P E Keck

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. doi request reprint Aripiprazole monotherapy in the treatment of acute bipolar I mania: a randomized, double-blind, placebo- and lithium-controlled study
    P E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, and Linder Center of HOPE, Mason, Ohio 45267, USA
    J Affect Disord 112:36-49. 2009
  2. ncbi request reprint New approaches in managing bipolar depression
    Paul E Keck
    Program Psychopharmacology Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 64:13-8. 2003
  3. ncbi request reprint Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placebo
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 68:1480-91. 2007
  4. ncbi request reprint Evaluation and management of breakthrough depressive episodes
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Psychiatry 65:11-5. 2004
  5. ncbi request reprint Carbamazepine and valproate in the maintenance treatment of bipolar disorder
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:13-7. 2002
  6. ncbi request reprint Pharmacologic treatment considerations in co-occurring bipolar and anxiety disorders
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    J Clin Psychiatry 67:8-15. 2006
  7. ncbi request reprint A randomized, double-blind, placebo-controlled 26-week trial of aripiprazole in recently manic patients with bipolar I disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Psychiatry 67:626-37. 2006
  8. ncbi request reprint Long-term management strategies to achieve optimal function in patients with bipolar disorder
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, and the General Clinical Research Center and Mental Health Care Line, Cincinnati Veterans Affairs Medical Center, Ohio 45267 0559, USA
    J Clin Psychiatry 67:19-24; discussion 36-42. 2006
  9. ncbi request reprint Defining and improving response to treatment in patients with bipolar disorder
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Clin Psychiatry 65:25-9. 2004
  10. ncbi request reprint Divalproex in the treatment of bipolar disorder
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670559, Cincinnati, OH 45267, USA
    Psychopharmacol Bull 37:67-73. 2003

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. doi request reprint Aripiprazole monotherapy in the treatment of acute bipolar I mania: a randomized, double-blind, placebo- and lithium-controlled study
    P E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, and Linder Center of HOPE, Mason, Ohio 45267, USA
    J Affect Disord 112:36-49. 2009
    ..To evaluate the efficacy and safety of aripiprazole as acute and maintenance of effect monotherapy for acute bipolar mania...
  2. ncbi request reprint New approaches in managing bipolar depression
    Paul E Keck
    Program Psychopharmacology Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 64:13-8. 2003
    ....
  3. ncbi request reprint Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placebo
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 68:1480-91. 2007
    ..Efficacy and tolerability of aripiprazole for relapse prevention in bipolar I disorder was, therefore, evaluated for 100 weeks...
  4. ncbi request reprint Evaluation and management of breakthrough depressive episodes
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Psychiatry 65:11-5. 2004
    ..Combination therapy with a mood stabilizer and an atypical antipsychotic may also be effective in managing bipolar depressive episodes...
  5. ncbi request reprint Carbamazepine and valproate in the maintenance treatment of bipolar disorder
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:13-7. 2002
    ..We reviewed the available data from randomized clinical trials of these agents in bipolar disorder to assess their efficacy and tolerability in the maintenance phase of illness management...
  6. ncbi request reprint Pharmacologic treatment considerations in co-occurring bipolar and anxiety disorders
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    J Clin Psychiatry 67:8-15. 2006
    ..Anxiety disorders are among the most commonly co-occurring psychiatric syndromes with bipolar disorder. The presence of co-occurring anxiety disorders has important prognostic and treatment implications...
  7. ncbi request reprint A randomized, double-blind, placebo-controlled 26-week trial of aripiprazole in recently manic patients with bipolar I disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Psychiatry 67:626-37. 2006
    ..To investigate the safety and efficacy of aripiprazole in preventing relapse of a mood episode in recently manic- or mixed-episode patients with bipolar I disorder stabilized on aripiprazole...
  8. ncbi request reprint Long-term management strategies to achieve optimal function in patients with bipolar disorder
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, and the General Clinical Research Center and Mental Health Care Line, Cincinnati Veterans Affairs Medical Center, Ohio 45267 0559, USA
    J Clin Psychiatry 67:19-24; discussion 36-42. 2006
    ..Substantial information is needed regarding the prevalence and causes of cognitive dysfunction in bipolar disorder, the effects of existing treatments on cognition, and long-term treatments to improve cognition and functioning...
