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Genomes and GenesSpecies | Electron KebebewSummaryAffiliation: University of California Country: USA Publications
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Publications
Results of rosiglitazone therapy in patients with thyroglobulin-positive and radioiodine-negative advanced differentiated thyroid cancerElectron Kebebew
Department of Surgery, University of California San Francisco UCSF, San Francisco, California 94143, USA
Thyroid 19:953-6. 2009..We investigated the efficacy and side effects of rosiglitazone therapy in patients with differentiated thyroid cancer of follicular cell origin that fails to take up radioiodine or is unresectable...- Are additional localization studies and referral indicated for patients with primary hyperparathyroidism who have negative sestamibi scan results?Dina M Elaraj
Department of Surgery, Feinberg School of Medicine, Northwestern University, 676 N St Clair St, Ste 650, Chicago, IL 60611, USA
Arch Surg 145:578-81. 2010..Additional imaging studies are useful to select patients who are candidates for minimally invasive parathyroidectomy, and referral is not indicated when results from a preoperative sestamibi scan are negative... 
Nonfunctioning parathyroid carcinoma: case report and review of literatureGustavo G Fernandez Ranvier
Department of Surgery, University of California, San Francisco, California, USA
Endocr Pract 13:750-7. 2007..To report a case of nonfunctioning parathyroid carcinoma that was incidentally found during a thyroidectomy for multinodular goiter...- Serum thyroglobulin is a poor diagnostic biomarker of malignancy in follicular and Hurthle-cell neoplasms of the thyroidInsoo Suh
Department of Surgery, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0470, USA
Am J Surg 200:41-6. 2010..However, some clinicians measure preoperative Tg as a diagnostic cancer marker despite lack of supporting evidence. We examined whether Tg accurately predicts malignancy in follicular or Hürthle-cell neoplasms... - Diagnostic and prognostic value of cell-cycle regulatory genes in malignant thyroid neoplasmsElectron Kebebew
San Francisco Comprehensive Cancer Center, University of California, San Francisco, CA 94143 1674, USA
World J Surg 30:767-74. 2006..We hypothesized that genes that regulate cell-cycle progression would be differentially expressed in malignant versus benign thyroid nodules and could serve as diagnostic markers and markers of disease aggressiveness... - Multiple genetic alterations in papillary thyroid cancer are associated with younger age at presentationWillieford Moses
Department of Surgery, University of California, San Francisco, California 94143, USA
J Surg Res 160:179-83. 2010..There is a significant gender and age disparity in thyroid cancer incidence and outcome. The molecular basis for these divergent clinical presentations and outcome are essentially unknown... - A phase II trial of rosiglitazone in patients with thyroglobulin-positive and radioiodine-negative differentiated thyroid cancerElectron Kebebew
Department of Surgery, University of California, San Francisco, CA 94143, USA
Surgery 140:960-6; discussion 966-7. 2006..Rosiglitazone is a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist that has been shown to induce differentiation, cell cycle arrest, and apoptosis in a variety of human cancers including thyroid cancer... - Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF(V600E) positive papillary thyroid cancersDaniel T Ruan
Department of Surgery, University of California, San Francisco, San Francisco, Calif, USA
Surgery 144:908-13; discussion 913-4. 2008..The purpose of this study was to determine if Mig-6 expression is associated with EGFR expression or surgical outcomes in PTC... - Identification of biomarkers of adrenocortical carcinoma using genomewide gene expression profilingGustavo G Fernandez-Ranvier
Department of Surgery, J David Gladstone Institutes Genomics Core Laboratory, University of California, San Francisco, CA 94143 1674, USA
Arch Surg 143:841-6; discussion 846. 2008..The gene expression profiles of benign and malignant adrenocortical tumors are different... - Prospective evaluation of the rate and impact of hemolysis on intraoperative parathyroid hormone (IOPTH) assay resultsJacob Moalem
Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
Ann Surg Oncol 17:2963-9. 2010..Retrospective evidence suggested that hemolysis may artificially lower IOPTH results. Falsely decreased IOPTH measurements could result in either failed parathyroidectomy or unnecessary bilateral neck exploration... - Tumor size predicts malignant potential in Hürthle cell neoplasms of the thyroidRebecca S Sippel
Department of Surgery, University of California San Francisco and the UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, CA 94143, USA
World J Surg 32:702-7. 2008..We sought to determine if the primary tumor size correlated with the risk of malignancy in patients with a preoperative FNA diagnosis of a Hürthle cell neoplasm... 
