EGE KAVALALI

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function
    Mohd W Akhtar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 29:8288-97. 2009
  2. ncbi request reprint Synaptic mechanisms underlying rapid antidepressant action of ketamine
    Ege T Kavalali
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Psychiatry 169:1150-6. 2012
  3. ncbi request reprint Synaptic vesicle reuse and its implications
    Ege T Kavalali
    Center for Basic Neuroscience and Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, 75390 9111, USA
    Neuroscientist 12:57-66. 2006
  4. ncbi request reprint SNARE interactions in membrane trafficking: a perspective from mammalian central synapses
    Ege T Kavalali
    Center for Basic Neuroscience and Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75390 9111, USA
    Bioessays 24:926-36. 2002
  5. doi request reprint Spontaneous neurotransmission: an independent pathway for neuronal signaling?
    Ege T Kavalali
    Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas, USA
    Physiology (Bethesda) 26:45-53. 2011
  6. pmc Multiple vesicle recycling pathways in central synapses and their impact on neurotransmission
    Ege T Kavalali
    Department of Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
    J Physiol 585:669-79. 2007
  7. ncbi request reprint An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission
    Yildirim Sara
    Center for Basic Neuroscience, Department of Physiology, The University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 45:563-73. 2005
  8. ncbi request reprint Fast vesicle recycling supports neurotransmission during sustained stimulation at hippocampal synapses
    Yildirim Sara
    Center for Basic Neuroscience and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 22:1608-17. 2002
  9. ncbi request reprint Selective capability of SynCAM and neuroligin for functional synapse assembly
    Yildirim Sara
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 25:260-70. 2005
  10. ncbi request reprint Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion
    Ferenc Deak
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 26:6668-76. 2006

