William Kaufmann

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Radiation clastogenesis and cell cycle checkpoint function as functional markers of breast cancer risk
    William K Kaufmann
    Lineberger Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Carcinogenesis 27:2519-27. 2006
  2. ncbi request reprint Dangerous entanglements
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center and Center for Environmental Health and Susceptibility, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Trends Mol Med 12:235-7. 2006
  3. pmc The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement
    Keziban Unsal-Kaçmaz
    Lineberger Comprehensive Cancer Center, CB 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell Biol 27:3131-42. 2007
  4. ncbi request reprint Initiating the uninitiated: replication of damaged DNA and carcinogenesis
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599 7295, USA
    Cell Cycle 6:1460-7. 2007
  5. pmc Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Invest Dermatol 128:175-87. 2008
  6. pmc The human intra-S checkpoint response to UVC-induced DNA damage
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Carcinogenesis 31:751-65. 2010
  7. ncbi request reprint Caffeine and human DNA metabolism: the magic and the mystery
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mutat Res 532:85-102. 2003
  8. ncbi request reprint Degradation of ATM-independent decatenation checkpoint function in human cells is secondary to inactivation of p53 and correlated with chromosomal destabilization
    William K Kaufmann
    CB7295, Rm 31 325, Lineberger Comprehensive Cancer Center, UNC CH, Chapel Hill, North Carolina 27599 7295, USA
    Cell Cycle 1:210-9. 2002
  9. pmc An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage
    Timothy P Heffernan
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 22:8552-61. 2002
  10. ncbi request reprint ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase
    Paula B Deming
    Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, and Center for Environmental Health and Susceptibility, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 277:36832-8. 2002

Research Grants

  1. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 1999
  2. Profiles of Sucsceptibility to Toxicant Stress
    William Kaufmann; Fiscal Year: 2007
  3. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2007
  4. The System of Response to DNA Damage Suppresses Environmental Melanomagenesis
    William Kaufmann; Fiscal Year: 2007
  5. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2006
  6. Profiles of Sucsceptibility to Toxicant Stress
    William Kaufmann; Fiscal Year: 2005
  7. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2005
  8. S Checkpoint Function in Human Fibroblasts
    William Kaufmann; Fiscal Year: 2004
  9. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2004
  10. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2003

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Radiation clastogenesis and cell cycle checkpoint function as functional markers of breast cancer risk
    William K Kaufmann
    Lineberger Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Carcinogenesis 27:2519-27. 2006
    ..This study tested whether sporadic breast cancer was associated with constitutive radiation hypersensitivity...
  2. ncbi request reprint Dangerous entanglements
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center and Center for Environmental Health and Susceptibility, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Trends Mol Med 12:235-7. 2006
    ..Ex vivo expansion of stem cells might have the unintended consequence of encouraging malignant progression...
  3. pmc The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement
    Keziban Unsal-Kaçmaz
    Lineberger Comprehensive Cancer Center, CB 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell Biol 27:3131-42. 2007
    ....
  4. ncbi request reprint Initiating the uninitiated: replication of damaged DNA and carcinogenesis
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599 7295, USA
    Cell Cycle 6:1460-7. 2007
    ..Recent studies indicate that checkpoint responses may act at the very point of replication of damaged DNA to slow DNA chain elongation, inhibit replicon initiation and suppress initiation of carcinogenesis...
  5. pmc Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Invest Dermatol 128:175-87. 2008
    ..The results suggest that defects in DNA damage checkpoints may be recognized in melanomas through analysis of gene expression...
  6. pmc The human intra-S checkpoint response to UVC-induced DNA damage
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Carcinogenesis 31:751-65. 2010
    ..The role of the intra-S checkpoint response in protecting against solar radiation carcinogenesis remains to be determined...
  7. ncbi request reprint Caffeine and human DNA metabolism: the magic and the mystery
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mutat Res 532:85-102. 2003
    ....
