HAIG KAZAZIAN

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc L1 retrotransposon-mediated stable gene silencing
    Nuo Yang
    Department of Genetics, University of Pennsylvania Philadelphia, PA 19104, USA
    Nucleic Acids Res 33:e57. 2005
  2. pmc Many LINE1 elements contribute to the transcriptome of human somatic cells
    Sanjida H Rangwala
    Department of Genetics, University of Pennsylvania School of Medicine, Hamilton Walk, Philadelphia, Pennsylvania 19104, USA
    Genome Biol 10:R100. 2009
  3. pmc Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle
    Randy J Chandler
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Med Genet 8:64. 2007
  4. ncbi request reprint Mobile elements: drivers of genome evolution
    Haig H Kazazian
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 303:1626-32. 2004
  5. ncbi request reprint The impact of L1 retrotransposons on the human genome
    H H Kazazian
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia 19104, USA
    Nat Genet 19:19-24. 1998
  6. ncbi request reprint LINE drive. retrotransposition and genome instability
    Haig H Kazazian
    Department of Genetics, School of Medicine, 475 Clinical Research Building, 415 Curie Boulevard, University of Pennsylvania, Philadelphia 19105, USA
    Cell 110:277-80. 2002
  7. ncbi request reprint Genetics. L1 retrotransposons shape the mammalian genome
    H H Kazazian
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 289:1152-3. 2000
  8. ncbi request reprint Mobile elements and disease
    H H Kazazian
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Genet Dev 8:343-50. 1998
  9. ncbi request reprint Long-term efficacy of adeno-associated virus serotypes 8 and 9 in hemophilia a dogs and mice
    Rita Sarkar
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104 6145, USA
    Hum Gene Ther 17:427-39. 2006
  10. pmc More active human L1 retrotransposons produce longer insertions
    Alexander H Farley
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Nucleic Acids Res 32:502-10. 2004

Research Grants

  1. MEDICAL GENETICS RESEARCH TRAINING GRANT
    HAIG KAZAZIAN; Fiscal Year: 2007
  2. Human variation in retrotransposon activity
    HAIG KAZAZIAN; Fiscal Year: 2006
  3. FASEB Conference: Mamalian Mobile Elements
    HAIG KAZAZIAN; Fiscal Year: 2005
  4. Preclinical gene correction of hemophilia A
    HAIG KAZAZIAN; Fiscal Year: 2009
  5. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2005
  6. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2004
  7. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2003
  8. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2002
  9. Preclinical gene correction of hemophilia A
    Haig H Kazazian; Fiscal Year: 2010
  10. MEDICAL GENETICS RESEARCH TRAINING GRANT
    HAIG KAZAZIAN; Fiscal Year: 2007

