Research Topics
Genomes and Genes
| Temitope O KekuSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and WhitesTemitope O Keku
Department of Medicine, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, 27599 7032, USA
Cancer Causes Control 23:1127-38. 2012....
Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whitesRobert C Millikan
Department of Epidemiology, School of Public Health, and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
Breast Cancer Res 6:R264-74. 2004..Results suggest that the Ala allele increases the risk of breast cancer and modifies the effects of environmental exposures that produce oxidative damage to DNA...
Insulin resistance, apoptosis, and colorectal adenoma riskTemitope O Keku
Department of Medicine, University of North Carolina, Chapel Hill, 27599 7555, USA
Cancer Epidemiol Biomarkers Prev 14:2076-81. 2005..These findings suggest that insulin may act early in the adenoma-carcinoma sequence to promote the development of colorectal adenoma by decreasing apoptosis in the normal mucosa...- Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomasTemitope O Keku
Department of Medicine and Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
BMC Cancer 8:143. 2008..We evaluated the association between tissue or plasma IGFBP-3 and risk of colorectal adenomas or low apoptosis... - Apoptosis in normal rectal mucosa, baseline adenoma characteristics, and risk of future adenomasTemitope O Keku
Department of Medicine and Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer Epidemiol Biomarkers Prev 17:306-10. 2008..If confirmed in larger studies, apoptosis could potentially be used to identify patients at highest risk for developing new adenomas... - Gene testing: what the health professional needs to knowTemitope O Keku
Center for Gastrointestinal Biology and Disease and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
J Nutr 133:3754S-3757S. 2003..To meet these demands, physicians and other health professionals should use available educational genetic resources to provide adequate patient care... - Family history of colon cancer: what does it mean and how is it useful?Temitope O Keku
Center for Gastrointestinal Biology and Disease, CB 7555, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7555, USA
Am J Prev Med 24:170-6. 2003..Family history of colon cancer can be deconstructed into causal and noncausal explanations, which include genetic factors, environmental factors, gene-environment interactions, misclassification, and differences in screening... - 5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whitesTemitope Keku
Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7555, USA
Cancer Epidemiol Biomarkers Prev 11:1611-21. 2002.... - Antioxidant and DNA methylation-related nutrients and risk of distal colorectal cancerChristina Dawn Williams
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, McGavran Greenberg Hall, Chapel Hill, NC 27599, USA
Cancer Causes Control 21:1171-81. 2010.... - Does physical activity modify the association between body mass index and colorectal adenomas?Magda Guilera
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599, USA
Nutr Cancer 51:140-5. 2005..Our results suggest that physical activity may modify the association between obesity and colorectal adenoma until a high level of obesity is achieved. Apoptosis does not appear to be associated with obesity or physical activity... - Nonsteroidal anti-inflammatory drugs, apoptosis, and colorectal adenomasChristopher Martin
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, 27599, USA
Gastroenterology 123:1770-7. 2002..CONCLUSIONS: Our observations suggest that NSAID use and higher levels of mucosal apoptosis are independently associated with a lower prevalence of adenomas. The study shows a strong field effect for apoptosis... - The association between diabetes, insulin use, and colorectal cancer among Whites and African AmericansLisa C Vinikoor
University of North Carolina, Chapel Hill, NC 27599 7555, USA
Cancer Epidemiol Biomarkers Prev 18:1239-42. 2009..No association was present among African Americans. Insulin use was also positively associated with rectal cancer among Whites... - Dietary patterns, food groups, and rectal cancer risk in Whites and African-AmericansChristina Dawn Williams
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
Cancer Epidemiol Biomarkers Prev 18:1552-61. 2009..We examined the relationship between food groups and dietary patterns and risk for rectal cancer in non-Hispanic Whites and African-Americans... - Selenium, folate, and colon cancerAlexandra Connelly-Frost
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Nutr Cancer 61:165-78. 2009..Importantly, weight loss, stage at diagnosis, or time from diagnosis to blood draw did not appear to produce strong bias in our study... - 5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancerAllison M Eaton
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7555, USA