Molecular testing for somatic mutations improves the accuracy of thyroid fine-needle aspiration biopsyWillieford Moses
Department of Surgery, University of California, San Francisco, CA 94143, USA
World J Surg 34:2589-94. 2010..To determine the clinical utility of genetic testing in thyroid FNA biopsy, we conducted a prospective clinical trial...- Clinical and molecular features of papillary thyroid cancer in adolescents and young adultsMenno R Vriens
Department of Surgery, University of California at San Francisco, San Francisco, California, USA
Cancer 117:259-67. 2011..In this study, the authors compared the molecular and clinical features of papillary thyroid cancer (PTC) in AYAs with the same features among patients in other age groups... - Extent of disease at presentation and outcome for adrenocortical carcinoma: have we made progress?Electron Kebebew
Department of Surgery, University of California, San Francisco, Box 1674, San Francisco, CA 94143 1674, USA
World J Surg 30:872-8. 2006..Recent studies suggest that this has led to earlier stage of ACC at diagnosis, more curative operations, and better survival... - Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis?Gustavo G Fernandez-Ranvier
Department of Surgery, University of California at San Francisco, San Francisco, California 94143 1674, USA
Cancer 110:255-64. 2007..Parathyroid carcinoma, atypical parathyroid adenoma, and parathyromatosis can be differentiated relatively easily from typical parathyroid adenomas, but distinguishing them from each other is more difficult... - Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13Gustavo G Fernandez-Ranvier
Department of Surgery, University of California, San Francisco, School of Medicine, UCSF Mt Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94143 1674, USA
World J Surg 32:873-81. 2008..As genes on this chromosome may be important in the pathogenesis of adrenocortical carcinoma, we compared their expression profile between benign and malignant adrenocortical tissue... - Is adrenal venous sampling necessary in all patients with hyperaldosteronism before adrenalectomy?Rasa Zarnegar
Department of Surgery, University of California San Francisco Medical Center, San Francisco, CA, USA
J Vasc Interv Radiol 19:66-71. 2008..To evaluate whether selective rather than universal use of adrenal vein sampling (AVS) may be warranted in patients with hyperaldosteronism to characterize and lateralize disease before adrenalectomy... - Distinct loci on chromosome 1q21 and 6q22 predispose to familial nonmedullary thyroid cancer: a SNP array-based linkage analysis of 38 familiesInsoo Suh
Department of Surgery, University of California, San Francisco, CA, USA
Surgery 146:1073-80. 2009..We aimed to identify loci linked to FNMTC susceptibility using single-nucleotide polymorphism (SNP) array-based linkage analysis in a broad sampling of affected families... - Does the presence of additional thyroid nodules on ultrasound alter the risk of malignancy in patients with a follicular neoplasm of the thyroid?Rebecca S Sippel
Department of Surgery, University of California San Francisco, and the UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, CA 94143 1674, USA
Surgery 142:851-7; discussion 857.e1-2. 2007..We sought to determine whether the presence of additional thyroid nodules on preoperative ultrasound decreased the risk of malignancy in a patient with a follicular neoplasm... - Comparison of clinical characteristics at diagnosis and during follow-up in 118 patients with Hurthle cell or follicular thyroid cancerYevgeniya Kushchayeva
Department of Surgery, University of California San Francisco, UCSF Mt Zion Medical Center, 1600 Divisadero Street C347, San Francisco, CA 94143 1674, USA
Am J Surg 195:457-62. 2008..Hurthle cell cancer (HCC) is considered by some to be a variant of follicular cancer (FC), but many think it is a distinct histologic tumor with a more aggressive behavior... - Predictors of single-gland vs multigland parathyroid disease in primary hyperparathyroidism: a simple and accurate scoring modelElectron Kebebew
Comprehensive Cancer Center and Department of Surgery, University of California, San Francisco, USA
Arch Surg 141:777-82; discussion 782. 2006.... - Metastatic papillary thyroid cancer misdiagnosed as non-small [corrected] cell lung cancerJacob Moalem
Division of Surgical Oncology, Department of Surgery, University of Rochester, Rochester, New York 14642, USA
Thyroid 21:319-23. 2011..As thyroid cancers commonly spread to the lungs, metastatic thyroid cancer should be included in the differential diagnosis of a pulmonary lesion or lesions... - Candidate genes associated with malignant pheochromocytomas by genome-wide expression profilingInsoo Suh
Department of Surgery, University of California, San Francisco, CA 94143 1674, USA
Ann Surg 250:983-90. 2009..To improve our understanding of the molecular mechanisms involved in malignant pheochromocytoma by examining differences in the gene expression profile between benign and malignant tumors... - Diagnostic and extent of disease multigene assay for malignant thyroid neoplasmsElectron Kebebew
