitor of RANKL that diminishes progression of CaP growth in bone through inhibition of bone remodeling...
  23. pmc Cancer interaction with the bone microenvironment: a workshop of the National Institutes of Health Tumor Microenvironment Study Section
    Michael L Cher
    Department of Urology, Wayne State University School of Medicine, 4160 John R, Suite 1017, Detroit, MI 48201, USA
    Am J Pathol 168:1405-12. 2006
  24. pmc Detection and isolation of circulating tumor cells in urologic cancers: a review
    Robert D Loberg
    Department of Urology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 0946, USA
    Neoplasia 6:302-9. 2004
    ..The purpose of this review is to present the methods for the detection and isolation of circulating tumor cells and to discuss the importance of circulating tumor cells in the biology and treatment of urologic cancers...
  25. ncbi request reprint Type I collagen receptor (alpha 2 beta 1) signaling promotes the growth of human prostate cancer cells within the bone
    Christopher L Hall
    Department of Urology, The University of Michigan, Ann Arbor, MI 48109 0940, USA
    Cancer Res 66:8648-54. 2006
    ..We conclude that collagen I attachment mediated by alpha(2)beta(1) initiates motility programs through RhoC and suggest a mechanism for prostate cancer metastasis to the bone...
  26. pmc An in vivo mouse model for human prostate cancer metastasis
    Aaron M Havens
    Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA
    Neoplasia 10:371-80. 2008
    ..We propose that this new model may be particularly useful in exploring the molecular events in early metastasis, identifying the metastatic niche, and studying issues pertaining to dormancy...
  27. ncbi request reprint Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    Russell S Taichman
    Department of Periodontics, Prevention, and Geriatrics, and the Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Cancer Res 62:1832-7. 2002
    ..Collectively, these results suggest that prostate cancers and perhaps other neoplasms may use the SDF-1/CXCR4 pathway to spread to bone...
  28. ncbi request reprint Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis
    Zheng Fu
    Program in Immunology, School of Medicine, University of Michigan, Ann Arbor 48109 0940, USA
    J Natl Cancer Inst 95:878-89. 2003
    ..We examined whether RKIP functions as a suppressor of metastasis...
  29. pmc Separation of retinoid-induced epidermal and dermal thickening from skin irritation
    James Varani
    Department of Pathology, The University of Michigan, 1301 Catherine Road, Box 0602, Ann Arbor, MI 48109, USA
    Arch Dermatol Res 295:255-62. 2003
    ..Intraperitoneal injection of either 14-all-trans-RA or MDI-301 also resulted in epidermal and dermal thickening. Irritation of skin was not observed in these animals but splenomegaly was prominent in animals treated with either agent...
  30. ncbi request reprint Vascular endothelial growth factor contributes to prostate cancer-mediated osteoblastic activity
    Yasuhide Kitagawa
    Department of Urology, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 65:10921-9. 2005
    ..These results show that VEGF contributes to prostate cancer-induced osteoblastic activity in vivo...
  31. pmc Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase
    Christopher L Hall
    Department of Urology, The University of Michigan, Ann Arbor, MI 48109 0940, USA
    Neoplasia 10:797-803. 2008
    ..We conclude that the ligation of alpha(2)beta(1) by collagen I activates RhoC guanosine triphosphatase, which mediates PCa invasion, and suggests a mechanism for the preferential metastasis of PCa cells within the bone...
  32. doi request reprint Histotripsy focal ablation of implanted prostate tumor in an ACE-1 canine cancer model
    George R Schade
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Urol 188:1957-64. 2012
    ..We used the ACE-1 prostate tumor model and evaluated the feasibility of treating prostate tumors with histotripsy...
  33. ncbi request reprint Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis
    Ilona Kryczek
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109 0669, USA
    Am J Physiol Cell Physiol 292:C987-95. 2007
    ..In this review, we consider the pathological nature and characteristics of the CXCL12/CXCR4 pathway in the tumor microenvironment. Strategies for therapeutically targeting the CXCL12/CXCR4 axis also are discussed...
  34. ncbi request reprint NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF
    Bae Keun Park
    Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, 1011 North University Avenue, Ann Arbor, Michigan 48109, USA
    Nat Med 13:62-9. 2007
    ....