Cancer Epidemiol Biomarkers Prev 14:2023-9. 2005..These results indicate that the relationship between MTHFR genotypes and MSI is influenced by folate status... - Associations of red meat, fat, and protein intake with distal colorectal cancer riskChristina Dawn Williams
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Drive, Chapel Hill, NC 27599, USA
Nutr Cancer 62:701-9. 2010..77). Red meat consumption in Whites was associated with a marginally significant risk reduction (Q4 OR = 0.66, 95% CI = 0.43-1.00). Our results do not support the hypotheses that fat, protein, and red meat increase the risk of distal CRC... - Circulating levels of inflammatory cytokines and risk of colorectal adenomasSangmi Kim
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7555, USA
Cancer Res 68:323-8. 2008..56 (95% CI, 1.03-2.36) and 1.66 (95% CI, 1.10-2.52), respectively. Our findings indicate that systemic inflammation might be involved in the early development of colorectal neoplasia... - Longitudinal changes in lifestyle behaviors and health status in colon cancer survivorsJessie A Satia
Department of Nutrition and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA
Cancer Epidemiol Biomarkers Prev 13:1022-31. 2004..Health care providers should communicate with persons diagnosed with colon cancer to ensure that they are making healthy lifestyle changes... - Vitamin C intake and apoptosis in normal rectal epitheliumAlexandra E Connelly
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7555, USA
Cancer Epidemiol Biomarkers Prev 12:559-65. 2003..Given that high apoptosis may lower colorectal cancer risk, vitamin C supplements may be contraindicated for patients with a history of adenomas... - Genetic heterogeneity in colorectal cancer associations between African and European americansSonia S Kupfer
Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois 60637, USA
Gastroenterology 139:1677-85, 1685.e1-8. 2010..None of these studies included African Americans, who have the highest incidence and mortality from CRC in the United States. For the 10 genomic regions, we performed an association study of Americans of African and European descent... - Hospital-to-hospital variation in lymph node detection after colorectal resectionEric A Miller
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, USA
Cancer 101:1065-71. 2004..4; 95% CI, 0.1-1.2). CONCLUSIONS: The current study suggests that patients at low-volume hospitals may have their tumors pathologically understaged more frequently compared with patients at high- and medium-volume hospitals... - A population-based cohort study comparing laparoscopic cholecystectomy and open cholecystectomySteven L Zacks
Department of Medicine, University of North Carolina at Chapel Hill, USA
Am J Gastroenterol 97:334-40. 2002..Based on lower costs and better outcomes, LC seems to be the treatment of choice for acute and chronic cholecystitis... - Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomasXiang Jun Shen
Center for Gastrointestinal Biology and Disease University of North Carolina at Chapel Hill, NC, USA
Gut Microbes 1:138-47. 2010..Extension of these findings could lead to strategies to manipulate the microbiota to prevent colorectal adenomas and cancer as well as to identify individuals at high risk... - Assessment of serum proteomics to detect large colon adenomasDavid F Ransohoff
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
Cancer Epidemiol Biomarkers Prev 17:2188-93. 2008..They also highlight the importance of understanding sources of "noise" and "bias" in studies of proteomics assays... - Gastric cancer and the high combination prevalence of host cytokine genotypes and Helicobacter pylori in HondurasDouglas R Morgan
Department of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
Clin Gastroenterol Hepatol 4:1103-11. 2006..We investigated the cytokine profile in the Latino population, specifically Honduras, a high-incidence region, and the use of the combination prevalence of H pylori and genotypes in identifying high-risk populations... - Calcium, vitamin D, and apoptosis in the rectal epitheliumEric A Miller
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7555, USA
Cancer Epidemiol Biomarkers Prev 14:525-8. 2005..6; 95% CI, 1.1-6.2) and slightly lower levels in patients with adenomas (OR, 0.6; 95% CI, 0.2-2.2). CONCLUSION: These results are consistent with a calcium and vitamin D-mediated apoptotic mechanism in colon carcinogenesis... - Increased rectal microbial richness is associated with the presence of colorectal adenomas in humansNina Sanapareddy
Department of Bioinformatics and Genomics, University of North Carolina, Charlotte, NC, USA
ISME J 6:1858-68. 2012..This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas... - Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosaAdriana C Vidal
Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, USA
