KENNETH contact KAUSHANSKY

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding
    D F Sabath
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Blood 94:365-7. 1999
  2. ncbi request reprint Tyrosine 462 of the membrane-proximal F'-G' loop of murine Mpl is not essential for high-affinity binding of thrombopoietin
    D F Sabath
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Cytokine 12:127-33. 2000
  3. ncbi request reprint Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes
    Supantitra Chanprasert
    Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
    Cell Signal 18:1212-8. 2006
  4. ncbi request reprint Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation
    Amy E Geddis
    Department of Pediatrics, Hematology Oncology, University of California San Diego, San Diego, California, USA ageddis ucsd edu
    Cell Cycle 5:538-45. 2006
  5. pmc YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation
    Ian S Hitchcock
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Blood 112:2222-31. 2008
  6. pmc The chronic myeloproliferative disorders and mutation of JAK2: Dameshek's 54 year old speculation comes of age
    Kenneth Kaushansky
    Department of Medicine, Division of Hematology Oncology, University of California, San Diego, 402 Dickinson Street, Suite 380, CA 92103 8811, USA
    Best Pract Res Clin Haematol 20:5-12. 2007
  7. ncbi request reprint Thrombopoietin: accumulating evidence for an important biological effect on the hematopoietic stem cell
    Kenneth Kaushansky
    Department of Medicine, University of California, San Diego, San Diego, California 92103, USA
    Ann N Y Acad Sci 996:39-43. 2003
  8. ncbi request reprint Thrombopoietin: a tool for understanding thrombopoiesis
    K Kaushansky
    Department of Medicine, University of California San Diego, San Diego, CA, USA
    J Thromb Haemost 1:1587-92. 2003
  9. ncbi request reprint Thrombopoietin and the hematopoietic stem cell
    Kenneth Kaushansky
    Department of Medicine, 402 Dickinson Street, Suite 380, San Diego, CA 92103 8811, USA
    Ann N Y Acad Sci 1044:139-41. 2005
  10. pmc Historical review: megakaryopoiesis and thrombopoiesis
    Kenneth Kaushansky
    Department of Medicine, University of California, San Diego, CA 92103 8811, USA
    Blood 111:981-6. 2008

Research Grants

  1. MOLECULAR AND CELLULAR BIOLOGY OF THROMBOPOIETIN
    Kenneth Kaushansky; Fiscal Year: 2002
  2. Cell biology of megakaryocytes and platelets 2005
    Kenneth Kaushansky; Fiscal Year: 2005
  3. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 2006
  4. MOLECULAR AND CELLULAR BIOLOGY OF THROMBOPOIETIN
    Kenneth Kaushansky; Fiscal Year: 2007
  5. 2007 Cell Biology of Megakaryocytes and Platelets GRC
    Kenneth Kaushansky; Fiscal Year: 2007
  6. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 2001
  7. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 1991
  8. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 1993
  9. MOLECULAR AND CELLULAR BIOLOGY OF THROMBOPOIETIN
    KENNETH contact KAUSHANSKY; Fiscal Year: 2010

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding
    D F Sabath
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Blood 94:365-7. 1999
    ..Both mutant receptors failed to bind 125I-Tpo. These results suggest that the membrane-distal CRM of Mpl acts as a brake on cell proliferation and that this region is required for ligand binding...
  2. ncbi request reprint Tyrosine 462 of the membrane-proximal F'-G' loop of murine Mpl is not essential for high-affinity binding of thrombopoietin
    D F Sabath
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Cytokine 12:127-33. 2000
    ..This study suggests that unlike the corresponding Tyr(421)of the common human beta chain, Tyr(462)of murine Mpl is not required for high-affinity ligand binding, although it may be located in proximity to the ligand binding site...
  3. ncbi request reprint Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes
    Supantitra Chanprasert
    Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
    Cell Signal 18:1212-8. 2006
    ..Therefore, we conclude that TPO stimulates c-myc expression in primary megakaryocytes through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR...