Collaborators

Detail Information

Publications43

  1. pmc L1 retrotransposon-mediated stable gene silencing
    Nuo Yang
    Department of Genetics, University of Pennsylvania Philadelphia, PA 19104, USA
    Nucleic Acids Res 33:e57. 2005
    ..Our system provides a novel strategy for stable gene silencing that is easy and efficient, and it may have potential applications for ex vivo and in vivo molecular therapy...
  2. pmc Many LINE1 elements contribute to the transcriptome of human somatic cells
    Sanjida H Rangwala
    Department of Genetics, University of Pennsylvania School of Medicine, Hamilton Walk, Philadelphia, Pennsylvania 19104, USA
    Genome Biol 10:R100. 2009
    ..We also examined expression of a select number of elements in different individuals...
  3. pmc Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle
    Randy J Chandler
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Med Genet 8:64. 2007
    ..Current treatment regimens rely on dietary management and, in severely affected patients, liver or combined liver-kidney transplantation. For undetermined reasons, transplantation does not correct the biochemical phenotype...
  4. ncbi request reprint Mobile elements: drivers of genome evolution
    Haig H Kazazian
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 303:1626-32. 2004
    ..Although the host can often control their numbers, massive expansions of retrotransposons have been tolerated during evolution. Now mobile elements are becoming useful tools for learning more about genome evolution and gene function...
  5. ncbi request reprint The impact of L1 retrotransposons on the human genome
    H H Kazazian
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia 19104, USA
    Nat Genet 19:19-24. 1998
    ..We review the impact of retrotransposons and how new insight is likely to lead to important practical applications for these intriguing mobile elements...
  6. ncbi request reprint LINE drive. retrotransposition and genome instability
    Haig H Kazazian
    Department of Genetics, School of Medicine, 475 Clinical Research Building, 415 Curie Boulevard, University of Pennsylvania, Philadelphia 19105, USA
    Cell 110:277-80. 2002
    ..If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution...
  7. ncbi request reprint Genetics. L1 retrotransposons shape the mammalian genome
    H H Kazazian
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 289:1152-3. 2000
    ..And just how do they do this?...zip to page 1152 to find out...
  8. ncbi request reprint Mobile elements and disease
    H H Kazazian
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Genet Dev 8:343-50. 1998
    ..The mechanism by which they retrotranspose and in turn aide the retrotransposition of non-autonomous elements is being elucidated...
  9. ncbi request reprint Long-term efficacy of adeno-associated virus serotypes 8 and 9 in hemophilia a dogs and mice
    Rita Sarkar
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104 6145, USA
    Hum Gene Ther 17:427-39. 2006
    ..Even so, translation of these robust vectors either in appropriate large animals or human beings remains challenging...
  10. pmc More active human L1 retrotransposons produce longer insertions
    Alexander H Farley
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Nucleic Acids Res 32:502-10. 2004
    ..We suggest that the region containing residues 1220 and 1259 may be important in the binding of ORF2p to L1 RNA to facilitate reverse transcription...
  11. pmc Exon-trapping mediated by the human retrotransposon SVA
    Dustin C Hancks
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genome Res 19:1983-91. 2009
    ....
  12. ncbi request reprint A mouse model of human L1 retrotransposition
    Eric M Ostertag
    Department of Genetics and University of Pennsylvania School of Medicine, 475 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 32:655-60. 2002
    ..In addition to providing a valuable in vivo model of retrotransposition in mammals, these mice are an important step in the development of a new random mutagenesis system...
  13. pmc An important role for RUNX3 in human L1 transcription and retrotransposition
    Nuo Yang
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Nucleic Acids Res 31:4929-40. 2003
    ....
  14. pmc LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex
    John L Goodier
    Dept of Genetics, University of Pennsylvania School of Medicine, Rm 515 CRB, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 27:6469-83. 2007
    ..We suggest that targeting ORF1p, and possibly the L1 RNP, to stress granules is a mechanism for controlling retrotransposition and its associated genetic and cellular damage...
  15. ncbi request reprint A potential role for the nucleolus in L1 retrotransposition
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Hum Mol Genet 13:1041-8. 2004
    ..These findings help explain the presence of chimeras between L1s and small RNA gene sequences recently discovered in the human genome...
