Temitope O Keku

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Fusobacterium is associated with colorectal adenomas
    Amber N McCoy
    Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS ONE 8:e53653. 2013
  2. pmc Fusobacterium spp. and colorectal cancer: cause or consequence?
    Temitope O Keku
    Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Electronic address
    Trends Microbiol 21:506-8. 2013
  3. doi request reprint Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites
    Temitope O Keku
    Department of Medicine, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, 27599 7032, USA
    Cancer Causes Control 23:1127-38. 2012
  4. pmc Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites
    Robert C Millikan
    Department of Epidemiology, School of Public Health, and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 6:R264-74. 2004
  5. ncbi request reprint Gene testing: what the health professional needs to know
    Temitope O Keku
    Center for Gastrointestinal Biology and Disease and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Nutr 133:3754S-3757S. 2003
  6. pmc Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas
    Temitope O Keku
    Department of Medicine and Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    BMC Cancer 8:143. 2008
  7. ncbi request reprint Family history of colon cancer: what does it mean and how is it useful?
    Temitope O Keku
    Center for Gastrointestinal Biology and Disease, CB 7555, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Am J Prev Med 24:170-6. 2003
  8. ncbi request reprint 5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites
    Temitope Keku
    Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7555, USA
    Cancer Epidemiol Biomarkers Prev 11:1611-21. 2002
  9. pmc Apoptosis in normal rectal mucosa, baseline adenoma characteristics, and risk of future adenomas
    Temitope O Keku
    Department of Medicine and Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 17:306-10. 2008
  10. ncbi request reprint Insulin resistance, apoptosis, and colorectal adenoma risk
    Temitope O Keku
    Department of Medicine, University of North Carolina, Chapel Hill, 27599 7555, USA
    Cancer Epidemiol Biomarkers Prev 14:2076-81. 2005

Detail Information

Publications92

  1. pmc Fusobacterium is associated with colorectal adenomas
    Amber N McCoy
    Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS ONE 8:e53653. 2013
    ..33, p = 0.06 while it was 0.44, p = 0.01 for Fusobacterium and IL-10. These results support a link between the abundance of Fusobacterium in colonic mucosa and adenomas and suggest a possible role for mucosal inflammation in this process...
  2. pmc Fusobacterium spp. and colorectal cancer: cause or consequence?
    Temitope O Keku
    Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Electronic address
    Trends Microbiol 21:506-8. 2013
    ..Recent studies have implicated overabundance of Fusobacterium in association with colorectal adenomas and cancer. Two articles published in Cell Host & Microbe provide insights into the Fusobacterium-CRC relationship. ..
  3. doi request reprint Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites
    Temitope O Keku
    Department of Medicine, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, 27599 7032, USA
    Cancer Causes Control 23:1127-38. 2012
    ....
  4. pmc Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites
    Robert C Millikan
    Department of Epidemiology, School of Public Health, and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 6:R264-74. 2004
    ..Results suggest that the Ala allele increases the risk of breast cancer and modifies the effects of environmental exposures that produce oxidative damage to DNA...
  5. ncbi request reprint Gene testing: what the health professional needs to know
    Temitope O Keku
    Center for Gastrointestinal Biology and Disease and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Nutr 133:3754S-3757S. 2003
    ..To meet these demands, physicians and other health professionals should use available educational genetic resources to provide adequate patient care...
  6. pmc Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas
    Temitope O Keku
    Department of Medicine and Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    BMC Cancer 8:143. 2008
    ..We evaluated the association between tissue or plasma IGFBP-3 and risk of colorectal adenomas or low apoptosis...
  7. ncbi request reprint Family history of colon cancer: what does it mean and how is it useful?
    Temitope O Keku
    Center for Gastrointestinal Biology and Disease, CB 7555, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Am J Prev Med 24:170-6. 2003
    ..Family history of colon cancer can be deconstructed into causal and noncausal explanations, which include genetic factors, environmental factors, gene-environment interactions, misclassification, and differences in screening...
  8. ncbi request reprint 5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites
    Temitope Keku
    Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7555, USA
    Cancer Epidemiol Biomarkers Prev 11:1611-21. 2002
    ....
  9. pmc Apoptosis in normal rectal mucosa, baseline adenoma characteristics, and risk of future adenomas
    Temitope O Keku
    Department of Medicine and Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 17:306-10. 2008
    ..If confirmed in larger studies, apoptosis could potentially be used to identify patients at highest risk for developing new adenomas...