  4. ncbi request reprint Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation
    Amy E Geddis
    Department of Pediatrics, Hematology Oncology, University of California San Diego, San Diego, California, USA ageddis ucsd edu
    Cell Cycle 5:538-45. 2006
    ..This work explores the mechanism of a normally occurring furrowing defect in a nonmalignant primary cell...
  5. pmc YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation
    Ian S Hitchcock
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Blood 112:2222-31. 2008
    ..Our data establishes that c-Mpl cytoplasmic YRRL motifs are responsible for both Tpo-mediated internalization via interactions with AP2 and lysosomal targeting after endocytosis...
  6. pmc The chronic myeloproliferative disorders and mutation of JAK2: Dameshek's 54 year old speculation comes of age
    Kenneth Kaushansky
    Department of Medicine, Division of Hematology Oncology, University of California, San Diego, 402 Dickinson Street, Suite 380, CA 92103 8811, USA
    Best Pract Res Clin Haematol 20:5-12. 2007
    ....
  7. ncbi request reprint Thrombopoietin: accumulating evidence for an important biological effect on the hematopoietic stem cell
    Kenneth Kaushansky
    Department of Medicine, University of California, San Diego, San Diego, California 92103, USA
    Ann N Y Acad Sci 996:39-43. 2003
    ..Although the molecular mechanisms responsible for these findings are only now being explored, it is expected that a greater understanding of the roles played by TPO in HSC physiology will lead to novel therapeutic opportunities...
  8. ncbi request reprint Thrombopoietin: a tool for understanding thrombopoiesis
    K Kaushansky
    Department of Medicine, University of California San Diego, San Diego, CA, USA
    J Thromb Haemost 1:1587-92. 2003
    ..This review will focus on our current understanding of these processes...
  9. ncbi request reprint Thrombopoietin and the hematopoietic stem cell
    Kenneth Kaushansky
    Department of Medicine, 402 Dickinson Street, Suite 380, San Diego, CA 92103 8811, USA
    Ann N Y Acad Sci 1044:139-41. 2005
    ..We found that TPO enhances the transcription of HoxB4, induces the nuclear localization of HoxA9, and upregulates VEGF expression by reducing the ubiquination of hypoxia inducible factor...
  10. pmc Historical review: megakaryopoiesis and thrombopoiesis
    Kenneth Kaushansky
    Department of Medicine, University of California, San Diego, CA 92103 8811, USA
    Blood 111:981-6. 2008
    ....
  11. doi request reprint Molecular mechanisms of thrombopoietin signaling
    K Kaushansky
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0671, USA
    J Thromb Haemost 7:235-8. 2009
    ..This review will focus on these pathways in normal and neoplastic hematopoiesis...
  12. ncbi request reprint Bloodlines: the importance of mentoring for the future of hematology
    Kenneth Kaushansky
    Department of Medicine, University of California San Diego 92103 8811, La Jolla, USA
    Blood 109:1353-4. 2007
  13. ncbi request reprint Immunology. The root of platelet production
    Amy E Geddis
    Departments of Pediatrics and Medicine, University of California, San Diego, CA 92103 8811, USA
    Science 317:1689-91. 2007
  14. pmc ASCI Presidential Address: Mentoring and teaching clinical investigation
    Kenneth Kaushansky
    Department of Medicine, University of California, San Diego, CA 92103 8811, USA
    J Clin Invest 114:1165-8. 2004
  15. pmc The molecular mechanisms that control thrombopoiesis
    Kenneth Kaushansky
    Department of Medicine, Division of Hematology Oncology, University of California, San Diego, California 92103 3931, USA
    J Clin Invest 115:3339-47. 2005
    ....
