Rakez Kayed

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. doi request reprint Prefilament tau species as potential targets for immunotherapy for Alzheimer disease and related disorders
    Rakez Kayed
    George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX 77555 0857, USA
    Curr Opin Immunol 21:359-63. 2009
  2. ncbi request reprint Characterization of tau oligomeric seeds in progressive supranuclear palsy
    Julia E Gerson
    Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston TX 77555, USA
    Acta Neuropathol Commun 2:73. 2014
  3. pmc Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
    Cristian A Lasagna-Reeves
    George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX 77555 1045, USA
    Sci Rep 2:700. 2012
  4. ncbi request reprint The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes
    Cristian A Lasagna-Reeves
    Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX, USA
    Acta Neuropathol Commun 2:56. 2014
  5. pmc Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
    SUHAIL RASOOL
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Mol Neurodegener 7:37. 2012
  6. doi request reprint Molecular mechanisms of amyloid oligomers toxicity
    Rakez Kayed
    The George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Alzheimers Dis 33:S67-78. 2013
  7. pmc Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Mol Neurodegener 5:57. 2010
  8. pmc Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin
    Thuzar M Shin
    Zilhka Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA
    Mol Neurodegener 3:16. 2008
  9. pmc Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Mol Neurodegener 2:18. 2007
  10. ncbi request reprint Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease
    Rakez Kayed
    Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    Hum Vaccin 6:931-5. 2010

