Research Topics
| Brian KavanaghSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Detail Information
Publications
Interim analysis of a prospective phase I/II trial of SBRT for liver metastasesBrian D Kavanagh
Department of Radiation Oncology, University of Colorado, Aurora, Colorado 80045, USA
Acta Oncol 45:848-55. 2006..This interim analysis indicates that a very high rate of durable in-field tumor control can be safely achieved with SBRT to 1-3 liver lesions as administered in this protocol, to a prescription dose of 60 Gy in 3 fractions...- The dosimetric effect of inhomogeneity correction in dynamic conformal arc stereotactic body radiation therapy for lung tumorsBrian D Kavanagh
Department of Radiation Oncology, University of Colorado, Aurora, Colorado, USA
J Appl Clin Med Phys 7:58-63. 2006..In reports of SBRT, it will be helpful to maintain clear communication about the type of IC used to avoid future uncertainties about true normal tissue tolerance and tumor dose-response relationships... - Clinical application of intensity-modulated radiotherapy for locally advanced cervical cancerBrian D Kavanagh
Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80010 0510, USA
Semin Radiat Oncol 12:260-71. 2002.... - How should we describe the radioblologic effect of extracranial stereotactic radlosurgery: equivalent uniform dose or tumor control probability?B D Kavanagh
Department of Radiation Oncology, University of Colorado Health Sciences Centers, Aurora, Colorado 80010 0510, USA
Med Phys 30:321-4. 2003..While EUD appears more robust for the prospective description of ESR, TCP is expected to remain more valuable for a post hoc estimation of radiosensitivity parameters... - Stereotactic radiosurgery and stereotactic body radiation therapy: an overview of technical considerations and clinical applicationsBrian D Kavanagh
Department of Radiation Oncology, University of Colorado Comprehensive Cancer Center, 1665 North Ursula Street, Aurora, CO 80045, USA
Hematol Oncol Clin North Am 20:87-95. 2006..It will be especially interesting to investigate how SRS and SBRT might best be combined with new molecularly targeted systemic agents as the field of oncology progresses through the twenty-first century... - The promise of stereotactic body radiation therapy in a new era of oncologyBrian D Kavanagh
University of Colorado Comprehensive Cancer Center, Aurora, CO, USA
Front Radiat Ther Oncol 40:340-51. 2007..Here, the history of SBRT is briefly reviewed, and a projection of the anticipated role of SBRT within the context of multimodality cancer treatment regimens of the future is presented... 
Clinical experience shows that catastrophic late effects associated with ablative fractionation can be avoided by technological innovationBrian Kavanagh
Department of Radiation Oncology, University of Colorado Denver, Aurora, CO 80045, USA
Semin Radiat Oncol 18:223-8. 2008..Furthermore, until the cancer problem is solved once and for all, it is the obligation of the radiation oncology community to continue to pursue new means to improve on results of the past...- Liver, renal, and retroperitoneal tumors: stereotactic radiotherapyBrian D Kavanagh
Department of Radiation Oncology, University of Colorado Comprehensive Cancer Center, Aurora, CO 80045, USA
Front Radiat Ther Oncol 40:415-26. 2007.... - Outcomes and effect of radiotherapy in patients with stage I or II diffuse large B-cell lymphoma: a surveillance, epidemiology, and end results analysisAri Ballonoff
Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO, USA
Int J Radiat Oncol Biol Phys 72:1465-71. 2008..To assess disease-specific survival (DSS), overall survival (OS), and the effect of radiotherapy (RT) in patients with localized diffuse large B-cell lymphoma (DLBCL)... - Regional normal lung tissue density changes in patients treated with stereotactic body radiation therapy for lung tumorsQuentin Diot
Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado Electronic address
Int J Radiat Oncol Biol Phys 84:1024-30. 2012..To describe regional lung tissue density changes in normal lung tissue of patients with primary and metastatic lung tumors who received stereotactic body radiation therapy (SBRT)... - Dosimetric and deformation effects of image-guided interventions during stereotactic body radiation therapy of the prostate using an endorectal balloonBernard L Jones
Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Med Phys 39:3080-8. 2012..This work assessed the dosimetric impact of manual interventions on ERB position in patients receiving prostate SBRT and investigated the impact of ERB interventions on prostate shape... - Dosimetric effect of online image-guided anatomical interventions for postprostatectomy cancer patientsQuentin Diot
Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Int J Radiat Oncol Biol Phys 79:623-32. 2011..To assess daily variations in delivered doses in postprostatectomy patients, using kilovoltage cone-beam CT (CBCT) datasets acquired before and after interventions to correct for observed distortions in volume/shape of rectum and bladder... - Impact of induction chemotherapy on estimated risk of radiation pneumonitis in small cell lung cancerNeha P Amin
Departments of Radiation Oncology, University of Colorado, School of Medicine, Aurora, Colorado, USA
J Thorac Oncol 6:1553-62. 2011..This study compared radiation therapy (RT) plans based on pre- and postchemotherapy computed tomography (CT) scans of patients with SCLC to estimate the reduced risk of radiation pneumonitis (RP) after receiving chemotherapy... - Biological-based optimization and volumetric modulated arc therapy delivery for stereotactic body radiation therapyQuentin Diot
Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
Med Phys 39:237-45. 2012.... - Observation of a dose-control relationship for lung and liver tumors after stereotactic body radiation therapyRobert McCammon
Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO, USA
Int J Radiat Oncol Biol Phys 73:112-8. 2009..To determine prognostic factors for local control of primary or metastatic tumors within the lung or liver treated with stereotactic body radiation therapy (SBRT) within a single institution... - Cardiac mortality in patients with stage I and II diffuse large B-cell lymphoma treated with and without radiation: a surveillance, epidemiology, and end-results analysisThomas J Pugh
Department of Radiation Oncology, University of Colorado Comprehensive Cancer Center, Colorado, USA
Int J Radiat Oncol Biol Phys 76:845-9. 2010..We hypothesize that patients treated without RT, i.e., those who are treated with greater total chemotherapy cycles and hence cumulative anthracycline exposure, are at increased risk of cardiac mortality... - Impact of anatomical interventions on the localization of post-prostatectomy cancer patientsQuentin Diot
Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado 80045, USA
Med Phys 37:629-37. 2010..In this work, the impact of anatomical interventions on the localization data from post-prostatectomy patients who received image-guided IMRT was analyzed... - Preoperative capecitabine and accelerated intensity-modulated radiotherapy in locally advanced rectal cancer: a phase II trialAri Ballonoff
Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045 0508, USA
Am J Clin Oncol 31:264-70. 2008.... - Stereotactic ablative radiation therapy for primary lung tumorsJohn H Heinzerling
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cancer J 17:28-32. 2011.... - Visual sensations during megavoltage radiotherapy to the orbit attributable to Cherenkov radiationFrancis Newman
Department of Radiation Oncology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
Med Phys 35:77-80. 2008..001 s. A single 500 keV electron traversing 1 mm of water will induce nearly 15 Cherenkov visible range photons. We propose that a portal image involving the eye will produce sufficient Cherenkov radiation to be detected by the retina... - Toxicity assessment of pelvic intensity-modulated radiotherapy with hypofractionated simultaneous integrated boost to prostate for intermediate- and high-risk prostate cancerRobert McCammon
Department of Radiation Oncology, University of Colorado Denver, Aurora, CO 80045 0508, USA
Int J Radiat Oncol Biol Phys 75:413-20. 2009..To evaluate the toxicity of pelvic intensity-modulated radiotherapy (IMRT) with hypofractionated simultaneous integrated boost (SIB) to the prostate for patients with intermediate- to high-risk prostate cancer... - Hodgkin lymphoma-related vanishing bile duct syndrome and idiopathic cholestasis: statistical analysis of all published cases and literature reviewAri Ballonoff
Department of Radiation Oncology, University of Colorado, Comprehensive Cancer Center, Aurora, CO 80045 0510, USA