  9. ncbi request reprint Defining and improving response to treatment in patients with bipolar disorder
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Clin Psychiatry 65:25-9. 2004
    ..Psychoeducation for patients and families and interpersonal psychotherapy also can help prolong remission...
  10. ncbi request reprint Divalproex in the treatment of bipolar disorder
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670559, Cincinnati, OH 45267, USA
    Psychopharmacol Bull 37:67-73. 2003
    ..The results of randomized, controlled trials of valproate in the treatment of bipolar disorder are reviewed along with their implications for clinical practice...
  11. ncbi request reprint Bipolar disorder, obesity, and pharmacotherapy-associated weight gain
    Paul E Keck
    Division of Clinical Neuroscience, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 64:1426-35. 2003
    ..This risk may be due to factors associated with the illness itself and/or with medications used to treat bipolar disorder...
  12. ncbi request reprint Bipolar depression: a new role for atypical antipsychotics?
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 7:34-40. 2005
    ..001 versus placebo). These initial findings suggest that atypical antipsychotics may prove to be important future treatments for patients with bipolar depression...
  13. ncbi request reprint Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  14. ncbi request reprint A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania
    Paul E Keck
    Biological Psychiatry Program, Department of Psychiatry, University of Cincinnati College of Medicine, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Am J Psychiatry 160:1651-8. 2003
    ..The authors compared the efficacy and safety of aripiprazole, a novel antipsychotic, to placebo for treatment of patients in an acute manic or mixed episode of bipolar disorder...
  15. ncbi request reprint Comparison of patients with early-, typical-, and late-onset affective psychosis
    K W Sax
    Department of Psychiatry, University of Cincinnati College of Medicine, OH, USA
    Am J Psychiatry 154:1299-301. 1997
    ..The authors compared the clinical characteristics and family history of patients with early-onset (before age 18), typical-onset (at 20-25 years), and late-onset (after age 35) affective psychosis at the time of first hospitalization...
  16. ncbi request reprint Bipolar disorder
    P E Keck
    Department of Psychiatry, Biological Psychiatry Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Med Clin North Am 85:645-61, ix. 2001
    ..Fortunately, several medications are now available to treat the acute mood episodes of bipolar disorder and to prevent further episodes with maintenance treatment...
  17. ncbi request reprint A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group
    C L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78284 7792, USA
    Arch Gen Psychiatry 57:481-9. 2000
    ..This study compared the efficacy of divalproex, lithium, and placebo as prophylactic therapy...
  18. ncbi request reprint Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  19. ncbi request reprint Pharmacologic loading in the treatment of acute mania
    P E Keck
    Biological Psychiatry Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Bipolar Disord 2:42-6. 2000
    ..Further double-blind, controlled studies with adequate sample sizes comparing loading strategies with more gradual titration schedules of candidate antimanic agents are needed...
  20. ncbi request reprint A pilot study of rapid lithium administration in the treatment of acute mania
    P E Keck
    Biological Psychiatry Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Bipolar Disord 3:68-72. 2001
    ..A secondary aim was to provide preliminary data regarding the efficacy of this strategy in ameliorating manic, depressive, and psychotic symptoms...
  21. ncbi request reprint Long-term therapy of bipolar illness
    Paul E Keck
    University of Cincinnati College of Medicine, USA
    J Fam Pract . 2003
  22. ncbi request reprint Ethnicity and diagnosis in patients with affective disorders
    Stephen M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Clin Psychiatry 64:747-54. 2003
    ..Why this occurs is unknown. Extending prior work, the authors hypothesized that first-rank symptoms distract clinicians so that they fail to identify affective disorders in African Americans...
  23. ncbi request reprint Maintenance efficacy of divalproex in the prevention of bipolar depression
    Laszlo Gyulai
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1374-82. 2003
    ....
  24. ncbi request reprint Analyses of treatment-emergent mania with olanzapine/fluoxetine combination in the treatment of bipolar depression
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:611-6. 2005
    ..These subanalyses compare treatment-emergent mania rates in bipolar I depressed patients treated with olanzapine, placebo, or olanzapine/fluoxetine combination...