  35. pmc Loss of Raf kinase inhibitory protein induces radioresistance in prostate cancer
    Kathleen M Woods Ignatoski
    Department of Urology, University of Michigan Health System, Ann Arbor, MI 48109 0940, USA
    Int J Radiat Oncol Biol Phys 72:153-60. 2008
    ..Chemotherapeutic agents have been shown to induce tumor apoptosis through induction of RKIP expression. Our goal was to test whether RT similarly induces apoptosis through induction of RKIP expression...
  36. ncbi request reprint Bisphosphonate induces apoptosis and inhibits pro-osteoclastic gene expression in prostate cancer cells
    Hideki Asahi
    Department of Urology, School of Medicine, Kanazawa University, Kanazawa, Japan
    Int J Urol 13:593-600. 2006
    ..To determine the direct effects of bisphosphonate on prostate cancer, we examined the effects of minodronate on prostatic cancer cell growth and the expression of apoptosis-related proteins and osteoclastogenic factors...
  37. pmc Heat stress-induced heat shock protein 70 expression is dependent on ERK activation in zebrafish (Danio rerio) cells
    Jill M Keller
    Departments of Urology and Pathology, School of Medicine, University of Michigan, Ann Arbor, MI 48109 0940, USA
    Comp Biochem Physiol A Mol Integr Physiol 150:307-14. 2008
    ..This suggests that the heat shock response in zebrafish utilizes a similar signaling pathway to that of mammals and that zebrafish are a good model for comparative studies of heat shock response...
  38. ncbi request reprint Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice
    Lauren Wallner
    Department of Urology, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 66:3087-95. 2006
    ..These data show that IL-6 contributes to the development of androgen independence in prostate cancer and suggest that it mediates this effect, in part, through modulation of p300 and CBP...
  39. ncbi request reprint Role of Wnts in prostate cancer bone metastases
    Christopher L Hall
    Department of Urology, The University of Michigan, Ann Arbor, Michigan, USA
    J Cell Biochem 97:661-72. 2006
    ..This model suggests that targeting both osteolytic activity and osteoblastic activity will provide efficacy for therapy of CaP bone metastases...
  40. pmc Change in markers of bone metabolism with chemotherapy for advanced prostate cancer: interleukin-6 response is a potential early indicator of response to therapy
    Kathleen M Woods Ignatoski
    Department of Urology, University of Michigan, Ann Arbor, Michigan, USA
    J Interferon Cytokine Res 29:105-12. 2009
    ..03). Elevated IL-6 levels and reductions in IL-6 levels early in treatment may reflect ultimate clinical response to docetaxel-based regimens...
  41. ncbi request reprint A glycolytic mechanism regulating an angiogenic switch in prostate cancer
    Jianhua Wang
    Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109, USA
    Cancer Res 67:149-59. 2007
    ..These data suggest that PGK1 is a critical downstream target of the chemokine axis and an important regulator of an "angiogenic switch" that is essential for tumor and metastatic growth...
  42. ncbi request reprint Pathogenesis and treatment of prostate cancer bone metastases: targeting the lethal phenotype
    Robert D Loberg
    University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 23:8232-41. 2005
    ..Here, we review the current therapeutic strategies for targeting the prostate cancer-bone microenvironment and several single- and multiagent targeted approaches to the treatment of advanced prostate cancer that are under development...
  43. ncbi request reprint In vivo real-time imaging of TGF-beta-induced transcriptional activation of the RANK ligand gene promoter in intraosseous prostate cancer
    Jian Zhang
    Department of Pathology and Unit for Laboratory Animal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Prostate 59:360-9. 2004
    ....
  44. ncbi request reprint Vascular endothelial growth factor contributes to the prostate cancer-induced osteoblast differentiation mediated by bone morphogenetic protein
    Jinlu Dai
    Department of Pathology, School of Medicine, University Michigan, Ann Arbor, Michigan, USA
    Cancer Res 64:994-9. 2004
    ..These results suggest a novel function for VEGF in skeletal metastases. Specifically, VEGF promotes osteoblastic lesion formation at prostate cancer bone metastatic sites...