Acta Oncol 47:962-70. 2008..The available literature consists primarily of case reports, resulting in little clarity as to the clinical course and ideal treatment for this disease... - Prostate cancer in a man with multiple previous cancersThomas Flaig
University of Colorado, Health Sciences Center, Aurora, Colorado, USA
Oncology (Williston Park) 21:611-4. 2007 - Microscopic and macroscopic tumor and parenchymal effects of liver stereotactic body radiotherapyC C Olsen
Department of Radiation Oncology, University of Colorado, Denver, Aurora, CO 80045 000508, USA
Int J Radiat Oncol Biol Phys 73:1414-24. 2009..To describe the histologic and volumetric changes in normal liver tissue after stereotactic body radiotherapy (SBRT) for liver metastases... - Long-term local control and survival after concomitant boost accelerated radiotherapy for locally advanced cervix cancerB D Kavanagh
Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University Richmond 23298-0058, USA
Am J Clin Oncol 24:113-9. 2001.... - A phase I study of RSR13, a radiation-enhancing hemoglobin modifier: tolerance of repeated intravenous doses and correlation of pharmacokinetics with pharmacodynamicsB D Kavanagh
Department of Radiation Oncology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0058, USA
Int J Radiat Oncol Biol Phys 49:1133-9. 2001.... - Gynecologic brachytherapy: digital fluoroscopy for placement verification and treatment planningB D Kavanagh
Department of Radiation Oncology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0058, USA
Radiology 215:900-3. 2000..Intraoperative digital fluoroscopy can facilitate both placement verification and dosimetric planning for gynecologic brachytherapy... 
RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H miceS R Khandelwal
Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
Br J Cancer 79:814-20. 1999..Additional preclinical experimentation is needed to define better the optimum dose-scheduling conditions for clinical applications...- Toward a unified survival curve: in regard to Park et al. (IntJ Radiat Oncol Biol Phys 2008;70:847-852) and Krueger et al. (Int J Radiat Oncol Biol Phys 2007;69:1262-1271)Brian D Kavanagh
Int J Radiat Oncol Biol Phys 71:958-9. 2008 - Technical considerations in the application of intensity-modulated radiotherapy as a concomitant integrated boost for locally-advanced cervix cancerTracey E Schefter
Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora 80010 0510, USA
Med Dosim 27:177-84. 2002..This is especially relevant to the possible introduction of intrafractional movement and resulting inaccuracy, as well as facility efficiency... - A phase I dose-escalation study of fractionated stereotactic radiosurgery in combination with gefitinib in patients with recurrent malignant gliomasAmanda L Schwer
Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045 0508, USA
Int J Radiat Oncol Biol Phys 70:993-1001. 2008..To determine the maximum tolerated dose (MTD) of fractionated stereotactic radiosurgery (SRS) with gefitinib in patients with recurrent malignant gliomas... - The effect of high-dose-rate brachytherapy dwell sequence on cell survivalMark R Arnfield
Department of Radiation Oncology, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298, USA
Int J Radiat Oncol Biol Phys 52:850-7. 2002..We investigated the possible effects of the sequence in which dose is delivered at two different dose rates, representative of dose rates that occur during an HDR treatment... - Stereotactic body radiation therapyRobert D Timmerman
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Curr Probl Cancer 29:120-57. 2005 - Stereotactic body radiation therapy. Rationale, techniques, applications, and optimizationDanny Y Song
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
Oncology (Williston Park) 18:1419-30; discussion 1430, 1432, 1435-6. 2004..This article provides an overview of the rationale and results of SBRT for specific indications, descriptions of some methods of treatment delivery, and discussion of potential areas of future investigation... - Extracranial radiosurgery (stereotactic body radiation therapy) for oligometastasesBrian D Kavanagh
Department of Radiation Oncology, University of Colorado Comprehensive Cancer Center, Aurora, CO, USA