  25. ncbi request reprint Cerebrospinal fluid and plasma beta-endorphin in combat veterans with post-traumatic stress disorder
    D G Baker
    Psychiatry Service, Cincinnati Veterans Affairs Medical Center, OH 15220, USA
    Psychoneuroendocrinology 22:517-29. 1997
    ..Poor correlation between CSF and plasma ir beta END limits use of plasma measures to assess CNS opioid activity...
  26. ncbi request reprint Attentional improvement following quetiapine fumarate treatment in schizophrenia
    K W Sax
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Schizophr Res 33:151-5. 1998
    ..These results suggest that quetiapine produces a significant improvement in attentional functioning in patients with schizophrenia...
  27. doi request reprint Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial
    Anna I Guerdjikova
    Department of Psychiatry, University of Cincinnati College of Medicine, Lindner Center of HOPE, Mason, Ohio 45040, USA
    Int Clin Psychopharmacol 24:150-8. 2009
    ..As a result of an exceptionally high placebo response, it is likely that for efficacy measures except for body weight and metabolic indices, the study was incapable of detecting potentially clinically important drug-placebo difference...
  28. ncbi request reprint Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  29. ncbi request reprint A placebo-controlled, crossover trial of granisetron in SRI-induced sexual dysfunction
    E B Nelson
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267-0559, USA
    J Clin Psychiatry 62:469-73. 2001
    ..A significant placebo response may be associated with the treatment of SRI-induced sexual dysfunction...
  30. ncbi request reprint Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder
    S L McElroy
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Am J Psychiatry 158:420-6. 2001
    ..Therefore, the authors assessed comorbid lifetime and current axis I disorders in 288 patients with bipolar disorder and the relationships of these comorbid disorders to selected demographic and historical illness variables...
  31. ncbi request reprint Placebo-controlled study of quetiapine monotherapy in ambulatory bipolar spectrum disorder with moderate-to-severe hypomania or mild mania
    Susan L McElroy
    Lindner Center of HOPE, Mason, Ohio 45040, USA
    J Affect Disord 124:157-63. 2010
    ..There are no randomized, placebo-controlled data for quetiapine in outpatients with bipolar spectrum disorder (ambulatory BSD) and moderate-to-severe hypomanic or mild manic symptoms (hypomania/mild mania)...
  32. ncbi request reprint The effect of multiple doses of cimetidine on the steady-state pharmacokinetics of quetiapine in men with selected psychotic disorders
    Stephen M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychopharmacol 22:201-5. 2002
    ..No serious adverse events were observed during quetiapine treatment. No clinically relevant alterations in quetiapine pharmacokinetics were observed after cimetidine coadministration in patients with psychotic disorders...
  33. ncbi request reprint Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
    ..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder...
  34. ncbi request reprint Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study
    Lori L Altshuler
    Department of Psychiatry, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    J Clin Psychiatry 70:450-7. 2009
    ..To assess long-term outcome in bipolar disorder, subjects were prospectively followed after receiving acute treatment for bipolar depression...
  35. ncbi request reprint Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Compr Psychiatry 44:263-9. 2003
    ..The lack of observable prognostic impact may have been, in part, due to the relatively high morbidity and poor functional outcome of a substantial portion of the total cohort...
  36. ncbi request reprint A retrospective chart review of intramuscular ziprasidone for agitation in children and adolescents on psychiatric units: prospective studies are needed
    Drew H Barzman
    Children s Hospital Medical Center, Division of Child and Adolescent Psychiatry, Cincinnati, Ohio 45229 3039, USA
    J Child Adolesc Psychopharmacol 17:503-9. 2007
    ..Our secondary objective was to examine demographic and clinical factors associated with treatment response...
  37. ncbi request reprint Prevalence and description of psychotic features in bipolar mania
    E Dunayevich
    Clinical Psychobiology Program, Department of Psychiatry, University of Cincinnati, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Curr Psychiatry Rep 2:286-90. 2000
    ..Careful assessment of prior psychiatric history, family history, and treatment response can aid in the differentiation of affective disorders with psychotic features from psychotic disorders...
