Carl Keen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The use of a commercial vegetable juice as a practical means to increase vegetable intake: a randomized controlled trial
    Sonia F Shenoy
    Department of Nutrition, University of California Davis, Davis, California 95616, USA
    Nutr J 9:38. 2010
  2. pmc Weight loss in individuals with metabolic syndrome given DASH diet counseling when provided a low sodium vegetable juice: a randomized controlled trial
    Sonia F Shenoy
    Department of Nutrition, University of California, Davis, USA
    Nutr J 9:8. 2010
  3. pmc The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders: the potential influence of zinc status as an example
    Carl L Keen
    Department of Nutrition, University of California, Davis, Davis, CA 95616, USA
    Biofactors 36:125-35. 2010
  4. ncbi request reprint Cocoa antioxidants and cardiovascular health
    Carl L Keen
    Department of Nutrition, Hackettstown, New Jersey, USA
    Am J Clin Nutr 81:298S-303S. 2005
  5. ncbi request reprint Developmental consequences of trace mineral deficiencies in rodents: acute and long-term effects
    Carl L Keen
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 133:1477S-80S. 2003
  6. ncbi request reprint The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications
    Carl L Keen
    Department of Nutrition and Internal Medicine, University of California, Davis, CA 95616, USA
    J Nutr 133:1597S-1605S. 2003
  7. ncbi request reprint Chocolate: food as medicine/medicine as food
    C L Keen
    Department of Nutrition, University of California at Davis, 95616, USA
    J Am Coll Nutr 20:436S-439S; discussion 440S-442S. 2001
  8. ncbi request reprint Nutritional aspects of manganese from experimental studies
    C L Keen
    Department of Nutrition, University of California, Davis 95616, USA
    Neurotoxicology 20:213-23. 1999
  9. ncbi request reprint Effect of copper deficiency on prenatal development and pregnancy outcome
    C L Keen
    Department of Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 67:1003S-1011S. 1998
  10. ncbi request reprint Enhancing effect of maternal zinc deficiency and 137Cs gamma-irradiation on the frequency of fetal malformations in mice
    L A Hanna
    Department of Nutrition, University of California, Davis 95616, USA
    Teratog Carcinog Mutagen 17:127-37. 1997

Research Grants

  1. NUTRITIONAL FACTORS IN MAMMALIAN DEVELOPMENT
    Carl Keen; Fiscal Year: 2001
  2. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
  3. COPPER NUTRITION AND DEVELOPMENT
    Carl Keen; Fiscal Year: 2004
  4. Pre & Postdoctoral Training in Nutrition
    Carl Keen; Fiscal Year: 2005
  5. COPPER NUTRITION AND DEVELOPMENT
    Carl Keen; Fiscal Year: 1993
  6. NUTRITIONAL FACTORS IN MAMMALIAN DEVELOPMENT
    Carl Keen; Fiscal Year: 1993
  7. NUTRITIONAL FACTORS IN MAMMALIAN DEVELOPMENT
    Carl Keen; Fiscal Year: 1992
  8. NUTRITIONAL FACTORS IN MAMMALIAN DEVELOPMENT
    Carl Keen; Fiscal Year: 2009

Detail Information

Publications90

  1. pmc The use of a commercial vegetable juice as a practical means to increase vegetable intake: a randomized controlled trial
    Sonia F Shenoy
    Department of Nutrition, University of California Davis, Davis, California 95616, USA
    Nutr J 9:38. 2010
    ..The secondary aim is to assess the effect of a vegetable juice on measures of cardiovascular health...
  2. pmc Weight loss in individuals with metabolic syndrome given DASH diet counseling when provided a low sodium vegetable juice: a randomized controlled trial
    Sonia F Shenoy
    Department of Nutrition, University of California, Davis, USA
    Nutr J 9:8. 2010
    ..Weight loss is thought to be a key to improving all aspects of metabolic syndrome. Research studies have suggested benefits from diets rich in vegetables and fruits in helping individuals reach and achieve healthy weights...
  3. pmc The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders: the potential influence of zinc status as an example
    Carl L Keen
    Department of Nutrition, University of California, Davis, Davis, CA 95616, USA
    Biofactors 36:125-35. 2010
    ....
  4. ncbi request reprint Cocoa antioxidants and cardiovascular health
    Carl L Keen
    Department of Nutrition, Hackettstown, New Jersey, USA
    Am J Clin Nutr 81:298S-303S. 2005
    ..This review discusses the bioactivity of flavanols in the context of cardiovascular health, with respect to their bioavailability, their antioxidant properties, and their vascular effects...
  5. ncbi request reprint Developmental consequences of trace mineral deficiencies in rodents: acute and long-term effects
    Carl L Keen
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 133:1477S-80S. 2003
    ..Epigenetic defects combined with subtle morphological abnormalities can influence an individual's risk for certain chronic diseases and thus influence his or her risk for morbidity and mortality later in life...