  16. ncbi request reprint Mpl and the hematopoietic stem cell
    K Kaushansky
    Department of Medicine, Division of Hematology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Leukemia 16:738-9. 2002
  17. ncbi request reprint Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors
    A E Geddis
    Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington 98195-7710, USA
    J Biol Chem 276:34473-9. 2001
    ..Phosphatidylinositol 3-kinase activity is likely to be involved in regulating the G(1)/S transition...
  18. ncbi request reprint Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice
    H Ku
    Department of Medicine, Medical University of South Carolina, Charleston, USA
    Blood 87:4544-51. 1996
    ..Based on these observations, we propose that ML can function as an early acting cytokine and stimulate the proliferation of cell cycle dormant progenitors by shortening their G0 period...
  19. ncbi request reprint Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production
    V C Broudy
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Leukoc Biol 57:719-25. 1995
    ..This study outlines the cloning and biological characterization in vitro and in vivo of thrombopoietin, a major regulator of platelet production...
  20. ncbi request reprint Kinetics of endomitosis in primary murine megakaryocytes
    C E Carow
    Department of Medicine, University of Washington, Seattle 98195 7710, USA
    J Cell Physiol 188:291-303. 2001
    ....
  21. ncbi request reprint Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells
    A Karsan
    Department of Medicine, Division of Hematology, University of Washington, Seattle, 98195, USA
    Blood 87:3089-96. 1996
    ..Additionally, vascular smooth muscle cells and various nonhematopoietic tissues express human Al, indicating that human Al is a widely expressed Bcl-2 homologue...
  22. ncbi request reprint Thrombopoietin promotes beta1-integrin-mediated adhesion in hematopoietic cells via the small GTPase Rapl
    Ian S Hitchcock
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Exp Hematol 35:793-801. 2007
    ..Thrombopoietin (TPO) has previously been shown to stimulate adhesion. in certain hematopoietic cell types, although the exact mechanisms by which adhesion is promoted remain elusive...
  23. ncbi request reprint Thrombopoietin stimulates vascular endothelial cell growth factor (VEGF) production in hematopoietic stem cells
    Keita Kirito
    Department of Hematology, University of Yamanashi, Yamanashi, Japan
    Cell Cycle 4:1729-31. 2005
    ....
  24. ncbi request reprint Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells
    Keita Kirito
    Department of Medicine, Division of Hematology Oncology, University of California, San Diego, 92103, USA
    Blood 102:3172-8. 2003
    ..Together, these data provide a molecular pathway by which a growth factor can modulate a transcription factor and thereby help direct a critical developmental process...
  25. ncbi request reprint The Mpl receptor expressed on endothelial cells does not contribute significantly to the regulation of circulating thrombopoietin levels
    Amy E Geddis
    Department of Pediatrics, University of California San Diego, San Diego, 92037, USA
    Exp Hematol 34:82-6. 2006
    ..We hypothesized that the c-mpl expressed on ECs would contribute to the regulation of circulating TPO levels...
  26. ncbi request reprint Lineage-specific hematopoietic growth factors
    Kenneth Kaushansky
    Department of Medicine, Division of Hematology Oncology, University of California San Diego, San Diego, USA
    N Engl J Med 354:2034-45. 2006
  27. pmc Transcriptional regulation of bone marrow thrombopoietin by platelet proteins
    Bryan McIntosh
    Department of Medicine, University of California San Diego, San Diego, CA 92103 8811, USA
    Exp Hematol 36:799-806. 2008
    ..9-kb region between 250-bp upstream of the transcriptional initiation site and the middle of the second intron are able to mediate the transcriptional repression...
  28. ncbi request reprint Transcriptional regulation of megakaryopoiesis: thrombopoietin signaling and nuclear factors
    Keita Kirito
    Department of Hematology, Yamanashi Medical University, Yamansahi Ken, Japan
    Curr Opin Hematol 13:151-6. 2006
    ..Thrombopoietin, the primary regulator of megakaryopoiesis, acts by modulating several nuclear transcription factors. This review focuses on recent studies that have provided new insights into the functional roles of these proteins...