Endocrine Surgery and Oncology Program, San Francisco Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143 1674, USA
Cancer 106:2592-7. 2006..The purpose of the current study was to determine the accuracy of novel candidate diagnostic markers to distinguish benign from malignant thyroid neoplasms, and to predict the extent of disease... - Id1 gene expression is up-regulated in hyperplastic and neoplastic thyroid tissue and regulates growth and differentiation in thyroid cancer cellsElectron Kebebew
San Francisco Comprehensive Cancer Center, University of California, San Francisco, California 94143 1674, USA
J Clin Endocrinol Metab 89:6105-11. 2004.... - Should pheochromocytoma size influence surgical approach? A comparison of 90 malignant and 60 benign pheochromocytomasWen T Shen
Department of Surgery, University of California San Francisco, Hellman Building C3 47, 1600 Divisadero Street, San Francisco, CA 94143, USA
Surgery 136:1129-37. 2004..The aim of this study was to determine if pheochromocytoma size should affect the choice of surgical approach... - Risk assessment in 457 adrenal cortical carcinomas: how much does tumor size predict the likelihood of malignancy?Cord Sturgeon
Department of Surgery, University of California, San Francisco, USA
J Am Coll Surg 202:423-30. 2006..The recent NIH consensus conference did not make a definitive recommendation about management of 4- to 6-cm nonfunctioning incidentalomas... - Patterns of antibiotic prophylaxis use for thyroidectomy and parathyroidectomy: results of an international survey of endocrine surgeonsJacob Moalem
Department of Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Am Coll Surg 210:949-56. 2010..Although cervical endocrine operations are classified as clean cases, and prophylactic antibiotics (pABX) are generally not indicated, practice patterns vary... - Defining a molecular phenotype for benign and malignant parathyroid tumorsGustavo G Fernandez-Ranvier
Department of Surgery, University of California at San Francisco, San Francisco, California 94143 1674, USA
Cancer 115:334-44. 2009.... - Does the 3-gene diagnostic assay accurately distinguish benign from malignant thyroid neoplasms?Daniel Shibru
Department of Surgery, University of California at San Francisco, San Francisco, California 94143 1674, USA
Cancer 113:930-5. 2008..The aim of the current study was to determine the diagnostic accuracy of the 3-gene assay in thyroid tissue and in FNA biopsy for distinguishing benign from malignant thyroid neoplasms... - Localization of recurrent thyroid cancer using intraoperative ultrasound-guided dye injectionRebecca S Sippel
Department of Surgery, University of Wisconsin Madison, Madison, WI, USA
World J Surg 33:434-9. 2009..The goal of this study was to evaluate the utility of preincision ultrasound-guided injection of blue dye into the abnormal lymph nodes to facilitate their safe and efficient removal... - Lung transplantation for pulmonary metastases and radiation-induced pulmonary fibrosis after radioactive iodine ablation of extensive lung metastases from papillary thyroid carcinomaJames Lee
Endocrine Surgery Department, University of California, San Francisco, California, USA
Thyroid 17:367-9. 2007 - GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidismElectron Kebebew
Department of Surgery, University of California San Francisco, Box 1674, San Francisco, CA 94143, USA
Surgery 136:1261-6. 2004..The glial cell missing gene, GCMB , encodes a transcription factor, which is a master regulator of parathyroid development. We postulated that the GCMB gene might play a role in parathyroid tumorigenesis in hyperparathyroidism... - Indication and timing of thyroid surgery for patients with hereditary medullary thyroid cancer syndromesJennifer B Ogilvie
Department of Surgery, Endocrine Surgery and Oncology Program, University of California-San Francisco, 1600 Divisadero Street, San Francisco, CA 94143, USA
J Natl Compr Canc Netw 4:139-47. 2006..This review covers the diagnosis, evaluation, timing of surgical management, and optimal follow-up of patients with hereditary medullary thyroid cancer syndromes... - Does routine consultation of thyroid fine-needle aspiration cytology change surgical management?Yah Y Tan
Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 1674, USA
J Am Coll Surg 205:8-12. 2007..We sought to determine the concordance rates between FNA interpretations at referring institutions and our center to determine if they alter surgical management... - The number of needle passes affects the accuracy of parathyroid hormone assay with intraoperative parathyroid aspirationMarlon A Guerrero
Department of Surgery, University of Arizona, Tucson, AZ 85724, USA