Research Grants

Collaborators

Detail Information

Publications43

  1. pmc Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function
    Mohd W Akhtar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 29:8288-97. 2009
    ..Therefore, we propose that HDAC1 and HDAC2 form a developmental switch that controls synapse maturation and function acting in a manner dependent on the maturational states of neuronal networks...
  2. ncbi request reprint Synaptic mechanisms underlying rapid antidepressant action of ketamine
    Ege T Kavalali
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Psychiatry 169:1150-6. 2012
    ....
  3. ncbi request reprint Synaptic vesicle reuse and its implications
    Ege T Kavalali
    Center for Basic Neuroscience and Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, 75390 9111, USA
    Neuroscientist 12:57-66. 2006
    ..Therefore, elucidation of the mechanisms that underlie the synaptic vesicle cycle may reveal novel therapeutic targets for brain disorders...
  4. ncbi request reprint SNARE interactions in membrane trafficking: a perspective from mammalian central synapses
    Ege T Kavalali
    Center for Basic Neuroscience and Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75390 9111, USA
    Bioessays 24:926-36. 2002
    ..Such analysis can provide a molecular basis for synaptic processes including certain forms of short-term synaptic plasticity...
  5. doi request reprint Spontaneous neurotransmission: an independent pathway for neuronal signaling?
    Ege T Kavalali
    Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas, USA
    Physiology (Bethesda) 26:45-53. 2011
    ..This article will examine the role of spontaneous release events in neuronal signaling by focusing on aspects that distinguish this process from evoked neurotransmission, and evaluate the mechanisms that may underlie this segregation...
  6. pmc Multiple vesicle recycling pathways in central synapses and their impact on neurotransmission
    Ege T Kavalali
    Department of Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
    J Physiol 585:669-79. 2007
    ..Moreover, our studies showed that synaptic vesicle reuse is a highly plastic process as it varies widely among synapses and can adapt to changes in chronic activity levels...
  7. ncbi request reprint An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission
    Yildirim Sara
    Center for Basic Neuroscience, Department of Physiology, The University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 45:563-73. 2005
    ..Taken together these results suggest that spontaneously recycling vesicles and activity-dependent recycling vesicles originate from distinct pools with limited cross-talk with each other...
  8. ncbi request reprint Fast vesicle recycling supports neurotransmission during sustained stimulation at hippocampal synapses
    Yildirim Sara
    Center for Basic Neuroscience and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 22:1608-17. 2002
    ..These results suggest a role for fast vesicle recycling as a functional homeostatic mechanism that prevents vesicle depletion and maintains synaptic responses in the face of intense stimulation...
  9. ncbi request reprint Selective capability of SynCAM and neuroligin for functional synapse assembly
    Yildirim Sara
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 25:260-70. 2005
    ..These results suggest that both NL1 and SynCAM act similarly and specifically in artificial synapse induction but that this process does not reflect a shared physiological function of these molecules...
  10. ncbi request reprint Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion
    Ferenc Deak
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 26:6668-76. 2006
    ..Furthermore, the fusion reactions underlying evoked and spontaneous release differ mechanistically...
  11. pmc Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2
    Alexander A Chubykin
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Neuron 54:919-31. 2007
    ..This hypothesis reconciles the overexpression and knockout phenotypes and suggests that neuroligins contribute to the use-dependent formation of neural circuits...
  12. ncbi request reprint Minimum essential factors required for vesicle mobilization at hippocampal synapses
    Marina G Mozhayeva
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 24:1680-8. 2004
    ..These results suggest that in hippocampal synapses, vesicle mobilization and replenishment of the readily releasable pool require GTP and Ca2+ but do not necessitate ATP-dependent priming and SNARE recycling...
  13. pmc Reelin signaling antagonizes beta-amyloid at the synapse
    Murat S Durakoglugil
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:15938-43. 2009
    ..We propose a model in which Abeta, Reelin, and ApoE receptors modulate neurotransmission and thus synaptic stability as opposing regulators of synaptic gain control...
  14. pmc Molecular substrates mediating lanthanide-evoked neurotransmitter release in central synapses
    ChiHye Chung
    Department of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    J Neurophysiol 100:2089-100. 2008
    ..For the delayed action, La3+ may act intracellularly after its entry or through intracellular Ca2+ via a mechanism that does not require synaptobrevin-2...
  15. pmc Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery
    Ferenc Deak
    Department of Neuroscience and Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 29:8639-48. 2009
    ....
  16. pmc Rett syndrome and the impact of MeCP2 associated transcriptional mechanisms on neurotransmission
    Lisa M Monteggia
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 65:204-10. 2009
    ..In addition, this work will also help delineate a key pathway that regulates properties of neurotransmission in the central nervous system that may underlie additional neuropsychiatric disorders...
  17. doi request reprint Synaptic vesicle endocytosis: get two for the price of one?
    ChiHye Chung
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Neuron 61:333-4. 2009
    ..In this issue of Neuron, Zhu et al. reveal a surprising facet of this coupling by showing that, at low frequencies, fusion of a single vesicle leads to retrieval of two vesicles with dissimilar attributes...
  18. ncbi request reprint TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses
    Bryan W Luikart
    Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    J Neurosci 25:3774-86. 2005
    ..We conclude that TrkB signaling has a cell-autonomous role required for normal development of both presynaptic and postsynaptic components of the Schaffer collateral synapse...
  19. pmc Deletion of CASK in mice is lethal and impairs synaptic function
    Deniz Atasoy
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 104:2525-30. 2007
    ....
  20. pmc Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion
    Ferenc Deak
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    EMBO J 25:2856-66. 2006
    ....
  21. ncbi request reprint SynCAM, a synaptic adhesion molecule that drives synapse assembly
    Thomas Biederer
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 297:1525-31. 2002
    ....
  22. ncbi request reprint Phorbol esters target the activity-dependent recycling pool and spare spontaneous vesicle recycling
    Tuhin Virmani
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 25:10922-9. 2005
    ....
  23. pmc Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmission
    ChiHye Chung
    Departments of Neuroscience, Pharmacology, and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 30:1363-76. 2010