Collaborators

Detail Information

Publications35

  1. doi request reprint Prefilament tau species as potential targets for immunotherapy for Alzheimer disease and related disorders
    Rakez Kayed
    George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX 77555 0857, USA
    Curr Opin Immunol 21:359-63. 2009
    ..More recently, alternative approaches have begun to target the microtubule binding protein tau, a component of neurofibrillary tangles. Immunotherapies based upon oligomeric species of tau represent a promising new approach for AD...
  2. ncbi request reprint Characterization of tau oligomeric seeds in progressive supranuclear palsy
    Julia E Gerson
    Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston TX 77555, USA
    Acta Neuropathol Commun 2:73. 2014
    ..Recent studies from our laboratory and others have provided evidence that tau oligomers, not NFTs, are the most toxic species in neurodegenerative tauopathies and seed the pathological spread of tau...
  3. pmc Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
    Cristian A Lasagna-Reeves
    George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX 77555 1045, USA
    Sci Rep 2:700. 2012
    ..The conformation and hydrophobicity of tau oligomers play a critical role in the initiation and spread of tau pathology in the naïve host in a manner reminiscent of sporadic AD...
  4. ncbi request reprint The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes
    Cristian A Lasagna-Reeves
    Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX, USA
    Acta Neuropathol Commun 2:56. 2014
    ..These findings establish the pathological significance of tau APFs in vivo and highlight their suitability as therapeutic targets for several neurodegenerative tauopathies. ..
  5. pmc Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
    SUHAIL RASOOL
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Mol Neurodegener 7:37. 2012
    ..However, autoimmune side effects have halted the development of vaccines based on full length human Aβ. Further development of an effective vaccine depends on overcoming these side effects while maintaining an effective immune response...
  6. doi request reprint Molecular mechanisms of amyloid oligomers toxicity
    Rakez Kayed
    The George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Alzheimers Dis 33:S67-78. 2013
    ....
  7. pmc Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Mol Neurodegener 5:57. 2010
    ..Recent evidence suggests that soluble amyloid oligomers and not the insoluble amyloid fibrils may represent the primary pathological species of protein aggregates...
  8. pmc Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin
    Thuzar M Shin
    Zilhka Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA
    Mol Neurodegener 3:16. 2008
    ..The investigation of vitronectin aggregation is significant since the formation of oligomeric and fibrillar structures are common features of amyloid proteins...
  9. pmc Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Mol Neurodegener 2:18. 2007
    ..Conformation dependent antibodies have been reported that specifically recognize distinct assembly states of amyloids, including prefibrillar oligomers and fibrils...
  10. ncbi request reprint Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease
    Rakez Kayed
    Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    Hum Vaccin 6:931-5. 2010
    ..Herein, I discuss the evidence supporting the critical role of tau oligomers in AD, the potential and challenges for targeting them by immunotherapy as a novel approach for AD treatment...
  11. ncbi request reprint Tau oligomers as potential targets for immunotherapy for Alzheimer's disease and tauopathies
    C A Lasagna-Reeves
    George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555 0857, USA
    Curr Alzheimer Res 8:659-65. 2011
    ..Herein, we discuss the evidence supporting the critical role of tau oligomers in AD, the potential and challenges for targeting them by immunotherapy as a novel approach for AD treatment...
  12. pmc Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
    Cristian A Lasagna-Reeves
    George P, and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, Departments of Neurology, and Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555 1045, USA
    Mol Neurodegener 6:39. 2011
    ..abstract:..
  13. pmc α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases
    Zane S Martin
    Departments of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA
    J Neurochem 120:440-52. 2012
    ..These results indicate that exogenously applied αSyn oligomers impact neuronal function and produce memory deficits through mechanisms that involve CaN activation...
  14. ncbi request reprint Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles
    Diana L Castillo-Carranza
    Mitchell Center for Neurodegenerative Diseases, Departments of Neurology, Neuroscience, and Cell Biology, Sealy Center for Vaccine Development, University of Texas Medical Branch, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555
    J Neurosci 34:4260-72. 2014
    ..These findings provide the first direct evidence in support of a critical role for tau oligomers in disease progression and validate tau oligomers as a target for the treatment of AD and other neurodegenerative tauopathies. ..
  15. doi request reprint Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity
    Cristian A Lasagna-Reeves
    George and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1045, USA
    Biochem Biophys Res Commun 430:963-8. 2013
    ..Our results suggest that under certain circumstances, cancer could be considered a protein-conformation disease...
  16. ncbi request reprint Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
    Cristian A Lasagna-Reeves
    University of Texas Medical Branch, 301 University Blvd, Medical Research Building, Room 10 138C, Galveston, TX, USA
    FASEB J 26:1946-59. 2012
    ..These data are the first to characterize the role of tau oligomers in the natural history of NFTs, and they highlight the suitability of tau oligomers as therapeutic targets in AD and related tauopathies...
  17. doi request reprint Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis
    Audra L Clos
    George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Am Acad Dermatol 65:1023-31. 2011
    ..To date, relatively little is known about the process of amyloidogenesis in the skin; however, investigators recently have identified small amyloid species, known as oligomers, which give rise to large amyloid fibrillar aggregates...
