Andreas N Kavazis

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. doi request reprint Exercise preconditioning of the myocardium
    Andreas N Kavazis
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Sports Med 39:923-35. 2009
  2. pmc Exercise training induces a cardioprotective phenotype and alterations in cardiac subsarcolemmal and intermyofibrillar mitochondrial proteins
    Andreas N Kavazis
    Applied Physiology and Kinesiology, Proteomics Division, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Heart Circ Physiol 297:H144-52. 2009
  3. pmc Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production
    Andreas N Kavazis
    Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 46:842-50. 2009
  4. doi request reprint Endurance exercise attenuates ventilator-induced diaphragm dysfunction
    Ashley J Smuder
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA
    J Appl Physiol (1985) 112:501-10. 2012
  5. ncbi request reprint Diaphragmatic proteasome function is maintained in the ageing Fisher 344 rat
    Andreas N Kavazis
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Exp Physiol 92:895-901. 2007
  6. doi request reprint Exercise protects cardiac mitochondria against ischemia-reperfusion injury
    Youngil Lee
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Med Sci Sports Exerc 44:397-405. 2012
  7. doi request reprint Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Crit Care Med 39:1749-59. 2011
  8. pmc Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation
    Joseph M McClung
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL, USA
    Crit Care Med 37:1373-9. 2009
  9. doi request reprint Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle
    Ashley J Smuder
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida, USA
    J Appl Physiol (1985) 111:1190-8. 2011
  10. pmc Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy
    Kisuk Min
    Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
    J Appl Physiol (1985) 111:1459-66. 2011