  38. ncbi request reprint The effects of antecedent substance abuse on the development of first-episode psychotic mania
    S M Strakowski
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    J Psychiatr Res 30:59-68. 1996
    ..Additional prospective studies of patients with new onset bipolar disorder and antecedent substance abuse syndromes are needed to further clarify the complex relationships between substance abuse and bipolar disorder...
  39. ncbi request reprint Antidepressant treatment of fibromyalgia. A meta-analysis and review
    L M Arnold
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Psychosomatics 41:104-13. 2000
    ....
  40. ncbi request reprint Ziprasidone in the short-term treatment of patients with schizoaffective disorder: results from two double- blind, placebo-controlled, multicenter studies
    P E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267-0559, USA
    J Clin Psychopharmacol 21:27-35. 2001
    ..These results suggest that ziprasidone may have efficacy in the treatment of affective as well as psychotic symptoms of schizoaffective disorder, with a low side-effect burden...
  41. ncbi request reprint Randomized, double-blind, placebo-controlled study of divalproex extended release loading monotherapy in ambulatory bipolar spectrum disorder patients with moderate-to-severe hypomania or mild mania
    Susan L McElroy
    4075 Old Western Row Road, Mason, OH 45040, USA
    J Clin Psychiatry 71:557-65. 2010
    ..To determine whether divalproex extended release (ER) would be effective in outpatients with DSM-IV-TR-diagnosed ambulatory bipolar spectrum disorder (BSD) and moderate-to-severe hypomanic or mild manic symptoms (hypomania/mild mania)...
  42. ncbi request reprint Advances in the pharmacologic treatment of bipolar depression
    Paul E Keck
    Division of Psychopharmacology Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 53:671-9. 2003
    ....
  43. ncbi request reprint Aripiprazole: a partial dopamine D2 receptor agonist antipsychotic
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and General Clinical Research Center, Mental Health Service Line, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, USA
    Expert Opin Investig Drugs 12:655-62. 2003
    ..In addition, aripiprazole was not associated with significant weight gain or QTc prolongation in both acute and long-term treatment trials...
  44. doi request reprint Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression
    Mark A Frye
    Department of Psychiatry, Mayo Mood Clinic and Research Program, Mayo Clinic, 200 First St, S W, Rochester, MN 55901, USA
    Am J Psychiatry 166:164-72. 2009
    ..This study examined the correlates associated with treatment-emergent mania in patients receiving adjunctive antidepressant treatment for bipolar depression...
  45. ncbi request reprint Severity of bipolarity in hospitalized manic adolescents with history of stimulant or antidepressant treatment
    Cesar A Soutullo
    University of Cincinnati, Department of Psychiatry, Biological Psychiatry and Psychotic and Bipolar Disorders Research Programs, PO Box 670559, 231 Bethesda Avenue, Cincinnati, OH 45267 0559, USA
    J Affect Disord 70:323-7. 2002
    ..Childhood bipolarity (BP) and ADHD frequently co-occur, these children often receive stimulants...
  46. ncbi request reprint Frontosubcortical neuroanatomy and the continuous performance test in mania
    K W Sax
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Am J Psychiatry 156:139-41. 1999
    ..The authors examined whether Continuous Performance Test scores correlate with frontosubcortical volumes in bipolar disorder...
  47. ncbi request reprint Definition, evaluation, and management of treatment refractory mania
    P E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Psychopharmacol Bull 35:130-48. 2001
    ..Field testing of treatment algorithms and systematic collection of data from naturalistic treatment studies should provide much-needed data regarding the efficacy of antimanic agents in treatment refractory mania...
  48. ncbi request reprint Evaluation of bipolar disorder in inpatients with prelingual deafness
    N A Shapira
    Department of Psychiatry, University of Cincinnati College of Medicine, USA
    Am J Psychiatry 156:1267-9. 1999
    ..This study retrospectively examined the occurrence of bipolar disorder in patients with prelingual deafness who were hospitalized for a psychiatric disorder...