  8. ncbi request reprint Degradation of ATM-independent decatenation checkpoint function in human cells is secondary to inactivation of p53 and correlated with chromosomal destabilization
    William K Kaufmann
    CB7295, Rm 31 325, Lineberger Comprehensive Cancer Center, UNC CH, Chapel Hill, North Carolina 27599 7295, USA
    Cell Cycle 1:210-9. 2002
    ..These observations lead to a new model of genetic instability, in which attenuation of G2 decatenatory checkpoint function permits cells to enter mitosis with insufficiently decatenated chromatids, leading to aneuploidy and polyploidy...
  9. pmc An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage
    Timothy P Heffernan
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 22:8552-61. 2002
    ..Taken together, these data suggest that the UVC-induced S checkpoint response of inhibition of replicon initiation is mediated by ATR signaling through Chk-1 and is independent of ATM, Nbs1, and Mre11...
  10. ncbi request reprint ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase
    Paula B Deming
    Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, and Center for Environmental Health and Susceptibility, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 277:36832-8. 2002
    ..Moreover, the results demonstrate an important role for the topoisomerase II-dependent G(2) checkpoint in the preservation of human genomic stability...
  11. pmc The Epstein-Barr virus immediate-early protein BZLF1 induces expression of E2F-1 and other proteins involved in cell cycle progression in primary keratinocytes and gastric carcinoma cells
    Amy Mauser
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    J Virol 76:12543-52. 2002
    ....
  12. pmc Coupling of human circadian and cell cycles by the timeless protein
    Keziban Unsal-Kaçmaz
    Department of Biochemistry and Biophysics, Mary Ellen Jones Building CB 7260, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Mol Cell Biol 25:3109-16. 2005
    ....
  13. pmc Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress
    Michael G Kemp
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 285:16562-71. 2010
    ..Our results therefore indicate that RPA-covered ssDNA not only supports recruitment and activation of ATR but also, through Tipin and Claspin, it plays an important role in the action of ATR on its critical downstream target Chk1...
  14. pmc Ataxia telangiectasia-mutated dependent DNA damage checkpoint functions regulate gene expression in human fibroblasts
    Tong Zhou
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, CB 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Mol Cancer Res 5:813-22. 2007
    ..The reduced change in DNA damage response genes and the attenuated repression of cell cycle-regulated genes may account for the defects in cell cycle checkpoint function in AT cells...
  15. pmc Cdc7-Dbf4 and the human S checkpoint response to UVC
    Timothy P Heffernan
    Department of Pathology and Laboratory Medicine, University of North Carolina Chapel Hill, NC 27599, USA
    J Biol Chem 282:9458-68. 2007
    ..These findings implicate a Dbf4-dependent kinase as a possible target of the ATR- and Chk1-dependent S checkpoint response to UVC...
  16. pmc Similar nucleotide excision repair capacity in melanocytes and melanoma cells
    Shobhan Gaddameedhi
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Cancer Res 70:4922-30. 2010
    ..We concluded that melanoma cells retain capacity for nucleotide excision repair, the loss of which probably does not commonly contribute to melanoma progression...
  17. pmc Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage
    Yang Yang
    Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 41:2296-312. 2013
    ....
  18. ncbi request reprint Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts
    Nicole M King
    Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7525, USA
    DNA Repair (Amst) 4:714-24. 2005
    ....
  19. ncbi request reprint Checkpoint regulation of replication dynamics in UV-irradiated human cells
    Paul D Chastain
    Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7525 USA
    Cell Cycle 5:2160-7. 2006
    ..These findings illustrate the concordance of data derived from different experimental approaches, thus strengthening the evidence that the activation of the intra-S checkpoint by UVC is dependent on the ATR and Chk1 kinases...
  20. ncbi request reprint Cell cycle in plants: decatenation checkpoint is conserved across the two metazoan kingdoms
    William K Kaufmann
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295 USA
    Cell Cycle 1:176-7. 2002
  21. doi request reprint Analysis of the topoisomerase II-dependent decatenation G2 checkpoint and checkpoint kinases in human cells
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, US
    Methods Mol Biol 582:155-66. 2009
    ..This chapter details the methods for assay of decatenation G2 checkpoint function and checkpoint kinase activities...
  22. pmc In silico construction of a protein interaction landscape for nucleotide excision repair
    Nancy Tran
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Cell Biochem Biophys 53:101-14. 2009
    ..Our analysis offers a computational framework that can be applied to construct landscapes for other biological processes...