  45. ncbi request reprint Stromal factors involved in prostate carcinoma metastasis to bone
    Carlton R Cooper
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0946, USA
    Cancer 97:739-47. 2003
    ..Stromal elements in the primary and metastatic target organs are important mediators of tumor cell intravasation, chemoattraction, adhesion to target organ microvascular endothelium, extravasation, and growth at the metastatic site...
  46. ncbi request reprint Bone turnover mediates preferential localization of prostate cancer in the skeleton
    Abraham Schneider
    Department of Periodontics Prevention Geriatrics, School of Dentistry, Room 3343, University of Michigan, 1011 North University Avenue, Ann Arbor, Michigan 48109 1078, USA
    Endocrinology 146:1727-36. 2005
    ..Overall, these studies provide new evidence that skeletal sites rich in marrow cellularity under active turnover offer a more congenial microenvironment to facilitate cancer localization in the skeleton...
  47. ncbi request reprint Osteoblasts induce prostate cancer proliferation and PSA expression through interleukin-6-mediated activation of the androgen receptor
    Yi Lu
    Department of Urology, University of Michigan, Ann Arbor, Michigan, USA
    Clin Exp Metastasis 21:399-408. 2004
    ..Furthermore, these data underscore the importance of cross-talk between tumor and the bone microenvironment in the development of CaP bone metastases...
  48. ncbi request reprint Prostate cancer cells promote osteoblastic bone metastases through Wnts
    Christopher L Hall
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 0940, USA
    Cancer Res 65:7554-60. 2005
    ..Blocking Wnt activity converted the C4-2B cells to a highly osteolytic tumor. Taken together, these data show that Wnts contribute to the mechanism through which prostate cancer induces osteoblastic activity...
  49. ncbi request reprint Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism
    Jinlu Dai
    Department of Urology, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109 0940, USA
    Cancer Res 65:8274-85. 2005
    ..These data show that prostate cancer promotes osteoblastic activity through BMP-6 and that, in addition to its bone effects, suggest that BMPs promote the ability of the prostate cancer cells to invade the bone microenvironment...
  50. ncbi request reprint Osteoblasts produce soluble factors that induce a gene expression pattern in non-metastatic prostate cancer cells, similar to that found in bone metastatic prostate cancer cells
    Zheng Fu
    Program in Immunology, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Prostate 51:10-20. 2002
    ..To investigate the biology of prostate cancer skeletal metastases, we compared gene expression between the non-metastatic LNCaP cell line and its derivative cell line C4-2B that metastasizes to bone...
  51. ncbi request reprint Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer
    Zheng Fu
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 0940, USA
    Prostate 66:248-56. 2006
    ..However, the prognostic significance of RKIP expression and its association with metastasis in PCa patients is unknown...
  52. ncbi request reprint Characterization of C4-2 prostate cancer bone metastases and their response to castration
    Jesco Pfitzenmaier
    Department of Urology, University of Washington, Seattle 98195, Washington, USA
    J Bone Miner Res 18:1882-8. 2003
    ..Here we describe characterization of a model consisting of direct injection of C4-2 cells into tibias...
  53. ncbi request reprint Characterization of the heat shock response in mature zebrafish (Danio rerio)
    Jill M Murtha
    Unit for Laboratory Animal Medicine and Department of Pathology, University of Michigan, Box 0940 CCGCB, Room 5304, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0940, USA
    Exp Gerontol 38:683-91. 2003
    ....
  54. ncbi request reprint Phase II evaluations of cilengitide in asymptomatic patients with androgen-independent prostate cancer: scientific rationale and study design
    Kathleen W Beekman
    Genitourinary Oncology Service, Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, 48109, USA
    Clin Genitourin Cancer 4:299-302. 2006
    ....
  55. ncbi request reprint Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts
    Chen Chen
    Department of Periodontics Prevention Geriatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:29121-9. 2004
    ..These novel findings indicate that the MAPK pathway plays a selective but important role in the actions of PTHrP...
