Research Topics
| Walter KayeSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Neurobiology of anorexia and bulimia nervosaWalter Kaye
University of California, San Diego, 8950 Villa La Jolla Drive, Suite C207, La Jolla, CA 92037, United States
Physiol Behav 94:121-35. 2008..In summary, this article reviews findings in brain chemistry and neuroimaging that shed new light on understanding the psychopathology of these difficult and frustrating disorders...
Eating disorder symptomatology among ballet dancersRebecca Ringham
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Int J Eat Disord 39:503-8. 2006..The current study sought to compare eating disorder symptomatology among ballet dancers and individuals with restricting anorexia nervosa (RAN), bulimia nervosa (BN), and no eating pathology...- Linkage analysis of anorexia nervosa incorporating behavioral covariatesBernie Devlin
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
Hum Mol Genet 11:689-96. 2002..50, P = 0.00035). By comparing our results to those implemented using more standard linkage methods, we find the covariates convey substantial information for the linkage analysis... - Genetic analysis of bulimia nervosa: methods and sample descriptionWalter H Kaye
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Int J Eat Disord 35:556-70. 2004..The current study presents the clinical characteristics of this sample as well as a description of the study methodology... - Neuroimaging studies in eating disordersGuido K Frank
Department of Eating Disorders Research, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
CNS Spectr 9:539-48. 2004..Taken together, these findings give promise for future investigations with the hope of delineating brain pathways that contribute to the etiology of EDs.. - 5HT2A receptor binding is increased in borderline personality disorderPaul H Soloff
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Biol Psychiatry 62:580-7. 2007..We examined 5HT(2A) receptor binding potential (BP) in impulsive subjects with BPD, with positron emission tomography neuroimaging with [(18)F] altanserin... - Comorbidity of anxiety disorders with anorexia and bulimia nervosaWalter H Kaye
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara St, Suite 600, Iroquois Bldg, Pittsburgh, PA 15213, USA
Am J Psychiatry 161:2215-21. 2004.... - Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studiesWalter H Kaye
University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, United States
Physiol Behav 85:73-81. 2005..Alterations of these circuits may affect mood and impulse control as well as the motivating and hedonic aspects of feeding behavior. Such imaging studies may offer insights into new pharmacology and psychotherapy approaches... - Brain imaging of serotonin after recovery from anorexia and bulimia nervosaWalter H Kaye
University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Iroquois Building, PA 15213, USA
Physiol Behav 86:15-7. 2005..Alterations of these circuits may affect mood and impulse control as well as the motivating and hedonic aspects of feeding behavior. Such imaging studies may offer insights into new pharmacology and psychotherapy approaches... - The evaluation of brain activity in response to taste stimuli--a pilot study and method for central taste activation as assessed by event-related fMRIGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, Room 132, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Neurosci Methods 131:99-105. 2003..We developed a standardized method for the assessment of brain activation in response to taste stimuli... - Anxiolytic effects of acute tryptophan depletion in anorexia nervosaWalter H Kaye
Department of Psychiatry, Anorexia and Bulimia Nervosa Research Module, University of Pittsburgh Medical School, 600 Iroquois Building, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Int J Eat Disord 33:257-67; discussion 268-70. 2003..Dieting in AN, which serves to reduce plasma levels of tryptophan (TRP), may serve to reduce symptoms of dysphoric mood... 
New insights into symptoms and neurocircuit function of anorexia nervosaWalter H Kaye
Eating Disorder Treatment and Research Program, Department of Psychiatry, University of California, San Diego, La Jolla Village Professional Center, 8950 Villa La Jolla Drive, Suite C 207, La Jolla, California 92037, USA
Nat Rev Neurosci 10:573-84. 2009..For example, altered insula activity could explain interoceptive dysfunction, and altered striatal activity might shed light on altered reward modulation in people with anorexia nervosa...- Features associated with excessive exercise in women with eating disordersHemal Shroff
Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, and Center for Eating Disorders at Sheppard and Enoch Pratt Hospital, Towson, MD, USA
Int J Eat Disord 39:454-61. 2006..CONCLUSION: Excessive exercise may be associated particularly with the purging subtype of AN as well as with a constellation of anxious/obsessional temperament and personality characteristics among women with eating disorders... - Personality traits after recovery from eating disorders: do subtypes differ?Angela Wagner
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 39:276-84. 2006..We compared individuals recovered from anorexia (AN) and bulimia nervosa (BN) to determine characteristics that are shared by or distinguish eating disorder (ED) subtypes... - The genetics of anorexia nervosa collaborative study: methods and sample descriptionWalter H Kaye
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania
Int J Eat Disord 41:289-300. 2008..Supported by National Institute of Mental Health (NIMH), this 12-site international collaboration seeks to identify genetic variants that affect risk for anorexia nervosa (AN)... - Relationships between features associated with vomiting in purging-type eating disordersLauren Reba
Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599-7160, USA
Int J Eat Disord 38:287-94. 2005..Specifically targeting treatment to decrease duration of exposure to this dangerous symptom continues to be an important clinical objective... - Altered brain activity in women recovered from bulimic-type eating disorders after a glucose challenge: a pilot studyGuido K Frank
Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 39:76-9. 2006..However, this is a small sample and the current study will need replication in a larger sample size with investigation of additional regions of interest... - Suicide attempts in anorexia nervosaCynthia M Bulik
Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB 7160, Chapel Hill, NC 27599 7160, USA
Psychosom Med 70:378-83. 2008..To explore prevalence and patterns of suicidal attempts in persons with anorexia nervosa (AN)... - Positron emission tomography studies in eating disorders: multireceptor brain imaging, correlates with behavior and implications for pharmacotherapyGuido K Frank
Department of Child and Adolescent Psychiatry, Center for Eating Disorders Research, School of Medicine, University of California San Diego, 92123, USA
Nucl Med Biol 32:755-61. 2005..These recognized receptors may now help us to move away from rather nonspecific treatment approaches in psychiatric research and clinic to the possibility of more syndrome- and symptom-specific treatment approaches... - Influence of overanxious disorder of childhood on the expression of anorexia nervosaT J Raney
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
Int J Eat Disord 41:326-32. 2008..This study investigates the prevalence of overanxious disorder (OAD) among women with AN and explores how OAD impacts AN symptoms and personality traits... - Serotonin transporter binding after recovery from eating disordersUrsula F Bailer
Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 195:315-24. 2007..Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN)... - Smoking in eating disordersDoris Anzengruber
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7160, USA
Eat Behav 7:291-9. 2006..Given the high prevalence, the impact of ongoing smoking on maintenance of eating disorders symptoms is worthy of both clinical and research attention... - Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosaUrsula F Bailer
Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, Pittsburgh, University of Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 61:1090-9. 2007..Because little is known about 5-HT receptor function in AN, positron emission tomography (PET) imaging with 5-HT receptor-specific radioligands was used to characterize 5-HT1A and 5-HT2A receptors... - Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosaAngela Wagner
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 33:513-23. 2008..These data provide the first evidence that individuals with AN process taste stimuli differently than controls, based on differences in neural activation patterns... - Altered reward processing in women recovered from anorexia nervosaAngela Wagner
University of Pittsburgh, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Psychiatry 164:1842-9. 2007..Building on previous findings of altered striatal dopamine binding in anorexia nervosa, the authors sought to assess the response of the anterior ventral striatum to reward and loss in this disorder... - Impulse control disorders in women with eating disordersFernando Fernandez-Aranda
Department of Psychiatry, University Hospital of Bellvitge, Barcelona, Spain
Psychiatry Res 157:147-57. 2008..Untreated ICD may complicate recovery from eating disorders... - Symptom profile of major depressive disorder in women with eating disordersFernando Fernandez Aranda
Department of Psychiatry, University Hospital of Bellvitge, Barcelona, Spain
Aust N Z J Psychiatry 41:24-31. 2007..The temporal relation between EDs and MDD onset was analyzed to determine differences in the course and nature of MDD when experienced prior to versus after the onset of the ED... - Patterns of menstrual disturbance in eating disordersAndréa Poyastro Pinheiro
Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7160, USA
Int J Eat Disord 40:424-34. 2007..To describe menstrual disturbance in eating disorders (ED)... - Regional cerebral blood flow after recovery from anorexia or bulimia nervosaGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 40:488-92. 2007..Abnormalities of regional cerebral blood flow (rCBF) have been found in individuals who are ill with anorexia (AN) or bulimia nervosa (BN). Little is known about whether rCBF normalizes after recovery from AN and BN... - The relation among perfectionism, obsessive-compulsive personality disorder and obsessive-compulsive disorder in individuals with eating disordersKatherine A Halmi
New York Presbyterian Hospital-Westchester Division, Weill Medical College of Cornell University, White Plains, New York, USA
Int J Eat Disord 38:371-4. 2005..The pairing of perfectionism with OCPD may be a relevant core behavioral feature underlying vulnerability to ED... - Linkage analysis of anorexia and bulimia nervosa cohorts using selected behavioral phenotypes as quantitative traits or covariatesSilviu-Alin Bacanu
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213-2593, USA