  16. pmc Tracking an embryonic L1 retrotransposition event
    Eline T Luning Prak
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 405B Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 100:1832-7. 2003
    ..The retrotransposition event characterized here has occurred at a very early stage in the development of an L1-EGFP transgenic founder mouse...
  17. doi request reprint Retrotransposons revisited: the restraint and rehabilitation of parasites
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Cell 135:23-35. 2008
    ..Recent insights and new technologies promise answers to fundamental questions about the biology of transposable elements...
  18. pmc Discrete subcellular partitioning of human retrotransposon RNAs despite a common mechanism of genome insertion
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:1712-25. 2010
    ..Such variability predicts significant differences in the life cycles of these elements...
  19. ncbi request reprint Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype
    Rita Sarkar
    Department of Genetics, University of Pennsylvania 415 Curie Blvd, CRB Rm 475, Philadelphia, PA 19104, USA
    Blood 103:1253-60. 2004
    ..We also evaluated AAV8 against AAV2 in intraportal and tail vein injections. AAV8 gave 100% correction of plasma FVIII activity irrespective of the vector type or route of administration...
  20. pmc L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism
    Hiroki Kano
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 23:1303-12. 2009
    ..Thus, L1 creates somatic mosaicism during mammalian development, suggesting a role for L1 in carcinogenesis and other disease...
  21. pmc A novel testis ubiquitin-binding protein gene arose by exon shuffling in hominoids
    Daria V Babushok
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genome Res 17:1129-38. 2007
    ..PIPSL is a tightly regulated, testis-specific novel ubiquitin-binding protein formed by an unusual exon-shuffling mechanism in hominoid primates and represents a key example of rapid evolution of a testis-specific gene...
  22. pmc High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes
    Adam D Ewing
    University of Pennsylvania Department of Genetics, Philadelphia, Pennsylvania 19104, USA
    Genome Res 20:1262-70. 2010
    ..05 is between 3000 and 10,000...
  23. pmc SVA elements are nonautonomous retrotransposons that cause disease in humans
    Eric M Ostertag
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, USA
    Am J Hum Genet 73:1444-51. 2003
    ..SVA elements, like Alus and L1s, occasionally insert into genes and cause disease. Furthermore, SVA elements are probably mobilized in trans by active L1 elements...
  24. pmc Recombinant canine B-domain-deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model
    Denise E Sabatino
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 114:4562-5. 2009
    ..These data establish the framework to quantitatively investigate the efficacy and safety in preclinical studies of novel therapies for hemophilia A...
  25. pmc Evidence consistent with human L1 retrotransposition in maternal meiosis I
    Brook Brouha
    Department of Genetics, University of Pennsylvania School of Medicine, 475 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Am J Hum Genet 71:327-36. 2002
    ..Since the mother carries a potential precursor allele and the insertion was on the patient's maternal X chromosome, it is highly likely that the insertion originated during maternal meiosis I...
  26. ncbi request reprint Progress in understanding the biology of the human mutagen LINE-1
    Daria V Babushok
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6145, USA
    Hum Mutat 28:527-39. 2007
    ..Finally, we discuss the role of L1 as a mutagen, using the latest findings in L1 biology to illuminate molecular mechanisms of L1-mediated gene disruption...
  27. ncbi request reprint L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells
    Nuo Yang
    Department of Genetics, University of Pennsylvania School of Medicine, Rm 475 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Struct Mol Biol 13:763-71. 2006
    ..L1-specific siRNAs are among the first natural siRNAs reported in mammalian systems. This work may contribute to understanding the regulatory role of abundant antisense transcripts in eukaryotic genomes...
  28. pmc Hot L1s account for the bulk of retrotransposition in the human population
    Brook Brouha
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 100:5280-5. 2003
    ..Thus, our data indicate that most L1 retrotransposition in the human population stems from hot L1s, with the remaining elements playing a lesser role in genome plasticity...
  29. doi request reprint SnapShot: Vertebrate transposons
    Prabhat K Mandal
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 135:192-192.e1. 2008
  30. pmc Extensive individual variation in L1 retrotransposition capability contributes to human genetic diversity
    Maria del Carmen Seleme