  56. pmc EGFR ligand switch in late stage prostate cancer contributes to changes in cell signaling and bone remodeling
    Alyse M DeHaan
    Department of Urology, University of Michigan Health System, Ann Arbor, Michigan 48109 0654, USA
    Prostate 69:528-37. 2009
    ..Since the microenvironment of metastases has been shown to play a role in the survival of the tumor, we examined whether the ligands had effects on cell survival and proliferation in early and late PCa...
  57. pmc Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis
    Christopher L Hall
    Department of Urology, The University of Michigan, Ann Arbor, Michigan, USA
    Prostate 68:1396-404. 2008
    ..We previously demonstrated through over-expression of the Wnt inhibitor dickkopf-1 (DKK-1) that Wnts contribute to the osteoblastic component of PCa osseous lesions in vivo...
  58. doi request reprint Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms
    Jinlu Dai
    Department of Urology, University of Michigan Health System, Ann Arbor, Michigan 48109 0940, USA
    Cancer Res 68:5785-94. 2008
    ..These results show a clear link between Wnts and BMPs in PCa-induced osteoblast differentiation and provide novel targets, including the noncanonical Wnt pathway, for therapy of PCa...
  59. pmc Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production
    Karen McLean
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Clin Invest 121:3206-19. 2011
    ..Taken together, our data suggest that MSCs in the ovarian tumor microenvironment have an expression profile that promotes tumorigenesis and that BMP inhibition may be an effective therapeutic approach for ovarian cancer...
  60. ncbi request reprint In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging
    Jian Zhang
    Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA
    Exp Gerontol 39:239-47. 2004
    ..We conclude that ability of ROS to act as secondary messengers and induce gene expression may contribute to the aging process...
  61. ncbi request reprint Eleventh Prouts Neck Meeting on Prostate Cancer: emerging strategies in prostate cancer therapy
    Evan T Keller
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 67:9613-5. 2007
  62. ncbi request reprint Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression
    Ilona Kryczek
    Department of Surgery, University of Mechigan, Ann Arbor, MI 48109, USA
    J Immunol 179:1423-6. 2007
    ..Thus, the IL-17(+) T cell pool may be controlled by the local cytokine profile in the microenvironment...
  63. ncbi request reprint Why should we still care about oncogenes?
    Kathleen M Diehl
    Department of Urology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0940, USA
    Mol Cancer Ther 6:418-27. 2007
    ..New drugs and combination therapies are being designed that will bypass the resistance mechanisms...
  64. ncbi request reprint Osteoprotegerin abrogates chronic alcohol ingestion-induced bone loss in mice
    Jian Zhang
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, USA
    J Bone Miner Res 17:1256-63. 2002
    ..Furthermore, they suggest that OPG achieves this through its ability to abrogate ethanol-induced promotion of osteoclastogenesis and promote osteoblast proliferation...
  65. ncbi request reprint The role of Wnts in bone metastases
    Christopher L Hall
    Department of Urology, The University of Michigan, RM 5304 CCGCB, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0940, USA
    Cancer Metastasis Rev 25:551-8. 2006
    ..We provide a model that the affect of Wnt inhibitors on tumor development is dependent on the tumor micro-environment and suggest that DKK-1 is a switch which transitions CaP bone metastases from osteolytic to osteoblastic...
  66. ncbi request reprint Hematologic and serum biochemical values for zebrafish (Danio rerio)
    Jill M Murtha
    Unit for Laboratory Animal Medicine, Department of Pathology, University of Michigan, Room 5304 CCGCB, 1500 E Medical Center Drive, Ann Arbor, Michigan 48109 0940, USA
    Comp Med 53:37-41. 2003
    ..We believe results such as these will help define normal adult zebrafish, which have a tremendous potential for use in the study of human disease and aging...
  67. ncbi request reprint The adrenal androgen androstenediol is present in prostate cancer tissue after androgen deprivation therapy and activates mutated androgen receptor
    Atsushi Mizokami
    Department of Urology, Kanazawa University, Kanazawa, Japan
    Cancer Res 64:765-71. 2004
    ..However, low concentration of adiol induced more AR nuclear translocation than DHT in LNCaP cells and not PC-3 cells transfected with AR. These results indicate that adiol may cause the progression of PCa even after hormone therapy...