Collaborators

Detail Information

Publications31

  1. doi request reprint Exercise preconditioning of the myocardium
    Andreas N Kavazis
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Sports Med 39:923-35. 2009
    ..Finally, in hopes of stimulating debate and future research, this review concludes with a discussion of unanswered questions related to exercise-induced cardioprotection...
  2. pmc Exercise training induces a cardioprotective phenotype and alterations in cardiac subsarcolemmal and intermyofibrillar mitochondrial proteins
    Andreas N Kavazis
    Applied Physiology and Kinesiology, Proteomics Division, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Heart Circ Physiol 297:H144-52. 2009
    ..Importantly, based on our findings, pharmacological or other interventions could be used to develop a strategy of protecting the myocardium during an ischemic attack...
  3. pmc Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production
    Andreas N Kavazis
    Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 46:842-50. 2009
    ..In conclusion, these results are consistent with the concept that diaphragmatic inactivity promotes an increase in mitochondrial ROS emission, mitochondrial oxidative damage, and mitochondrial respiratory dysfunction...
  4. doi request reprint Endurance exercise attenuates ventilator-induced diaphragm dysfunction
    Ashley J Smuder
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA
    J Appl Physiol (1985) 112:501-10. 2012
    ..These findings are important and establish the need for future experiments to determine the mechanism(s) responsible for exercise-induced diaphragm protection...
  5. ncbi request reprint Diaphragmatic proteasome function is maintained in the ageing Fisher 344 rat
    Andreas N Kavazis
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Exp Physiol 92:895-901. 2007
    ....
  6. doi request reprint Exercise protects cardiac mitochondria against ischemia-reperfusion injury
    Youngil Lee
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Med Sci Sports Exerc 44:397-405. 2012
    ....
  7. doi request reprint Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Crit Care Med 39:1749-59. 2011
    ..Therefore, identifying the site(s) of mechanical ventilation- induced reactive oxygen species production in the diaphragm is important...
  8. pmc Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation
    Joseph M McClung
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL, USA
    Crit Care Med 37:1373-9. 2009
    ..To investigate whether apocynin protects the diaphragm from wasting and oxidative stress during mechanical ventilation (MV)...
  9. doi request reprint Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle
    Ashley J Smuder
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida, USA
    J Appl Physiol (1985) 111:1190-8. 2011
    ..Collectively, our findings indicate that DOX administration increases the expression of autophagy genes in skeletal muscle, and that exercise can protect skeletal muscle against DOX-induced activation of autophagy...
  10. pmc Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy
    Kisuk Min
    Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
    J Appl Physiol (1985) 111:1459-66. 2011
    ....
  11. ncbi request reprint Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuli
    Andreas N Kavazis
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Heart Circ Physiol 294:H928-35. 2008
    ..Furthermore, these results are consistent with the concept that exercise-induced mitochondrial adaptations contribute to exercise-induced cardioprotection...
  12. doi request reprint Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 44:193-201. 2008
    ..Understanding the molecular basis for exercise-induced cardioprotection will provide the required knowledge base to develop therapeutic approaches to protect the heart during an IR insult...
  13. pmc Mechanical ventilation-induced oxidative stress in the diaphragm: role of heme oxygenase-1
    Darin J Falk
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Chest 139:816-24. 2011
    ..We tested the hypothesis that HO-1 acts as a pro-oxidant in the diaphragm during prolonged MV...
  14. ncbi request reprint Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise
    Keith C DeRuisseau
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Antioxid Redox Signal 8:539-47. 2006
    ..085). In summary, although CR elevated the mRNA of key antioxidant enzymes in the diaphragm, lifelong CR alone or in combination with voluntary exercise did not alter diaphragm CS activity, antioxidant protein quantity, or GSH levels...
  15. pmc Experimental guidelines for studies designed to investigate the impact of antioxidant supplementation on exercise performance
    Scott K Powers
    Dept of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Int J Sport Nutr Exerc Metab 20:2-14. 2010
    ....
  16. pmc Oxidation enhances myofibrillar protein degradation via calpain and caspase-3
    Ashley J Smuder
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 49:1152-60. 2010
    ..These findings provide a mechanistic link connecting oxidative stress with accelerated myofibrillar proteolysis during disuse muscle atrophy...
  17. pmc Prolonged mechanical ventilation alters diaphragmatic structure and function
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Crit Care Med 37:S347-53. 2009
    ..To review current knowledge about the impact of prolonged mechanical ventilation on diaphragmatic function and biology...
  18. pmc Nuclear factor-κB signaling contributes to mechanical ventilation-induced diaphragm weakness*
    Ashley J Smuder
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL, USA
    Crit Care Med 40:927-34. 2012
    ..We tested the hypothesis that nuclear factor-κB activation plays a key signaling role in mechanical ventilation-induced diaphragmatic weakness and that oxidative stress is required for nuclear factor-κB activation...
  19. pmc Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72
    Andreas N Kavazis
    Applied Physiology and Kinesiology, University of Florida, USA
    Am J Physiol Heart Circ Physiol 299:H1515-24. 2010
    ..Finally, our data are consistent with the concept that increases in cardiac mitochondrial antioxidant enzymes may contribute to exercise-induced cardioprotection...
  20. pmc Reactive oxygen species are signalling molecules for skeletal muscle adaptation
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, FL 32611, USA
    Exp Physiol 95:1-9. 2010
    ..e. exercise training) and during prolonged periods of muscular inactivity (i.e. immobilization). In an effort to stimulate further research, we conclude with a discussion of unanswered questions about redox signalling in skeletal muscle...
  21. pmc Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophy
    Joseph M McClung
    Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, FL 32611, USA
    Am J Respir Crit Care Med 175:150-9. 2007
    ..Unloading the diaphragm via mechanical ventilation (MV) results in rapid diaphragmatic fiber atrophy. It is unknown whether the myonuclear domain (cytoplasmic myofiber volume/myonucleus) of diaphragm myofibers is altered during MV...
  22. pmc Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle
    Ashley J Smuder
    Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
    J Appl Physiol (1985) 110:935-42. 2011
    ..Together, these novel results demonstrate that muscular exercise is a useful countermeasure that can protect skeletal muscle against Dox treatment-induced oxidative stress and protease activation in skeletal muscles...
  23. ncbi request reprint Selective downregulation of ubiquitin conjugation cascade mRNA occurs in the senescent rat soleus muscle
    Keith C DeRuisseau
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Exp Gerontol 40:526-31. 2005
    ..Furthermore, the decline in E2(14k) and MuRF1 mRNA levels may contribute to altered substrate degradation by the UCC in the soleus muscle of senescent rats...
  24. doi request reprint Reactive oxygen species: impact on skeletal muscle
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA
    Compr Physiol 1:941-69. 2011
    ..Ongoing research continues to explore the redox-sensitive targets in muscle that are responsible for both redox regulation of muscle adaptation and oxidant-mediated muscle fatigue...
  25. ncbi request reprint Mechanisms of disuse muscle atrophy: role of oxidative stress
    Scott K Powers
    Department of Applied Physiology and Kinesiology, PO Box 118225, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Regul Integr Comp Physiol 288:R337-44. 2005
    ..By discussing unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field...
  26. ncbi request reprint Oxidative stress and disuse muscle atrophy
    Scott K Powers
    Department of Applied Physiology and Kinesiology, PO Box 118205, University of Florida, Gainesville, FL 32611, USA
    J Appl Physiol (1985) 102:2389-97. 2007
    ..By presenting unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field...
  27. doi request reprint Mechanisms of exercise-induced cardioprotection
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida and
    Physiology (Bethesda) 29:27-38. 2014
    ..This review summarizes the development of exercise-induced cardioprotection and the mechanisms responsible for this important adaptive response. ..
  28. doi request reprint Doxorubicin-induced markers of myocardial autophagic signaling in sedentary and exercise trained animals
    Ashley J Smuder
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA
    J Appl Physiol (1985) 115:176-85. 2013
    ....
  29. pmc Nitric oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cells
    Vitor A Lira
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    J Physiol 588:3551-66. 2010
    ..Further, this study supports a proposed model of synergistic interaction between AMPK and NOS that is critical for maintenance of metabolic function in skeletal muscle cells...
  30. ncbi request reprint Ischemia-reperfusion-induced cardiac injury: a brief review
    Scott K Powers
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    Med Sci Sports Exerc 39:1529-36. 2007
    ..Finally, in hopes of stimulating future research, this review will also identify important gaps in our knowledge of IR-induced myocardial injury...
  31. ncbi request reprint Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm
    Keith C DeRuisseau
    Center for Exercise Science, Univ of Florida, Rm 25 FLG, Gainesville, FL 32611, USA
    J Appl Physiol 98:1314-21. 2005
    ....