Am J Surg 200:701-5; discussion 705-6. 2010..However, the reported aspiration technique varies in the literature. We sought to determine if the number of passes affected the accuracy of PTH analysis... - Central neck lymph node dissection for papillary thyroid cancer: comparison of complication and recurrence rates in 295 initial dissections and reoperationsWen T Shen
Department of Surgery, University of California, San Francisco Mt Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94115, USA
Arch Surg 145:272-5. 2010..Critics of this approach argue that reoperative CLND has higher complication and recurrence rates than initial CLND. We sought to test this argument, using it as our hypothesis... - Prevalence, clinicopathologic features, and somatic genetic mutation profile in familial versus sporadic nonmedullary thyroid cancerWillieford Moses
School of Medicine, University of California, San Francisco, California, USA
Thyroid 21:367-71. 2011..Patients with FNMTC present at a younger age. Somatic mutations and extent of disease are similar in sporadic and FNMTC cases... - Gene-expression profiling of adrenocortical carcinomaInsoo Suh
Department of Surgery, University of California, San Francisco, CA 94143, USA
Expert Rev Mol Diagn 9:343-51. 2009..In this article, we discuss the limitations of the clinical management of ACC, and the gene-expression profile studies that have attempted to address these limitations... - ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsyElectron Kebebew
Endocrine Surgery and Oncology Program, Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
Ann Surg 242:353-61; discussion 361-3. 2005..The objective of this study was to determine whether genes that regulate cellular invasion and metastasis are differentially expressed and could serve as diagnostic markers of malignant thyroid nodules... - The prevalence and prognostic value of BRAF mutation in thyroid cancerElectron Kebebew
Department of Surgery, University of California, San Francisco, San Francisco, California 94143 1674, USA
Ann Surg 246:466-70; discussion 470-1. 2007..To examine the prevalence of BRAF mutation among thyroid cancer histologic subtypes and determine the association of BRAF mutation with indicators of poor prognosis for papillary thyroid cancer and patient outcome... - Extent of disease and practice patterns for medullary thyroid cancerElectron Kebebew
Department of Surgery, University of California, San Francisco, San Francisco, CA 94143-1674, USA
J Am Coll Surg 200:890-6. 2005..A high proportion of patients continue to receive less than optimal initial surgical treatment... - Do patients undergoing parathyroidectomy for primary hyperparathyroidism in San Francisco, CA, and Bursa, Turkey, differ?Turkay Kirdak
Department of Surgery, University of California at San Francisco Mount Zion Medical Center, San Francisco, CA, USA
Am J Surg 198:188-92. 2009.... - Malignant pheochromocytomaRasa Zarnegar
Department of Surgery, University California San Francisco, Comprehensive Cancer Center at Mount Zion, Medical Center, 1600 Divisadero Street, Hellman Building, Room C347, San Francisco, CA 94143 1764, USA
Surg Oncol Clin N Am 15:555-71. 2006.... - The aldosteronoma resolution score: predicting complete resolution of hypertension after adrenalectomy for aldosteronomaRasa Zarnegar
Department of Surgery, Weill Cornell Medical College, New York, NY 10021, USA
Ann Surg 247:511-8. 2008..To develop a prediction model using information readily available, at clinical presentation, which could determine whether patients with aldosterone-producing adenomas would have complete resolution of hypertension after adrenalectomy... - Observation or laparoscopic adrenalectomy for adrenal incidentaloma? A surgical decision analysisLaurent Brunaud
Department of Surgery, University California San Francisco and Mount Zion Medical Center, Mount Zion Medical Center, San Francisco, CA, USA
Med Sci Monit 12:CR355-62. 2006..A decision analysis model was used to identify relevant variables for selecting the optimal management (observation versus adrenalectomy)... - Should total thyroidectomy become the preferred procedure for surgical management of Graves' disease?Geeta Lal
Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Thyroid 15:569-74. 2005..Total or near-total thyroidectomy obviates these disadvantages and can be performed without increased complication rates, thus appearing to be the preferred extent of thyroidectomy for Graves' disease... - Anaplastic thyroid carcinoma. Treatment outcome and prognostic factorsElectron Kebebew
Department of Surgery, University of California San Francisco, San Francisco, CA 94143 1674, USA
Cancer 103:1330-5. 2005..The authors analyzed prognostic factors and treatment outcomes in patients with ATC reported in the National Cancer Institute's Surveillance, Epidemiology, and End Results data base... - Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cellsWen T Shen
Department of Surgery, Endocrine Surgery Laboratory, UCSF/Mt. Zion Medical Center, San Francisco, CA 94143-1674, USA