  10. ncbi request reprint Insulin resistance, apoptosis, and colorectal adenoma risk
    Temitope O Keku
    Department of Medicine, University of North Carolina, Chapel Hill, 27599 7555, USA
    Cancer Epidemiol Biomarkers Prev 14:2076-81. 2005
    ..These findings suggest that insulin may act early in the adenoma-carcinoma sequence to promote the development of colorectal adenoma by decreasing apoptosis in the normal mucosa...
  11. pmc Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa
    Adriana C Vidal
    Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, USA
    BMC Cancer 12:389. 2012
    ..However few studies have evaluated IGFBP-1 and C-peptide in relation to adenomatous polyps, the only known precursor for CRC...
  12. pmc Antioxidant and DNA methylation-related nutrients and risk of distal colorectal cancer
    Christina Dawn Williams
    Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, McGavran Greenberg Hall, Chapel Hill, NC 27599, USA
    Cancer Causes Control 21:1171-81. 2010
    ....
  13. ncbi request reprint Does physical activity modify the association between body mass index and colorectal adenomas?
    Magda Guilera
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599, USA
    Nutr Cancer 51:140-5. 2005
    ..Our results suggest that physical activity may modify the association between obesity and colorectal adenoma until a high level of obesity is achieved. Apoptosis does not appear to be associated with obesity or physical activity...
  14. pmc Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University Medical Center, Box 2914, Durham, NC 27710, USA
    J Natl Med Assoc 101:711-6. 2009
    ..Factors associated with variation in circulating levels of these peptide hormones remain unclear...
  15. ncbi request reprint Nonsteroidal anti-inflammatory drugs, apoptosis, and colorectal adenomas
    Christopher Martin
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, 27599, USA
    Gastroenterology 123:1770-7. 2002
    ..We examined grossly normal rectal mucosa in patients with adenomas and adenoma-free controls to assess the associations between NSAID use, adenomatous polyps, and apoptosis...
  16. pmc Circulating levels of inflammatory cytokines and risk of colorectal adenomas
    Sangmi Kim
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7555, USA
    Cancer Res 68:323-8. 2008
    ..56 (95% CI, 1.03-2.36) and 1.66 (95% CI, 1.10-2.52), respectively. Our findings indicate that systemic inflammation might be involved in the early development of colorectal neoplasia...
  17. pmc The association between diabetes, insulin use, and colorectal cancer among Whites and African Americans
    Lisa C Vinikoor
    University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Cancer Epidemiol Biomarkers Prev 18:1239-42. 2009
    ..No association was present among African Americans. Insulin use was also positively associated with rectal cancer among Whites...
  18. pmc Dietary patterns, food groups, and rectal cancer risk in Whites and African-Americans
    Christina Dawn Williams
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 18:1552-61. 2009
    ..We examined the relationship between food groups and dietary patterns and risk for rectal cancer in non-Hispanic Whites and African-Americans...
  19. pmc Selenium, folate, and colon cancer
    Alexandra Connelly-Frost
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Nutr Cancer 61:165-78. 2009
    ..Importantly, weight loss, stage at diagnosis, or time from diagnosis to blood draw did not appear to produce strong bias in our study...
  20. pmc Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans
    Nina Sanapareddy
    Department of Bioinformatics and Genomics, University of North Carolina, Charlotte, NC, USA
    ISME J 6:1858-68. 2012
    ..This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas...
  21. pmc Association of plasma endotoxin, inflammatory cytokines and risk of colorectal adenomas
    Melissa Kang
    Center for Gastrointestinal Biology and Disease, University of North Carolina, 103 Mason Farm Road, 7340 Medical Biomolecular Research Building, CB 7032, 27599 7032, Chapel Hill, NC 27599, USA
    BMC Cancer 13:91. 2013
    ..Given the evidence linking inflammation and colorectal cancer, we sought to determine if plasma endotoxin concentrations are associated with indicators of systemic or local inflammation and colorectal adenomas...
  22. pmc Associations of red meat, fat, and protein intake with distal colorectal cancer risk
    Christina Dawn Williams
    Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Drive, Chapel Hill, NC 27599, USA
    Nutr Cancer 62:701-9. 2010
    ..77). Red meat consumption in Whites was associated with a marginally significant risk reduction (Q4 OR = 0.66, 95% CI = 0.43-1.00). Our results do not support the hypotheses that fat, protein, and red meat increase the risk of distal CRC...