    ..This result lends additional support to the notion that synapses harbor distinct vesicle populations with divergent release properties that maintain independent forms of neurotransmission...
  24. ncbi request reprint Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission
    Peter Bronk
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurophysiol 98:794-806. 2007
    ..Together, these results suggest that SNAP-25 has a more significant role in calcium-secretion coupling than synaptobrevin-2...
  25. pmc Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling
    Tuhin Virmani
    Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    EMBO J 22:5347-57. 2003
    ..These results suggest that alternative splicing of synaptotagmin 7 acts as a molecular switch, which targets vesicles to fast and slow recycling pathways...
  26. pmc Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recycling
    Catherine R Wasser
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    J Physiol 579:413-29. 2007
    ..These results suggest that synaptic cholesterol balances evoked and spontaneous neurotransmission by hindering spontaneous synaptic vesicle turnover and sustaining evoked exo-endocytosis...
  27. ncbi request reprint MeCP2-dependent transcriptional repression regulates excitatory neurotransmission
    Erika D Nelson
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Curr Biol 16:710-6. 2006
    ..Taken together, these results suggest a role for MeCP2 in control of excitatory presynaptic function through regulation of gene expression...
  28. pmc Activity-dependent augmentation of spontaneous neurotransmission during endoplasmic reticulum stress
    Elena Nosyreva
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 30:7358-68. 2010
    ....
  29. ncbi request reprint Synaptic vesicle recycling adapts to chronic changes in activity
    Tuhin Virmani
    Center for Basic Neuroscience, Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 26:2197-206. 2006
    ..Furthermore, during these functional modifications, synapses use alternate strategies to adjust to changes in activity...
  30. ncbi request reprint Development of vesicle pools during maturation of hippocampal synapses
    Marina G Mozhayeva
    Center for Basic Neuroscience and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 22:654-65. 2002
    ..Taken together, these results expose a mechanism that ensures functionally effective allocation of a limited number of vesicles in a CNS synapse...
  31. ncbi request reprint Reelin modulates NMDA receptor activity in cortical neurons
    Ying Chen
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 25:8209-16. 2005
    ..Thus, Reelin may physiologically modulate learning and memory by modulating NMDA receptor functions...
  32. ncbi request reprint Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice
    Tuhin Virmani
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neurobiol Dis 20:314-23. 2005
    ..We conclude that from an early age, neurons deficient in PPT1 enzyme activity display intrinsically abnormal properties that could potentially explain key features of the clinical disease, such as myoclonus and seizures...
  33. pmc Dynamin-independent synaptic vesicle retrieval?
    HELMUT KRAMER
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Nat Neurosci 11:6-8. 2008
    ..A new study proposes that synaptic vesicle endocytosis at a large synaptic terminal is partly independent of dynamin and GTP hydrolysis, suggesting a new mechanism leading to vesicle fission and maintenance of neurotransmission...
  34. doi request reprint Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation
    Erika D Nelson
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:395-406. 2008
    ..These results uncover a means by which NMDA receptor-mediated synaptic activity drives DNA demethylation within mature neurons and suppresses basal synaptic function...
  35. ncbi request reprint Fast synaptic vesicle reuse slows the rate of synaptic depression in the CA1 region of hippocampus
    Mert Ertunc
    Center for Basic Neuroscience and Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 27:341-54. 2007
    ..These results indicate that synaptic vesicle trafficking impacts the kinetics of short-term synaptic plasticity at an extremely rapid time scale...
  36. ncbi request reprint Reciprocal interaction of serotonin and neuronal activity in regulation of cAMP-responsive element-dependent gene expression
    Melissa A Mahgoub
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390 9070, USA
    J Pharmacol Exp Ther 317:88-96. 2006
    ..Taken together, these results suggest a reciprocal inhibitory interaction between neuronal activity and 5-HT in the regulation of cAMP response element-dependent gene expression in hippocampal neurons...
  37. pmc MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function
    Ana C Barbosa
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 105:9391-6. 2008
    ..We conclude that MEF2C limits excessive synapse formation during activity-dependent refinement of synaptic connectivity and thus facilitates hippocampal-dependent learning and memory...
  38. ncbi request reprint Presynaptic unsilencing: searching for a mechanism
    Deniz Atasoy
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 50:345-6. 2006
    ..show that a brief burst of action potentials rapidly awaken silent synapses by increasing the availability of synaptic vesicles for fusion through BDNF-triggered presynaptic actin remodeling mediated by the small GTPase Cdc42...
  39. pmc Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapses
    Meng Zhao
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    J Neurophysiol 105:1506-15. 2011
    ..Our data suggest that Cc2d1a is required for mouse survival and performs essential function in controlling functional maturation of synapses...
  40. pmc NMDA receptor activation by spontaneous glutamatergic neurotransmission
    Felipe Espinosa
    Dept of Neuroscience, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    J Neurophysiol 101:2290-6. 2009
    ..Collectively these results indicate that NMDA receptors significantly contribute to signaling at rest in the absence of dendritic depolarizations or concomitant AMPA receptor activity...
  41. pmc Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway
    Erika S Piedras-Renteria
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305 5345, USA
    Proc Natl Acad Sci U S A 101:3609-14. 2004
    ..Changes in endocytotic proteins, signal transduction kinases, and candidates for Ca(2+)-sensing molecules were consistent with implications of the direct physiological experiments...
  42. ncbi request reprint Seeking a function for spontaneous neurotransmission
    ChiHye Chung
    Nat Neurosci 9:989-90. 2006
  43. ncbi request reprint Synaptobrevin is essential for fast synaptic-vesicle endocytosis
    Ferenc Deak
    Center for Basic Neuroscience, Howard Hughes Medical Institute, USA
    Nat Cell Biol 6:1102-8. 2004
    ..Thus, synaptobrevin is essential for two fast synapse-specific membrane trafficking reactions: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid reuse of synaptic vesicles...

Research Grants12

  1. The role of vesicle recycling in synaptic depression
    EGE KAVALALI; Fiscal Year: 2007
    ..This information will also be critical for a better understanding of the pathologies underlying several neurological and psychiatric illnesses ranging from epilepsy to schizophrenia. ..
  2. Role of SNARE Interactions in Central Synapse Function
    EGE KAVALALI; Fiscal Year: 2007
    ..abstract_text> ..
  3. Role of SNARE Interactions in Central Synapse Function
    Ege T Kavalali; Fiscal Year: 2010
    ....