Research Topics
Genomes and Genes | EGE KAVALALISummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and functionMohd W Akhtar
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Neurosci 29:8288-97. 2009..Therefore, we propose that HDAC1 and HDAC2 form a developmental switch that controls synapse maturation and function acting in a manner dependent on the maturational states of neuronal networks...
Synaptic mechanisms underlying rapid antidepressant action of ketamineEge T Kavalali
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, USA
Am J Psychiatry 169:1150-6. 2012....- Synaptic vesicle reuse and its implicationsEge T Kavalali
Center for Basic Neuroscience and Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, 75390 9111, USA
Neuroscientist 12:57-66. 2006..Therefore, elucidation of the mechanisms that underlie the synaptic vesicle cycle may reveal novel therapeutic targets for brain disorders... - SNARE interactions in membrane trafficking: a perspective from mammalian central synapsesEge T Kavalali
Center for Basic Neuroscience and Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75390 9111, USA
Bioessays 24:926-36. 2002..Such analysis can provide a molecular basis for synaptic processes including certain forms of short-term synaptic plasticity... 
Spontaneous neurotransmission: an independent pathway for neuronal signaling?Ege T Kavalali
Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas, USA
Physiology (Bethesda) 26:45-53. 2011..This article will examine the role of spontaneous release events in neuronal signaling by focusing on aspects that distinguish this process from evoked neurotransmission, and evaluate the mechanisms that may underlie this segregation...- Multiple vesicle recycling pathways in central synapses and their impact on neurotransmissionEge T Kavalali
Department of Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
J Physiol 585:669-79. 2007..Moreover, our studies showed that synaptic vesicle reuse is a highly plastic process as it varies widely among synapses and can adapt to changes in chronic activity levels... - An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmissionYildirim Sara
Center for Basic Neuroscience, Department of Physiology, The University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA
Neuron 45:563-73. 2005..Taken together these results suggest that spontaneously recycling vesicles and activity-dependent recycling vesicles originate from distinct pools with limited cross-talk with each other... - Fast vesicle recycling supports neurotransmission during sustained stimulation at hippocampal synapsesYildirim Sara
Center for Basic Neuroscience and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111, USA
J Neurosci 22:1608-17. 2002..These results suggest a role for fast vesicle recycling as a functional homeostatic mechanism that prevents vesicle depletion and maintains synaptic responses in the face of intense stimulation... - Selective capability of SynCAM and neuroligin for functional synapse assemblyYildirim Sara
Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Neurosci 25:260-70. 2005..These results suggest that both NL1 and SynCAM act similarly and specifically in artificial synapse induction but that this process does not reflect a shared physiological function of these molecules... - Structural determinants of synaptobrevin 2 function in synaptic vesicle fusionFerenc Deak
Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Neurosci 26:6668-76. 2006..Furthermore, the fusion reactions underlying evoked and spontaneous release differ mechanistically... - Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2Alexander A Chubykin
Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
Neuron 54:919-31. 2007..This hypothesis reconciles the overexpression and knockout phenotypes and suggests that neuroligins contribute to the use-dependent formation of neural circuits... - Minimum essential factors required for vesicle mobilization at hippocampal synapsesMarina G Mozhayeva
Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111, USA
J Neurosci 24:1680-8. 2004..These results suggest that in hippocampal synapses, vesicle mobilization and replenishment of the readily releasable pool require GTP and Ca2+ but do not necessitate ATP-dependent priming and SNARE recycling... - Reelin signaling antagonizes beta-amyloid at the synapseMurat S Durakoglugil
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 106:15938-43. 2009..We propose a model in which Abeta, Reelin, and ApoE receptors modulate neurotransmission and thus synaptic stability as opposing regulators of synaptic gain control... - Molecular substrates mediating lanthanide-evoked neurotransmitter release in central synapsesChiHye Chung
Department of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