  23. ncbi request reprint DNA damage responses protect xeroderma pigmentosum variant from UVC-induced clastogenesis
    Marila Cordeiro-Stone
    Department of Pathology and Laboratory Medicine, University of NC at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Carcinogenesis 23:959-65. 2002
    ..These responses protect human cells from chromosomal aberrations, especially when other pathways, such as accurate lesion bypass, are lost...
  24. pmc A mathematical model for human nucleotide excision repair: damage recognition by random order assembly and kinetic proofreading
    Kevin J Kesseler
    Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7255, USA
    J Theor Biol 249:361-75. 2007
    ..Finally, a comparison between the random order assembly with kinetic proofreading model and a sequential assembly model is made. This investigation reveals the advantages of the random order assembly/kinetic proofreading model...
  25. ncbi request reprint Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma
    Janiel M Shields
    Department of Biochemistry and Biophysics, The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Cancer Res 67:1502-12. 2007
    ..These results show a molecularly distinct melanoma subtype that does not require ERK activation or epithelial-mesenchymal transformation for progression...
  26. pmc Identification of primary transcriptional regulation of cell cycle-regulated genes upon DNA damage
    Tong Zhou
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cell Cycle 6:972-81. 2007
    ..Changes in expression of these genes after IR treatment derived from both direct transcriptional regulation and cell cycle synchronization...
  27. pmc Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence
    Tong Zhou
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health Perspect 114:553-9. 2006
    ....
  28. pmc The Epstein-Barr virus immediate-early protein BZLF1 induces both a G(2) and a mitotic block
    Amy Mauser
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    J Virol 76:10030-7. 2002
    ..While the G(2) block is associated with decreased cyclin B1 in host cells and can be rescued by overexpression of cyclin B1, the mechanism for the mitotic defect is as yet undetermined...
  29. ncbi request reprint Cell-type-specific responses to chemotherapeutics in breast cancer
    Melissa A Troester
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Cancer Res 64:4218-26. 2004
    ..Similarities between in vivo and in vitro responses help to identify important response mechanisms to chemotherapeutics...
  30. doi request reprint Ubiquitylation of proliferating cell nuclear antigen and recruitment of human DNA polymerase eta
    Nana Nikolaishvili-Feinberg
    Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center and Center for Environmental Health and Susceptibility, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Biochemistry 47:4141-50. 2008
    ..These results demonstrate that PCNA ubiquitylation at K164 of PCNA is not required in vitro for pol eta to gain access to replication complexes at forks stalled by T (wedge)T and to catalyze TLS across this dimer...
  31. pmc A novel method for large tree visualization
    Jeff Heard
    Renaissance Computing Institute, 100 Europa Drive, Chapel Hill, NC 27519, USA
    Bioinformatics 25:557-8. 2009
    ..Clustering analysis can be performed on these trees to obtain clusters of proteins, and we need an efficient way to visualize the clustering results. We present a novel tree visualization tool to help with such analyses...
  32. ncbi request reprint Toxicogenomics: transcription profiling for toxicology assessment
    Tong Zhou
    Center for Drug Safety Sciences, The Hamner Institutes for Health Sciences, University of North Carolina at Chapel Hill, Research Triangle Park, NC, USA
    EXS 99:325-66. 2009
    ....
  33. pmc Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes
    Jeff W Chou
    Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Bioinformatics 8:427. 2007
    ..The approach utilizes the underlying structure of gene expression data to extract patterns and identify co-expressed genes that are responsive to experimental conditions...
  34. ncbi request reprint ATM requirement in gene expression responses to ionizing radiation in human lymphoblasts and fibroblasts
    Cynthia L Innes
    Growth Control and Cancer Group, National Institute of Environmental Health Sciences, PO Box 12233, MD D2 03, Research Triangle Park, NC 27709, USA
    Mol Cancer Res 4:197-207. 2006
    ..Interestingly, after 5 Gy IR, lymphoblasts displayed ATM-independent responses not seen in the fibroblasts at this dose, which likely reflect signaling through ATM-related kinases, e.g., ATR, in the absence of ATM function...
