P J Keely
Affiliation: University of North Carolina
- Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)KP J Keely
Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599 7365, USA
Nature 390:632-6. 1997..PI(3)K inhibition also disrupts actin structures, suggesting that activation of PI(3)K by Cdc42 and Rac1 alters actin organization, leading to increased motility and invasiveness...
- R-Ras signals through specific integrin alpha cytoplasmic domains to promote migration and invasion of breast epithelial cellsP J Keely
Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Cell Biol 145:1077-88. 1999..Thus, R-Ras communicates with specific integrin alpha cytoplasmic domains through a unique combination of signaling pathways to promote cell migration and invasion...
- Ras and Rho protein induction of motility and invasion in T47D breast adenocarcinoma cellsP J Keely
Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, USA
Methods Enzymol 333:256-66. 2001..While a complete understanding of metastasis will ultimately need to employ in vivo studies, the migration and invasion assays presented here are good initial assessments of events that are relevant to the metastatic cascade...
- Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkageP P Provenzano
Department of Pharmacology, University of Wisconsin, Madison, WI, USA
Oncogene 28:4326-43. 2009..As such, we propose that increased matrix stiffness explains part of the mechanism behind increased epithelial proliferation and cancer risk in human patients with high breast tissue density...