BMC Cancer 12:389. 2012..However few studies have evaluated IGFBP-1 and C-peptide in relation to adenomatous polyps, the only known precursor for CRC... - Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcomeJanelle M Hoskins
Division of Pharmacotherapy and Experimental Therapeutics, Institute for Pharmacogenomics and Individualized Therapy, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS ONE 7:e41954. 2012..As the CRC risk SNPs may also influence disease outcome, thus in this study, we evaluated whether they influence patient survival... - Aspirin may be more effective in preventing colorectal adenomas in patients with higher BMI (United States)Sangmi Kim
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7555, USA
Cancer Causes Control 17:1299-304. 2006..The more pronounced effect of 325 mg aspirin in individuals with higher BMI suggests a possible protective role of anti-inflammatory aspirin against increased adipose-driven cytokines among obese subjects... - A randomized trial of rofecoxib for the chemoprevention of colorectal adenomasJohn A Baron
Department of Medicine, The Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, USA
Gastroenterology 131:1674-82. 2006..We conducted a randomized, placebo-controlled, double-blind trial to assess whether use of the selective COX-2 inhibitor rofecoxib would reduce the risk of colorectal adenomas... - The burden of gastrointestinal and liver diseases, 2006Nicholas J Shaheen
Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Gastroenterol 101:2128-38. 2006..CONCLUSIONS: Gastrointestinal and liver diseases are significant contributors to the morbidity, mortality, and health-care expenditures of the U.S. population... - Race and colorectal cancer screening: a population-based study in North CarolinaDeborah A Fisher
Department of Medicine, Duke University Medical Center, Institute for Clinical and Epidemiological Research, Durham Veterans Affairs Medical Center, Durham, NC, USA
N C Med J 65:12-5. 2004..The purpose of this study was to determine if colorectal cancer screening rates are different between blacks and whites while controlling for potential confounders... - Tea intake and risk of colon cancer in African-Americans and whites: North Carolina colon cancer studyDora Il'yasova
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer Causes Control 14:767-72. 2003..Tea polyphenols have been shown to exhibit anti-cancer activity, but the epidemiological findings are inconsistent. We examined the association between tea consumption and colon cancer in a population-based study in North Carolina... - Fusobacterium is associated with colorectal adenomasAmber N McCoy
Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
PLoS ONE 8:e53653. 2013..33, p = 0.06 while it was 0.44, p = 0.01 for Fusobacterium and IL-10. These results support a link between the abundance of Fusobacterium in colonic mucosa and adenomas and suggest a possible role for mucosal inflammation in this process... - Differences in microbial signatures between rectal mucosal biopsies and rectal swabsFelix Araujo-Perez
Division of Gastroenterology and Hepatology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Gut Microbes 3:530-5. 2012..0001) and Eubacteria (p = 0.0003) in swab samples compared with biopsies. Our findings suggest that rectal swabs and rectal mucosal samples provide different views of the microbiota in the large intestine... - Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndromeIan M Carroll
Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, 27599 7080, USA
Am J Physiol Gastrointest Liver Physiol 301:G799-807. 2011.... - Suboptimal rates of cervical testing among women with inflammatory bowel diseaseMillie D Long
Division of Gastroenterology and Hepatology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
Clin Gastroenterol Hepatol 7:549-53. 2009..We aimed to determine cervical testing rates among women with IBD, specifically those on immunosuppressant medications, and to identify risk factors associated with low incidence of screening... - Direct health care costs of Crohn's disease and ulcerative colitis in US children and adultsMichael D Kappelman
Division of Pediatric Gastroenterology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Gastroenterology 135:1907-13. 2008.... - The effect of hospital and surgeon volume on outcomes for rectal cancer surgeryTalya Salz
Department of Health Policy and Administration, University of North Carolina, Chapel Hill, North Carolina 27599 7411, USA
Clin Gastroenterol Hepatol 6:1185-93. 2008..As more technically challenging surgeries, such as total mesorectal resection, become more widespread it will be important to evaluate the impact of hospital and surgeon volume on outcomes... - Associations between trans fatty acid consumption and colon cancer among Whites and African Americans in the North Carolina colon cancer study ILisa C Vinikoor