  23. ncbi request reprint 5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer
    Allison M Eaton
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7555, USA
    Cancer Epidemiol Biomarkers Prev 14:2023-9. 2005
    ..These results indicate that the relationship between MTHFR genotypes and MSI is influenced by folate status...
  24. ncbi request reprint Longitudinal changes in lifestyle behaviors and health status in colon cancer survivors
    Jessie A Satia
    Department of Nutrition and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA
    Cancer Epidemiol Biomarkers Prev 13:1022-31. 2004
    ..Health care providers should communicate with persons diagnosed with colon cancer to ensure that they are making healthy lifestyle changes...
  25. ncbi request reprint Vitamin C intake and apoptosis in normal rectal epithelium
    Alexandra E Connelly
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7555, USA
    Cancer Epidemiol Biomarkers Prev 12:559-65. 2003
    ..Given that high apoptosis may lower colorectal cancer risk, vitamin C supplements may be contraindicated for patients with a history of adenomas...
  26. pmc Genetic heterogeneity in colorectal cancer associations between African and European americans
    Sonia S Kupfer
    Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Gastroenterology 139:1677-85, 1685.e1-8. 2010
    ..None of these studies included African Americans, who have the highest incidence and mortality from CRC in the United States. For the 10 genomic regions, we performed an association study of Americans of African and European descent...
  27. ncbi request reprint Gastric cancer and the high combination prevalence of host cytokine genotypes and Helicobacter pylori in Honduras
    Douglas R Morgan
    Department of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Clin Gastroenterol Hepatol 4:1103-11. 2006
    ..We investigated the cytokine profile in the Latino population, specifically Honduras, a high-incidence region, and the use of the combination prevalence of H pylori and genotypes in identifying high-risk populations...
  28. pmc Differences in microbial signatures between rectal mucosal biopsies and rectal swabs
    Felix Araujo-Perez
    Division of Gastroenterology and Hepatology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Gut Microbes 3:530-5. 2012
    ..0001) and Eubacteria (p = 0.0003) in swab samples compared with biopsies. Our findings suggest that rectal swabs and rectal mucosal samples provide different views of the microbiota in the large intestine...
  29. ncbi request reprint A population-based cohort study comparing laparoscopic cholecystectomy and open cholecystectomy
    Steven L Zacks
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Am J Gastroenterol 97:334-40. 2002
    ..The aims of this study were to characterize the morbidity, mortality, and costs of LC and OC in a large unselected cohort of patients...
  30. ncbi request reprint Hospital-to-hospital variation in lymph node detection after colorectal resection
    Eric A Miller
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, USA
    Cancer 101:1065-71. 2004
    ..It is possible that inadequate lymph node recovery and/or assessment could contribute to disparities in survival, with particular variation according to hospital volume...
  31. pmc Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas
    Xiang Jun Shen
    Center for Gastrointestinal Biology and Disease University of North Carolina at Chapel Hill, NC, USA
    Gut Microbes 1:138-47. 2010
    ..Extension of these findings could lead to strategies to manipulate the microbiota to prevent colorectal adenomas and cancer as well as to identify individuals at high risk...
  32. pmc Assessment of serum proteomics to detect large colon adenomas
    David F Ransohoff
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Cancer Epidemiol Biomarkers Prev 17:2188-93. 2008
    ..They also highlight the importance of understanding sources of "noise" and "bias" in studies of proteomics assays...
  33. ncbi request reprint Calcium, vitamin D, and apoptosis in the rectal epithelium
    Eric A Miller
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Cancer Epidemiol Biomarkers Prev 14:525-8. 2005
    ..This report describes the associations of calcium intake and 25-hydroxyvitamin D levels with apoptosis in colorectal epithelium...
  34. doi request reprint Somatic gene mutations in African Americans may predict worse outcomes in colorectal cancer
    Melissa Kang
    Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA
    Cancer Biomark 13:359-66. 2013
    ..African Americans have worse outcomes in colorectal cancer (CRC) than Caucasians. We sought to determine if KRAS, BRAF and PIK3CA mutations might contribute to the racial differences in CRC outcome...
  35. pmc Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome
    Janelle M Hoskins
    Division of Pharmacotherapy and Experimental Therapeutics, Institute for Pharmacogenomics and Individualized Therapy, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e41954. 2012
    ..As the CRC risk SNPs may also influence disease outcome, thus in this study, we evaluated whether they influence patient survival...
