Research Topics

Yoshihiro Kawaoka


Affiliation: University of Wisconsin
Country: USA


  1. Oishi K, Yamayoshi S, Kawaoka Y. Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity. J Virol. 2015;89:8661-5 pubmed publisher
    ..These six basic amino acids enabled a PA deletion mutant to suppress protein expression at a level comparable to that of wild-type PA-X. ..
  2. Yang H, Chen Y, Qiao C, He X, Zhou H, Sun Y, et al. Prevalence, genetics, and transmissibility in ferrets of Eurasian avian-like H1N1 swine influenza viruses. Proc Natl Acad Sci U S A. 2016;113:392-7 pubmed publisher
    ..Our study shows the potential of EAH1N1 SIVs to transmit efficiently in humans and suggests that immediate action is needed to prevent the efficient transmission of EAH1N1 SIVs to humans. ..
  3. Saphire E, Schendel S, Fusco M, Gangavarapu K, Gunn B, Wec A, et al. Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection. Cell. 2018;174:938-952.e13 pubmed publisher
    ..This comprehensive dataset provides a rubric to evaluate novel antibodies and vaccine responses and a roadmap for therapeutic development for EBOV and related viruses. ..
  4. Fan S, Hatta M, Kim J, Le M, Neumann G, Kawaoka Y. Amino acid changes in the influenza A virus PA protein that attenuate avian H5N1 viruses in mammals. J Virol. 2014;88:13737-46 pubmed publisher
    ..The PA protein thus plays a role in the pathogenicity of highly pathogenic H5N1 influenza viruses. ..
  5. Watanabe T, Watanabe S, Maher E, Neumann G, Kawaoka Y. Pandemic potential of avian influenza A (H7N9) viruses. Trends Microbiol. 2014;22:623-31 pubmed publisher
    ..In this review, we summarize the characteristic features of the novel H7N9 viruses and assess their pandemic potential. ..
  6. Oishi K, Yamayoshi S, Kozuka Hata H, Oyama M, Kawaoka Y. N-Terminal Acetylation by NatB Is Required for the Shutoff Activity of Influenza A Virus PA-X. Cell Rep. 2018;24:851-860 pubmed publisher
    ..Taken together, our findings demonstrate that N-terminal acetylation is required for the shutoff activity of PA-X and for viral polymerase activity. ..
  7. Watanabe T, Kawakami E, Shoemaker J, Lopes T, Matsuoka Y, Tomita Y, et al. Influenza virus-host interactome screen as a platform for antiviral drug development. Cell Host Microbe. 2014;16:795-805 pubmed publisher
    ..Thus, virus-host interactome screens are powerful strategies to identify targetable host factors and guide antiviral drug development. ..
  8. Marzi A, Halfmann P, Hill Batorski L, Feldmann F, Shupert W, Neumann G, et al. Vaccines. An Ebola whole-virus vaccine is protective in nonhuman primates. Science. 2015;348:439-42 pubmed publisher
  9. Kawaoka Y. H5N1: Flu transmission work is urgent. Nature. 2012;482:155 pubmed publisher

More Information


  1. Watanabe T, Zhong G, Russell C, Nakajima N, Hatta M, Hanson A, et al. Circulating avian influenza viruses closely related to the 1918 virus have pandemic potential. Cell Host Microbe. 2014;15:692-705 pubmed publisher
  2. Neumann G, Kawaoka Y. Transmission of influenza A viruses. Virology. 2015;479-480:234-46 pubmed publisher
    ..Here, we summarize our current knowledge of the contributions of HA, PB2, and other viral components to virus transmission and the formation of new virus lineages. ..
  3. Watanabe T, Kawaoka Y. Influenza virus-host interactomes as a basis for antiviral drug development. Curr Opin Virol. 2015;14:71-8 pubmed publisher
  4. Hanson A, Imai M, Hatta M, McBride R, Imai H, Taft A, et al. Identification of Stabilizing Mutations in an H5 Hemagglutinin Influenza Virus Protein. J Virol. 2015;90:2981-92 pubmed publisher
    ..The ability to bind to human-type receptors, together with physical stability and an altered pH threshold for HA conformational change, may facilitate avian influenza virus transmission via respiratory droplets in mammals. ..
  5. Ping J, Lopes T, Neumann G, Kawaoka Y. Development of high-yield influenza B virus vaccine viruses. Proc Natl Acad Sci U S A. 2016;113:E8296-E8305 pubmed publisher
    ..These influenza B virus vaccine backbones can be used for improved vaccine virus production. ..
  6. Shoemaker J, Lopes T, Ghosh S, Matsuoka Y, Kawaoka Y, Kitano H. CTen: a web-based platform for identifying enriched cell types from heterogeneous microarray data. BMC Genomics. 2012;13:460 pubmed publisher
    ..CTen is available at ..