  49. ncbi request reprint Ziprasidone: a new atypical antipsychotic
    P E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio, USA
    Expert Opin Pharmacother 2:1033-42. 2001
    ..Unlike newer agents, it does not appear to be associated with weight gain in most patients...
  50. ncbi request reprint What makes a drug a primary mood stabilizer?
    P E Keck
    Biological Psychiatry Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Mol Psychiatry 7:S8-14. 2002
    ..In addition, potential pharmacological mechanisms underlying mood-stabilizing effects of established compounds are reviewed...
  51. ncbi request reprint Comparison of obese men and women with binge eating disorder seeking weight management
    A I Guerdjikova
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Eat Weight Disord 12:e19-23. 2007
    ....
  52. pmc Characterizing impulsivity in mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Universtiy of Cincinnati College of Medicine, Cincinnati, OH, USA
    Bipolar Disord 11:41-51. 2009
    ....
  53. ncbi request reprint Risk of diabetes mellitus associated with atypical antipsychotic use among patients with bipolar disorder: A retrospective, population-based, case-control study
    Jeff J Guo
    College of Pharmacy, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0004, USA
    J Clin Psychiatry 67:1055-61. 2006
    ..Drug-induced diabetes onset has not been adequately quantified in patients with bipolar disorder, although atypical antipsychotics have been widely used as new mood stabilizers...
  54. ncbi request reprint Phenomenology associated with age at onset in patients with bipolar disorder at their first psychiatric hospitalization
    Nick C Patel
    College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267 0004, USA
    Bipolar Disord 8:91-4. 2006
    ..To compare the clinical presentation of patients with early-onset (age <18 years) and typical-onset (age 20-30 years) bipolar disorder at the time of first hospitalization...
  55. ncbi request reprint Ziprasidone: efficacy and safety in patients with bipolar disorder
    Nick C Patel
    University of Cincinnati, College of Pharmacy and Department of Psychiatry, College of Medicine, 3225 Eden Avenue, PO Box 670004, Cincinnati, OH 45267 0004, USA
    Expert Rev Neurother 6:1129-38. 2006
    ..Ziprasidone is considered as a first-line treatment option in patients with bipolar manic or mixed episodes, with or without psychosis and displays a favorable side-effect profile...
  56. ncbi request reprint Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0559, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Arch Gen Psychiatry 62:851-8. 2005
    ..Alcohol-use disorders are common co-occurring conditions affecting bipolar patients, and this co-occurrence is negatively associated with outcome...
  57. ncbi request reprint Olanzapine in the treatment of pathological gambling: a negative randomized placebo-controlled trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 69:433-40. 2008
    ..Olanzapine is a second-generation antipsychotic with mood-stabilizing properties and antagonistic activity at several dopamine receptors. The purpose of this study was to evaluate olanzapine in the treatment of pathological gambling...
  58. ncbi request reprint Lithium augmentation of topiramate for bipolar disorder with comorbid binge eating disorder and obesity
    Renu Kotwal
    Department of Psychiatry, Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Hum Psychopharmacol 21:425-31. 2006
    ..To evaluate the effectiveness of lithium augmentation of topiramate on mood symptoms, binge eating behavior, and body weight in obese bipolar patients with binge eating disorder (BED) seeking weight management...
  59. ncbi request reprint Dopamine and serotonin receptor binding and antipsychotic efficacy
    Neil M Richtand
    Psychiatry Service, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH, USA
    Neuropsychopharmacology 32:1715-26. 2007
    ..2) Increasing 5-HT(2C) and 5-HT(2A) receptor-binding affinities also facilitate antipsychotic efficacy. (3) Increasing 5-HT(1A) receptor-binding affinity, in contrast, reduces antipsychotic efficacy...
  60. ncbi request reprint Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    J Affect Disord 101:275-81. 2007
    ..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole...
  61. ncbi request reprint Atomoxetine in the treatment of binge-eating disorder: a randomized placebo-controlled trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    J Clin Psychiatry 68:390-8. 2007
    ..Binge-eating disorder (BED) is associated with obesity. Atomoxetine is a highly selective norepinephrine reuptake inhibitor associated with weight loss. The purpose of this study was to evaluate atomoxetine in the treatment of BED...