J Neurophysiol 100:2089-100. 2008..For the delayed action, La3+ may act intracellularly after its entry or through intracellular Ca2+ via a mechanism that does not require synaptobrevin-2... - Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machineryFerenc Deak
Department of Neuroscience and Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Neurosci 29:8639-48. 2009.... - Rett syndrome and the impact of MeCP2 associated transcriptional mechanisms on neurotransmissionLisa M Monteggia
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Biol Psychiatry 65:204-10. 2009..In addition, this work will also help delineate a key pathway that regulates properties of neurotransmission in the central nervous system that may underlie additional neuropsychiatric disorders... - Synaptic vesicle endocytosis: get two for the price of one?ChiHye Chung
Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
Neuron 61:333-4. 2009..In this issue of Neuron, Zhu et al. reveal a surprising facet of this coupling by showing that, at low frequencies, fusion of a single vesicle leads to retrieval of two vesicles with dissimilar attributes... - TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapsesBryan W Luikart
Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
J Neurosci 25:3774-86. 2005..We conclude that TrkB signaling has a cell-autonomous role required for normal development of both presynaptic and postsynaptic components of the Schaffer collateral synapse... - Deletion of CASK in mice is lethal and impairs synaptic functionDeniz Atasoy
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
Proc Natl Acad Sci U S A 104:2525-30. 2007.... - Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusionFerenc Deak
Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
EMBO J 25:2856-66. 2006.... - SynCAM, a synaptic adhesion molecule that drives synapse assemblyThomas Biederer
Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 297:1525-31. 2002.... - Phorbol esters target the activity-dependent recycling pool and spare spontaneous vesicle recyclingTuhin Virmani
Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111, USA
J Neurosci 25:10922-9. 2005.... - Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmissionChiHye Chung
Departments of Neuroscience, Pharmacology, and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Neurosci 30:1363-76. 2010..This result lends additional support to the notion that synapses harbor distinct vesicle populations with divergent release properties that maintain independent forms of neurotransmission... - Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmissionPeter Bronk
Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Neurophysiol 98:794-806. 2007..Together, these results suggest that SNAP-25 has a more significant role in calcium-secretion coupling than synaptobrevin-2... - Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recyclingTuhin Virmani
Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
EMBO J 22:5347-57. 2003..These results suggest that alternative splicing of synaptotagmin 7 acts as a molecular switch, which targets vesicles to fast and slow recycling pathways... - Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recyclingCatherine R Wasser
Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
J Physiol 579:413-29. 2007..These results suggest that synaptic cholesterol balances evoked and spontaneous neurotransmission by hindering spontaneous synaptic vesicle turnover and sustaining evoked exo-endocytosis... - MeCP2-dependent transcriptional repression regulates excitatory neurotransmissionErika D Nelson
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390, USA
Curr Biol 16:710-6. 2006..Taken together, these results suggest a role for MeCP2 in control of excitatory presynaptic function through regulation of gene expression... - Activity-dependent augmentation of spontaneous neurotransmission during endoplasmic reticulum stressElena Nosyreva
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Neurosci 30:7358-68. 2010.... - Synaptic vesicle recycling adapts to chronic changes in activityTuhin Virmani
Center for Basic Neuroscience, Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111, USA
J Neurosci 26:2197-206. 2006..Furthermore, during these functional modifications, synapses use alternate strategies to adjust to changes in activity... - Development of vesicle pools during maturation of hippocampal synapsesMarina G Mozhayeva
Center for Basic Neuroscience and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111, USA
J Neurosci 22:654-65. 2002..Taken together, these results expose a mechanism that ensures functionally effective allocation of a limited number of vesicles in a CNS synapse... - Reelin modulates NMDA receptor activity in cortical neuronsYing Chen