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Nutr Cancer 61:427-36. 2009..In conclusion, trans fatty acid consumption is not associated with colon cancer and does not contribute to disparities in colon cancer rates... - Gastrointestinal endoscopy nurse experience and polyp detection during screening colonoscopyEvan S Dellon
Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
Clin Gastroenterol Hepatol 6:1342-7. 2008..The effect of gastrointestinal endoscopy nursing experience on polyp detection is unknown. The aim of this study was to determine whether nurse experience is associated with odds of polyp detection... - Utilization of healthcare resources by U.S. children and adults with inflammatory bowel diseaseMichael D Kappelman
University of North Carolina Chapel Hill, Chapel Hill, North Carolina
Inflamm Bowel Dis 17:62-8. 2011..The objectives were to describe the healthcare utilization associated with IBD in an insured U.S. population and to determine how sociodemographic factors impact healthcare utilization in this population... - Isotretinoin use and the risk of inflammatory bowel disease: a case-control studySeth D Crockett
Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
Am J Gastroenterol 105:1986-93. 2010..Isotretinoin is commonly prescribed for the treatment of severe acne. Although cases of inflammatory bowel disease (IBD) have been reported in isotretinoin users, a causal association remains unproven... - Dietary patterns and colon cancer risk in Whites and African Americans in the North Carolina Colon Cancer StudyJessie A Satia
Department of Nutrition, Schools of Public Health and Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Nutr Cancer 61:179-93. 2009..These findings may explain some of the racial differences in colon cancer incidence and underscore the importance of examining diet-cancer associations in different population subgroups... - A causal association between isotretinoin and inflammatory bowel disease has yet to be establishedSeth D Crockett
Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, CB 7080, Chapel Hill, North Carolina 27599, USA
Am J Gastroenterol 104:2387-93. 2009..Case reports have described a possible association between isotretinoin and inflammatory bowel disease (IBD). We critically appraised the literature on this association to assess whether it supports a causal relationship... - Bone health in a tertiary-care gastroenterology and hepatology populationMillie D Long
Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC 27599 7080, USA
Dig Dis Sci 55:2263-9. 2010..Glucocorticoid use is a major risk factor for osteoporosis. Overall rates of glucocorticoid use and bone health preventive measures in gastroenterology and hepatology populations are unknown... - Thiazolidinedione use and ulcerative colitis-related flares: an exploratory analysis of administrative dataJennifer L Lund
Department of Epidemiology, University of North Carolina, Gillings School of Global Public Health, Chapel Hill, North Carolina, USA
Inflamm Bowel Dis 17:787-94. 2011..We examined the association between thiazolidinedione use and ulcerative colitis (UC)-related flares... - Risk of diagnosed fractures in children with inflammatory bowel diseasesMichael D Kappelman
Department of Pediatrics, Division of Pediatric Gastroenterology, University of North Carolina Chapel Hill, North Carolina 27599, USA
Inflamm Bowel Dis 17:1125-30. 2011..We sought to evaluate fracture risk in children with IBD as compared to unaffected controls and determine whether this risk is affected by geographical region (a proxy for sun/vitamin D exposure) and oral steroid use... - Increased risk for non-melanoma skin cancer in patients with inflammatory bowel diseaseMillie D Long
Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina 27599 7080, USA
Clin Gastroenterol Hepatol 8:268-74. 2010..We evaluated the risk of non-melanoma skin cancer (NMSC) in patients with IBD and determined how immunosuppressive and biologic medications affect this risk... - Diagnostic ionizing radiation exposure in a population-based sample of children with inflammatory bowel diseasesLena Palmer
Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Am J Gastroenterol 104:2816-23. 2009..In this study, we describe this exposure in a population-based sample of children with IBD and determine the characteristics associated with moderate radiation exposure... - trans-Fatty acid consumption and its association with distal colorectal cancer in the North Carolina Colon Cancer Study IILisa C Vinikoor
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Cancer Causes Control 21:171-80. 2010..98 (95%CI: 0.47, 2.05) and 0.87 (95%CI 0.42, 1.81), respectively]. In conclusion, high consumption of trans-fatty acids was positively associated with distal colorectal cancer among Whites... - Direct-to-consumer and physician promotion of tegaserod correlated with physician visits, diagnoses, and prescriptionsSpencer D Dorn
Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
