Peter M Kekenes-Huskey

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Modeling effects of L-type ca(2+) current and na(+)-ca(2+) exchanger on ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometries
    Peter M Kekenes-Huskey
    Department of Pharmacology, University of California San Diego La Jolla, CA, USA
    Front Physiol 3:351. 2012
  2. pmc Molecular and subcellular-scale modeling of nucleotide diffusion in the cardiac myofilament lattice
    Peter M Kekenes-Huskey
    Department of Pharmacology, University of Arizona, California Electronic address
    Biophys J 105:2130-40. 2013
  3. pmc Molecular basis of calcium-sensitizing and desensitizing mutations of the human cardiac troponin C regulatory domain: a multi-scale simulation study
    Peter Michael Kekenes-Huskey
    Department of Pharmacology, Center for Theoretical Biological Physics, National Computational Biomedical Resource and Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America
    PLoS Comput Biol 8:e1002777. 2012
  4. pmc Calcium binding and allosteric signaling mechanisms for the sarcoplasmic reticulum Ca²+ ATPase
    Peter M Kekenes-Huskey
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    Protein Sci 21:1429-43. 2012
  5. pmc Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit
    Johan Hake
    Department of Bioengineering, University of California San Diego, CA, USA
    J Physiol 590:4403-22. 2012
  6. pmc Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study
    Steffen Lindert
    Department of Pharmacology, NSF Center for Theoretical Biological Physics, National Biomedical Computation Resource, University of California San Diego, La Jolla, California 92093, United States
    J Phys Chem B 116:8449-59. 2012
  7. pmc Long-timescale molecular dynamics simulations elucidate the dynamics and kinetics of exposure of the hydrophobic patch in troponin C
    Steffen Lindert
    Department of Pharmacology, University of California San Diego, La Jolla, California, USA
    Biophys J 103:1784-9. 2012
  8. pmc A model study of sequential enzyme reactions and electrostatic channeling
    Changsun Eun
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093, USA
    J Chem Phys 140:105101. 2014
  9. pmc Influence of neighboring reactive particles on diffusion-limited reactions
    Changsun Eun
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093, USA
    J Chem Phys 139:044117. 2013

Detail Information

Publications9

  1. pmc Modeling effects of L-type ca(2+) current and na(+)-ca(2+) exchanger on ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometries
    Peter M Kekenes-Huskey
    Department of Pharmacology, University of California San Diego La Jolla, CA, USA
    Front Physiol 3:351. 2012
    ..Our studies indicate that improved structural and functional models could improve our understanding of the contributions of L-type and Na(+)/Ca(2+) exchanger fluxes to intracellular Ca(2+) dynamics...
  2. pmc Molecular and subcellular-scale modeling of nucleotide diffusion in the cardiac myofilament lattice
    Peter M Kekenes-Huskey
    Department of Pharmacology, University of Arizona, California Electronic address
    Biophys J 105:2130-40. 2013
    ..A reaction-diffusion model of the half-sarcomere further suggests that diffusional anisotropy may lead to modest adenine nucleotide gradients in the myoplasm under physiological conditions. ..
  3. pmc Molecular basis of calcium-sensitizing and desensitizing mutations of the human cardiac troponin C regulatory domain: a multi-scale simulation study
    Peter Michael Kekenes-Huskey
    Department of Pharmacology, Center for Theoretical Biological Physics, National Computational Biomedical Resource and Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America
    PLoS Comput Biol 8:e1002777. 2012
    ..Our observations based on the structure and dynamics of mutant TnC provide rationale for binding trends observed in GOF and LOF mutants and will guide the development of inotropic drugs that target TnC...
  4. pmc Calcium binding and allosteric signaling mechanisms for the sarcoplasmic reticulum Ca²+ ATPase
    Peter M Kekenes-Huskey
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    Protein Sci 21:1429-43. 2012
    ..Together these data provide structural and dynamical insights into a multistep process involving Ca²⁺ binding and catalytic transitions...
  5. pmc Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit
    Johan Hake
    Department of Bioengineering, University of California San Diego, CA, USA
    J Physiol 590:4403-22. 2012
    ..Finally, we show that including the Na(+)/Ca(2+) exchanger inside the dyadic cleft does not alter local [Ca(2+)] during a spark...
  6. pmc Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study
    Steffen Lindert
    Department of Pharmacology, NSF Center for Theoretical Biological Physics, National Biomedical Computation Resource, University of California San Diego, La Jolla, California 92093, United States
    J Phys Chem B 116:8449-59. 2012
    ..We furthermore indicate the essential role of electrostatic steering in facilitating diffusion-limited binding of Ca(2+)...
  7. pmc Long-timescale molecular dynamics simulations elucidate the dynamics and kinetics of exposure of the hydrophobic patch in troponin C
    Steffen Lindert
    Department of Pharmacology, University of California San Diego, La Jolla, California, USA
    Biophys J 103:1784-9. 2012
    ..In addition, these simulations corroborate that cardiac wild-type TnC does not open on timescales relevant to contraction without calcium being bound...
  8. pmc A model study of sequential enzyme reactions and electrostatic channeling
    Changsun Eun
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093, USA
    J Chem Phys 140:105101. 2014
    ..These findings shed light on the interplay of long-range interactions and enzyme distributions in coupled enzyme-catalyzed reactions, and their influence on signaling in biological systems. ..
  9. pmc Influence of neighboring reactive particles on diffusion-limited reactions
    Changsun Eun
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093, USA
    J Chem Phys 139:044117. 2013
    ..Our model study has broad implications in the general understanding of competition and local crowding on diffusion-limited chemical reactions. ..