Research Topics
| Andreas N KavazisSummaryAffiliation: University of Florida Country: USA Publications
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Detail Information
Publications
Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant productionAndreas N Kavazis
Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Free Radic Biol Med 46:842-50. 2009..In conclusion, these results are consistent with the concept that diaphragmatic inactivity promotes an increase in mitochondrial ROS emission, mitochondrial oxidative damage, and mitochondrial respiratory dysfunction...
Exercise preconditioning of the myocardiumAndreas N Kavazis
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
Sports Med 39:923-35. 2009..Finally, in hopes of stimulating debate and future research, this review concludes with a discussion of unanswered questions related to exercise-induced cardioprotection...- Exercise training induces a cardioprotective phenotype and alterations in cardiac subsarcolemmal and intermyofibrillar mitochondrial proteinsAndreas N Kavazis
Applied Physiology and Kinesiology, Proteomics Division, University of Florida, Gainesville, FL 32611, USA
Am J Physiol Heart Circ Physiol 297:H144-52. 2009..Importantly, based on our findings, pharmacological or other interventions could be used to develop a strategy of protecting the myocardium during an ischemic attack... - Endurance exercise attenuates ventilator-induced diaphragm dysfunctionAshley J Smuder
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA
J Appl Physiol 112:501-10. 2012..These findings are important and establish the need for future experiments to determine the mechanism(s) responsible for exercise-induced diaphragm protection... 
Diaphragmatic proteasome function is maintained in the ageing Fisher 344 ratAndreas N Kavazis
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Exp Physiol 92:895-901. 2007....- Exercise protects cardiac mitochondria against ischemia-reperfusion injuryYoungil Lee
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Med Sci Sports Exerc 44:397-405. 2012.... - Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weaknessScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
Crit Care Med 39:1749-59. 2011..Therefore, identifying the site(s) of mechanical ventilation- induced reactive oxygen species production in the diaphragm is important... - Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilationJoseph M McClung
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL, USA
Crit Care Med 37:1373-9. 2009..To investigate whether apocynin protects the diaphragm from wasting and oxidative stress during mechanical ventilation (MV)... - Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscleAshley J Smuder
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida, USA
J Appl Physiol 111:1190-8. 2011..Collectively, our findings indicate that DOX administration increases the expression of autophagy genes in skeletal muscle, and that exercise can protect skeletal muscle against DOX-induced activation of autophagy... - Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophyKisuk Min
Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
J Appl Physiol 111:1459-66. 2011.... - Exercise-induced cardioprotection against myocardial ischemia-reperfusion injuryScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Free Radic Biol Med 44:193-201. 2008..Understanding the molecular basis for exercise-induced cardioprotection will provide the required knowledge base to develop therapeutic approaches to protect the heart during an IR insult... - Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuliAndreas N Kavazis
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Am J Physiol Heart Circ Physiol 294:H928-35. 2008..Furthermore, these results are consistent with the concept that exercise-induced mitochondrial adaptations contribute to exercise-induced cardioprotection... - Oxidation enhances myofibrillar protein degradation via calpain and caspase-3Ashley J Smuder
Center for Exercise Science, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Free Radic Biol Med 49:1152-60. 2010..These findings provide a mechanistic link connecting oxidative stress with accelerated myofibrillar proteolysis during disuse muscle atrophy... - Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exerciseKeith C DeRuisseau
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
Antioxid Redox Signal 8:539-47. 2006..085). In summary, although CR elevated the mRNA of key antioxidant enzymes in the diaphragm, lifelong CR alone or in combination with voluntary exercise did not alter diaphragm CS activity, antioxidant protein quantity, or GSH levels... - Mechanical ventilation-induced oxidative stress in the diaphragm: role of heme oxygenase-1Darin J Falk
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
Chest 139:816-24. 2011..We tested the hypothesis that HO-1 acts as a pro-oxidant in the diaphragm during prolonged MV... - Experimental guidelines for studies designed to investigate the impact of antioxidant supplementation on exercise performanceScott K Powers
Dept of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
Int J Sport Nutr Exerc Metab 20:2-14. 2010.... - Prolonged mechanical ventilation alters diaphragmatic structure and functionScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
Crit Care Med 37:S347-53. 2009..To review current knowledge about the impact of prolonged mechanical ventilation on diaphragmatic function and biology... - Nuclear factor-κB signaling contributes to mechanical ventilation-induced diaphragm weakness*Ashley J Smuder
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL, USA
Crit Care Med 40:927-34. 2012..We tested the hypothesis that nuclear factor-κB activation plays a key signaling role in mechanical ventilation-induced diaphragmatic weakness and that oxidative stress is required for nuclear factor-κB activation... - Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72Andreas N Kavazis
Applied Physiology and Kinesiology, University of Florida, USA
Am J Physiol Heart Circ Physiol 299:H1515-24. 2010..Finally, our data are consistent with the concept that increases in cardiac mitochondrial antioxidant enzymes may contribute to exercise-induced cardioprotection... - Reactive oxygen species are signalling molecules for skeletal muscle adaptationScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, FL 32611, USA
Exp Physiol 95:1-9. 2010..e. exercise training) and during prolonged periods of muscular inactivity (i.e. immobilization). In an effort to stimulate further research, we conclude with a discussion of unanswered questions about redox signalling in skeletal muscle... - Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophyJoseph M McClung
Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, FL 32611, USA
Am J Respir Crit Care Med 175:150-9. 2007..Unloading the diaphragm via mechanical ventilation (MV) results in rapid diaphragmatic fiber atrophy. It is unknown whether the myonuclear domain (cytoplasmic myofiber volume/myonucleus) of diaphragm myofibers is altered during MV... - Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscleAshley J Smuder
Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
J Appl Physiol 110:935-42. 2011..Together, these novel results demonstrate that muscular exercise is a useful countermeasure that can protect skeletal muscle against Dox treatment-induced oxidative stress and protease activation in skeletal muscles... - Selective downregulation of ubiquitin conjugation cascade mRNA occurs in the senescent rat soleus muscleKeith C DeRuisseau
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Exp Gerontol 40:526-31. 2005..Furthermore, the decline in E2(14k) and MuRF1 mRNA levels may contribute to altered substrate degradation by the UCC in the soleus muscle of senescent rats... - Oxidative stress and disuse muscle atrophyScott K Powers
Department of Applied Physiology and Kinesiology, PO Box 118205, University of Florida, Gainesville, FL 32611, USA
J Appl Physiol 102:2389-97. 2007..By presenting unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field... - Mechanisms of disuse muscle atrophy: role of oxidative stressScott K Powers
Department of Applied Physiology and Kinesiology, PO Box 118225, University of Florida, Gainesville, FL 32611, USA
Am J Physiol Regul Integr Comp Physiol 288:R337-44. 2005..By discussing unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field... - Nitric oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cellsVitor A Lira
Center for Exercise Science, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
J Physiol 588:3551-66. 2010..Further, this study supports a proposed model of synergistic interaction between AMPK and NOS that is critical for maintenance of metabolic function in skeletal muscle cells... - Ischemia-reperfusion-induced cardiac injury: a brief reviewScott K Powers
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
Med Sci Sports Exerc 39:1529-36. 2007..Finally, in hopes of stimulating future research, this review will also identify important gaps in our knowledge of IR-induced myocardial injury... - Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragmKeith C DeRuisseau
Center for Exercise Science, Univ. of Florida, Rm 25 FLG, Gainesville, FL 32611, USA
J Appl Physiol 98:1314-21. 2005....