  18. doi request reprint Inhaled insulin forms toxic pulmonary amyloid aggregates
    Cristian A Lasagna-Reeves
    George and Cynthia Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, 301 University Boulevard, Medical Research Building, Room 10 138C, Galveston, Texas 77555 1045, USA
    Endocrinology 151:4717-24. 2010
    ..These insulin deposits resemble the amyloid structures implicated in protein misfolding disorders, such as Alzheimer's and Parkinson's diseases, and could as well be deleterious in nature...
  19. pmc Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice
    Kelly T Dineley
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 1043, USA
    J Neurosci Res 88:2923-32. 2010
    ..Collectively, these results indicate that CaN activation may play a central role in mediating synaptic and memory disruption induced by acute oligomeric A beta treatment in mice...
  20. pmc Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease
    Caterina M Hernandez
    Department of Neurology, Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Neurosci 30:2442-53. 2010
    ....
  21. ncbi request reprint Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds
    Diana L Castillo-Carranza
    Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX, USA Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA
    J Alzheimers Dis 40:S97-S111. 2014
    ..These results support the critical role of oligomeric tau in disease progression and validate tau oligomers as a potential drug target. ..
  22. pmc Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies
    Bridget E Hawkins
    Sealy Center for Vaccine Development University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 288:17042-50. 2013
    ..These findings suggest that diagnostic tools and therapeutics that target only toxic forms of Tau may provide earlier detection and safe, more effective treatments for tauopathies associated with repetitive neurotrauma...
  23. ncbi request reprint Tau aggregates as immunotherapeutic targets
    Diana L Castillo-Carranza
    George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 1045, USA
    Front Biosci (Schol Ed) 5:426-38. 2013
    ....
  24. doi request reprint Therapeutic removal of amyloid deposits in cutaneous amyloidosis by localised intra-lesional injections of anti-amyloid antibodies
    Audra L Clos
    Department of Neurology, University of Texas Medical Branch, George and Cynthia Mitchell Center for Neurodegenerative Diseases, Galveston, TX 77555, USA
    Exp Dermatol 19:904-11. 2010
    ..Given the accessibility and amyloid localization in this disease, direct i.d. injections of conformational antibodies could be a convenient and direct method for treatment...
  25. doi request reprint Preparation and characterization of neurotoxic tau oligomers
    Cristian A Lasagna-Reeves
    The George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 1045, United States
    Biochemistry 49:10039-41. 2010
    ..We show that both Aβ and α-synuclein oligomers induce tau aggregation and the formation of β-sheet-rich neurotoxic tau oligomers...
  26. ncbi request reprint Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins
    Marcos J Guerrero-Muñoz
    Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX, USA Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA
    Biochem Pharmacol 88:468-78. 2014
    ..In this review, we focus on therapeutic approaches against shared features of toxic oligomeric structures and future directions. ..
  27. doi request reprint Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains
    Cristian A Lasagna-Reeves
    George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX 77555 1045, USA
    FEBS Lett 585:3052-7. 2011
    ....
  28. pmc Differential activation of the ER stress factor XBP1 by oligomeric assemblies
    Diana L Castillo-Carranza
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Neurochem Res 37:1707-17. 2012
    ..These results illustrate the biological complexity of these structurally related assemblies and argue that oligomer toxicity depends on the activation of amyloid-specific cellular responses...
  29. ncbi request reprint A specific amyloid-beta protein assembly in the brain impairs memory
    Sylvain Lesne
    Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 440:352-7. 2006
    ..We propose that Abeta*56 impairs memory independently of plaques or neuronal loss, and may contribute to cognitive deficits associated with Alzheimer's disease...
  30. ncbi request reprint Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta
    Elizabeth Head
    Institute for Brain Aging and Dementia, Department of Neurology, University of California, 1259 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4540, USA
    Vaccine 24:2824-34. 2006
    ..A nonsignificant increase in CSF Abeta(1-40) and decrease in Abeta(1-40/1-42) in cortex was detected. Canines may be a useful system for testing an Abeta vaccine...
  31. pmc Design of metastable β-sheet oligomers from natively unstructured peptide
    Marcos J Guerrero-Muñoz
    Department of Neurology, The George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, Departments of Biochemistry and Molecular Biology, The Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, United States
    ACS Chem Neurosci 4:1520-3. 2013
    ..These structures were characterized by multiple biophysical and biochemical techniques that show characteristic features of oligomers. Finally, this preparation was not detected by three different sequence dependent prion antibodies. ..
  32. pmc Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain
    Cristian A Lasagna-Reeves
    Department of Neurology, George P and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas 77555 1045, USA
    J Biol Chem 286:22122-30. 2011
    ..Our results together with previous studies suggest that the prevention of amyloid-β annular protofibril formation could be a relevant target for the prevention of amyloid-β toxicity in Alzheimer disease...
  33. pmc Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis
    Audra L Clos
    Department of Dermatology, MD Anderson Cancer Center, University of Texas Houston, TX, USA
    Front Neurol 3:5. 2012
    ..In the present review, we discuss the relevance of the "brain-skin connection" in different neurodegenerative amyloidosis, not only at the pathological level, but also as a strategy for the treatment of these diseases...