  62. ncbi request reprint Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    J Clin Psychiatry 67:1897-906. 2006
    ..Binge eating disorder (BED) is associated with obesity. Zonisamide is a novel antiepileptic drug associated with weight loss. The purpose of this study was to evaluate zonisa-mide in the treatment of BED associated with obesity...
  63. ncbi request reprint Risk of diabetes mellitus associated with atypical antipsychotic use among Medicaid patients with bipolar disorder: a nested case-control study
    Jeff J Guo
    College of Pharmacy, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0004, USA
    Pharmacotherapy 27:27-35. 2007
    ..To quantify the risk of diabetes mellitus associated with atypical antipsychotics compared with conventional antipsychotics in managed care Medicaid patients with bipolar disorder...
  64. ncbi request reprint Gabapentin in the treatment of fibromyalgia: a randomized, double-blind, placebo-controlled, multicenter trial
    Lesley M Arnold
    University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, and Newton Wellesley Hospital, Newton, MA, USA
    Arthritis Rheum 56:1336-44. 2007
    ..To assess the efficacy and safety of gabapentin in patients with fibromyalgia...
  65. ncbi request reprint Treatment costs related to bipolar disorder and comorbid conditions among Medicaid patients with bipolar disorder
    Jeff J Guo
    Division of Pharmacy Practice and Administrative Sciences, College of Pharmacy and the Institute for the Study of Health, University of Cincinnati Academic Health Center, 3225 Eden Avenue, Cincinnati, OH 45267 0004, USA
    Psychiatr Serv 58:1073-8. 2007
    ..This study assessed costs among patients with bipolar disorder for treatment related to bipolar disorder and to comorbid conditions. Risk factors associated with costs were also assessed...
  66. ncbi request reprint Relationship of open acute mania treatment to blinded maintenance outcome in bipolar I disorder
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Affect Disord 107:127-33. 2008
    ..No published studies have statistically evaluated the relationship between the outcomes in maintenance treatment and the principal acute agent...
  67. doi request reprint Treatment costs and health care utilization for patients with bipolar disorder in a large managed care population
    Jeff J Guo
    College of Pharmacy, University of Cincinnati Medical Center, Cincinnati, OH, USA
    Value Health 11:416-23. 2008
    ....
  68. ncbi request reprint The Texas implementation of medication algorithms update for treatment of bipolar I disorder
    Roy H Perlis
    Bipolar Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    J Clin Psychiatry 66:818-20. 2005
  69. ncbi request reprint Familiality of temperament in bipolar disorder: support for a genetic spectrum
    Lynn Evans
    Department of Psychiatry, UCSD, School of Medicine, University of California, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    J Affect Disord 85:153-68. 2005
    ..We predicted that a gradient of scores would be observed from those with BP to those with major depression to unaffected relatives to controls...
  70. ncbi request reprint Moderators of placebo response to antipsychotic treatment in patients with schizophrenia: a meta-regression
    Jeffrey A Welge
    Biological Psychiatry Program, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Bethesda Avenue, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Psychopharmacology (Berl) 166:1-10. 2003
    ..Therefore, it is of great importance to identify factors that moderate response to placebo in such trials...
  71. ncbi request reprint Redefining mood stabilization
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Affect Disord 73:163-9. 2003
    ..No available agent meets the criteria for a comprehensive mood-stabilizer, although lithium comes the closest...
  72. ncbi request reprint Atypical antipsychotics in the treatment of bipolar disorder
    Stephen M Strakowski
    Department of Psychiatry, University of Cincinnati College of Medicine, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Expert Opin Pharmacother 4:751-60. 2003
    ..Atypical antipsychotics offer different side effect profiles than older antipsychotics, which may be of benefit for some patients. Consequently, atypical antipsychotics provide an important treatment option for bipolar patients...
  73. ncbi request reprint Clinical pharmacodynamics and pharmacokinetics of antimanic and mood-stabilizing medications
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:3-11. 2002
    ..We reviewed the clinical pharmacodynamics and pharmacokinetics of these agents to provide a summary of these properties relevant to clinical practice...