  36. ncbi request reprint Aspirin may be more effective in preventing colorectal adenomas in patients with higher BMI (United States)
    Sangmi Kim
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Cancer Causes Control 17:1299-304. 2006
    ..The more pronounced effect of 325 mg aspirin in individuals with higher BMI suggests a possible protective role of anti-inflammatory aspirin against increased adipose-driven cytokines among obese subjects...
  37. ncbi request reprint The burden of gastrointestinal and liver diseases, 2006
    Nicholas J Shaheen
    Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Gastroenterol 101:2128-38. 2006
    ..Digestive and liver diseases are a source of significant morbidity, mortality, and health-care costs for the U.S. population. An annual report of the toll of these diseases could be helpful to clinicians, policymakers, and researchers...
  38. ncbi request reprint A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas
    John A Baron
    Department of Medicine, The Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, USA
    Gastroenterology 131:1674-82. 2006
    ..We conducted a randomized, placebo-controlled, double-blind trial to assess whether use of the selective COX-2 inhibitor rofecoxib would reduce the risk of colorectal adenomas...
  39. ncbi request reprint Tea intake and risk of colon cancer in African-Americans and whites: North Carolina colon cancer study
    Dora Il'yasova
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer Causes Control 14:767-72. 2003
    ..Tea polyphenols have been shown to exhibit anti-cancer activity, but the epidemiological findings are inconsistent. We examined the association between tea consumption and colon cancer in a population-based study in North Carolina...
  40. ncbi request reprint Race and colorectal cancer screening: a population-based study in North Carolina
    Deborah A Fisher
    Department of Medicine, Duke University Medical Center, Institute for Clinical and Epidemiological Research, Durham Veterans Affairs Medical Center, Durham, NC, USA
    N C Med J 65:12-5. 2004
    ..The purpose of this study was to determine if colorectal cancer screening rates are different between blacks and whites while controlling for potential confounders...
  41. pmc Suboptimal rates of cervical testing among women with inflammatory bowel disease
    Millie D Long
    Division of Gastroenterology and Hepatology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Clin Gastroenterol Hepatol 7:549-53. 2009
    ..We aimed to determine cervical testing rates among women with IBD, specifically those on immunosuppressant medications, and to identify risk factors associated with low incidence of screening...
  42. ncbi request reprint Dietary patterns and colon cancer risk in Whites and African Americans in the North Carolina Colon Cancer Study
    Jessie A Satia
    Department of Nutrition, Schools of Public Health and Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Nutr Cancer 61:179-93. 2009
    ..These findings may explain some of the racial differences in colon cancer incidence and underscore the importance of examining diet-cancer associations in different population subgroups...
  43. pmc Direct health care costs of Crohn's disease and ulcerative colitis in US children and adults
    Michael D Kappelman
    Division of Pediatric Gastroenterology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 135:1907-13. 2008
    ....
  44. pmc The effect of hospital and surgeon volume on outcomes for rectal cancer surgery
    Talya Salz
    Department of Health Policy and Administration, University of North Carolina, Chapel Hill, North Carolina 27599 7411, USA
    Clin Gastroenterol Hepatol 6:1185-93. 2008
    ..As more technically challenging surgeries, such as total mesorectal resection, become more widespread it will be important to evaluate the impact of hospital and surgeon volume on outcomes...
  45. pmc Direct-to-consumer and physician promotion of tegaserod correlated with physician visits, diagnoses, and prescriptions
    Spencer D Dorn
    Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
    Gastroenterology 137:518-24, 524.e1-2. 2009
    ..We sought to determine the relationship between promotion of tegaserod and the number of office visits for abdominal pain, constipation, and bloating; diagnoses of irritable bowel syndrome (IBS); and tegaserod prescriptions...
  46. pmc Thiazolidinedione use and ulcerative colitis-related flares: an exploratory analysis of administrative data
    Jennifer L Lund
    Department of Epidemiology, University of North Carolina, Gillings School of Global Public Health, Chapel Hill, North Carolina, USA
    Inflamm Bowel Dis 17:787-94. 2011
    ..We examined the association between thiazolidinedione use and ulcerative colitis (UC)-related flares...