  29. ncbi request reprint The American Society of Hematology: a success at age 50
    Ernst R Jaffé
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    Blood 111:11-5. 2008
    ..The next 50 years of ASH are likely to see many profound changes, but one thing is almost certain-our dedication to fostering clinical and scientific excellence in hematology will continue as the Society's raison d'etre...
  30. pmc Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout
    Ian S Hitchcock
    Department of Medicine, University of California San Diego, La Jolla 92093, USA
    Blood 111:596-604. 2008
    ..These studies establish clear roles for FAK in megakaryocyte growth and platelet function, setting the stage for manipulation of this component of the Tpo signaling apparatus for therapeutic benefit...
  31. ncbi request reprint Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression
    Amy E Geddis
    Department of Pediatrics, Hematology Oncology, University of California, San Diego, La Jolla, California 92093, USA
    Cell Cycle 6:455-60. 2007
    ..This finding has important implications for the potential mechanisms for cytokinesis failure in endomitosis...
  32. pmc Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha
    Keita Kirito
    Department of Medicine, Division of Hematology Oncology, University of California San Diego, San Diego, CA, USA
    Blood 105:4258-63. 2005
    ..Along with previous findings that TPO affects Hox transcription factors that regulate HSC proliferation, these data contribute to our growing understanding of the mechanisms by which a hormone can influence stem cell development...
  33. ncbi request reprint Engagement of integrin alpha4beta1 enhances thrombopoietin-induced megakaryopoiesis
    Norma E Fox
    Department of Medicine, University of California San Diego, 92103 8811, USA
    Exp Hematol 33:94-9. 2005
    ..Moreover, a number of other hematopoietic cell types, including stem cells and erythroid progenitors, have been shown to engage and be affected by integrin ligands...
  34. ncbi request reprint Thrombopoietin: a pan-hematopoietic cytokine
    Amy E Geddis
    Division of Hematology, University of Washington School of Medicine, Box 357710, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Cytokine Growth Factor Rev 13:61-73. 2002
    ..Our growing appreciation of how cytokine signaling pathways are translated into megakaryocyte development is discussed...
  35. ncbi request reprint Thrombopoietin: from theory to reality
    Kenneth Kaushansky
    Department of Medicine, University of California, USA
    Int J Hematol 76:343-5. 2002
    ..The net result is the expansion of cells that give rise to mature platelets, a process that can be accentuated by the therapeutic administration of the hormone to thrombocytopenic patients...
  36. pmc Thrombopoietin expands hematopoietic stem cells after transplantation
    Norma Fox
    University of California San Diego School of Medicine, Department of Medicine, San Diego, California 92103 8811, USA
    J Clin Invest 110:389-94. 2002
    ..Our results establish that TPO greatly promotes the self-renewal and expansion of HSCs in vivo following marrow transplantation...
  37. ncbi request reprint The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production
    Kenneth Kaushansky
    Division of Hematology, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, Washington, WA 98195, USA
    Oncogene 21:3359-67. 2002
    ..This review attempts to distill what has been learned of the molecular and cellular biology of TPO and its receptor during the past several years, and links this information to several new insights into human disease and its treatment...
  38. ncbi request reprint Identification and characterization of an isoform of murine Mpl
    Diana F Sabath
    Department of Medicine, University of Washington, Harborview Medical Center, 325 Ninth Ave, Box 359756, Seattle, WA 98104, USA
    Biochim Biophys Acta 1574:383-6. 2002
    ..In summary, c-mpl-II is an isoform of murine Mpl expressed by megakaryocytes that lacks a 60 amino acid region required for surface expression of the protein...
  39. ncbi request reprint Lineage-specific growth factors can compensate for stem and progenitor cell deficiencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF receptor-deficient mice
    Kenneth Kaushansky
    University of Washington School of Medicine, Divisions of Hematology and Infectious Diseases, Seattle, WA 98195, USA
    Blood 99:3573-8. 2002
    ....