Gastroenterology 137:518-24, 524.e1-2. 2009..We sought to determine the relationship between promotion of tegaserod and the number of office visits for abdominal pain, constipation, and bloating; diagnoses of irritable bowel syndrome (IBS); and tegaserod prescriptions... - Consumption of trans-fatty acid and its association with colorectal adenomasLisa C Vinikoor
Department of Epidemiology, Center for Gastrointestinal Biology and Disease, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7555, USA
Am J Epidemiol 168:289-97. 2008..These results suggest that consumption of high amounts of trans-fatty acid may increase the risk of colorectal neoplasia, and they provide additional support to recommendations to limit trans-fatty acid consumption... - Reported use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors was not associated with reduced recurrence of colorectal adenomasJeffrey T Wei
Division of Gastroenterology and Hepatology, University of North Carolina, Campus Box 7080, Chapel Hill, NC 27599, USA
Cancer Epidemiol Biomarkers Prev 14:1026-7. 2005..Lack of statistical power from limited exposure to HMG-CoA reductase inhibitors might be responsible for the lack of association... - Risk of prostate cancer in a randomized clinical trial of calcium supplementationJohn A Baron
Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
Cancer Epidemiol Biomarkers Prev 14:586-9. 2005..CONCLUSION: In this randomized controlled clinical trial, there was no increase in prostate cancer risk associated with calcium supplementation and some suggestion of a protective effect... - Recognition and treatment of irritable bowel syndrome among women with chronic pelvic painRachel E Williams
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Am J Obstet Gynecol 192:761-7. 2005..We sought to describe irritable bowel syndrome (IBS) treatment among women with chronic pelvic pain... - Eating frequency and colon cancer riskJeffrey T Wei
Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill 27599 7080, USA
Nutr Cancer 50:16-22. 2004..03; 95% CI = 0.74-1.44). No significant associations were detected among women. Decreased eating frequency was associated with a lower risk of colon cancer among men but not women... - Prevalence and characteristics of irritable bowel syndrome among women with chronic pelvic painRachel E Williams
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Obstet Gynecol 104:452-8. 2004..We sought to evaluate whether there are unique characteristics associated with irritable bowel syndrome (IBS) within a population that has chronic pelvic pain... - Quality of colon carcinoma pathology reporting: a process of care studyJeffrey T Wei
Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7080, USA
Cancer 100:1262-7. 2004..The objectives of the current study were to describe pathology reporting for colon carcinoma, evaluate potential variations in reporting, and identify areas for improvement... - Associations of micronutrients with colon cancer risk in African Americans and whites: results from the North Carolina Colon Cancer StudyJessie Satia-Abouta
Department of Nutrition, School of Public Health, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
Cancer Epidemiol Biomarkers Prev 12:747-54. 2003.... - Constipation, laxative use, and colon cancer in a North Carolina populationMalcolm C Roberts
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599-7080, USA
Am J Gastroenterol 98:857-64. 2003..CONCLUSIONS: This study provides support for a positive association between constipation and increased risk for colon cancer. Women, especially black women with constipation, seem to be at the highest risk... - A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancerRobert S Sandler
Department of Medicine, University of North Carolina, Chapel Hill 27599 7555, USA
N Engl J Med 348:883-90. 2003..Experimental studies in animals and observational studies in humans suggest that regular aspirin use may decrease the risk of colorectal adenomas, the precursors to most colorectal cancers... - Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancerNicholas J Shaheen
Center for Gastrointestinal Biology and Disease and Division of Digestive Diseases and Nutrition, University of North Carolina, Chapel Hill 27599 7080, USA
J Natl Cancer Inst 95:154-9. 2003..Mutations in the hemochromatosis (HFE) gene are associated with increased total body iron stores in some individuals. We assessed the risk of colon cancer among individuals with and without HFE gene mutations... - Chemoprevention of gastrointestinal malignancies with nonsteroidal antiinflammatory drugsNicholas J Shaheen
Division of Digestive Diseases and Nutrition and the Center for Gastrointestinal Biology and Disease, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
Cancer 94:950-63. 2002..The newer COX-2 specific agents may provide a less GI-toxic alternative to nonselective NSAIDs as chemoprotective agents... - Clinical practice. Screening for colorectal cancerDavid F Ransohoff