  6. ncbi request reprint The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications
    Carl L Keen
    Department of Nutrition and Internal Medicine, University of California, Davis, CA 95616, USA
    J Nutr 133:1597S-1605S. 2003
    ..An implication of the above is that the frequency and severity of pregnancy complications may be reduced through an improvement in the micronutrient status of the mother...
  7. ncbi request reprint Chocolate: food as medicine/medicine as food
    C L Keen
    Department of Nutrition, University of California at Davis, 95616, USA
    J Am Coll Nutr 20:436S-439S; discussion 440S-442S. 2001
    ..These flavonoids have potent antioxidant and antiplatelet activities following consumption of cocoa or chocolate...
  8. ncbi request reprint Nutritional aspects of manganese from experimental studies
    C L Keen
    Department of Nutrition, University of California, Davis 95616, USA
    Neurotoxicology 20:213-23. 1999
    ..Similarly, confirmed cases of manganese toxicity in humans are currently restricted to cases of exposure to high levels of airborne manganese, and to cases when manganese excretory pathways are compromised...
  9. ncbi request reprint Effect of copper deficiency on prenatal development and pregnancy outcome
    C L Keen
    Department of Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 67:1003S-1011S. 1998
    ..Current data suggest that changes in free radical defense mechanisms, connective tissue metabolism, and energy production can all contribute to the dysmorphogenesis associated with developmental copper deficiency...
  10. ncbi request reprint Enhancing effect of maternal zinc deficiency and 137Cs gamma-irradiation on the frequency of fetal malformations in mice
    L A Hanna
    Department of Nutrition, University of California, Davis 95616, USA
    Teratog Carcinog Mutagen 17:127-37. 1997
    ..Irradiation on GD8 under adequate Zn conditions had no effect on any parameter, but GD8 irradiation during maternal Zn deficiency had an additive effect on the frequency of fetal malformations...
  11. ncbi request reprint Chronic consumption of a flavanol- and procyanindin-rich diet is associated with reduced levels of 8-hydroxy-2'-deoxyguanosine in rat testes
    Timothy J Orozco
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr Biochem 14:104-10. 2003
    ..These results support the concept that a diet rich in flavanols and procyanidins can improve oxidant defense and reduce tissue markers for oxidative stress, although these effects can be tissue specific...
  12. ncbi request reprint Copper-deficient rat embryos are characterized by low superoxide dismutase activity and elevated superoxide anions
    Susan N Hawk
    Department of Nutrition, University of California at Davis, Davis, California 95616 8869, USA
    Biol Reprod 68:896-903. 2003
    ..Thus, Cu deficiency resulted in embryos with malformations and reduced SOD enzyme activity. Increased ROS concentrations in the Cu-deficient embryo may cause oxidative damage and contribute to the occurrence of developmental defects...
  13. ncbi request reprint The anti-inflammatory properties of cocoa flavanols
    Carlo Selmi
    Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis, School of Medicine, Davis, CA 95616, USA
    J Cardiovasc Pharmacol 47:S163-71; discussion S172-6. 2006
    ..If so, then flavanol-rich cocoa could be a potential candidate for the treatment, or possibly prevention, of the broad array of chronic diseases that are linked to dysfunctional inflammatory responses...
  14. ncbi request reprint Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa
    Roberta R Holt
    Department of Nutrition, University of California, Davis 95616 8669, USA
    Am J Clin Nutr 76:798-804. 2002
    ....
  15. pmc Influence of cocoa flavanols and procyanidins on free radical-induced human erythrocyte hemolysis
    Qin Yan Zhu
    Department of Nutrition, University of California, Davis, CA 95616 8669, USA
    Clin Dev Immunol 12:27-34. 2005
    ..5 to 20 microM. Erythrocytes from subjects consuming flavonoid-rich cocoa show reduced susceptibility to free radical-induced hemolysis (p < 0.05)...
  16. ncbi request reprint Inhibitory effects of cocoa flavanols and procyanidin oligomers on free radical-induced erythrocyte hemolysis
    Qin Yan Zhu
    Department of Nutrition, University of California Davis, One Shields Avenue, Davis, CA 95616 8669, USA
    Exp Biol Med (Maywood) 227:321-9. 2002
    ..Conversely, plasma obtained from rats given the cocoa extract improved the resistance of erythrocytes obtained from rats given water only. These results show cocoa flavanols and procyanidins can provide membrane protective effects...
  17. ncbi request reprint Dietary flavanols and platelet reactivity
    Roberta R Holt
    Department of Nutrition, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
    J Cardiovasc Pharmacol 47:S187-96; discussion S206-9. 2006
    ..In addition, we will briefly review the body of literature with regard to other flavanol-rich foods and beverages, and possible mechanisms of action...