  40. ncbi request reprint Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation
    Jonathan G Drachman
    Puget Sound Blood Center, Seattle, Washington 98104, USA
    J Biol Chem 277:23544-53. 2002
    ..Although the nature of the signal transduction pathway is not yet known, this second proliferative event is likely to regulate c-myc expression...
  41. pmc JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells
    Shengming Zhao
    Division of Hematology, University of Washington, Seattle, WA, USA
    EMBO J 21:2159-67. 2002
    ..These findings suggest that a simple two-component signal can drive MHPC self-renewal...
  42. ncbi request reprint Etiology of the myeloproliferative disorders: the role of thrombopoietin
    Kenneth Kaushansky
    Department of Medicine, University of California at San Diego Medical Center, San Diego, CA 92103, USA
    Semin Hematol 40:6-9. 2003
    ..Thus, TPO and Mpl may prove to be effective targets for both diagnosis and therapeutic management of MPD...
  43. ncbi request reprint Inherited thrombocytopenias: toward a molecular understanding of disorders of platelet production
    Amy E Geddis
    Department of Pediatrics, University of California, San Diego, USA
    Curr Opin Pediatr 16:15-22. 2004
    ..To review the defined syndromes of inherited thrombocytopenia and discuss new genetic data for several disorders that shed light on the process of megakaryopoiesis...
  44. ncbi request reprint Megakaryocytes require thrombospondin-2 for normal platelet formation and function
    Themis R Kyriakides
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Blood 101:3915-23. 2003
    ..We conclude that the uptake of TSP2 by MKs from the marrow milieu is required for proper MK function and the release of functionally competent platelets...
  45. ncbi request reprint Cross-reactivity between erythropoietin and thrombopoietin at the level of Mpl does not account for the thrombocytosis seen in iron deficiency
    Amy E Geddis
    J Pediatr Hematol Oncol 25:919-20; author reply 920. 2003
  46. pmc Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells
    Keita Kirito
    Department of Medicine, University of California San Diego School of Medicine, 402 Dickinson St, Suite 380, San Diego, CA 92103 8811, USA
    Mol Cell Biol 24:6751-62. 2004
    ..Our data suggest that TPO controls HSC development through the regulation of multiple members of the Hox family of transcription factors through multiple mechanisms...
  47. ncbi request reprint Megakaryocytes express functional Aurora-B kinase in endomitosis
    Amy E Geddis
    Division of Pediatric Hematology Oncology, University of California San Diego UCSD, 9500 Gilman Dr, Mailcode 0665, La Jolla, CA 92093, USA
    Blood 104:1017-24. 2004
    ..These results suggest that EnM MKs appropriately express functional Aurora-B kinase and related proteins in early anaphase, making a simple deficiency of this protein an unlikely explanation for polyploidy in this cell type...
  48. ncbi request reprint On the molecular origins of the chronic myeloproliferative disorders: it all makes sense
    Kenneth Kaushansky
    Department of Medicine, Division of Hematology Oncology, University of California San Diego, 402 Dickinson St, Ste 380, San Diego, CA 92103 8811, USA
    Blood 105:4187-90. 2005
  49. ncbi request reprint PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1)
    Takafumi Nakao
    Department of Medicine, Division of Hematology Oncology, University of California San Diego, La Jolla, California, USA
    Cell Cycle 7:257-66. 2008
    ....
  50. doi request reprint A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies
    Keita Kirito
    Haematologica 93:155-6. 2008
    ..Among the three affected individuals, two members developed myeloid malignancies. Sequence studies demonstrate that all affected individuals of the pedigree display a heterozygous single nucleotide deletion in exon 8 of the RUNX1 gene...