Surgery 138:979-84; discussion 984-5. 2005..These findings suggest that VA may be useful clinically for patients with thyroid cancers of follicular cell origin... - Hemolysis falsely decreases intraoperative parathyroid hormone levelsJacob Moalem
University of California, San Francisco, CA, USA
Am J Surg 197:222-6. 2009..Falsely decreased IOPTH measurements could result in false-negative or false-positive results and lead to failed parathyroidectomy or unnecessary additional exploration... - Prognostic indications for Hürthle cell cancerYevgeniya Kushchayeva
Endocrine Surgical Oncology, Department of Surgery, University of California-San Francisco/Mount Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94143-1674, USA
World J Surg 28:1266-70. 2004..Disease-free survivals were 65.0% and 40.5% at 5 and 10 years, respectively. Our findings show that gender and stage of disease influence the prognosis of patients with HCC... - Adrenocortical carcinoma in the United States: treatment utilization and prognostic factorsKarl Y Bilimoria
Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Cancer 113:3130-6. 2008..The authors' objectives were to examine treatment utilization and factors associated with long-term survival after resection of ACC in a large, national, patient population... - The helix-loop-helix protein, Id-1, is overexpressed and regulates growth in papillary thyroid cancerElectron Kebebew
Department of Surgery Department of Pathology, University of California, San Francisco, CA 94143, USA
Surgery 134:235-41. 2003..Furthermore, deregulated expression of Id proteins has been observed in some human malignancies. Therefore we hypothesized that the Id-1 gene may play a role in papillary thyroid carcinogenesis... - Tertiary hyperparathyroidism: histologic patterns of disease and results of parathyroidectomyElectron Kebebew
Department of Surgery, University of California, San Francisco 94143 1674, USA
Arch Surg 139:974-7. 2004..Patients with tertiary hyperparathyroidism (THPT) commonly have parathyroid hyperplasia and should have a bilateral neck exploration with subtotal or total parathyroidectomy with autotransplantation to obtain long-term cure... - Reasons for conversion from laparoscopic to open or hand-assisted adrenalectomy: review of 261 laparoscopic adrenalectomies from 1993 to 2003Wen T Shen
Department of Surgery, University of California, San Francisco/Mt Zion Medical Center, San Francisco, California 94143-1674, USA
World J Surg 28:1176-9. 2004..All eight of the tumors removed were at least 5 cm in size (range 5-16 cm). The mean length of hospitalization was 4.4 days (range 3-8 days)... - Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitorsElliot J Mitmaker
Department of Surgery, University of California, San Francisco, CA, USA
Surgery 149:504-11. 2011.... - Less-than-subtotal parathyroidectomy increases the risk of persistent/recurrent hyperparathyroidism after parathyroidectomy in tertiary hyperparathyroidism after renal transplantationFrederic Triponez
Division of Endocrine Surgical Oncology, University of California at San Francisco, San Francisco, CA, USA
Surgery 140:990-7; discussion 997-9. 2006..The optimal surgical approach for tertiary hyperparathyroidism (HPT) after kidney transplantation is unknown. Existing studies are limited by small sample size, lack of adjustment for kidney function, and no long-term follow-up... - Id1 gene expression and regulation in human thyroid tissueElectron Kebebew
University of California, San Francisco, Department of Surgery and UCSF Comprehensive Cancer Center, San Francisco, California 94143, USA
Thyroid 15:522-30. 2005.... - Two hundred and two consecutive operations for secondary hyperparathyroidism: has medical management changed the profiles of patients requiring parathyroidectomy?Wen T Shen
Department of Surgery, University of California, San Francisco, CA 94115, USA
Surgery 146:296-9. 2009..Because of improvements in the medical management of end-stage renal disease, some surgeons perceive that they now perform fewer operations for secondary hyperparathyroidism, and that current patients have more advanced disease... - Waiting for change: symptom resolution after adrenalectomy for Cushing's syndromeRebecca S Sippel
Section of Endocrine Surgery, Department of Surgery, University of Wisconsin Madison, Madison, Wis, USA
Surgery 144:1054-60; discussion 1060-1. 2008..The debilitating symptoms and physical changes from Cushing's syndrome may resolve after treatment, but the time course to resolution is not well established... - Clinical features and genetic predisposition to hereditary nonmedullary thyroid cancerMenno R Vriens
Department of Surgery, University of California, San Francisco, California, USA
Thyroid 19:1343-9. 2009..The goal of this article was to review our current knowledge on the hereditary nonmedullary thyroid cancer... - Calciphylaxis: rare but fatalAmarjit Dosanjh
Department of Surgery, University of California-San Francisco, Mount Zion Medical Center, San Francisco, CA, USA
Curr Surg 62:455-8. 2005