Claudia Kawas

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Amyloid imaging and cognitive decline in nondemented oldest-old: the 90+ Study
    Claudia H Kawas
    Department of Neurology, University of California, Irvine, Irvine, CA, USA
    Alzheimers Dement 9:199-203. 2013
  2. pmc Alzheimer's and dementia in the oldest-old: a century of challenges
    Claudia H Kawas
    Department of Neurology, University of California, Irvine, CA 92697 4540, USA
    Curr Alzheimer Res 3:411-9. 2006
  3. pmc Medications and diet: protective factors for AD?
    Claudia H Kawas
    Department of Neurology, Institute for Brain Aging and Dementia, University of California Irvine, 1121 Gillespie, Irvine, CA 92627 4540, USA
    Alzheimer Dis Assoc Disord 20:S89-96. 2006
  4. ncbi request reprint Clinical practice. Early Alzheimer's disease
    Claudia H Kawas
    Institute for Brain Aging and Dementia and the Departments of Neurology and Neurobiology and Behavior, University of California, Irvine, CA 92697 4540, USA
    N Engl J Med 349:1056-63. 2003
  5. ncbi request reprint Visual memory predicts Alzheimer's disease more than a decade before diagnosis
    C H Kawas
    Alzheimer s Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 60:1089-93. 2003
  6. pmc Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease
    Ellen Grober
    Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
    J Int Neuropsychol Soc 14:266-78. 2008
  7. pmc High levels of serum C-reactive protein are associated with greater risk of all-cause mortality, but not dementia, in the oldest-old: results from The 90+ Study
    B Adar Kravitz
    Department of Neurobiology and Behavior, University of California at Irvine, Irvine, California, USA
    J Am Geriatr Soc 57:641-6. 2009
  8. pmc Neuropsychological data in nondemented oldest old: the 90+ Study
    Christina Whittle
    Institute of Brain Aging and Dementia, University of California, Irvine, CA, USA
    J Clin Exp Neuropsychol 29:290-9. 2007
  9. pmc Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype
    Daniel J Berlau
    Institute of Brain Aging and Dementia, University of California, Irvine, 1515 Hewitt Hall, Irvine, CA 92697 1400, USA
    Arch Neurol 64:1193-6. 2007
  10. pmc The prevalence of disability in the oldest-old is high and continues to increase with age: findings from The 90+ Study
    Daniel J Berlau
    Institute for Brain Aging and Dementia, University of California, Irvine, USA
    Int J Geriatr Psychiatry 24:1217-25. 2009