  51. ncbi request reprint Thrombocytosis in an infant with high thrombopoietin concentrations
    Jane Hankins
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Hematol Oncol 26:142-5. 2004
    ..This case may represent a case of atypical ET in which thrombocytosis results from TPO stimulation rather than clonal proliferation. Measuring TPO concentrations may be warranted for children with unexplained extreme thrombocytosis...
  52. pmc Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities
    Thomas R Coleman
    The Kenneth S Warren Institute, Warren Pharmaceuticals, Ossining, NY 10562, USA
    Proc Natl Acad Sci U S A 103:5965-70. 2006
    ..These preclinical findings suggest that nonerythropoietic tissue-protective ligands, which appear to elicit fewer adverse effects, may be especially useful in clinical settings for tissue protection...
  53. ncbi request reprint The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3
    Tania Habib
    Division of Hematology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Biochemistry 41:8725-31. 2002
    ....
  54. ncbi request reprint The glycan domain of thrombopoietin (TPO) acts in trans to enhance secretion of the hormone and other cytokines
    Hannah M Linden
    Division of Hematology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 277:35240-7. 2002
    ..The cellular location of TGD action is likely to be within the ER or earlier in the secretory pathway...
  55. ncbi request reprint Physician-scientists: preparation, opportunities, and national need
    Kenneth Kaushansky
    Department of Medicine, University of California San Diego, University of California San Diego Medical Center, San Diego, California 92103 8811, USA
    Exp Biol Med (Maywood) 228:1258-60. 2003
  56. pmc Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
    Chloe C Feral
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0726, USA
    J Clin Invest 116:715-23. 2006
    ..We conclude that interference with alpha4 integrin signaling can selectively impair mononuclear leukocyte recruitment to sites of inflammation while sparing vital functions of alpha4 integrins in development and hematopoiesis...
  57. ncbi request reprint Celebrate hematology
    Kenneth Kaushansky
    Blood 100:4257-8. 2002
  58. pmc Hematopoietic growth factors, signaling and the chronic myeloproliferative disorders
    Kenneth Kaushansky
    Department of Medicine, Division of Hematology Oncology, University of California, 402 Dickinson Street, Suite 380, San Diego, CA 92103 8811, USA
    Cytokine Growth Factor Rev 17:423-30. 2006
    ....

Research Grants36

  1. MOLECULAR AND CELLULAR BIOLOGY OF THROMBOPOIETIN
    Kenneth Kaushansky; Fiscal Year: 2002
    ..Together, the proposed work should advance our understanding of hematopoietic regulation, potentially providing new opportunities to rationally intervene to stimulate normal or suppress neoplastic blood cell production. ..
  2. Cell biology of megakaryocytes and platelets 2005
    Kenneth Kaushansky; Fiscal Year: 2005
    ..This application is a request for partial funds to support the attendance of speakers and discussion leaders, and selected postdoctoral fellows and students at this important new meeting. ..
  3. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 2006
    ....
  4. MOLECULAR AND CELLULAR BIOLOGY OF THROMBOPOIETIN
    Kenneth Kaushansky; Fiscal Year: 2007
    ..It is hoped that the successful completion of these studies will further our understanding of hematopoiesis. ..
  5. 2007 Cell Biology of Megakaryocytes and Platelets GRC
    Kenneth Kaushansky; Fiscal Year: 2007
    ..This application is a request for partial funds to support the attendance of participants (i.e. speakers, discussion leaders, postdoctoral fellows, students, etc.) at this important scientific meeting. ..
  6. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 2001
    ....
  7. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 1991
    ..The strategy will involve subtraction hybridization to enrich mRNA for the growth factor, generation of a cDNA library in an expression vector, and identification of useful clones by biological assays...
  8. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 1993
    ....
  9. MOLECULAR AND CELLULAR BIOLOGY OF THROMBOPOIETIN
    KENNETH contact KAUSHANSKY; Fiscal Year: 2010
    ..The results of these studies will provide new insights into the role of thrombopoietin signaling in normal as well as malignant cells. ..