  47. pmc Utilization of healthcare resources by U.S. children and adults with inflammatory bowel disease
    Michael D Kappelman
    University of North Carolina Chapel Hill, Chapel Hill, North Carolina
    Inflamm Bowel Dis 17:62-8. 2011
    ..The objectives were to describe the healthcare utilization associated with IBD in an insured U.S. population and to determine how sociodemographic factors impact healthcare utilization in this population...
  48. pmc Isotretinoin use and the risk of inflammatory bowel disease: a case-control study
    Seth D Crockett
    Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Am J Gastroenterol 105:1986-93. 2010
    ..Isotretinoin is commonly prescribed for the treatment of severe acne. Although cases of inflammatory bowel disease (IBD) have been reported in isotretinoin users, a causal association remains unproven...
  49. pmc Bone health in a tertiary-care gastroenterology and hepatology population
    Millie D Long
    Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC 27599 7080, USA
    Dig Dis Sci 55:2263-9. 2010
    ..Glucocorticoid use is a major risk factor for osteoporosis. Overall rates of glucocorticoid use and bone health preventive measures in gastroenterology and hepatology populations are unknown...
  50. pmc Increased risk for non-melanoma skin cancer in patients with inflammatory bowel disease
    Millie D Long
    Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina 27599 7080, USA
    Clin Gastroenterol Hepatol 8:268-74. 2010
    ..We evaluated the risk of non-melanoma skin cancer (NMSC) in patients with IBD and determined how immunosuppressive and biologic medications affect this risk...
  51. pmc trans-Fatty acid consumption and its association with distal colorectal cancer in the North Carolina Colon Cancer Study II
    Lisa C Vinikoor
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Cancer Causes Control 21:171-80. 2010
    ..98 (95%CI: 0.47, 2.05) and 0.87 (95%CI 0.42, 1.81), respectively]. In conclusion, high consumption of trans-fatty acids was positively associated with distal colorectal cancer among Whites...
  52. pmc Associations between trans fatty acid consumption and colon cancer among Whites and African Americans in the North Carolina colon cancer study I
    Lisa C Vinikoor
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Nutr Cancer 61:427-36. 2009
    ..In conclusion, trans fatty acid consumption is not associated with colon cancer and does not contribute to disparities in colon cancer rates...
  53. pmc A causal association between isotretinoin and inflammatory bowel disease has yet to be established
    Seth D Crockett
    Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, CB 7080, Chapel Hill, North Carolina 27599, USA
    Am J Gastroenterol 104:2387-93. 2009
    ..Case reports have described a possible association between isotretinoin and inflammatory bowel disease (IBD). We critically appraised the literature on this association to assess whether it supports a causal relationship...
  54. pmc Diagnostic ionizing radiation exposure in a population-based sample of children with inflammatory bowel diseases
    Lena Palmer
    Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Am J Gastroenterol 104:2816-23. 2009
    ..In this study, we describe this exposure in a population-based sample of children with IBD and determine the characteristics associated with moderate radiation exposure...
  55. pmc Risk of diagnosed fractures in children with inflammatory bowel diseases
    Michael D Kappelman
    Department of Pediatrics, Division of Pediatric Gastroenterology, University of North Carolina Chapel Hill, North Carolina 27599, USA
    Inflamm Bowel Dis 17:1125-30. 2011
    ..We sought to evaluate fracture risk in children with IBD as compared to unaffected controls and determine whether this risk is affected by geographical region (a proxy for sun/vitamin D exposure) and oral steroid use...
  56. pmc Gastrointestinal endoscopy nurse experience and polyp detection during screening colonoscopy
    Evan S Dellon
    Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
    Clin Gastroenterol Hepatol 6:1342-7. 2008
    ..The effect of gastrointestinal endoscopy nursing experience on polyp detection is unknown. The aim of this study was to determine whether nurse experience is associated with odds of polyp detection...
  57. ncbi request reprint The effect of physician permission versus notification on research recruitment through cancer registries (United States)
    Laura M Beskow
    Department of Health Policy and Administration, School of Public Health, University of North Carolina, Chapel Hill, USA
    Cancer Causes Control 17:315-23. 2006
    ..To determine how physicians responded when investigators inquired about contacting patients identified through a central cancer registry, and to examine participation rates under physician permission versus notification approaches...
  58. ncbi request reprint A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer
    Robert S Sandler
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7555, USA
    N Engl J Med 348:883-90. 2003
    ..Experimental studies in animals and observational studies in humans suggest that regular aspirin use may decrease the risk of colorectal adenomas, the precursors to most colorectal cancers...