    Department of Genetics, Division of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:6611-6. 2006
    ..These data suggest that individual variation in retrotransposition potential makes an important contribution to human genetic diversity...
  31. pmc L1 integration in a transgenic mouse model
    Daria V Babushok
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genome Res 16:240-50. 2006
    ..We propose a unified model of L1 integration that explains all of the characteristic features of L1 retrotransposition, such as 5' truncations, inversions, extra nucleotide additions, and 5' boundary and inversion point microhomologies...
  32. pmc The L1 retrotransposition assay: a retrospective and toolkit
    Sanjida H Rangwala
    Department of Genetics, University of Pennsylvania School of Medicine, 564 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Methods 49:219-26. 2009
    ..Finally, we provide detailed protocols on the application of the retrotransposition assay, including lists of constructs available in the L1 research community and cell lines in which this assay has been applied...
  33. ncbi request reprint Phenotypic correction of a mouse model of hemophilia A using AAV2 vectors encoding the heavy and light chains of FVIII
    Ciaran D Scallan
    Avigen, Inc, 1201 Harbor Bay Parkway, Alameda, CA 94502, USA
    Blood 102:3919-26. 2003
    ..This strategy may potentially be useful for other large therapeutic proteins that contain functionally distinct domains...
  34. ncbi request reprint Genetics: LINEs in mind
    Eric M Ostertag
    Nature 435:890-1. 2005
  35. ncbi request reprint Mobile elements and mammalian genome evolution
    Prescott L Deininger
    Department of Environmental Health Sciences, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Curr Opin Genet Dev 13:651-8. 2003
    ....
  36. pmc L1 retrotransposition in nondividing and primary human somatic cells
    Shuji Kubo
    Department of Medicine, UCLA School of Medicine, 675 Charles E Young Drive South, MRL 1551, Los Angeles, CA 90095 7019, USA
    Proc Natl Acad Sci U S A 103:8036-41. 2006
    ..Thus, these data indicate that L1 retrotransposition can occur in nondividing somatic cells...
  37. ncbi request reprint Dual vectors expressing murine factor VIII result in sustained correction of hemophilia A mice
    Cathryn Mah
    Department of Pediatrics, Department of Molecular Genetics and Microbiology, and Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610 0266, USA
    Hum Gene Ther 14:143-52. 2003
    ..Because the murine form of the gene was used in the mouse model, less than 1 Bethesda unit of inhibitors was noted. This work demonstrates the feasibility of using rAAV vectors for the long-term treatment of hemophilia A...
  38. pmc Allelic heterogeneity in LINE-1 retrotransposition activity
    Sheila M Lutz
    Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0618, USA
    Am J Hum Genet 73:1431-7. 2003
    ..2A retrotransposition efficiency. Thus, common L1 alleles can vary widely in their retrotransposition potential. We propose that such allelic heterogeneity can influence the potential L1 mutational load present in an individual genome...
  39. ncbi request reprint Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A
    Ingrid Hrachovinova
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 USA
    Nat Med 9:1020-5. 2003
    ..This significantly improved the kinetics of fibrin formation in the hemophilia A mice and normalized their tail-bleeding time. P-sel-Ig treatment could become a new approach to sustained control of bleeding in hemophilia...
  40. ncbi request reprint Two independent retrotransposon insertions at the same site within the coding region of BTK
    Mary Ellen Conley
    Department of Pediatrics, University of Tennessee College of Medicine, Memphis, Tennessee 38105, USA
    Hum Mutat 25:324-5. 2005
    ..A better understanding of the factors that make this site vulnerable will shed light on the mechanisms of LINE-1 mediated insertional mutagenesis...
  41. pmc Lower inhibitor development in hemophilia A mice following administration of recombinant factor VIII-O-phospho-L-serine complex
    Vivek S Purohit
    Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Amherst, New York 14260 1200, USA
    J Biol Chem 280:17593-600. 2005
    ..Our results suggest that factor VIII-O-phospho-l-serine complex may be beneficial to increase the physical stability and reduce immunogenicity of recombinant factor VIII preparations...
  42. ncbi request reprint L1 retrotransposition can occur early in human embryonic development
    José A J M van den Hurk
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Hum Mol Genet 16:1587-92. 2007
    ..These findings provide evidence that L1 retrotransposition can occur very early in human embryonic development...
  43. pmc Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism
    Randy J Chandler
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Genet Metab 89:64-73. 2006
    ..elegans RNAi and deletion mutants...