  18. ncbi request reprint Effects of flavonoid-rich beverages on prostacyclin synthesis in humans and human aortic endothelial cells: association with ex vivo platelet function
    John A Polagruto
    Department of Nutrition, University of California, Davis, California 95616, USA
    J Med Food 6:301-8. 2003
    ..These results indicate that the HAEC model system can provide a qualitative means to screen food and food-derived products for biologic activity related to cardiovascular health...
  19. doi request reprint Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and indices of metabolic syndrome in animal models
    Swati Kalgaonkar
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Phytother Res 24:1223-8. 2010
    ..Collectively, these results support the concept that the flavanols present in FRLFE are well absorbed and bioactive...
  20. ncbi request reprint Cocoa procyanidins inhibit proliferation and angiogenic signals in human dermal microvascular endothelial cells following stimulation by low-level H2O2
    Thomas P Kenny
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, California 95616, USA
    Exp Biol Med (Maywood) 229:765-71. 2004
    ..If these observations are applicable in vivo, they suggest a beneficial effect for cells overexpressing ErbB2, such as in specific neoplasias..
  21. pmc (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans
    Hagen Schroeter
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 103:1024-9. 2006
    ..Collectively, our data demonstrate that the human ingestion of the flavanol (-)-epicatechin is, at least in part, causally linked to the reported vascular effects observed after the consumption of flavanol-rich cocoa...
  22. ncbi request reprint Zinc deficiency-induced cell death
    Michael S Clegg
    Department of Nutrition, University of California at Davis, Davis, CA 95616, USA
    IUBMB Life 57:661-9. 2005
    ..Additionally, during zinc deficiency endogenous survival pathways such as NF-kappaB are inhibited in their transactivation potential. The above factors contribute to the irreversible commitment of the zinc deficient cell to death...
  23. ncbi request reprint Copper, oxidative stress, and human health
    Janet Y Uriu-Adams
    Department of Nutrition, One Shields Ave, University of California Davis, Davis, CA 95616, USA
    Mol Aspects Med 26:268-98. 2005
    ..The concept that excess Cu may be a precipitating factor in Alzheimer's disease is discussed...
  24. ncbi request reprint Diabetes and dietary copper alter 67Cu metabolism and oxidant defense in the rat
    Janet Y Uriu-Adams
    Department of Nutrition, University of California at Davis, Davis, CA 95616 8669, USA
    J Nutr Biochem 16:312-20. 2005
    ..Such diabetes-related metabolic alterations were taken as measures of increased oxidative stress and inflammation, which may have implications in the progression of diabetes-related pathologies...
  25. pmc Flavonoid-membrane interactions: a protective role of flavonoids at the membrane surface?
    Patricia I Oteiza
    Department of Biological Chemistry, IQUIFIB UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Clin Dev Immunol 12:19-25. 2005
    ..We suggest that interactions of polyphenols at the surface of bilayers through hydrogen bonding, can act to reduce the access of deleterious molecules (i.e. oxidants), thus protecting the structure and function of membranes...
  26. doi request reprint The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo
    Javier I Ottaviani
    Department of Nutrition, University of California at Davis, Davis, CA 95616, USA
    Free Radic Biol Med 50:237-44. 2011
    ..Overall, these results indicate that the proposed beneficial health effects associated with the consumption of flavanol-containing foods will significantly depend on the stereochemical configuration of the flavanols ingested...
  27. ncbi request reprint Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal women
    Janice F Wang-Polagruto
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Cardiovasc Pharmacol 47:S177-86; discussion S206-9. 2006
    ..In addition, our results suggest that reductions in plasma soluble vascular cell adhesion molecule-1 after chronic consumption of a flavanol-rich cocoa may be mechanistically linked to improved vascular reactivity...
  28. doi request reprint Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity
    Louise Lanoue
    Department of Nutrition, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
    Exp Biol Med (Maywood) 235:77-89. 2010
    ..We predict that these compounds are likely to have limited leukemogenic potential at physiological concentrations...
  29. doi request reprint Public safety and dietary supplementation
    M Eric Gershwin
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, California 95616, USA
    Ann N Y Acad Sci 1190:104-17. 2010
    ..More importantly, we provide a working plan for addressing this important issue...
  30. doi request reprint Influence of copper on early development: prenatal and postnatal considerations
    Janet Y Uriu-Adams
    Department of Nutrition, University of California, Davis, Davis, CA 95616, USA
    Biofactors 36:136-52. 2010
    ..Although Cu-containing IUDs are an effective method for increasing intrauterine Cu concentrations and for reducing the risk of pregnancy, high amounts of dietary Cu are not thought to represent a direct developmental risk...
  31. doi request reprint Effects of a flavonol-rich diet on select cardiovascular parameters in a Golden Syrian hamster model
    Swati Kalgaonkar
    Department of Nutrition, University of California Davis, Davis, California 95616, USA
    J Med Food 13:108-15. 2010
    ..Results obtained from this study support the concept that the chronic consumption of a flavonoid-rich diet can be beneficial with respect to cardiovascular health...