Research Grants

Collaborators

Detail Information

Publications35

  1. pmc Amyloid imaging and cognitive decline in nondemented oldest-old: the 90+ Study
    Claudia H Kawas
    Department of Neurology, University of California, Irvine, Irvine, CA, USA
    Alzheimers Dement 9:199-203. 2013
    ..The goal of this study was to examine cross-sectional and longitudinal associations between cognitive performance and beta amyloid (Aβ) load determined by florbetapir F18 positron emission tomography (PET) in nondemented oldest-old...
  2. pmc Alzheimer's and dementia in the oldest-old: a century of challenges
    Claudia H Kawas
    Department of Neurology, University of California, Irvine, CA 92697 4540, USA
    Curr Alzheimer Res 3:411-9. 2006
    ....
  3. pmc Medications and diet: protective factors for AD?
    Claudia H Kawas
    Department of Neurology, Institute for Brain Aging and Dementia, University of California Irvine, 1121 Gillespie, Irvine, CA 92627 4540, USA
    Alzheimer Dis Assoc Disord 20:S89-96. 2006
    ..At present, there is insufficient evidence to make public health recommendations, but these studies can provide potentially important clues and new avenues for clinical and laboratory research...
  4. ncbi request reprint Clinical practice. Early Alzheimer's disease
    Claudia H Kawas
    Institute for Brain Aging and Dementia and the Departments of Neurology and Neurobiology and Behavior, University of California, Irvine, CA 92697 4540, USA
    N Engl J Med 349:1056-63. 2003
  5. ncbi request reprint Visual memory predicts Alzheimer's disease more than a decade before diagnosis
    C H Kawas
    Alzheimer s Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 60:1089-93. 2003
    ....
  6. pmc Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease
    Ellen Grober
    Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
    J Int Neuropsychol Soc 14:266-78. 2008
    ..It also supports the view that VIQ as estimated by the AMNART does not decline during the preclinical onset of AD...
  7. pmc High levels of serum C-reactive protein are associated with greater risk of all-cause mortality, but not dementia, in the oldest-old: results from The 90+ Study
    B Adar Kravitz
    Department of Neurobiology and Behavior, University of California at Irvine, Irvine, California, USA
    J Am Geriatr Soc 57:641-6. 2009
    ..To evaluate whether high levels of C-reactive protein (CRP) in serum are associated with greater risk of all-cause dementia or mortality in the oldest-old...
  8. pmc Neuropsychological data in nondemented oldest old: the 90+ Study
    Christina Whittle
    Institute of Brain Aging and Dementia, University of California, Irvine, CA, USA
    J Clin Exp Neuropsychol 29:290-9. 2007
    ..Cognitive performance declined with age for two-thirds of the tests. Performance on some tests was also affected by gender, education, and depression scores...
  9. pmc Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype
    Daniel J Berlau
    Institute of Brain Aging and Dementia, University of California, Irvine, 1515 Hewitt Hall, Irvine, CA 92697 1400, USA
    Arch Neurol 64:1193-6. 2007
    ..The apolipoprotein E (APOE) epsilon2 allele has been suggested as having a protective effect and delaying the age at onset of Alzheimer disease...
  10. pmc The prevalence of disability in the oldest-old is high and continues to increase with age: findings from The 90+ Study
    Daniel J Berlau
    Institute for Brain Aging and Dementia, University of California, Irvine, USA
    Int J Geriatr Psychiatry 24:1217-25. 2009
    ..To examine the prevalence and type of disability in the oldest-old (90+), the fastest growing age group in the United States...
  11. pmc Sensitivity and specificity of the mini-mental state examination for identifying dementia in the oldest-old: the 90+ study
    Kristin Kahle-Wrobleski
    Institute of Brain Aging and Dementia, University of California at Irvine, Irvine, California 92697, USA
    J Am Geriatr Soc 55:284-9. 2007
    ..To evaluate the sensitivity and specificity of the Mini-Mental State Examination (MMSE) in identifying dementia in the oldest-old when stratified by age and education...
  12. pmc APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old
    Daniel J Berlau
    Institute of Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 1400, USA
    Neurology 72:829-34. 2009
    ..This would predict, even with advanced age, that APOE2 carriers would be less likely to have dementia and less likely to meet pathologic criteria for AD...
  13. pmc Association of body mass index and weight change with all-cause mortality in the elderly
    Maria M Corrada
    Department of Neurology, School of Medicine, University of California, Irvine, 92697 1400, USA
    Am J Epidemiol 163:938-49. 2006
    ..This study highlights the influence on older-age mortality risk of being overweight or obese in young adulthood and underweight or obese in later life...
  14. pmc Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old
    B Adar Kravitz
    Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA, USA
    Alzheimers Dement 5:318-23. 2009
    ..Using a cross-sectional design, we examined whether high levels of serum CRP are associated with increased odds of prevalent dementia in the oldest-old...
  15. ncbi request reprint Neuronal localization of C1q in preclinical Alzheimer's disease
    Maria I Fonseca
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Neurobiol Dis 15:40-6. 2004
    ..Thus, it is possible that this neuronal-associated C1q reflects an early, but transient, response to injury that may modulate the progression of neurological dysfunction in AD...
  16. ncbi request reprint Estrogen replacement therapy, Alzheimer's disease, and mild cognitive impairment
    Ruth A Mulnard
    Departments of Neurology, and Neurobiology and Behavior, University of California Irvine, Gillespie NRF, Room 1113, Irvine, CA 92697 4540, USA
    Curr Neurol Neurosci Rep 4:368-73. 2004
    ..Additional basic and clinical investigations are necessary to examine different forms and dosages of estrogens, other populations, and the relevance of timing and duration of exposure...
  17. ncbi request reprint Synaptic proteins, neuropathology and cognitive status in the oldest-old
    Elizabeth Head
    Institute of Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Neurobiol Aging 30:1125-34. 2009
    ..Frontal cortex SYN protein levels may protect neuronal function in oldest-old individuals and reflect compensatory responses that may be involved with maintaining cognition...
  18. pmc Abnormal EEGs in cognitively and physically healthy oldest old: findings from the 90+ study
    Carrie Brumback Peltz
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California 92697 1400, USA
    J Clin Neurophysiol 27:292-5. 2010
