Younghoon Kee

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. pmc Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents
    Younghoon Kee
    Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, USA
    Mol Cancer Res 10:369-77. 2012
  2. pmc Molecular pathogenesis and clinical management of Fanconi anemia
    Younghoon Kee
    Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida 33620, USA
    J Clin Invest 122:3799-806. 2012
  3. pmc Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases
    Scott Cukras
    Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 9:e101844. 2014
  4. pmc The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway
    David Polito
    From the Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, Florida 33620
    J Biol Chem 289:7003-10. 2014

Collaborators

  • ALAN D D'ANDREA
  • Scott Cukras
  • David Polito
  • Paige Spence
  • Nicholas Morffy
  • Lisa Moreau
  • XiaoZhe Wang
  • Takbum Ohn

Detail Information

Publications4

  1. pmc Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents
    Younghoon Kee
    Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, USA
    Mol Cancer Res 10:369-77. 2012
    ..These results suggest that a combination of Nedd8 inhibition with ICL-inducing agents may be an effective strategy for sensitizing a subset of drug-resistant cancer cells...
  2. pmc Molecular pathogenesis and clinical management of Fanconi anemia
    Younghoon Kee
    Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida 33620, USA
    J Clin Invest 122:3799-806. 2012
    ..Here we review the clinical features, the diagnostic criteria, and the current and future therapies of FA and describe the current understanding of the molecular basis of the disease...
  3. pmc Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases
    Scott Cukras
    Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 9:e101844. 2014
    ..Therefore, UBE2M is required to maintain genome integrity by activating multiple Cullin ligases throughout the cell cycle. ..
  4. pmc The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway
    David Polito
    From the Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, Florida 33620
    J Biol Chem 289:7003-10. 2014
    ..Intriguingly, ectopic expression of the FANCE C terminus fragment alone in FA normal cells disrupts DNA repair, consolidating the importance of the FANCE-FANCD2 interaction in the DNA cross-link repair. ..