Am J Med Genet B Neuropsychiatr Genet 139:61-8. 2005..3); for covariate-based linkage analysis, five suggestive signals (for BMI at 4q13.1, for CM at 11p11.2 and 17q25.1, and for OBF at 17q25.1 and 15q26.2). Overlap between the two cohorts was minimal for substantial linkage signals... - Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinnessUrsula F Bailer
Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 29:1143-55. 2004..It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects... - Neurotransmitter and imaging studies in anorexia nervosa: new targets for treatmentNicole C Barbarich
Anorexia and Bulimia Nervosa Research Module, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, 600 Iroquois Building, Pittsburgh, PA 15213, USA
Curr Drug Targets CNS Neurol Disord 2:61-72. 2003..In summary, studies of pathophysiology are starting to nominate new candidates for treatment leading to the possibility of finding effective treatments for this often chronic or fatal disorder... - Application of a latent class analysis to empirically define eating disorder phenotypesPamela K Keel
Department of Psychology, Harvard University, Cambridge, MA, USA
Arch Gen Psychiatry 61:192-200. 2004..Diagnostic criteria for eating disorders influence how we recognize, research, and treat eating disorders, and empirically valid phenotypes are required for revealing their genetic bases... - A review of neuropeptide and neuroendocrine dysregulation in anorexia and bulimia nervosaUrsula F Bailer
University of Pittsburgh Medical Center, Anorexia and Bulimia Nervosa Research Module, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, 600 Iroquois Building, Pittsburgh, PA 15213, USA
Curr Drug Targets CNS Neurol Disord 2:53-9. 2003.... - Alcohol use disorder comorbidity in eating disorders: a multicenter studyCynthia M Bulik
Department of Psychiatry, University of North Carolina at Chapel Hill, 27599 7160, USA
J Clin Psychiatry 65:1000-6. 2004..Our aim was to explore the nature of the co-morbid relation between AUDs and eating disorders in a large and phenotypically well-characterized group of individuals... - Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosaNicole C Barbarich
Department of Psychiatry, University of Pittsburgh Medical School, Anorexia and Bulimia Nervosa Research Module, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 35:10-5. 2004..DISCUSSION: The results of this study suggest that supplement strategies are not a substitute for adequate nutrition and are ineffective in increasing the efficacy of fluoxetine in underweight AN subjects... - Personality characteristics of women before and after recovery from an eating disorderKelly L Klump
Department of Psychology, Michigan State University, East Lansing, MI 48824 1116, USA
Psychol Med 34:1407-18. 2004..This study compares personality characteristics among women who are ill with eating disorders, recovered from eating disorders, and those without eating or other Axis I disorder pathology... - Symptom fluctuation in eating disorders: correlates of diagnostic crossoverFederica Tozzi
Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Neurosciences Hospital, Chapel Hill, NC 27599-7160l, USA
Am J Psychiatry 162:732-40. 2005..These results indicate that personality and family characteristics may influence the course of eating disorders and may be informative for planning interventions... - Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635Ursula F Bailer
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 62:1032-41. 2005..These psychobiological alterations may be trait related and may contribute to the pathogenesis of AN... - Normal brain tissue volumes after long-term recovery in anorexia and bulimia nervosaAngela Wagner
Department of Psychiatry, Western Psychiatric Institute and Clinic, Presbyterian University Hospital, University of Pittsburgh School of Medicine, Pennsylvania, USA
Biol Psychiatry 59:291-3. 2006..CONCLUSIONS: These findings suggest that structural brain abnormalities are reversible in individuals with eating disorders after long-term recovery... - Reduced 5-HT2A receptor binding after recovery from anorexia nervosaGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 52:896-906. 2002..Altered 5-HT neurotransmission after recovery also supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of AN... - Neurobiology of anorexia nervosa: clinical implications of alterations of the function of serotonin and other neuronal systemsWalter H Kaye
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 37:S15-9; discussion S20-1. 2005.... - Olanzapine treatment of anorexia nervosa: a retrospective studyAmanda Malina
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 33:234-7. 2003..DISCUSSION: These data lend support to the possibility that olanzapine may be useful in AN patients. CONCLUSION: A controlled trial is necessary to prove that olanzapine is efficacious... - Features associated with diet pill use in individuals with eating disordersLauren Reba-Harrelson
Department of Psychiatry, University of North Carolina at Chapel Hill, NC, United States
Eat Behav 9:73-81. 2008..In the eating disorder population, vigilant screening for diet pill use should be routine clinical practice... - Obsessions and compulsions in anorexia nervosa subtypesKatherine A Halmi
New York Presbyterian Hospital Westchester Division, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
Int J Eat Disord 33:308-19. 2003..We examined the type and frequency of characteristic OCD obsessions and compulsions in a large sample of AN patients... - Personality, perfectionism, and attitudes toward eating in parents of individuals with eating disordersD Blake Woodside
Department of Psychiatry, Toronto General Hospital, Toronto, Ontario, Canada