    ..The high rates of EEG abnormalities found in these physically and cognitively healthy participants prompt reappraisal of pathologic significance in this unique population...
  19. pmc Dementia incidence continues to increase with age in the oldest old: the 90+ study
    Maria M Corrada
    Department of Neurology, University of California, Irvine, CA 92697 1400, USA
    Ann Neurol 67:114-21. 2010
    ..Here, we estimate age- and sex-specific incidence rates of all-cause dementia in people aged 90 years and older, including estimates for centenarians...
  20. pmc Session II: Mechanisms of age-related cognitive change and targets for intervention: neural circuits, networks, and plasticity
    Charles DeCarli
    Department of Neurology and Center for Neuroscience, University of California, Davis, USA
    J Gerontol A Biol Sci Med Sci 67:747-53. 2012
    ..Moreover, this understanding will assist in promoting the utilization of existing interventions, such as lifestyle and therapeutic modifiers of vascular disease...
  21. pmc Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 302:2663-70. 2009
    ..The herbal product Ginkgo biloba is taken frequently with the intention of improving cognitive health in aging. However, evidence from adequately powered clinical trials is lacking regarding its effect on long-term cognitive functioning...
  22. pmc Children of persons with Alzheimer disease: what does the future hold?
    Lissy Jarvik
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 22:6-20. 2008
    ..We examine the state of knowledge with respect to risk and protective factors for AD and recommend a research agenda with special emphasis on AD offspring...
  23. pmc Performance on MMSE sub-items and education level in presenilin-1 mutation carriers without dementia
    John M Ringman
    Alzheimer s Disease Center, UCLA Department of Neurology, Los Angeles, CA, USA
    Int Psychogeriatr 19:323-32. 2007
    ..Persons known to be at 50% risk for young-onset AD due to presenilin-1 (PSEN1) mutations provide the opportunity to assess which measures on the Mini-mental State Examination (MMSE) are most sensitive to these early changes...
  24. ncbi request reprint Survival following a diagnosis of Alzheimer disease
    Ron Brookmeyer
    Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Arch Neurol 59:1764-7. 2002
    ..Survival following a diagnosis of Alzheimer disease (AD) is important information for health planners, caregivers, patients, and their families...
  25. ncbi request reprint Computerized neuropsychiatric assessment of geriatric subjects by content analysis of brief samples of their speech
    Louis A Gottschalk
    Departments of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA
    Comput Inform Nurs 22:351-5. 2004
    ..The computerized content-analysis scores obtained from this elderly cohort reveal plausible deviations from the norms for younger people...
  26. ncbi request reprint Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease
    Anne K Vehmas
    Department of Pathology, Neuropathology Division, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205 2196, USA
    Neurobiol Aging 24:321-31. 2003
    ..Tau immunoreactivity appears as the strongest morphological correlate of dementia...
  27. ncbi request reprint Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA)
    Irina Mikolaenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    J Neuropathol Exp Neurol 64:156-62. 2005
    ..Finally, the coexistence of Abeta amyloid and alpha-synuclein pathology in AD brains suggests that the pathogenic mechanism/s leading to the accumulation of Abeta and alpha-synuclein may be similar...
  28. pmc The oldest old and the 90+ Study
    Claudia H Kawas
    Department of Neurology, Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA, USA
    Alzheimers Dement 4:S56-9. 2008
    ..Through our collective efforts, we will continue the scientific work that Leon so strongly supported...
  29. pmc Non-alcoholic beverage and caffeine consumption and mortality: the Leisure World Cohort Study
    Annlia Paganini-Hill
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, CA, USA
    Prev Med 44:305-10. 2007
    ..To examine the effects of non-alcoholic beverage and caffeine consumption on all-cause mortality in older adults...
  30. ncbi request reprint Depressive symptoms, sex, and risk for Alzheimer's disease
    Gloria Dal Forno
    Clinical Neurosciences, University Campus BioMedico and Associazione Fatebenefratelli per la Ricerca A Fa R, Via dei Compositori 130 132, 00128 Rome, Italy
    Ann Neurol 57:381-7. 2005
    ..We conclude that the impact of depressive symptoms on risk for dementia and AD may vary with sex. Further studies assessing separately the role of depression as a risk factor in men and women are necessary...
  31. ncbi request reprint Hippocampal neurons in pre-clinical Alzheimer's disease
    Mark J West
    Department of Neurobiology, Institute of Anatomy, Building 234, University Park, Aarhus 8000, Denmark
    Neurobiol Aging 25:1205-12. 2004
    ..However, we did not observe a significant loss of neurons in CA1 or any of the other subdivisions of the hippocampus in preclinical AD...
  32. ncbi request reprint Survival following dementia onset: Alzheimer's disease and vascular dementia
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, Seattle, WA 98115, USA
    J Neurol Sci 229:43-9. 2005
    ..4 years for mixed dementia, and 11.0 years for matched controls with normal cognition. While persons with VaD died primarily from cerebrovascular disease, those with AD/mixed dementia died more frequently from dementia/failure to thrive...
  33. pmc Increased longevity in older users of postmenopausal estrogen therapy: the Leisure World Cohort Study
    Annlia Paganini-Hill
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, USA
    Menopause 13:12-8. 2006
    ..To examine the effect of postmenopausal estrogen therapy (ET), including duration and recency of use, on all-cause mortality in older women...
  34. pmc Diet and the risk for Alzheimer's disease
    Claudia H Kawas
    Ann Neurol 59:877-9. 2006
  35. ncbi request reprint Informed consent for Alzheimer's disease clinical trials: a survey of clinical investigators
    Jason H T Karlawish
    Internal Ethics Committee of the Alzheimer s Disease Cooperative Study
    IRB 24:1-5. 2002

Research Grants10

  1. Clinical and Pathological Studies in the Oldest Old
    Claudia Kawas; Fiscal Year: 2007
    ..abstract_text> ..
  2. Clinical and Pathological Studies in the Oldest Old
    Claudia Kawas; Fiscal Year: 2006
    ..abstract_text> ..
  3. Clinical and Pathological Studies in the Oldest Old
    Claudia H Kawas; Fiscal Year: 2010
    ..The potential public health implications are enormous for the fastest growing segment of our population. ..