Department of Medicine, University of North Carolina at Chapel Hill, 27599-7080, USA
N Engl J Med 346:40-4. 2002 - Patient perspectives on research recruitment through cancer registriesLaura M Beskow
Department of Health Policy and Administration, School of Public Health, University of North Carolina, CB 7411, McGavran Greenberg Hall, Chapel Hill, NC 27599 7411, USA
Cancer Causes Control 16:1171-5. 2005..To gain preliminary insight into patients' levels of awareness and preferences about research recruitment through cancer registries... - Serious adverse events with infliximab: analysis of spontaneously reported adverse eventsRichard A Hansen
Center for Pharmaceutical Outcomes and Policy, Division of Pharmaceutical Outcomes and Policy, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Clin Gastroenterol Hepatol 5:729-35. 2007..The aims of this study were to explore adverse event signals with infliximab by using a long period of post-marketing experience, stratifying by indication... - A diet high in fruits and low in meats reduces the risk of colorectal adenomasGregory L Austin
Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Nutr 137:999-1004. 2007..A high-fruit, low-meat diet appears to be protective against colorectal adenomas compared with a dietary pattern of increased vegetable and meat consumption... - Moderate alcohol consumption protects against colorectal adenomas in smokersGregory L Austin
Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC 27599 7080, USA
Dig Dis Sci 53:116-22. 2008..Although some studies have shown an association between alcohol consumption and colorectal adenomas, the effect of moderate alcohol consumption is not well defined, nor is the interaction between alcohol and smoking... - Cholecystectomy and the risk of recurrent colorectal adenomasLisa C Vinikoor
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7555, USA
Cancer Epidemiol Biomarkers Prev 16:1523-5. 2007..34; 95% CI, 0.97-1.85) but the 95% CIs included the null in both cases. We conclude that the increased risk for colorectal cancer following cholecystectomy seems to be due to a biological process occurring after the adenoma has developed... - Cholecystectomy and the risk of colorectal adenomasLisa C Vinikoor
Department of Epidemiology, School of Public Health, University of North Carolina, CB 7555, Chapel Hill, NC 27599 7555, USA
Dig Dis Sci 53:730-5. 2008..14 [95% CI 0.62-2.09]). Thus, we conclude that, although cholecystectomy is a risk factor for colorectal cancer, cholecystectomy is not a risk factor for colorectal adenomas... - Best hospitals?Robert S Sandler
Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina 27599 7555, USA
Gastroenterology 133:1064-7. 2007 - Research recruitment through US central cancer registries: balancing privacy and scientific issuesLaura M Beskow
Department of Health Policy and Administration, University of North Carolina School of Public Health, Chapel Hill 27599 7411, USA
Am J Public Health 96:1920-6. 2006..Further discussion about balanced recruitment approaches that protect patient privacy and encourage beneficial research is needed... - Selenium, apoptosis, and colorectal adenomasAlexandra Connelly-Frost
R Stuart Dickson Institute for Health Studies, 720 East Morehead Street, Charlotte, NC 28232, USA
Cancer Epidemiol Biomarkers Prev 15:486-93. 2006..Selenium is an essential trace element found in cereals, wheat, dairy products, meat, and fish. This micronutrient may prevent carcinogenesis through several biochemical pathways; one suggested pathway is enhanced apoptosis... - The effect of physician permission versus notification on research recruitment through cancer registries (United States)Laura M Beskow
Department of Health Policy and Administration, School of Public Health, University of North Carolina, Chapel Hill, USA
Cancer Causes Control 17:315-23. 2006..To determine how physicians responded when investigators inquired about contacting patients identified through a central cancer registry, and to examine participation rates under physician permission versus notification approaches... - Associations of total energy and macronutrients with colon cancer risk in African Americans and Whites: results from the North Carolina colon cancer studyJessie Satia-Abouta
Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Am J Epidemiol 158:951-62. 2003..These findings may provide an explanation for some of the racial differences in colon cancer incidence... - Association of plasma endotoxin, inflammatory cytokines and risk of colorectal adenomasMelissa Kang
Center for Gastrointestinal Biology and Disease, University of North Carolina, 103 Mason Farm Road, 7340 Medical Biomolecular Research Building, CB 7032, 27599 7032, Chapel Hill, NC 27599, USA