  74. ncbi request reprint The role of second-generation antipsychotic monotherapy in the rapid control of acute bipolar mania
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Psychiatry 66:5-11. 2005
    ..Therefore, selecting a second-generation antipsychotic requires consideration of how an agent's efficacy, onset of action, and adverse events profile influence its appropriateness for each patient...
  75. ncbi request reprint Antidepressants and suicidal behavior in bipolar disorder
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 8:596-617. 2006
    ....
  76. ncbi request reprint Predictors of response to treatment of acute bipolar manic episodes with divalproex sodium or placebo in 2 randomized, controlled, parallel-group trials
    Jeffrey A Welge
    Division of Clinical Neuroscience, Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH, USA
    J Clin Psychopharmacol 24:607-12. 2004
    ..Stratification on the basis of these prognostic factors may improve the power of future trials for the treatment of acute mania and may help explain patient response to treatment...
  77. ncbi request reprint Ziprasidone in the treatment of acute bipolar mania: a three-week, placebo-controlled, double-blind, randomized trial
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45627 0559, USA
    Am J Psychiatry 160:741-8. 2003
    ..The study evaluated the efficacy and tolerability of ziprasidone, compared with placebo, in the treatment of adult patients with acute bipolar mania...
  78. ncbi request reprint Family study of fibromyalgia
    Lesley M Arnold
    University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Arthritis Rheum 50:944-52. 2004
    ..To assess for familial aggregation of fibromyalgia (FM) and measures of tenderness and pain, and for familial coaggregation of FM and major mood disorder (major depressive disorder or bipolar disorder)...
  79. ncbi request reprint Impact of bipolar disorder on a U.S. community sample
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 64:425-32. 2003
    ..Bipolar symptoms have been associated with significant functional impairment. We conducted a study to determine the psychosocial impact of bipolar disorder in a U.S. community sample...
  80. ncbi request reprint Correlates of overweight and obesity in 644 patients with bipolar disorder
    Susan L McElroy
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:207-13. 2002
    ..Overweight and obesity are common clinical problems encountered in the treatment of bipolar disorder. We therefore assessed the prevalence and clinical correlates of overweight, obesity, and extreme obesity in 644 bipolar patients...
  81. ncbi request reprint A randomized, placebo-controlled, double-blind, flexible-dose study of fluoxetine in the treatment of women with fibromyalgia
    Lesley M Arnold
    Women s Health Research Program, Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0559, USA
    Am J Med 112:191-7. 2002
    ..To assess the efficacy of fluoxetine in the treatment of patients with fibromyalgia...
  82. ncbi request reprint Comorbidity of bipolar and eating disorders: distinct or related disorders with shared dysregulations?
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, P O Box 670559, 231 Bethesda Avenue, Cincinnati, OH 45267 0559, USA
    J Affect Disord 86:107-27. 2005
    ..The co-occurrence of bipolar and eating disorders, though of major clinical and public health importance, remains relatively unexamined...
  83. ncbi request reprint An open trial of olanzapine in the treatment of patients with psychotic depression
    E B Nelson
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267-0559, USA
    Ann Clin Psychiatry 13:147-51. 2001
    ..001). The results of this pilot study suggest that olanzapine may be an effective treatment for some patients with unipolar psychotic depression. However, these observations require replication in randomized, controlled trials...
  84. ncbi request reprint Failure of glucagon-like peptide-1 to induce panic attacks or anxiety in patients with panic disorder
    J R Strawn
    Cincinnati Veterans Affairs Medical Center, Research Service, Cincinnati, OH 45220, USA
    J Psychiatr Res 42:787-9. 2008
    ..These data suggest that in humans, intraveneously administered GLP-1 does not appear to have anxiogenic or panicogenic properties, even in patients at highest risk for such reactions...
  85. ncbi request reprint Health values of patients with bipolar disorder
    J Tsevat
    Section of Outcomes Research, Division of General Internal Medicine, Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
    Qual Life Res 9:579-86. 2000
    ..Despite a growing number of studies of patients' health values (utilities), little is known about health values of patients with mental illness, particularly bipolar (manic-depressive) disorder...