  32. doi request reprint Chocolate at heart: the anti-inflammatory impact of cocoa flavanols
    Carlo Selmi
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA 95616, USA
    Mol Nutr Food Res 52:1340-8. 2008
    ..Accordingly, rigorous controlled human studies with adequate follow-up and with the use of critical dietary questionnaires are needed to determine the effects of flavanols on the major endpoints of cardiovascular health...
  33. doi request reprint Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines
    Lucas Actis-Goretta
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr Biochem 19:797-808. 2008
    ..The therapeutic value of these compounds and their derivative forms as anticancer agents merits further investigation in whole animal models...
  34. ncbi request reprint Non-alcoholic fatty liver disease: the new epidemic and the need for novel nutritional approaches
    Carlo Selmi
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    J Med Food 10:563-5. 2007
    ..In this article we will attempt to put these concepts in perspective to highlight the need for future research including the use of medicinal food...
  35. ncbi request reprint Inflammation and oxidative stress in obstructive sleep apnea syndrome
    Carlo Selmi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Exp Biol Med (Maywood) 232:1409-13. 2007
    ..We discuss herein the recent literature that illustrates these new paradigms and speculate on possible implications and future scenarios...
  36. pmc Low nitric oxide: a key factor underlying copper-deficiency teratogenicity
    Soo Jin Yang
    Department of Nutrition, One Shields Avenue, University of California at Davis, Davis, CA 95616, USA
    Free Radic Biol Med 43:1639-48. 2007
    ..These data support the concept that Cu deficiency limits NO availability and alters NO-dependent signaling, which contributes to abnormal embryo and yolk sac development...
  37. ncbi request reprint Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells
    Thomas P Kenny
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis School of Medicine, 451 E Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    Exp Biol Med (Maywood) 232:293-300. 2007
    ..There were also unique differential responses in the mononuclear cell populations studied. We conclude that the oligomers are potent stimulators of both the innate immune system and early events in adaptive immunity...
  38. ncbi request reprint Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men
    Judith R Turnlund
    US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis 95616, USA
    Am J Clin Nutr 79:1037-44. 2004
    ..Short-term high copper intake does not appear to affect indexes of copper status or functions related to copper status, but the effects of long-term high copper intake are unknown...
  39. ncbi request reprint Stabilizing effect of ascorbic acid on flavan-3-ols and dimeric procyanidins from cocoa
    Qin Yan Zhu
    Department of Nutrition, University of California, Davis, California 95616, USA
    J Agric Food Chem 51:828-33. 2003
    ..The present results, although not directly transferable to in vivo conditions, suggest that ascorbic acid may stabilize cocoa flavanols and procyanidins in the intestine where the pH is neutral, or alkaline, before absorption...
  40. ncbi request reprint Cocoa and chocolate flavonoids: implications for cardiovascular health
    Francene M Steinberg
    Didactic Program in Dietetics, Department of Nutrition, University of California, Davis, CA, USA
    J Am Diet Assoc 103:215-23. 2003
    ..Applications of this knowledge include recommendations by health professionals to encourage individuals to consume a wide range of phytochemical-rich foods, which can include dark chocolate in moderate amounts...
  41. ncbi request reprint Pentameric procyanidins isolated from Theobroma cacao seeds selectively downregulate ErbB2 in human aortic endothelial cells
    Thomas P Kenny
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, California 95616, USA
    Exp Biol Med (Maywood) 229:255-63. 2004
    ..These results suggest specific dietary flavonoids are capable of selectively inhibiting ErbB2 and therefore may offer important insight into the design of therapeutic agents that target tumors overexpressing ErbB2...
  42. ncbi request reprint Stability of the flavan-3-ols epicatechin and catechin and related dimeric procyanidins derived from cocoa
    Qin Yan Zhu
    Department of Nutrition, University of California, Davis, California, USA
    J Agric Food Chem 50:1700-5. 2002
    ....
  43. doi request reprint Zinc and reproduction: effects of zinc deficiency on prenatal and early postnatal development
    Janet Y Uriu-Adams
    Department of Nutrition, University of California, Davis, Davis, California 95616, USA
    Birth Defects Res B Dev Reprod Toxicol 89:313-25. 2010
    ..Potential mechanisms underlying the teratogenic effects of zinc deficiency are reviewed. The potential value of maternal zinc supplementation in high risk pregnancies is discussed...
  44. ncbi request reprint Nutrition: milk and absorption of dietary flavanols
    Hagen Schroeter
    Department of Nutrition, University of California, Davis, California 95616, USA
    Nature 426:787-8; discussion 788. 2003
  45. ncbi request reprint Honey with high levels of antioxidants can provide protection to healthy human subjects
    Derek D Schramm
    Department of Nutrition, University of California, One Shields Avenue, Davis 95616 8669, USA
    J Agric Food Chem 51:1732-5. 2003
    ....