  68. ncbi request reprint RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis
    Devasis Chatterjee
    Department of Medicine, Brown University and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Biol Chem 279:17515-23. 2004
    ....
  69. ncbi request reprint Cyclooxygenase-2 promotes prostate cancer progression
    Hiroshi Fujita
    Department of Urology, Kanazawa University, Kanazawa City, Japan
    Prostate 53:232-40. 2002
    ..Several studies have reported that COX-2 overexpression is associated with carcinogenesis, cell growth, angiogenesis, apoptosis, and invasiveness in a variety of tumor types...
  70. pmc Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases
    Guojun Bu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Int J Cancer 123:1034-42. 2008
    ..Taken together, these results suggest that breast cancer-produced Dkk1 may be an important mechanistic link between primary breast tumors and secondary osteolytic bone metastases...
  71. ncbi request reprint The bisphosphonate YM529 inhibits osteolytic and osteoblastic changes and CXCR-4-induced invasion in prostate cancer
    Sotaro Miwa
    Department of Urology, Kanazawa University, Kanazawa, Japan
    Cancer Res 65:8818-25. 2005
    ..These results suggest that YM529 may inhibit cancer cell invasion into the bone matrix by repressing the expression of CXCR-4 in bone metastasis lesions...
  72. ncbi request reprint CCR2 expression correlates with prostate cancer progression
    Yi Lu
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240
    J Cell Biochem 101:676-85. 2007
    ..We found that CCR2 expression correlated with Gleason score and clinical pathologic stages, whereas lower levels of CCR2 were expressed in normal prostate tissues. These results suggest that CCR2 may contribute to PCa development...
  73. ncbi request reprint PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasion in vitro
    Yi Lu
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Int J Cancer 121:724-33. 2007
    ..We conclude that PTHrP-induced MCP-1 production by HBME and hFOB cells promotes osteoclast differentiation in vitro and such induction may play a critical role in PCa development in the bone microenvironment...
  74. ncbi request reprint Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption
    Yi Lu
    Department of Medicine, University of Pittsburgh, University Drive, Pittsburgh, PA 15240, USA
    Cancer Res 67:3646-53. 2007
    ..This study may provide novel therapeutic targets for treatment of prostate cancer skeletal metastasis...
  75. ncbi request reprint RANKL acts directly on RANK-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes
    Allison P Armstrong
    Department of Hematology, Amgen Inc, Seattle, Washington 98119, USA
    Prostate 68:92-104. 2008
    ..RANK expression has also been observed in some tumor cell types such as breast and colon, suggesting that RANKL may play a direct role on tumor cells...
  76. ncbi request reprint The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell lines
    Masashi Takeda
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan
    Prostate 67:955-67. 2007
    ..Although paclitaxel is used for hormone-resistant prostate cancer, relapse definitely occurs later. Details of the molecular mechanism responsible for paclitaxel- resistance remain unclear...
  77. ncbi request reprint Expression of the cytoskeleton linker protein ezrin in human cancers
    Benjamin Bruce
    Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Clin Exp Metastasis 24:69-78. 2007
    ....
  78. ncbi request reprint Opg, RANKl, and RANK in cancer metastasis: expression and regulation
    Julie M Brown
    Oncology Research Centre, UNSW Department of Clinical Medicine, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    Cancer Treat Res 118:149-72. 2004
  79. ncbi request reprint Issues of aging and geriatric medicine: relevance to cancer treatment and hematopoietic reconstitution
    William B Ershler
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
    Biol Blood Marrow Transplant 12:100-6. 2006
    ..Such assessment would also identify those who are likely to benefit from more aggressive treatments, including bone marrow or stem cell transplantation...
  80. ncbi request reprint Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta)
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mech Ageing Dev 125:149-51. 2004
    ..These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta...
  81. pmc Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation
    Glenda J Pettway
    Department of Biomedical Engineering, University of Michigan College of Engineering, USA
    Bone 42:806-18. 2008
    ..Since zoledronic acid reduced PTH-induced proliferation without reducing bone volume, these data suggest that combining PTH and bisphosphonate therapy warrants further investigation in the treatment of bone disorders...

