Affiliation: University of Minnesota
Tahara N, Kawakami H, Zhang T, Zarkower D, Kawakami Y. Temporal changes of Sall4 lineage contribution in developing embryos and the contribution of Sall4-lineages to postnatal germ cells in mice. Sci Rep. 2018;8:16410 pubmed publisher
..The Sall4 GFP-CreERT2 line can serve as a tool to monitor spatial-temporal contributions of Sall4 lineages as well as to perform gene manipulations in Sall4-expressing lineages. ..
Kawakami Y. Redefining the role of retinoic acid in limb development. Cell Rep. 2013;3:1337-8 pubmed publisher
..In this issue of Cell Reports, Cunningham et al. show that RA antagonizes fibroblast growth factors for limb initiation, but not for limb patterning. ..
Akiyama R, Kawakami H, Taketo M, Evans S, Wada N, Petryk A, et al
. Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the ?-catenin pathway. Dev Biol. 2014;387:37-48 pubmed publisher
Tahara N, Akiyama R, Theisen J, Kawakami H, Wong J, Garry D, et al
. Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules. Dev Biol. 2018;434:74-83 pubmed publisher
..Our results support a model in which Gata6 contributes to repression of Isl1 expression in the anterior of nascent hindlimb buds. ..
Kawakami Y, Marti M, Kawakami H, Itou J, Quach T, Johnson A, et al
. Islet1-mediated activation of the ?-catenin pathway is necessary for hindlimb initiation in mice. Development. 2011;138:4465-73 pubmed publisher
..Our study identifies Islet1 as a hindlimb-specific transcriptional regulator of initiation, and clarifies the controversy regarding the requirement of ?-catenin for limb initiation...
Akiyama R, Kawakami H, Wong J, Oishi I, Nishinakamura R, Kawakami Y. Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015;112:5075-80 pubmed publisher
..Therefore, our study identified a critical role of the Sall4-Gli3 system at the early steps of limb development for proper development of the appendicular skeletal elements. ..