  46. ncbi request reprint Zinc deficiency-induced iron accumulation, a consequence of alterations in iron regulatory protein-binding activity, iron transporters, and iron storage proteins
    Brad J Niles
    Department of Nutrition, University of California, Davis, California 95616 8669, USA
    J Biol Chem 283:5168-77. 2008
    ..These data support the concept that zinc deficiency can result in alterations in iron transporter, storage, and regulatory proteins, which facilitate iron accumulation...
  47. ncbi request reprint Reducing arginase activity via dietary manganese deficiency enhances endothelium-dependent vasorelaxation of rat aorta
    Jodi L Ensunsa
    Department of Nutrition, University of California at Davis, CA 95616, USA
    Exp Biol Med (Maywood) 229:1143-53. 2004
    ..These findings support our hypothesis that endothelium-dependent vasorelaxation is greater in aortic segments from rats that consume Mn- versus Mn+ diets; however, responses from small coronary arteries were unaffected...
  48. doi request reprint Cocoa flavanols and procyanidins can modulate the lipopolysaccharide activation of polymorphonuclear cells in vitro
    Thomas P Kenny
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California, Davis, California 95616, USA
    J Med Food 12:1-7. 2009
    ....
  49. ncbi request reprint Cocoa flavanol-enriched snack bars containing phytosterols effectively lower total and low-density lipoprotein cholesterol levels
    John A Polagruto
    Department of Nutrition, University of California, Davis, USA
    J Am Diet Assoc 106:1804-13. 2006
    ..There is emerging support for more diverse and lower-fat phytosterol-enriched matrixes. Controversy exists, however, over whether phytosterol-enriched foods affect serum fat-soluble vitamins...
  50. ncbi request reprint Developmental aluminum toxicity in mice can be modulated by low concentrations of minerals (Fe, Zn, P, Ca, Mg) in the diet
    Mari S Golub
    Department of Internal Medicine, University of California, Davis, CA 95616, USA
    Biol Trace Elem Res 93:213-26. 2003
    ..A basal diet was also used in which the NRC diet was supplemented with ascorbic acid, which promotes Al absorption. No modification of Al toxicity was seen with ascorbic acid supplementation...
  51. ncbi request reprint Abnormal development and increased 3-nitrotyrosine in copper-deficient mouse embryos
    Molly E Beckers-Trapp
    Department of Nutrition, One Shields Avenue, University of California Davis, Davis, CA 95616, USA
    Free Radic Biol Med 40:35-44. 2006
    ..g., altered nitric oxide metabolism may contribute to copper-deficiency-induced teratogenesis...
  52. ncbi request reprint Zinc influences the in vitro development of peri-implantation mouse embryos
    Lynn A Hanna
    Department of Nutrition, University of California, Davis, California 95616, USA
    Birth Defects Res A Clin Mol Teratol 67:414-20. 2003
    ..We investigated the influence of zinc (Zn) deficiency on embryonic development at the time of embryo implantation...
  53. doi request reprint Probiotics and immunity
    Andrea T Borchers
    Department of Nutrition, Allergy and Clinical Immunology, University of California at Davis, Davis, CA, USA
    J Gastroenterol 44:26-46. 2009
    ..However, the findings are too variable to allow firm conclusions as to the effectiveness of specific probiotics in these conditions...
  54. pmc Alterations in protein kinase C activity and processing during zinc-deficiency-induced cell death
    Susan S Chou
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616 8669, USA
    Biochem J 383:63-71. 2004
    ..These results support the concept that intracellular zinc concentrations influence PKC activity and processing, and that zinc-deficiency-induced apoptosis occurs in part through PKC-dependent pathways...
  55. ncbi request reprint Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development
    Robert G Ellis-Hutchings
    Department of Nutrition, University of California Davis, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 215:135-45. 2006
    ..These results support the concept that marginal vitamin A status in pregnant women may increase the risk for PBDE-induced disruptions in vitamin A and thyroid hormone homeostasis...
  56. ncbi request reprint Effects of copper deficiency on mouse yolk sac vasculature and expression of angiogenic mediators
    Soo Jin Yang
    Department of Nutrition, University of California Davis Department of Nutrition, Davis, CA 95616, USA
    Birth Defects Res B Dev Reprod Toxicol 77:445-54. 2006
    ..In diverse model systems, Cu treatment modulates angiogenesis, perhaps by influencing the activity of angiogenic mediators such as vascular endothelial growth factor (VEGF). Conversely, Cu chelators can suppress angiogenesis...
  57. ncbi request reprint Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc
    Gerardo G MacKenzie
    Department of Nutrition, University of California, Davis, 95616, USA
    J Neurochem 99:402-15. 2006
    ....