  35. ncbi request reprint Cell cycle checkpoint function in bladder cancer
    Sharon C Doherty
    Cancer and Ageing Research Group, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    J Natl Cancer Inst 95:1859-68. 2003
    ..Because bladder transitional cell carcinomas (TCCs) often contain numerous chromosomal aberrations and appear to have highly unstable genomes, we analyzed cell cycle checkpoint functions in a panel of TCC lines...
  36. ncbi request reprint Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses
    Richard P Beyer
    University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98195, USA
    Toxicol Sci 99:326-37. 2007
    ..We show that phenotypic anchoring of gene expression data is required for biologically meaningful analysis of toxicogenomic experiments...
  37. ncbi request reprint Standardizing global gene expression analysis between laboratories and across platforms
    Theodore Bammler
    Nat Methods 2:351-6. 2005
    ..These findings indicate that microarray results can be comparable across multiple laboratories, especially when a common platform and set of procedures are used...

Research Grants16

  1. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 1999
    ..This project will define inputs to the G2 checkpoint and identify mechanisms of inactivation in human fibroblasts. ..
  2. Profiles of Sucsceptibility to Toxicant Stress
    William Kaufmann; Fiscal Year: 2007
    ..The UNC-CH toxicogenomics research program has the scientific expertise and organizational infrastructure to provide significant and substantial benefits to the Toxicogenomics Research Consortium. ..
  3. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2007
    ..following DNA replication? Does ATR sends a signal through BRCA1 to inhibit Plkl when chromatid catenations are sensed? Is defective decatenation checkpoint function associated with genetic instability in cancer? ..
  4. The System of Response to DNA Damage Suppresses Environmental Melanomagenesis
    William Kaufmann; Fiscal Year: 2007
    ..Lessons learned in this program will also impact on methods of risk assessment by showing that the effective dose of a carcinogen falls during the multi-step development of cancer. PROGRAM AS AN INTEGRATED EFFORT ..
  5. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2006
    ..following DNA replication? Does ATR sends a signal through BRCA1 to inhibit Plkl when chromatid catenations are sensed? Is defective decatenation checkpoint function associated with genetic instability in cancer? ..
  6. Profiles of Sucsceptibility to Toxicant Stress
    William Kaufmann; Fiscal Year: 2005
    ..The UNC-CH toxicogenomics research program has the scientific expertise and organizational infrastructure to provide significant and substantial benefits to the Toxicogenomics Research Consortium. ..
  7. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2005
    ..following DNA replication? Does ATR sends a signal through BRCA1 to inhibit Plkl when chromatid catenations are sensed? Is defective decatenation checkpoint function associated with genetic instability in cancer? ..
  8. S Checkpoint Function in Human Fibroblasts
    William Kaufmann; Fiscal Year: 2004
    ..This project will define genetic components of the S checkpoint and elucidate signal transduction mechanisms that underlie S checkpoint response in diploid human fibroblasts. ..
  9. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2004
    ..following DNA replication? Does ATR sends a signal through BRCA1 to inhibit Plkl when chromatid catenations are sensed? Is defective decatenation checkpoint function associated with genetic instability in cancer? ..
  10. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2003
    ..following DNA replication? Does ATR sends a signal through BRCA1 to inhibit Plkl when chromatid catenations are sensed? Is defective decatenation checkpoint function associated with genetic instability in cancer? ..
  11. S Checkpoint Function in Human Fibroblasts
    William Kaufmann; Fiscal Year: 2003
    ..This project will define genetic components of the S checkpoint and elucidate signal transduction mechanisms that underlie S checkpoint response in diploid human fibroblasts. ..
  12. S Checkpoint Function in Human Fibroblasts
    William Kaufmann; Fiscal Year: 2002
    ..This project will define genetic components of the S checkpoint and elucidate signal transduction mechanisms that underlie S checkpoint response in diploid human fibroblasts. ..
  13. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2002
    ..This project will define inputs to the G2 checkpoint and identify mechanisms of inactivation in human fibroblasts. ..
  14. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2001
    ..This project will define inputs to the G2 checkpoint and identify mechanisms of inactivation in human fibroblasts. ..
  15. G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTS
    William Kaufmann; Fiscal Year: 2000
    ..This project will define inputs to the G2 checkpoint and identify mechanisms of inactivation in human fibroblasts. ..