Research Grants31

  1. MEDICAL GENETICS RESEARCH TRAINING GRANT
    HAIG KAZAZIAN; Fiscal Year: 2007
    ..This grant will fund up to three research years of the M.D. investigator in medical Genetics, and two years for M.D.-Ph.D. Fellows. ..
  2. Human variation in retrotransposon activity
    HAIG KAZAZIAN; Fiscal Year: 2006
    ..Using this data, we will determine the extent of variation in L1 retrotransposition capability that exists among different individuals and geographic groups. ..
  3. FASEB Conference: Mamalian Mobile Elements
    HAIG KAZAZIAN; Fiscal Year: 2005
    ..Thus, this conference will allow investigators in these interrelated fields to share information about exciting new findings, experimental challenges, and outstanding questions in the area of mammalian mobile elements. ..
  4. Preclinical gene correction of hemophilia A
    HAIG KAZAZIAN; Fiscal Year: 2009
    ..These results should make clinical trials with AAV vectors an appropriate next step. ..
  5. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2005
    ..Thus, this focused proposal will provide answers to key questions of L1 biology and likely lead to a useful mutagenesis system for determination of gene function. ..
  6. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2004
    ..Thus, this focused proposal will provide answers to key questions of L1 biology and likely lead to a useful mutagenesis system for determination of gene function. ..
  7. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2003
    ..Thus, this focused proposal will provide answers to key questions of L1 biology and likely lead to a useful mutagenesis system for determination of gene function. ..
  8. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2002
    ..Thus, this focused proposal will provide answers to key questions of L1 biology and likely lead to a useful mutagenesis system for determination of gene function. ..
  9. Preclinical gene correction of hemophilia A
    Haig H Kazazian; Fiscal Year: 2010
    ..These results should make clinical trials with AAV vectors an appropriate next step. ..
  10. MEDICAL GENETICS RESEARCH TRAINING GRANT
    HAIG KAZAZIAN; Fiscal Year: 2007
    ..This grant will fund up to three research years of the M.D. investigator in medical genetics, and two years for M.D./Ph.D. fellows. ..
  11. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 1999
    ..Lastly, they plan to initiate development of L1 elements into practical mutagenesis agents in mice. ..
  12. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2000
    ..Lastly, they plan to initiate development of L1 elements into practical mutagenesis agents in mice. ..
  13. Preclinical gene correction of hemophilia A
    Haig H Kazazian; Fiscal Year: 2010
    ..These results should make clinical trials with AAV vectors an appropriate next step. ..
  14. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2009
    ..These studies will increase greatly our knowledge of the biology of L1 retrotransposition. In addition, they will provide important new information towards the effort to use L1 as a random insertional mutagen in mammals. ..
  15. HUMAN TRANSPOSABLE ELEMENT
    Haig H Kazazian; Fiscal Year: 2009
    ..These studies will increase greatly our knowledge of the biology of L1 retrotransposition. In addition, they will provide important new information towards the effort to use L1 as a random insertional mutagen in mammals. ..
  16. HUMAN TRANSPOSABLE ELEMENT
    Haig H Kazazian; Fiscal Year: 2010
    ..These studies will increase greatly our knowledge of the biology of L1 retrotransposition. In addition, they will provide important new information towards the effort to use L1 as a random insertional mutagen in mammals. ..
  17. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2006
    ..These studies will increase greatly our knowledge of the biology of L1 retrotransposition. In addition, they will provide important new information towards the effort to use L1 as a random insertional mutagen in mammals. ..
  18. Preclinical gene correction of hemophilia A
    HAIG KAZAZIAN; Fiscal Year: 2007
    ..These results should make clinical trials with AAV vectors an appropriate next step. ..
  19. Human variation in retrotransposon activity
    HAIG KAZAZIAN; Fiscal Year: 2007
    ..Using this data, we will determine the extent of variation in L1 retrotransposition capability that exists among different individuals and geographic groups. ..
  20. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2001
    ..Lastly, they plan to initiate development of L1 elements into practical mutagenesis agents in mice. ..
  21. HUMAN TRANSPOSABLE ELEMENT
    HAIG KAZAZIAN; Fiscal Year: 2007
    ..These studies will increase greatly our knowledge of the biology of L1 retrotransposition. In addition, they will provide important new information towards the effort to use L1 as a random insertional mutagen in mammals. ..