S J Keely

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells
    S J Keely
    Department of Medicine, University of California, San Diego, California 92103, USA
    J Biol Chem 274:33449-54. 1999
  2. ncbi Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular ca(2+), PYK-2, and p60(src)
    S J Keely
    Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California 92103, USA
    J Biol Chem 275:12619-25. 2000
  3. ncbi p38 mitogen-activated protein kinase inhibits calcium-dependent chloride secretion in T84 colonic epithelial cells
    Stephen J Keely
    Department of Medicine, University of California, San Diego, California 92103, USA
    Am J Physiol Cell Physiol 284:C339-48. 2003
  4. ncbi Insulin and IGF-I inhibit calcium-dependent chloride secretion by T84 human colonic epithelial cells
    N Chang
    Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California 92103, USA
    Am J Physiol Gastrointest Liver Physiol 281:G129-37. 2001
  5. ncbi Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects
    K E Barrett
    Department of Medicine, University of California, San Diego, School of Medicine, California 92103, USA
    Annu Rev Physiol 62:535-72. 2000
  6. ncbi Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells
    M R Hoda
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California, USA
    Br J Surg 94:346-54. 2007
  7. ncbi Transactivation of the epidermal growth factor receptor mediates muscarinic stimulation of focal adhesion kinase in intestinal epithelial cells
    Sean O Calandrella
    Department of Medicine, University of California, San Diego, San Diego, California, USA
    J Cell Physiol 203:103-10. 2005
  8. ncbi Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses
    Lone S Bertelsen
    Division of Gastroenterology, Department of Medicine, University of California, Medical Center, San Diego, California 92103 8414, USA
    J Biol Chem 279:6271-9. 2004
  9. ncbi Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha
    Declan F McCole
    Department of Medicine, University of California, School of Medicine, San Diego, California 92103, USA
    J Biol Chem 277:42603-12. 2002
  10. ncbi Induction of Na+/K+/2Cl- cotransporter expression mediates chronic potentiation of intestinal epithelial Cl- secretion by EGF
    Fiona O'Mahony
    Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Am J Physiol Cell Physiol 294:C1362-70. 2008

Collaborators

  • M R Hoda
  • Alan F Hofmann
  • Cormac T Taylor
  • Declan F McCole
  • Eoin P Cummins
  • Fiona O'Mahony
  • K E Barrett
  • Sean O Calandrella
  • Kim E Barrett
  • Lone S Bertelsen
  • N Chang
  • Niamh E Mangan
  • Magdalena S Mroz
  • John J Callanan
  • Ferial Toumi
  • Padraic G Fallon
  • Gail Ferguson
  • Fergal Seeballuck
  • S Calandrella
  • J M Uribe

Detail Information

Publications12

  1. ncbi ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells
    S J Keely
    Department of Medicine, University of California, San Diego, California 92103, USA
    J Biol Chem 274:33449-54. 1999
    ..Differential dimerization with other ErbB family members may underlie the ability of the EGFR to propagate diverse inhibitory signals in response to activation by EGF or transactivation by CCh...
  2. ncbi Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular ca(2+), PYK-2, and p60(src)
    S J Keely
    Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California 92103, USA
    J Biol Chem 275:12619-25. 2000
    ..This pathway represents a mechanism that limits CCh-stimulated chloride secretion across intestinal epithelia...
  3. ncbi p38 mitogen-activated protein kinase inhibits calcium-dependent chloride secretion in T84 colonic epithelial cells
    Stephen J Keely
    Department of Medicine, University of California, San Diego, California 92103, USA
    Am J Physiol Cell Physiol 284:C339-48. 2003
    ..CCh-stimulated p38 activation constitutes a similar, but distinct and complementary, antisecretory signaling pathway to that of ERK MAPK...
  4. ncbi Insulin and IGF-I inhibit calcium-dependent chloride secretion by T84 human colonic epithelial cells
    N Chang
    Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California 92103, USA
    Am J Physiol Gastrointest Liver Physiol 281:G129-37. 2001
    ..Because insulin is released in a pulsatile fashion postprandially and IGF-I levels are elevated in pathological settings, our findings may have physiological and/or pathophysiological significance...
  5. ncbi Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects
    K E Barrett
    Department of Medicine, University of California, San Diego, School of Medicine, California 92103, USA
    Annu Rev Physiol 62:535-72. 2000
    ..The goal of our article is to review this area of investigation, with an emphasis on recent developments and their implications for the physiology and pathophysiology of chloride transport...
  6. ncbi Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells
    M R Hoda
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California, USA
    Br J Surg 94:346-54. 2007
    ....
  7. ncbi Transactivation of the epidermal growth factor receptor mediates muscarinic stimulation of focal adhesion kinase in intestinal epithelial cells
    Sean O Calandrella
    Department of Medicine, University of California, San Diego, San Diego, California, USA
    J Cell Physiol 203:103-10. 2005
    ..GqPCR-induced FAK activation is mediated by via a pathway involving transactivation of the EGFr and alterations in the actin cytoskeleton...
  8. ncbi Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses
    Lone S Bertelsen
    Division of Gastroenterology, Department of Medicine, University of California, Medical Center, San Diego, California 92103 8414, USA
    J Biol Chem 279:6271-9. 2004
    ..Through a mechanism that likely involves PI3K, transactivation of the EGFr is required for the full expression of cAMP-dependent Cl- secretory responses...
  9. ncbi Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha
    Declan F McCole
    Department of Medicine, University of California, School of Medicine, San Diego, California 92103, USA
    J Biol Chem 277:42603-12. 2002
    ..These findings have important implications for our understanding of the role of growth factors in regulating epithelial ion secretion...
  10. ncbi Induction of Na+/K+/2Cl- cotransporter expression mediates chronic potentiation of intestinal epithelial Cl- secretion by EGF
    Fiona O'Mahony
    Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Am J Physiol Cell Physiol 294:C1362-70. 2008
    ....
  11. ncbi Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships
    Stephen J Keely
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, California, USA
    Am J Physiol Gastrointest Liver Physiol 292:G290-7. 2007
    ..These studies indicate marked structural specificity for bile acid-induced chloride secretion and show that modification of bile acid structure by colonic bacteria modulates the secretory properties of these endogenous secretagogues...
  12. ncbi The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
    Eoin P Cummins
    UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Gastroenterology 134:156-65. 2008
    ..Both HIF-1 and NF-kappaB pathways are repressed by the action of hydroxylases through the hydroxylation of key regulatory molecules...