  58. ncbi request reprint Mushrooms, tumors, and immunity: an update
    Andrea T Borchers
    Rheumatology, Allergy, and Clinical Immunology, University of California Davis School of Medicine, Davis, California 95616, USA
    Exp Biol Med (Maywood) 229:393-406. 2004
    ..In this review, we will present the comparative biology with respect to both immunological and antitumor activities of mushroom extracts and also highlight the need for further evidence-based research...
  59. ncbi request reprint Food effects on the absorption and pharmacokinetics of cocoa flavanols
    Derek D Schramm
    Department of Nutrition, University of California, One Shields Avenue, Davis CA 95616 8669, USA
    Life Sci 73:857-69. 2003
    ..Based on C(max) and AUC values, this data suggests that the uptake of flavanols can be increased significantly by concurrent carbohydrate consumption...
  60. doi request reprint Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding
    Gerardo G MacKenzie
    Department of Nutrition, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Biochem Pharmacol 78:1252-62. 2009
    ..The results support the concept that B-type dimeric procyanidins can provide anti-inflammatory benefits due to their ability to reduce NF-kappaB binding to the DNA...
  61. doi request reprint The influence of gestational zinc deficiency on the fetal insulin-like growth factor axis in the rat
    Lynn A Hanna
    Department of Nutrition, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Exp Biol Med (Maywood) 235:206-14. 2010
    ..These observations suggest that differences in the fetal IGF axis between ZD and Paired groups contribute to the poor pregnancy outcome and enhanced fetal growth retardation observed with zinc deficiency...
  62. doi request reprint Prenatal zinc deficiency: influence on heart morphology and distribution of key heart proteins in a rat model
    Veronica Lopez
    Department of Nutrition, University of California, Davis, One Shields Ave, Meyer Hall, Davis, CA 95616, USA
    Biol Trace Elem Res 122:238-55. 2008
    ..We propose that Zn deficiency induced alterations in the distribution of Cx43 and HNK-1 in fetal hearts contribute to the occurrence of the developmental heart anomalies...
  63. ncbi request reprint Antioxidative activities of oolong tea
    Qin Yan Zhu
    Departments of Nutrition and Internal Medicine, University of California, Davis, California 95616 8669, USA
    J Agric Food Chem 50:6929-34. 2002
    ..The present results support the concept that oolong tea contains several low molecular weight antioxidants that may have health promotion activities...
  64. ncbi request reprint Effect of apple extracts on NF-kappaB activation in human umbilical vein endothelial cells
    Paul A Davis
    Department of Nutrition, University of California at Davis, 451 East Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    Exp Biol Med (Maywood) 231:594-8. 2006
    ..We suggest that AE downregulates NF-kappaB signaling and that this is indicative of an antioxidant effect of the flavonoids present in AE...
  65. ncbi request reprint Clinical and immunologic components of sarcoidosis
    Andrea T Borchers
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Clin Rev Allergy Immunol 25:289-303. 2003
    ..A minority of patients do progress to significant disease, including morbidity and mortality, and further research is needed to determine more appropriate and specific therapy for such situations...
  66. doi request reprint The effects of marginal maternal vitamin A status on penta-brominated diphenyl ether mixture-induced alterations in maternal and conceptal vitamin A and fetal development in the Sprague Dawley rat
    Robert G Ellis-Hutchings
    Department of Nutrition, University of California Davis, Davis, CA, USA
    Birth Defects Res B Dev Reprod Toxicol 86:48-57. 2009
    ..While penta-BDE mixtures are not strong teratogens in pregnant animals fed standard commercial laboratory diets, we hypothesized that they could be teratogenic under conditions of marginal vitamin A status...
  67. ncbi request reprint Cellular actions of Al at low (1.25 microM) concentrations in primary oligodendrocyte culture
    Mari S Golub
    Department of Internal Medicine, University of California Davis, 1 Shields Avenue, Davis, CA 95616, USA
    Brain Res 941:82-90. 2002
    ..In vivo, physiological Al ion may act by common cellular pathways in diverse cell types. These effects may be relevant to Al toxicological, pharmacological (immunoadjuvant), and physiological effects...
  68. ncbi request reprint Zinc status of human IMR-32 neuroblastoma cells influences their susceptibility to iron-induced oxidative stress
    Gerardo G MacKenzie
    Department of Biological Chemistry IQUIFIB UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Dev Neurosci 24:125-33. 2002
    ..These cells had altered morphology and high level of nucleosomes suggestive of cell death by apoptosis. These results support the concept that the zinc status of IMR-32 neuroblastoma cells modulates their sensitivity to iron overload...
  69. ncbi request reprint Influence of flavan-3-ols and procyanidins on UVC-mediated formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in isolated DNA
    Javier I Ottaviani
    Fisicoquímica PRALIB, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, Buenos Aires, Argentina
    Arch Biochem Biophys 406:203-8. 2002
    ..Both epimerism and degree of oligomerization are important determinants of the antioxidant activity of flavan-3-ols and procyanidins...