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 25:8209-16. 2005..Thus, Reelin may physiologically modulate learning and memory by modulating NMDA receptor functions... - Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout miceTuhin Virmani
Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Neurobiol Dis 20:314-23. 2005..We conclude that from an early age, neurons deficient in PPT1 enzyme activity display intrinsically abnormal properties that could potentially explain key features of the clinical disease, such as myoclonus and seizures... - Dynamin-independent synaptic vesicle retrieval?HELMUT KRAMER
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
Nat Neurosci 11:6-8. 2008..A new study proposes that synaptic vesicle endocytosis at a large synaptic terminal is partly independent of dynamin and GTP hydrolysis, suggesting a new mechanism leading to vesicle fission and maintenance of neurotransmission... - Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylationErika D Nelson
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 28:395-406. 2008..These results uncover a means by which NMDA receptor-mediated synaptic activity drives DNA demethylation within mature neurons and suppresses basal synaptic function... - Fast synaptic vesicle reuse slows the rate of synaptic depression in the CA1 region of hippocampusMert Ertunc
Center for Basic Neuroscience and Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Neurosci 27:341-54. 2007..These results indicate that synaptic vesicle trafficking impacts the kinetics of short-term synaptic plasticity at an extremely rapid time scale... - Reciprocal interaction of serotonin and neuronal activity in regulation of cAMP-responsive element-dependent gene expressionMelissa A Mahgoub
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390-9070, USA
J Pharmacol Exp Ther 317:88-96. 2006..Taken together, these results suggest a reciprocal inhibitory interaction between neuronal activity and 5-HT in the regulation of cAMP response element-dependent gene expression in hippocampal neurons... - MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and functionAna C Barbosa
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
Proc Natl Acad Sci U S A 105:9391-6. 2008..We conclude that MEF2C limits excessive synapse formation during activity-dependent refinement of synaptic connectivity and thus facilitates hippocampal-dependent learning and memory... - Presynaptic unsilencing: searching for a mechanismDeniz Atasoy
Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Neuron 50:345-6. 2006..show that a brief burst of action potentials rapidly awaken silent synapses by increasing the availability of synaptic vesicles for fusion through BDNF-triggered presynaptic actin remodeling mediated by the small GTPase Cdc42... - Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapsesMeng Zhao
Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
J Neurophysiol 105:1506-15. 2011..Our data suggest that Cc2d1a is required for mouse survival and performs essential function in controlling functional maturation of synapses... - NMDA receptor activation by spontaneous glutamatergic neurotransmissionFelipe Espinosa
Dept of Neuroscience, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
J Neurophysiol 101:2290-6. 2009..Collectively these results indicate that NMDA receptors significantly contribute to signaling at rest in the absence of dendritic depolarizations or concomitant AMPA receptor activity... - Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathwayErika S Piedras-Renteria
Department of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305 5345, USA
Proc Natl Acad Sci U S A 101:3609-14. 2004..Changes in endocytotic proteins, signal transduction kinases, and candidates for Ca(2+)-sensing molecules were consistent with implications of the direct physiological experiments... - Seeking a function for spontaneous neurotransmissionChiHye Chung
Nat Neurosci 9:989-90. 2006 - Synaptobrevin is essential for fast synaptic-vesicle endocytosisFerenc Deak
Center for Basic Neuroscience, Howard Hughes Medical Institute, USA
Nat Cell Biol 6:1102-8. 2004..Thus, synaptobrevin is essential for two fast synapse-specific membrane trafficking reactions: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid reuse of synaptic vesicles...
Research Grants
- The role of vesicle recycling in synaptic depressionEGE KAVALALI; Fiscal Year: 2007..This information will also be critical for a better understanding of the pathologies underlying several neurological and psychiatric illnesses ranging from epilepsy to schizophrenia. ..
- Role of SNARE Interactions in Central Synapse FunctionEGE KAVALALI; Fiscal Year: 2007..abstract_text> ..
- Role of SNARE Interactions in Central Synapse FunctionEge T Kavalali; Fiscal Year: 2010....