Barbara Kee

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..Our data suggest that E-proteins function in the control of differentiation and proliferation and that diminished E-protein activity results in apoptosis as a consequence of growth arrest...

..In this issue of Immunity, Ng et al. (2009) show that lymphoid-lineage priming occurs in hematopoietic stem cells and is dependent on the Ikaros transcription factor, as is repression of self-renewal genes during lymphoid differentiation...

..A model of lymphocyte lineage determination based on the antagonistic activity of transcriptional activating and repressing helix-loop-helix proteins is presented...

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..Our results reveal that E2A proteins play a critical role in supporting lymphoid specification from HSCs and that the reduced generation of LMPPs underlies the severe lymphocyte deficiencies observed in E2A-deficient mice...

..The B lymphocyte lineage provides a paradigm for how these events unfold to promote specification and commitment to a single developmental pathway...

..Our data show how pre-BCR signaling poises pre-B cells to undergo differentiation after escape from IL-7R signaling...

..The resulting map of regulatory interactions controlling stem cell differentiation provides a valuable resource for identification of novel hematopoietic regulators...

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..Our findings redefine the essential functions of Id2 in lymphoid development and provide insight into the dynamic regulation of E and Id proteins during this process...

..In this review, we discuss some of the known extrinsic stromal-cell derived factors and cell intrinsic transcription factors that function in guiding NK cell development...

..Our findings reveal that accumulation of NKT-like cells promotes conventional CD8(+) thymocytes to acquire innate lymphocyte characteristics...

..How these subsets arise from the conventional pathway of NK cell development and identification of the transcriptional networks that control their development are major challenges for future studies...

..More recently, Id3(-/-) mice on a C57BL/6 background were shown to have a dramatic expansion of gammadelta T cells...

..Our findings indicate that the activation of Notch1 is an important "second hit" for the transformation of E2A(-/-) T cell lymphomas and that Notch1 promotes survival through pre-TCR-dependent and -independent mechanisms...

..These findings identify NF-kappaB as one of the major mediators of Notch1-induced transformation and suggest that the NF-kappaB pathway is a potential target of future therapies of T-ALL...

..Our findings demonstrate distinct functionalities for the E protein activation domains in B lymphocytes and macrophages...

..Therefore, we propose that E2A proteins prevent lymphoma cell expansion, at least in part through regulation of Gfi1b and modulation of Gata3 expression...

..Therefore, Notch1 co-opts Lef1 during the process of transformation to maintain survival of T-cell lymphomas...

..Our studies will provide insight into how to how to manipulate this program to avoid disease and how therapeutic interventions will impact on NK cell development. ..

..Our study will reveal the mechanisms by which E protein transcription factors maintain hematopoietic stem cell function and promote differentiation toward the lymphoid lineages. ..

..Our studies will provide insight into how to how to manipulate this program to avoid disease and how therapeutic interventions will impact on NK cell development. ..

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..These studies will lead to a greater understanding of the genetic basis for lineage determination and will provide insight into the essential requirements for proper lymphocyte development. ..

..These studies will lead to a greater understanding of the genetic basis for lineage determination and will provide insight into the essential requirements for proper lymphocyte development. ..