  59. ncbi request reprint Patient perspectives on research recruitment through cancer registries
    Laura M Beskow
    Department of Health Policy and Administration, School of Public Health, University of North Carolina, CB 7411, McGavran Greenberg Hall, Chapel Hill, NC 27599 7411, USA
    Cancer Causes Control 16:1171-5. 2005
    ..To gain preliminary insight into patients' levels of awareness and preferences about research recruitment through cancer registries...
  60. ncbi request reprint Reported use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors was not associated with reduced recurrence of colorectal adenomas
    Jeffrey T Wei
    Division of Gastroenterology and Hepatology, University of North Carolina, Campus Box 7080, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 14:1026-7. 2005
    ..Lack of statistical power from limited exposure to HMG-CoA reductase inhibitors might be responsible for the lack of association...
  61. ncbi request reprint Constipation, laxative use, and colon cancer in a North Carolina population
    Malcolm C Roberts
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7080, USA
    Am J Gastroenterol 98:857-64. 2003
    ..The aim of this study was to determine whether bowel movement frequency and laxative use and type were associated with risk of colon cancer in white and black men and women...
  62. ncbi request reprint Risk of prostate cancer in a randomized clinical trial of calcium supplementation
    John A Baron
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Epidemiol Biomarkers Prev 14:586-9. 2005
    ..In some studies, high calcium intake has been associated with an increased risk of prostate cancer, but no randomized studies have investigated this issue...
  63. ncbi request reprint Recognition and treatment of irritable bowel syndrome among women with chronic pelvic pain
    Rachel E Williams
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Obstet Gynecol 192:761-7. 2005
    ..We sought to describe irritable bowel syndrome (IBS) treatment among women with chronic pelvic pain...
  64. ncbi request reprint Eating frequency and colon cancer risk
    Jeffrey T Wei
    Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill 27599 7080, USA
    Nutr Cancer 50:16-22. 2004
    ..03; 95% CI = 0.74-1.44). No significant associations were detected among women. Decreased eating frequency was associated with a lower risk of colon cancer among men but not women...
  65. ncbi request reprint Prevalence and characteristics of irritable bowel syndrome among women with chronic pelvic pain
    Rachel E Williams
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Obstet Gynecol 104:452-8. 2004
    ..We sought to evaluate whether there are unique characteristics associated with irritable bowel syndrome (IBS) within a population that has chronic pelvic pain...
  66. ncbi request reprint Quality of colon carcinoma pathology reporting: a process of care study
    Jeffrey T Wei
    Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7080, USA
    Cancer 100:1262-7. 2004
    ..The objectives of the current study were to describe pathology reporting for colon carcinoma, evaluate potential variations in reporting, and identify areas for improvement...
  67. ncbi request reprint Selenium, apoptosis, and colorectal adenomas
    Alexandra Connelly-Frost
    R Stuart Dickson Institute for Health Studies, 720 East Morehead Street, Charlotte, NC 28232, USA
    Cancer Epidemiol Biomarkers Prev 15:486-93. 2006
    ..Selenium is an essential trace element found in cereals, wheat, dairy products, meat, and fish. This micronutrient may prevent carcinogenesis through several biochemical pathways; one suggested pathway is enhanced apoptosis...
  68. pmc Research recruitment through US central cancer registries: balancing privacy and scientific issues
    Laura M Beskow
    Department of Health Policy and Administration, University of North Carolina School of Public Health, Chapel Hill 27599 7411, USA
    Am J Public Health 96:1920-6. 2006
    ..Further discussion about balanced recruitment approaches that protect patient privacy and encourage beneficial research is needed...
  69. ncbi request reprint Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer
    Nicholas J Shaheen
    Center for Gastrointestinal Biology and Disease and Division of Digestive Diseases and Nutrition, University of North Carolina, Chapel Hill 27599 7080, USA
    J Natl Cancer Inst 95:154-9. 2003
    ..Mutations in the hemochromatosis (HFE) gene are associated with increased total body iron stores in some individuals. We assessed the risk of colon cancer among individuals with and without HFE gene mutations...