  86. ncbi request reprint Residual catatonic state following neuroleptic malignant syndrome
    S N Caroff
    Department of Psychiatry, University of Pennsylvania School of Medicine, and the Department of Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 20:257-9. 2000
    ..Although patients may improve gradually with supportive care or pharmacotherapy, ECT can often be highly effective in treating the residual catatonic state that follows NMS...
  87. ncbi request reprint CSF norepinephrine concentrations in posttraumatic stress disorder
    T D Geracioti
    Mental Health Service, Veterans Affairs Medical Center, 3200 Vine St, Cincinnati, OH 45220, USA
    Am J Psychiatry 158:1227-30. 2001
    ..The goal of this study was to determine serial CSF norepinephrine levels in patients with PTSD...
  88. ncbi request reprint Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series
    S H Shaw
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    Mol Psychiatry 8:558-64. 2003
    ..These pedigrees provide additional evidence for at least one locus for BP disorder in 13q32, and are consistent with other reports of a possible genetic overlap between these disorders...
  89. ncbi request reprint Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder
    T B Barrett
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0603, USA
    Mol Psychiatry 8:546-57. 2003
    ..7 (chi(2)=9.6, one-sided P value=0.0019). Altogether, these data support the hypothesis that a dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of BPD...
  90. ncbi request reprint Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
    ..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study...
  91. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  92. ncbi request reprint Family study of fibromyalgia and affective spectrum disorder
    James I Hudson
    Biological Psychiatry Laboratory, McLean Hospital Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Biol Psychiatry 56:884-91. 2004
    ..Two predictions of the ASD hypothesis were tested: ASD, taken as a single entity, aggregates in families; and fibromyalgia coaggregates with other forms of ASD in families...
  93. ncbi request reprint Screening for bipolar disorder in the community
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, 77555 188, USA
    J Clin Psychiatry 64:53-9. 2003
    ..Our goal was to estimate the rate of positive screens for bipolar I and bipolar II disorders in the general population of the United States...
  94. ncbi request reprint Report of the Texas Consensus Conference Panel on medication treatment of bipolar disorder 2000
    Trisha Suppes
    Department of Psychiatry The University of Texas Southwestern Medical Center Dallas, 75390 9070, USA
    J Clin Psychiatry 63:288-99. 2002
    ....
  95. ncbi request reprint A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression
    Joseph R Calabrese
    University Hospitals of Cleveland and Case University School of Medicine, 11400 Euclid Ave, Suite 200, Cleveland, OH 44106, USA
    Am J Psychiatry 162:1351-60. 2005
    ..There is a major unmet need for effective options in the treatment of bipolar depression...
  96. ncbi request reprint A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
    ..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue...
  97. ncbi request reprint Number needed to treat and time to response/remission for quetiapine monotherapy efficacy in acute bipolar depression: evidence from a large, randomized, placebo-controlled study
    John Cookson
    The Department of Psychiatry, Royal London Hospital, London, UK
    Int Clin Psychopharmacol 22:93-100. 2007
    ..2%, quetiapine 300 mg/day: 3.9, and placebo: 3.9%). In conclusion, quetiapine compared with placebo significantly reduces time to response and remission compared with placebo, and has a favorable number needed to treat...
  98. ncbi request reprint Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism
    Eric Levander
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    J Affect Disord 101:211-7. 2007
    ..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)...
  99. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  100. ncbi request reprint Atypical antipsychotics in the treatment of mania: a meta-analysis of randomized, placebo-controlled trials
    Roy H Perlis
    Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:509-16. 2006
    ..However, there are no published comparisons of individual atypical antipsychotics for mania...
  101. ncbi request reprint Extended-release carbamazepine capsules as monotherapy in bipolar disorder : pooled results from two randomised, double-blind, placebo-controlled trials
    Richard H Weisler
    Department of Psychiatry and Behavioral Science, Duke University, Raleigh, North Carolina 27609, USA
    CNS Drugs 20:219-31. 2006
    ..By pooling data from these two trials, a more highly powered analysis of the efficacy and safety of CBZ-ERC in bipolar I disorder could be conducted...