  70. ncbi request reprint The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function
    Debra A Pearson
    Department of Human Biology, University of Wisconsin Green Bay, ES 301, 2420 Nicolet Drive, Green Bay, WI 54311, USA
    Thromb Res 106:191-7. 2002
    ..We investigated the effect of a flavanol-rich cocoa beverage (897 mg/ml) in combination with and in comparison to aspirin on platelet function and activation in healthy subjects...
  71. pmc Flavanols and platelet reactivity
    Debra A Pearson
    Department of Human Biology ES 301, University of Wisconsin Green Bay, Green Bay, WI 54311, USA
    Clin Dev Immunol 12:1-9. 2005
    ..These data, coupled with information from other studies, support the concept that flavanols present in cocoa and chocolate can modulate platelet function through a multitude of pathways...
  72. ncbi request reprint Chocolate consumption and platelet function
    Roberta R Holt
    JAMA 287:2212-3. 2002
  73. ncbi request reprint Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health
    Penny M Kris-Etherton
    Nutrition Department, The Pennsylvania State University, University Park, Pennsylvania, USA
    Curr Opin Lipidol 13:41-9. 2002
    ..Thus, approximate estimates of flavonoid rich chocolate needed to exert acute and chronic effects are 38 and 125 g, respectively. Collectively, the antioxidant effects of flavonoid-rich foods may reduce cardiovascular disease risk...
  74. ncbi request reprint Mineral metabolism in male cyclists during high-intensity endurance training
    Rudolph H Dressendorfer
    Faculty of Physical Education and Recreation at the University of Alberta, Edmonton, Canada
    Int J Sport Nutr Exerc Metab 12:63-72. 2002
    ..05), and performance further improved (p < .05) after the taper. Whereas Mg, Fe, Zn, and Cu metabolism remained unchanged throughout the study, greater renal Ca excretion was associated with very high intensity interval training...
  75. doi request reprint Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial
    Jan Balzer
    Department for Cardiology, Pulmonology, and Vascular Medicine, University Hospital RWTH Aachen, Aachen, Germany
    J Am Coll Cardiol 51:2141-9. 2008
    ..Our goal was to test feasibility and efficacy of a dietary intervention based on daily intake of flavanol-containing cocoa for improving vascular function of medicated diabetic patients...
  76. ncbi request reprint Metavanadate causes cellular accumulation of copper and decreased lysyl oxidase activity
    Changtai T Cui
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M561X5
    Toxicol Appl Pharmacol 199:35-43. 2004
    ..Taken together, these data suggest that pathways involving copper egress and lysyl oxidase activation are particularly sensitive to metavanadate exposure through processes that are predominately posttranslational...
  77. ncbi request reprint Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins
    Lucas Actis-Goretta
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Juni n 956, 1113, Buenos Aires, Argentina
    FEBS Lett 555:597-600. 2003
    ..As ACE is a membrane protein, the interaction of flavanols and procyanidins with the enzyme could be related to the number of hydroxyl groups on the procyanidins, which determine their capacity to be adsorbed on the membrane surface...
  78. ncbi request reprint Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells
    Gerardo G MacKenzie
    Departamento de Quimica Biologica, Instituto de Quimica y Fisicoquimica Biologicas, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina
    FASEB J 18:167-9. 2004
    ..A model is presented for possible interactions between DP-B and NF-kappaB proteins, which could lead to the inhibition of NF-kappaB binding to kappaB sites...
  79. ncbi request reprint Antioxidant and membrane effects of procyanidin dimers and trimers isolated from peanut and cocoa
    Sandra V Verstraeten
    IQUIFIB Department of Biological Chemistry UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
    J Agric Food Chem 53:5041-8. 2005
    ..As a consequence of this interaction, they can provide protection against the attack of oxidants and other molecules that challenge the integrity of the bilayer...
  80. pmc Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells
    Sandra V Verstraeten
    Department of Biological Chemistry, IQUIFIB UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD, Buenos Aires, Argentina
    Biochem J 378:579-87. 2004
    ..We suggest that the increased fluidity of the membrane secondary to zinc deficiency is in part due to a decrease in arachidonic acid content and the apoptosis-related changes in phosphatidylserine distribution...
  81. ncbi request reprint Trace elements and human health
    Cesar G Fraga
    Mol Aspects Med 26:233-4. 2005
  82. ncbi request reprint alpha-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells
    Gerardo G MacKenzie
    Department of Biological Chemistry, IQUIFIB, UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD, Argentina
    Free Radic Res 40:75-84. 2006
    ..Thus, LA and NAC can reduce the oxidative stress associated with zinc deficiency and the subsequent triggering of NF-kappaB- and AP-1-activation in neuronal cells...