BMC Cancer 13:91. 2013..Given the evidence linking inflammation and colorectal cancer, we sought to determine if plasma endotoxin concentrations are associated with indicators of systemic or local inflammation and colorectal adenomas... - RNA expression analysis of formalin-fixed paraffin-embedded tumorsShannon K Penland
Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
Lab Invest 87:383-91. 2007..Although only a minority of FFPE blocks could be analyzed, we show that informative RNA expression analysis can be derived from selected FFPE samples... - Suppressor of cytokine signaling 3 (SOCS3) is not an independent biomarker of colorectal adenoma riskKathryn E Hamilton
Department of Medicine and Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, 130 Mason Farm Road, Chapel Hill, North Carolina 27599 7545, USA
BMC Res Notes 3:144. 2010..As SOCS3 has been shown to inhibit the actions of IL-6 and TNFalpha in the intestine, we hypothesized that decreased SOCS3 expression in normal mucosa may predispose to adenomas and thus increase risk for CRC... - KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancerJen Jen Yeh
Department of Surgery, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, 450 West Drive, CB 7295, Chapel Hill, NC 27599 7295, USA
Mol Cancer Ther 8:834-43. 2009..Our results suggest that although MEK inhibitors show promise in colorectal cancer, KRAS/BRAF mutation status, but not ERK activation as previously thought, may be useful biomarkers for MEK inhibitor sensitivity... - Intestinal inflammation targets cancer-inducing activity of the microbiotaJanelle C Arthur
Department of Medicine, Pharmacology and Immunology Microbiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Science 338:120-3. 2012..This suggests that in mice, colitis can promote tumorigenesis by altering microbial composition and inducing the expansion of microorganisms with genotoxic capabilities... - IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblastsJames G Simmons
Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
Am J Physiol Gastrointest Liver Physiol 283:G809-18. 2002..We propose that during intestinal inflammation, regulation of activated phenotype and proliferation may require sequential actions of TGF-beta1 and IGF-I, but they may act in concert to increase collagen deposition... - Reduction of spontaneous and irradiation-induced apoptosis in small intestine of IGF-I transgenic miceHeather R Wilkins
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, 27599, USA
Am J Physiol Gastrointest Liver Physiol 283:G457-64. 2002..IGF-I regulates cell number by stimulating crypt cell proliferation and decreasing apoptosis preferentially within the stem cell compartment... - Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasiaHenry J Lin
Division of Medical Genetics, Department of Pediatrics, and the Research and Education Institute at Harbor University of California, Los Angeles Medical Center, Torrance, California 90502, USA
Cancer Epidemiol Biomarkers Prev 11:1305-15. 2002..28-1.56; 138 cases and 258 controls). Consistency of the results across all three of the studies is potentially compatible with a protective effect of the polymorphism, mimicking aspirin... - Calcium, dietary, and lifestyle factors in the prevention of colorectal adenomasEric A Miller
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Cancer 109:510-7. 2007..We examined the association between calcium and prevalence of adenomas and assessed whether the association was stronger in biologically plausible subgroups... - Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic studyLesley M Butler
University of California Davis, Department of Public Health Sciences, Division of Epidemiology, Davis, CA 95616, USA
Mutat Res 638:162-74. 2008.... - COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States)Leah B Sansbury
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 8325, USA
Cancer Causes Control 17:257-66. 2006..We explored the association between the COX-2 Val511Ala SNP and risk of colon cancer among 240 African American cases and 326 African American controls in a population-based, case-control study in North Carolina...
Research Grants
- Insulin Resistance and Colon Cancer in Blacks and WhitesTemitope Keku; Fiscal Year: 2005..The proposed project will advance the understanding of the role of insulin resistance in colon cancer among African Americans and whites. ..
- Intestinal Microbiota, Diet and Risk of Colorectal AdenomasTemitope Keku; Fiscal Year: 2009..The findings from this study could help identify individuals at high risk of adenomas as well as enhance the development of strategies to manipulate the intestinal microbiota to prevent colorectal adenomas and cancer ..
- Intestinal Microbiota, Diet and Risk of Colorectal AdenomasRobert S Sandler; Fiscal Year: 2010..The findings from this study could help identify individuals at high risk of adenomas as well as enhance the development of strategies to manipulate the intestinal microbiota to prevent colorectal adenomas and cancer ..