B K Kay

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains
    B K Kay
    Department of Pharmacology, University of Wisconsin Madison, Madison, Wisconsin 53706 1532, USA
    FASEB J 14:231-41. 2000
  2. ncbi Convergent evolution with combinatorial peptides
    B K Kay
    Department of Pharmacology, University of Wisconsin Madison, WI 53706 1532, USA
    FEBS Lett 480:55-62. 2000
  3. ncbi Screening phage-displayed combinatorial peptide libraries
    B K Kay
    Department of Pharmacology, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706 1532, USA
    Methods 24:240-6. 2001
  4. ncbi Identification of enzyme inhibitors from phage-displayed combinatorial peptide libraries
    B K Kay
    Department of Pharmacology, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706 1532, USA
    Comb Chem High Throughput Screen 4:535-43. 2001
  5. pmc Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery
    B K Kay
    Department of Pharmacology, University of Wisconsin Madison, 53706 1532, USA
    Protein Sci 8:435-8. 1999
  6. ncbi Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains
    M Yamabhai
    Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
    J Biol Chem 273:31401-7. 1998
  7. ncbi Molecular mechanism of NPF recognition by EH domains
    T de Beer
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Struct Biol 7:1018-22. 2000
  8. ncbi Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains
    E A Mosser
    Department of Pharmacology, University of Wisconsin Medical School, Madison 53706, USA
    Biochemistry 37:13686-95. 1998
  9. ncbi Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP
    N K Hussain
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
    Nat Cell Biol 3:927-32. 2001
  10. ncbi Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells
    N K Hussain
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada
    J Biol Chem 274:15671-7. 1999

Collaborators

Detail Information

Publications20

  1. ncbi The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains
    B K Kay
    Department of Pharmacology, University of Wisconsin Madison, Madison, Wisconsin 53706 1532, USA
    FASEB J 14:231-41. 2000
    ..Kay, B. K., Williamson, M. P., Sudol, M. The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains...
  2. ncbi Convergent evolution with combinatorial peptides
    B K Kay
    Department of Pharmacology, University of Wisconsin Madison, WI 53706 1532, USA
    FEBS Lett 480:55-62. 2000
    ..Thus, a fruitful approach for mapping protein-protein interactions is to isolate peptide ligands to a target protein and identify candidate interacting proteins in a sequenced genome by computer analysis...
  3. ncbi Screening phage-displayed combinatorial peptide libraries
    B K Kay
    Department of Pharmacology, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706 1532, USA
    Methods 24:240-6. 2001
    ..In this article, protocols and examples are provided to guide scientists who wish to identify peptide ligands to their favorite proteins...
  4. ncbi Identification of enzyme inhibitors from phage-displayed combinatorial peptide libraries
    B K Kay
    Department of Pharmacology, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706 1532, USA
    Comb Chem High Throughput Screen 4:535-43. 2001
    ..e., as a lead compound for peptidomimetic design or as displaceable probe in high-throughput screens of libraries of small molecules)...
  5. pmc Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery
    B K Kay
    Department of Pharmacology, University of Wisconsin Madison, 53706 1532, USA
    Protein Sci 8:435-8. 1999
    ..We have named this protein segment the ENTH domain, for Epsin N-terminal Homology domain, and hypothesize that it is a candidate for binding specific ligands and/or enzymatic activity in the cell...
  6. ncbi Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains
    M Yamabhai
    Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
    J Biol Chem 273:31401-7. 1998
    ..We propose that Intersectin is a component of the endocytic machinery...
  7. ncbi Molecular mechanism of NPF recognition by EH domains
    T de Beer
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Struct Biol 7:1018-22. 2000
    ....
  8. ncbi Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains
    E A Mosser
    Department of Pharmacology, University of Wisconsin Medical School, Madison 53706, USA
    Biochemistry 37:13686-95. 1998
    ..Mutation of PPXY-1, but not PPXY-2, inhibited the transactivation function of NF-E2, providing support for the hypothesis that WW domain interactions are important for NF-E2-mediated transactivation...
  9. ncbi Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP
    N K Hussain
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
    Nat Cell Biol 3:927-32. 2001
    ..These studies reveal a role for intersectin-l in a novel mechanism of N-WASP activation and in regulation of the actin cytoskeleton...
  10. ncbi Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells
    N K Hussain
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada
    J Biol Chem 274:15671-7. 1999
    ..These data suggest that the long and short forms of intersectin are components of the endocytic machinery in neurons and nonneuronal cells...
  11. ncbi Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins
    A B Sparks
    Department of Biology, University of North Carolina, Chapel Hill 27599, USA
    Nat Biotechnol 14:741-4. 1996
    ..The isolation of entire repertoires of modular domain-containing proteins will prove invaluable in genome analysis and in bringing new targets into drug discovery programs...
  12. pmc The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain
    X K Tong
    Department of Neurology, Montreal Neurological Institute, Montreal, QC H3A 2B4, Canada
    EMBO J 19:1263-71. 2000
    ..These results suggest that intersectin functions in cell signaling in addition to its role in endocytosis and may link these cellular processes...
  13. ncbi A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions
    V Ribon
    Department of Physiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    J Biol Chem 273:4073-80. 1998
    ..These results suggest that CAP may mediate signals for the formation of stress fibers and focal adhesions...
  14. pmc A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes
    V Ribon
    Department of Physiology, University of Michigan School of Medicine, Ann Arbor 48109, USA
    Mol Cell Biol 18:872-9. 1998
    ..Insulin stimulation resulted in the dissociation of CAP from the insulin receptor. Taken together, these data suggest that CAP represents a novel c-Cbl binding protein in 3T3-L1 adipocytes likely to participate in insulin signaling...
  15. ncbi Characterizing Class I WW domains defines key specificity determinants and generates mutant domains with novel specificities
    J Kasanov
    Department of Biology, University of North Carolina, Chapel Hill 27599-3280, USA
    Chem Biol 8:231-41. 2001
    ..The presence of these residues within an uncharacterized WW domain can be used to predict its ability to bind Pro-Xxx-Tyr containing peptide ligands...
  16. ncbi Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin
    K D Micheva
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 272:27239-45. 1997
    ..These data demonstrate that synaptojanin is present in two separate complexes in the nerve terminal and support an important role for endophilin in the regulation of synaptojanin function...
  17. ncbi SH3 domain-dependent interactions of endophilin with amphiphysin
    K D Micheva
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Que, Canada
    FEBS Lett 414:308-12. 1997
    ..The interaction is direct and mediated through a 43 amino acid region of amphiphysin containing the putative SH3 binding site. These data further support a role for amphiphysin I, II and endophilin in synaptic vesicle endocytosis...
  18. pmc Isolation of peptides from phage-displayed random peptide libraries that interact with the talin-binding domain of vinculin
    N B Adey
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Biochem J 324:523-8. 1997
    ..This study demonstrates that the vinculin-binding peptides interact with vinculin in a biologically relevant manner and represent an excellent tool for further study of the biochemistry of vinculin...
  19. pmc Potential for two isoforms of the A1 ribonucleoprotein in Xenopus laevis
    B K Kay
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280
    Proc Natl Acad Sci U S A 87:1367-71. 1990
    ..Our findings suggest that the isoforms are encoded by one or two genes and are the result of alternative splicing. We discuss the biological implications of having two forms of the A1 component of hnRNP particles...