  70. pmc Consumption of trans-fatty acid and its association with colorectal adenomas
    Lisa C Vinikoor
    Department of Epidemiology, Center for Gastrointestinal Biology and Disease, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Am J Epidemiol 168:289-97. 2008
    ..These results suggest that consumption of high amounts of trans-fatty acid may increase the risk of colorectal neoplasia, and they provide additional support to recommendations to limit trans-fatty acid consumption...
  71. ncbi request reprint Clinical practice. Screening for colorectal cancer
    David F Ransohoff
    Department of Medicine, University of North Carolina at Chapel Hill, 27599 7080, USA
    N Engl J Med 346:40-4. 2002
  72. ncbi request reprint Best hospitals?
    Robert S Sandler
    Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina 27599 7555, USA
    Gastroenterology 133:1064-7. 2007
  73. pmc Cholecystectomy and the risk of colorectal adenomas
    Lisa C Vinikoor
    Department of Epidemiology, School of Public Health, University of North Carolina, CB 7555, Chapel Hill, NC 27599 7555, USA
    Dig Dis Sci 53:730-5. 2008
    ..14 [95% CI 0.62-2.09]). Thus, we conclude that, although cholecystectomy is a risk factor for colorectal cancer, cholecystectomy is not a risk factor for colorectal adenomas...
  74. ncbi request reprint Cholecystectomy and the risk of recurrent colorectal adenomas
    Lisa C Vinikoor
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Cancer Epidemiol Biomarkers Prev 16:1523-5. 2007
    ..34; 95% CI, 0.97-1.85) but the 95% CIs included the null in both cases. We conclude that the increased risk for colorectal cancer following cholecystectomy seems to be due to a biological process occurring after the adenoma has developed...
  75. pmc Moderate alcohol consumption protects against colorectal adenomas in smokers
    Gregory L Austin
    Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC 27599 7080, USA
    Dig Dis Sci 53:116-22. 2008
    ..Although some studies have shown an association between alcohol consumption and colorectal adenomas, the effect of moderate alcohol consumption is not well defined, nor is the interaction between alcohol and smoking...
  76. ncbi request reprint Serious adverse events with infliximab: analysis of spontaneously reported adverse events
    Richard A Hansen
    Center for Pharmaceutical Outcomes and Policy, Division of Pharmaceutical Outcomes and Policy, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Clin Gastroenterol Hepatol 5:729-35. 2007
    ..The aims of this study were to explore adverse event signals with infliximab by using a long period of post-marketing experience, stratifying by indication...
  77. ncbi request reprint A diet high in fruits and low in meats reduces the risk of colorectal adenomas
    Gregory L Austin
    Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Nutr 137:999-1004. 2007
    ..A high-fruit, low-meat diet appears to be protective against colorectal adenomas compared with a dietary pattern of increased vegetable and meat consumption...
  78. ncbi request reprint Chemoprevention of gastrointestinal malignancies with nonsteroidal antiinflammatory drugs
    Nicholas J Shaheen
    Division of Digestive Diseases and Nutrition and the Center for Gastrointestinal Biology and Disease, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Cancer 94:950-63. 2002
    ..The newer COX-2 specific agents may provide a less GI-toxic alternative to nonselective NSAIDs as chemoprotective agents...
  79. ncbi request reprint Associations of micronutrients with colon cancer risk in African Americans and whites: results from the North Carolina Colon Cancer Study
    Jessie Satia-Abouta
    Department of Nutrition, School of Public Health, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 12:747-54. 2003
    ....
  80. ncbi request reprint Associations of total energy and macronutrients with colon cancer risk in African Americans and Whites: results from the North Carolina colon cancer study
    Jessie Satia-Abouta
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Epidemiol 158:951-62. 2003
    ..These findings may provide an explanation for some of the racial differences in colon cancer incidence...
  81. pmc KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer
    Jen Jen Yeh
    Department of Surgery, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, 450 West Drive, CB 7295, Chapel Hill, NC 27599 7295, USA
    Mol Cancer Ther 8:834-43. 2009
    ..Our results suggest that although MEK inhibitors show promise in colorectal cancer, KRAS/BRAF mutation status, but not ERK activation as previously thought, may be useful biomarkers for MEK inhibitor sensitivity...
  82. pmc Suppressor of cytokine signaling 3 (SOCS3) is not an independent biomarker of colorectal adenoma risk
    Kathryn E Hamilton
    Department of Medicine and Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, 130 Mason Farm Road, Chapel Hill, North Carolina 27599 7545, USA
    BMC Res Notes 3:144. 2010
    ..As SOCS3 has been shown to inhibit the actions of IL-6 and TNFalpha in the intestine, we hypothesized that decreased SOCS3 expression in normal mucosa may predispose to adenomas and thus increase risk for CRC...