Research Grants23

  1. AGING, GENE EXPRESSION AND OXIDATIVE STRESS
    Evan Keller; Fiscal Year: 2002
    ....
  2. Prostate Cancer Metastasis Suppressor: Role of RKIP
    Evan Keller; Fiscal Year: 2007
    ..when completed, we hope this work will lead to a better understanding of the mechanisms through which RKIP suppresses metastasis and hopefully identify specific targets to inhibit metastasis. ..
  3. ETHANOL MEDIATED OSTEOPOROSIS AND INTERLEUKIN 6
    Evan Keller; Fiscal Year: 1999
    ....
  4. Prostate Cancer Metastasis Suppressor: Role of RKIP
    Evan Keller; Fiscal Year: 2004
    ..when completed, we hope this work will lead to a better understanding of the mechanisms through which RKIP suppresses metastasis and hopefully identify specific targets to inhibit metastasis. ..
  5. VEGF and bone remodeling in skeletal metastases
    Evan Keller; Fiscal Year: 2004
    ..In this aim, we will test which VEGF isoform contributes to CaP cells' osteoblastic activity. We will also evaluate if VEGF induces this activity through MAPK. ..
  6. Prostate Cancer Metastasis Suppressor: Role of RKIP
    Evan Keller; Fiscal Year: 2005
    ..when completed, we hope this work will lead to a better understanding of the mechanisms through which RKIP suppresses metastasis and hopefully identify specific targets to inhibit metastasis. ..
  7. DEVELOPMENT OF MATURE ZEBRAFISH AS AN ANIMAL MODEL
    Evan Keller; Fiscal Year: 2005
    ....
  8. VEGF and bone remodeling in skeletal metastases
    Evan Keller; Fiscal Year: 2005
    ..In this aim, we will test which VEGF isoform contributes to CaP cells' osteoblastic activity. We will also evaluate if VEGF induces this activity through MAPK. ..
  9. Prostate Cancer Metastasis Suppressor: Role of RKIP
    Evan Keller; Fiscal Year: 2006
    ..when completed, we hope this work will lead to a better understanding of the mechanisms through which RKIP suppresses metastasis and hopefully identify specific targets to inhibit metastasis. ..
  10. DEVELOPMENT OF MATURE ZEBRAFISH AS AN ANIMAL MODEL
    Evan Keller; Fiscal Year: 2006
    ....
  11. DEVELOPMENT OF MATURE ZEBRAFISH AS AN ANIMAL MODEL
    Evan Keller; Fiscal Year: 2004
    ....
  12. VEGF and bone remodeling in skeletal metastases
    Evan Keller; Fiscal Year: 2003
    ..In this aim, we will test which VEGF isoform contributes to CaP cells' osteoblastic activity. We will also evaluate if VEGF induces this activity through MAPK. ..
  13. DEVELOPMENT OF MATURE ZEBRAFISH AS AN ANIMAL MODEL
    Evan Keller; Fiscal Year: 2003
    ....
  14. ETHANOL MEDIATED OSTEOPOROSIS AND INTERLEUKIN 6
    Evan Keller; Fiscal Year: 1999
    ....
  15. AGING, GENE EXPRESSION AND OXIDATIVE STRESS
    Evan Keller; Fiscal Year: 2000
    ....
  16. ETHANOL MEDIATED OSTEOPOROSIS AND INTERLEUKIN 6
    Evan Keller; Fiscal Year: 2000
    ....
  17. ETHANOL MEDIATED OSTEOPOROSIS AND INTERLEUKIN 6
    Evan Keller; Fiscal Year: 2001
    ....
  18. AGING, GENE EXPRESSION AND OXIDATIVE STRESS
    Evan Keller; Fiscal Year: 2001
    ....
  19. ETHANOL MEDIATED OSTEOPOROSIS AND INTERLEUKIN 6
    Evan Keller; Fiscal Year: 2001
    ....
  20. DEVELOPMENT OF MATURE ZEBRAFISH AS AN ANIMAL MODEL
    Evan Keller; Fiscal Year: 2002
    ....
  21. ETHANOL MEDIATED OSTEOPOROSIS AND INTERLEUKIN 6
    Evan Keller; Fiscal Year: 2002
    ....