Semin Radiat Oncol 16:77-84. 2006..With proper conduct though, SBRT can be an extremely effective treatment option for oligometastases... - The emperor's new isodose curvesBrian D Kavanagh
Med Phys 30:2559-60. 2003 - Partial breast brachytherapy after lumpectomy: low-dose-rate and high-dose-rate experienceDouglas W Arthur
Department of Radiation Oncology, Virginia Commonwealth University Medical College of Virginia Campus, Richmond, VA, USA
Int J Radiat Oncol Biol Phys 56:681-9. 2003..In a cohort of patients who received low-dose-rate (LDR) or high-dose-rate (HDR) PBB after lumpectomy, the clinical characteristics and treatment parameters were analyzed to identify predictors for an unfavorable cosmetic outcome... - Stereotactic body radiation therapy in multiple organ sitesRobert D Timmerman
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9183, USA
J Clin Oncol 25:947-52. 2007..Stereotactic body radiation therapy (SBRT) uses advanced technology to deliver a potent ablative dose to deep-seated tumors in the lung, liver, spine, pancreas, kidney, and prostate... - Dose as a function of liver volume and planning target volume in helical tomotherapy, intensity-modulated radiation therapy-based stereotactic body radiation therapy for hepatic metastasisJoseph M Baisden
Department of Radiation Oncology, Medical School, University of Virginia Health System, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 66:620-5. 2006..CONCLUSIONS: These data provide a framework for predicting the likely MTD for patients considered for Helical TomoTherapy liver SBRT... - A phase I trial of stereotactic body radiation therapy (SBRT) for liver metastasesTracey E Schefter
Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045 0510, USA
Int J Radiat Oncol Biol Phys 62:1371-8. 2005..To determine the maximum tolerated dose (MTD) of stereotactic body radiation therapy (SBRT) for liver metastases... - The effects of pentoxifylline on the survival of human glioma cells with continuous and intermittent stereotactic radiosurgery irradiationKerry W Eley
Department of Radiation Oncology, Medical College of Virginia Hospitals of Virginia Commonwealth University, Richmond, VA 23298 0058, USA
Int J Radiat Oncol Biol Phys 54:542-50. 2002.... - A theoretical model for the effects of reduced hemoglobin-oxygen affinity on tumor oxygenationBrian D Kavanagh
Department of Radiation Oncology, University of Colorado Health Sciences Center, Denver, CO, USA
Int J Radiat Oncol Biol Phys 53:172-9. 2002..CONCLUSIONS: The results support the administration of synthetic agents to increase P(50) during radiation treatment of tumors... - Short-term tumor control and acute toxicity after stereotactic radiosurgery for glomus jugulare tumorsSheri A Poznanovic
Department of Otolaryngology Head and Neck Surgery, University of Colorado School of Medicine, 4200 E 9th Avenue, Box B 205, Denver, CO 80262, USA
Otolaryngol Head Neck Surg 134:437-42. 2006..This study evaluates acute toxicity and short-term efficacy of single-fraction stereotactic radiosurgery (SRS) for the treatment of GJT... - Toward a unified target theory in oncologyBrian D Kavanagh
Future Oncol 2:435-6. 2006 - The role of alpha-blockers in the management of lower urinary tract symptoms in prostate cancer patients treated with radiation therapyE David Crawford
Department of Urologic Oncology, University of Colorado Health Sciences Center, Aurora, CO 80010, USA
Am J Clin Oncol 29:517-23. 2006.... - The North American experience with stereotactic body radiation therapy in non-small cell lung cancerRobert D Timmerman
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9183, USA
J Thorac Oncol 2:S101-12. 2007..In North America, the majority of prospective investigation using stereotactic body radiation therapy (SBRT) for thoracic targets has been carried out treating medically inoperable patients with non-small cell lung cancer... - Stereotactic body radiation therapy: a new paradigm in radiotherapy management of cancerTimothy D Solberg
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Am Coll Radiol 5:673-7. 2008 - Lung cancer: a model for implementing stereotactic body radiation therapy into practiceRobert Timmerman
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9183, USA
Front Radiat Ther Oncol 40:368-85. 2007..While mechanisms of this injury remain elusive, ongoing prospective trials offer the hope of finding the ideal application for SBRT in treating pulmonary targets...