  83. pmc Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer players
    Cesar G Fraga
    Fisicoquímica PRALIB, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Clin Dev Immunol 12:11-7. 2005
    ..The presence of significant quantities of flavanols in FCMC is likely to have been one of the contributing factors to these results...
  84. ncbi request reprint Use of vitamins, minerals, and other dietary supplements by 17- and 18-year-old students in Korea
    Sun H Kim
    Department of Home Economics Education, Kongju National University, Shinkwan dong, Kongju, Korea
    J Med Food 6:27-42. 2003
    ..Given the widespread use of DS by older teenagers, the contribution of these supplements to their overall health and well-being is a subject that clearly merits additional study...
  85. ncbi request reprint Influence of smoking on markers of oxidative stress and serum mineral concentrations in teenage girls in Korea
    Sun H Kim
    Department of Home Economics Education, Kongju National University, Kongju, South Korea
    Nutrition 19:240-3. 2003
    ..The purpose of this study was to examine the effect of cigarette smoking on serum oxidative damage, antioxidant status, and mineral concentrations in teenage girls...
  86. ncbi request reprint Effects of grape seed extract consumption on platelet function in postmenopausal women
    Sonia F Shenoy
    Thromb Res 121:431-2. 2007
  87. ncbi request reprint Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract
    John A Polagruto
    Department of Family and Consumer Science, Sacramento City College, Sacramento, CA, USA
    J Med Food 10:725-30. 2007
    ..Thus smokers may obtain some health benefits from the consumption of certain flavanol-rich foods, beverages, and supplements...
  88. ncbi request reprint Flavan-3-ols and procyanidins protect liposomes against lipid oxidation and disruption of the bilayer structure
    Sandra V Verstraeten
    IQUIFIB Department of Biological Chemistry UBA CONICET, University of Buenos Aires, Buenos Aires, Argentina
    Free Radic Biol Med 34:84-92. 2003
    ..Thus, flavanols and procyanidins can potentially reduce oxidative modifications of membranes by restraining the access of oxidants to the bilayer and the propagation of lipid oxidation in the hydrophobic membrane matrix...
  89. ncbi request reprint An 18-month follow-up study on the influence of smoking on blood antioxidant status of teenage girls in comparison with adult male smokers in Korea
    Sun H Kim
    Department of Food Service Management and Nutrition, Kongju National University, Kongju, South Korea
    Nutrition 20:437-44. 2004
    ..The influence of cigarette smoking on blood antioxidant status in teenage girls with a history of short-term smoking was followed over 18 mo...
  90. ncbi request reprint The embryolethality of lipopolysaccharide in CD-1 and metallothionein I-II null mice: lack of a role for induced zinc deficiency or metallothionein induction
    Tyra M Leazer
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 73:442-7. 2003
    ..In conclusion, while LPS can induce maternal hepatic MT and Zn redistribution in CD-1 mice, this does not appear to be a key mechanism leading to LPS embryotoxicity...

Research Grants31

  1. NUTRITIONAL FACTORS IN MAMMALIAN DEVELOPMENT
    Carl Keen; Fiscal Year: 2001
    ..Given that Zn deficiency can result in altered IGF metabolism, we hypothesize that a cell's ability to be rescued from apoptosis is reduced in Zn deficient embryos. ..
  2. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..Finally, they will examine the effects of the diets on the activation of NFkB and cell signaling pathways. ..
  3. COPPER NUTRITION AND DEVELOPMENT
    Carl Keen; Fiscal Year: 2004
    ..This information should provide new insights into the mechanisms underlying copper deficient pathologies and may contribute to our understanding of this process during human development. ..
  4. Pre & Postdoctoral Training in Nutrition
    Carl Keen; Fiscal Year: 2005
    ..Throughout our training we work to ensure that our graduates have vision and adaptability to work in environments where the skills and views of health professionals trained in nutrition are in urgent demand. ..
  5. COPPER NUTRITION AND DEVELOPMENT
    Carl Keen; Fiscal Year: 1993
    ..In addition, the results from these studies will have broad applications in developmental biology related to the teratogenicity of an important essential nutrient, i.e., copper...
  6. NUTRITIONAL FACTORS IN MAMMALIAN DEVELOPMENT
    Carl Keen; Fiscal Year: 1993
    ..3) Embryonic/fetal Zn deficiency can arise from a primary maternal Zn deficiency and/or from a disruption of normal maternal Zn metabolism elicited secondary to a maternal acute phase response...
  7. NUTRITIONAL FACTORS IN MAMMALIAN DEVELOPMENT
    Carl Keen; Fiscal Year: 1992
    ..The effect of zinc deficiency on immune responsiveness will be studied. The molecular localization of zinc and copper in animal tissues and its influence on absorption and metabolism of these elements in the neonate will be investigated...
  8. NUTRITIONAL FACTORS IN MAMMALIAN DEVELOPMENT
    Carl Keen; Fiscal Year: 2009
    ..abstract_text> ..