  83. ncbi request reprint RNA expression analysis of formalin-fixed paraffin-embedded tumors
    Shannon K Penland
    Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
    Lab Invest 87:383-91. 2007
    ..Although only a minority of FFPE blocks could be analyzed, we show that informative RNA expression analysis can be derived from selected FFPE samples...
  84. pmc Altered tissue metabolites correlate with microbial dysbiosis in colorectal adenomas
    Julia L Nugent
    School of Medicine, University of North Carolina at Chapel Hill, 321 South Columbia Street, Chapel Hill, North Carolina 27599, United States
    J Proteome Res 13:1921-9. 2014
    ..These findings suggest that metabolic products of bacteria may be responsible for the development of colorectal adenomas and CRC. ..
  85. pmc Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome
    Ian M Carroll
    Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, 27599 7080, USA
    Am J Physiol Gastrointest Liver Physiol 301:G799-807. 2011
    ....
  86. pmc Intestinal inflammation targets cancer-inducing activity of the microbiota
    Janelle C Arthur
    Department of Medicine, Pharmacology and Immunology Microbiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Science 338:120-3. 2012
    ..This suggests that in mice, colitis can promote tumorigenesis by altering microbial composition and inducing the expansion of microorganisms with genotoxic capabilities...
  87. ncbi request reprint IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts
    James G Simmons
    Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    Am J Physiol Gastrointest Liver Physiol 283:G809-18. 2002
    ..We propose that during intestinal inflammation, regulation of activated phenotype and proliferation may require sequential actions of TGF-beta1 and IGF-I, but they may act in concert to increase collagen deposition...
  88. ncbi request reprint Reduction of spontaneous and irradiation-induced apoptosis in small intestine of IGF-I transgenic mice
    Heather R Wilkins
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, 27599, USA
    Am J Physiol Gastrointest Liver Physiol 283:G457-64. 2002
    ..IGF-I regulates cell number by stimulating crypt cell proliferation and decreasing apoptosis preferentially within the stem cell compartment...
  89. ncbi request reprint Calcium, dietary, and lifestyle factors in the prevention of colorectal adenomas
    Eric A Miller
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Cancer 109:510-7. 2007
    ..We examined the association between calcium and prevalence of adenomas and assessed whether the association was stronger in biologically plausible subgroups...
  90. ncbi request reprint COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States)
    Leah B Sansbury
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 8325, USA
    Cancer Causes Control 17:257-66. 2006
    ..We explored the association between the COX-2 Val511Ala SNP and risk of colon cancer among 240 African American cases and 326 African American controls in a population-based, case-control study in North Carolina...
  91. pmc Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study
    Lesley M Butler
    University of California Davis, Department of Public Health Sciences, Division of Epidemiology, Davis, CA 95616, USA
    Mutat Res 638:162-74. 2008
    ....
  92. ncbi request reprint Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia
    Henry J Lin
    Division of Medical Genetics, Department of Pediatrics, and the Research and Education Institute at Harbor University of California, Los Angeles Medical Center, Torrance, California 90502, USA
    Cancer Epidemiol Biomarkers Prev 11:1305-15. 2002
    ..28-1.56; 138 cases and 258 controls). Consistency of the results across all three of the studies is potentially compatible with a protective effect of the polymorphism, mimicking aspirin...

Research Grants3

  1. Insulin Resistance and Colon Cancer in Blacks and Whites
    Temitope Keku; Fiscal Year: 2005
    ..The proposed project will advance the understanding of the role of insulin resistance in colon cancer among African Americans and whites. ..
  2. Intestinal Microbiota, Diet and Risk of Colorectal Adenomas
    Temitope Keku; Fiscal Year: 2009
    ..The findings from this study could help identify individuals at high risk of adenomas as well as enhance the development of strategies to manipulate the intestinal microbiota to prevent colorectal adenomas and cancer ..
  3. Intestinal Microbiota, Diet and Risk of Colorectal Adenomas
    Robert S Sandler; Fiscal Year: 2010
    ..The findings from this study could help identify individuals at high risk of adenomas as well as enhance the development of strategies to manipulate the intestinal microbiota to prevent colorectal adenomas and cancer ..