Int J Eat Disord 31:290-9. 2002..This study compares personality and eating-related traits in parents of probands with eating disorders, with age-band matched healthy normal controls... - Significant linkage on chromosome 10p in families with bulimia nervosaCynthia M Bulik
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Am J Hum Genet 72:200-7. 2003..92 and 3.39, meet the widely accepted criterion for genomewide significance. Another region on 14q meets the criterion for genomewide suggestive linkage, with MLSs of 1.97 (full sample) and 1.75 (subset) at 62 centimorgans from p-ter... - Temporal patterns of recovery across eating disorder subtypesAnn Von Holle
Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7160, USA
Aust N Z J Psychiatry 42:108-17. 2008..To compare patterns of recovery in individuals with index episodes of anorexia nervosa (AN) and bulimia nervosa (BN)... - Pain perception in recovered bulimia nervosa patientsDaniel Stein
Sheba Medical Center, 21Tel Hashomer, Israel
Int J Eat Disord 34:331-6. 2003..DISCUSSION: Decreased pain sensitivity persists after recovery from BN and may reflect altered modulatory function in this illness... - The relationship of body dysmorphic disorder and eating disorders to obsessive-compulsive disorderKatharine A Phillips
Brown Medical School, Providence, RI, USA
CNS Spectr 12:347-58. 2007..Additional research is needed on the relationship of BDD and eating disorders to OCD, including studies that directly compare them to OCD in a variety of domains, including phenomenology, family history, neurobiology, and etiology... - Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]racloprideGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of California San Diego, California, USA
Biol Psychiatry 58:908-12. 2005..Most intriguing is the possibility that individuals with AN might have a DA related disturbance of reward mechanisms contributing to altered hedonics of feeding behavior and their ascetic, anhedonic temperament... - Association of multiple DRD2 polymorphisms with anorexia nervosaAndrew W Bergen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
Neuropsychopharmacology 30:1703-10. 2005..Genetically transmitted variation in D2 dopamine receptor expression mediated by functional polymorphisms affecting transcription and translation efficiency may play a role in vulnerability to AN... - Features associated with laxative abuse in individuals with eating disordersFederica Tozzi
Department of Psychiatry, University of North Carolina at Chapel Hill, 1st floor Neurosciences Hospital, CB #7160, Chapel Hill, North Carolina 27599-7160, USA
Psychosom Med 68:470-7. 2006..CONCLUSIONS: The function of laxative abuse may differ across individuals with eating disorders, alternatively serving as a method of purging and a form of self-harm... - Neural correlates of habituation to taste stimuli in healthy womenAngela Wagner
University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, PA 15213, USA
Psychiatry Res 147:57-67. 2006..By contrast, for sequential blocks, both stimuli produced habituation in taste-related brain regions. These data suggest that habituation patterns in healthy subjects may depend on frequency and regularity of stimulus administration... - An open trial of olanzapine in anorexia nervosaNicole C Barbarich
Department of Psychiatry, University of Pittsburgh Medical School, Anorexia and Bulimia Nervosa Research Module, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Clin Psychiatry 65:1480-2. 2004..CONCLUSION: These data lend support to the possibility that olanzapine may be useful in treating anorexia nervosa. However, a controlled trial is necessary to demonstrate that olanzapine is efficacious... - Personality in men with eating disordersD Blake Woodside
Program for Eating Disorders, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
J Psychosom Res 57:273-8. 2004..This study compares personality variables of men with eating disorders to women with eating disorders... - Report of the National Institutes of Health workshop on overcoming barriers to treatment research in anorexia nervosaW Stewart Agras
Department of Psychiatry, Stanford University School of Medicine, Stanford, California, USA
Int J Eat Disord 35:509-21. 2004..DISCUSSION: It is crucial that treatment research in this area be prioritized... - Selection of eating-disorder phenotypes for linkage analysisCynthia M Bulik
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Am J Med Genet B Neuropsychiatr Genet 139:81-7. 2005..Linkage results appear in a subsequent report. Our report lays out a systematic roadmap for utilizing a rich set of phenotypes for genetic analyses, including the selection of linkage methods paired to those phenotypes... - Sucrose activates human taste pathways differently from artificial sweetenerGuido K W Frank
University of Colorado at Denver and Health Sciences Center, Department of Psychiatry, The Children s Hospital, Aurora, CO 80045, USA
Neuroimage 39:1559-69. 2008..This could have important implications on how effective artificial sweeteners are in their ability to substitute sugar intake...
Research Grants
- PET IMAGING AND SEROTONIN LIGANDS IN EATING DISORDERSWalter Kaye; Fiscal Year: 2005....
- Serotonin - A Trait Disturbance in Anorexia Nervosa?Walter Kaye; Fiscal Year: 2007..This is a resubmissien of a cemDetina renewal of MH46001. ..
- Family Therapy and Fluoxetine in the Treatment of Adolescent Anorexia NervosaWalter Kaye; Fiscal Year: 2007..From the public health perspective, development of effective treatments for adolescents will reduce the morbidity, mortality, and high costs associated with chronic AN. ..