Barbara Kee

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors
    Barbara L Kee
    Department of Biology, University of California San Diego, La Jolla, CA 92093, USA
    EMBO J 21:103-13. 2002
  2. ncbi request reprint Id3 induces growth arrest and caspase-2-dependent apoptosis in B lymphocyte progenitors
    Barbara L Kee
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 175:4518-27. 2005
  3. doi request reprint A s-myly route toward lymphoid differentiation
    Barbara L Kee
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 30:474-6. 2009
  4. ncbi request reprint Helix-loop-helix proteins in lymphocyte lineage determination
    B L Kee
    Department of Pathology, University of Chicago, IL 60637, USA
    Curr Top Microbiol Immunol 290:15-27. 2005
  5. doi request reprint E and ID proteins branch out
    Barbara L Kee
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Immunol 9:175-84. 2009
  6. pmc E2A proteins promote development of lymphoid-primed multipotent progenitors
    Sheila Dias
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 29:217-27. 2008
  7. pmc Transcriptional regulation of lymphocyte development
    Sheila Dias
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Curr Opin Genet Dev 18:441-8. 2008
  8. pmc Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development
    Malay Mandal
    Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
    Nat Immunol 10:1110-7. 2009
  9. ncbi request reprint A comprehensive transcriptional landscape of human hematopoiesis
    Barbara L Kee
    Committees on Immunology, Cancer Biology, and Development, Regeneration and Stem Cell Biology Department of Pathology, The University of Chicago, Chicago IL 60637, USA
    Cell Stem Cell 8:122-4. 2011
  10. pmc Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A
    Christopher S Seet
    Department of Pathology, University of Chicago, 5841 S Maryland Avenue, MC 1089, Chicago, IL 60637, USA
    J Exp Med 199:1689-700. 2004

Research Grants

Collaborators

Detail Information

Publications20

  1. pmc IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors
    Barbara L Kee
    Department of Biology, University of California San Diego, La Jolla, CA 92093, USA
    EMBO J 21:103-13. 2002
    ....
  2. ncbi request reprint Id3 induces growth arrest and caspase-2-dependent apoptosis in B lymphocyte progenitors
    Barbara L Kee
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 175:4518-27. 2005
    ..Our data suggest that E-proteins function in the control of differentiation and proliferation and that diminished E-protein activity results in apoptosis as a consequence of growth arrest...
  3. doi request reprint A s-myly route toward lymphoid differentiation
    Barbara L Kee
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 30:474-6. 2009
    ..In this issue of Immunity, Ng et al. (2009) show that lymphoid-lineage priming occurs in hematopoietic stem cells and is dependent on the Ikaros transcription factor, as is repression of self-renewal genes during lymphoid differentiation...
  4. ncbi request reprint Helix-loop-helix proteins in lymphocyte lineage determination
    B L Kee
    Department of Pathology, University of Chicago, IL 60637, USA
    Curr Top Microbiol Immunol 290:15-27. 2005
    ..A model of lymphocyte lineage determination based on the antagonistic activity of transcriptional activating and repressing helix-loop-helix proteins is presented...
  5. doi request reprint E and ID proteins branch out
    Barbara L Kee
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Immunol 9:175-84. 2009
    ....
  6. pmc E2A proteins promote development of lymphoid-primed multipotent progenitors
    Sheila Dias
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 29:217-27. 2008
    ..Our results reveal that E2A proteins play a critical role in supporting lymphoid specification from HSCs and that the reduced generation of LMPPs underlies the severe lymphocyte deficiencies observed in E2A-deficient mice...
  7. pmc Transcriptional regulation of lymphocyte development
    Sheila Dias
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Curr Opin Genet Dev 18:441-8. 2008
    ..The B lymphocyte lineage provides a paradigm for how these events unfold to promote specification and commitment to a single developmental pathway...
  8. pmc Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development
    Malay Mandal
    Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
    Nat Immunol 10:1110-7. 2009
    ..Our data show how pre-BCR signaling poises pre-B cells to undergo differentiation after escape from IL-7R signaling...
  9. ncbi request reprint A comprehensive transcriptional landscape of human hematopoiesis
    Barbara L Kee
    Committees on Immunology, Cancer Biology, and Development, Regeneration and Stem Cell Biology Department of Pathology, The University of Chicago, Chicago IL 60637, USA
    Cell Stem Cell 8:122-4. 2011
    ..The resulting map of regulatory interactions controlling stem cell differentiation provides a valuable resource for identification of novel hematopoietic regulators...
  10. pmc Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A
    Christopher S Seet
    Department of Pathology, University of Chicago, 5841 S Maryland Avenue, MC 1089, Chicago, IL 60637, USA
    J Exp Med 199:1689-700. 2004
    ....
  11. pmc Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity
    Markus D Boos
    Committee on Immunology, University of Chicago, Chicago, IL 60657, USA
    J Exp Med 204:1119-30. 2007
    ..Our findings redefine the essential functions of Id2 in lymphoid development and provide insight into the dynamic regulation of E and Id proteins during this process...
  12. doi request reprint Extrinsic and intrinsic regulation of early natural killer cell development
    Markus D Boos
    Committees on Immunology, The University of Chicago, Chicago, IL 60637, USA
    Immunol Res 40:193-207. 2008
    ..In this review, we discuss some of the known extrinsic stromal-cell derived factors and cell intrinsic transcription factors that function in guiding NK cell development...
  13. pmc SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics
    Mihalis Verykokakis
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Immunity 33:203-15. 2010
    ..Our findings reveal that accumulation of NKT-like cells promotes conventional CD8(+) thymocytes to acquire innate lymphocyte characteristics...
  14. pmc Multiple hats for natural killers
    Kevin Ramirez
    Committee on Immunology and Cancer Biology, Department of Pathology, The University of Chicago, Chicago, IL 60637, United States
    Curr Opin Immunol 22:193-8. 2010
    ..How these subsets arise from the conventional pathway of NK cell development and identification of the transcriptional networks that control their development are major challenges for future studies...
  15. pmc Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells
    Mihalis Verykokakis
    Department of Pathology, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 5:e9303. 2010
    ..More recently, Id3(-/-) mice on a C57BL/6 background were shown to have a dramatic expansion of gammadelta T cells...
  16. pmc Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms
    Erica J Reschly
    Department of Pathology, MC1089, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Blood 107:4115-21. 2006
    ..Our findings indicate that the activation of Notch1 is an important "second hit" for the transformation of E2A(-/-) T cell lymphomas and that Notch1 promotes survival through pre-TCR-dependent and -independent mechanisms...
  17. ncbi request reprint Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
    Tomas Vilimas
    Department of Medicine, Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue Chicago, Illinois 60637, USA
    Nat Med 13:70-7. 2007
    ..These findings identify NF-kappaB as one of the major mediators of Notch1-induced transformation and suggest that the NF-kappaB pathway is a potential target of future therapies of T-ALL...
  18. ncbi request reprint differential roles for the E2A activation domains in B lymphocytes and macrophages
    Savita Bhalla
    Department of Pathology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 180:1694-703. 2008
    ..Our findings demonstrate distinct functionalities for the E protein activation domains in B lymphocytes and macrophages...
  19. ncbi request reprint Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas
    Wei Xu
    Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA
    Blood 109:4406-14. 2007
    ..Therefore, we propose that E2A proteins prevent lymphoma cell expansion, at least in part through regulation of Gfi1b and modulation of Gata3 expression...
  20. ncbi request reprint Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas
    Christina Spaulding
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Blood 110:2650-8. 2007
    ..Therefore, Notch1 co-opts Lef1 during the process of transformation to maintain survival of T-cell lymphomas...

Research Grants17

  1. Regulation of Lymphocyte Development by HLH Proteins
    BARBARA LYNNE KEE; Fiscal Year: 2010
    ..Our studies will provide insight into how to how to manipulate this program to avoid disease and how therapeutic interventions will impact on NK cell development. ..
  2. Transcriptional Control of Hematopoiesis
    BARBARA LYNNE KEE; Fiscal Year: 2010
    ..Our study will reveal the mechanisms by which E protein transcription factors maintain hematopoietic stem cell function and promote differentiation toward the lymphoid lineages. ..
  3. Regulation of Lymphocyte Development by HLH Proteins
    BARBARA LYNNE KEE; Fiscal Year: 2010
    ..Our studies will provide insight into how to how to manipulate this program to avoid disease and how therapeutic interventions will impact on NK cell development. ..
  4. Mechanisms of Lymphocyte Gene Regulation by E2A and Notch1
    BARBARA LYNNE KEE; Fiscal Year: 2010
    ..abstract_text> ..
  5. Regulation of Lymphocyte Development by HLH Proteins
    Barbara Kee; Fiscal Year: 2007
    ..These studies will lead to a greater understanding of the genetic basis for lineage determination and will provide insight into the essential requirements for proper lymphocyte development. ..
  6. Regulation of Lymphocyte Development by Helix Loop Helix Proteins
    Barbara Kee; Fiscal Year: 2007
    ..These studies will lead to a greater understanding of the genetic basis for lineage determination and will provide insight into the essential requirements for proper lymphocyte development. ..