Research Topics
| PAUL LEON KAUFMANSummaryAffiliation: University of Wisconsin Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertensionKenneth S Kompass
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St, Louis, MO 63110, USA
BMC Neurosci 9:93. 2008..We used high-density oligonucleotide arrays to investigate whole genome transcriptional changes occurring at the optic nerve head during primate experimental glaucoma...- Enhancing trabecular outflow by disrupting the actin cytoskeleton, increasing uveoscleral outflow with prostaglandins, and understanding the pathophysiology of presbyopia interrogating Mother Nature: asking why, asking how, recognizing the signs, followinPaul L Kaufman
University of Wisconsin, School of Medicine and Public Health, Ophthalmology and Visual Sciences, 2870 University Ave, Suite 102, Madison, WI 53705, USA
Exp Eye Res 86:3-17. 2008..5) Global collaborations such as those involved in these studies will be essential in the future, as science becomes "bigger"... 
The effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyesXuyang Liu
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI, USA
Mol Vis 11:1112-21. 2005....- Aqueous humor dynamics and trabecular meshwork and anterior ciliary muscle morphologic changes with age in rhesus monkeysJohannes Gottanka
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
Invest Ophthalmol Vis Sci 44:2118-25. 2003..The TM findings are analogous to those in the aging human eye and are consistent with the age-related decrease in outflow facility reported in both humans and monkeys... - Adenovirus-mediated gene therapy using human p21WAF-1/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgeryTodd W Perkins
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 1300 University Ave, Room 6640 MSC, Madison, WI 53706-1532, USA
Arch Ophthalmol 120:941-9. 2002..CLINICAL RELEVANCE: Gene therapy with rAd.p21 may provide an effective antiproliferative for glaucoma filtration surgery, without the complications associated with mitomycin... - H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeysB Ann T Gabelt
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53792, USA
Invest Ophthalmol Vis Sci 45:2732-6. 2004..To determine whether H-7 can enhance outflow facility after trabecular meshwork obstruction by extracellular material that accumulates after long-term treatment of monkeys with the cholinesterase inhibitor echothiophate iodide (ECHO)... - Identification of the active site in the heparin II domain of fibronectin that increases outflow facility in cultured monkey anterior segmentsJose M Gonzalez
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
Invest Ophthalmol Vis Sci 50:235-41. 2009..To determine the active site in the Heparin II (HepII) domain of fibronectin that regulates outflow facility in cultured anterior segments and disrupts the actin cytoskeleton in transformed human trabecular meshwork (TM-1) cells... - Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rageJulie A Kiland
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
Trans Am Ophthalmol Soc 107:146-58. 2009.... - Aqueous humor dynamics in monkeys after topical 8-iso PGE(2)Jennifer L Seeman
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792, USA
Invest Ophthalmol Vis Sci 45:892-9. 2004..CONCLUSIONS: The present findings are consistent with lowering of IOP by 8-iso PGE(2), primarily by increasing Fu. A direct effect on the trabecular meshwork was not indicated by these in vivo studies... - Heparin II domain of fibronectin mediates contractility through an alpha4beta1 co-signaling pathwayMarie K Schwinn
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI 53706, USA
Exp Cell Res 316:1500-12. 2010..This is the first time that the PPRARI sequence in the HepII domain has been shown to serve as a physiological alpha4beta1 ligand, suggesting that alpha4beta1 integrin may be a key regulator of tissue contractility... - Effects of latrunculin B on outflow facility, intraocular pressure, corneal thickness, and miotic and accommodative responses to pilocarpine in monkeysMehmet Okka
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin, USA
Trans Am Ophthalmol Soc 102:251-7; discussion 257-9. 2004..Multiple doses reduce IOP more than a single dose. LAT-B dose-dependently relaxes the iris sphincter and ciliary muscle, with some separation of the miotic and accommodative effects... - Surgical lowering of elevated intraocular pressure in monkeys prevents progression of glaucomatous diseaseRobert W Nickells
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA
Exp Eye Res 84:729-36. 2007.... - Effects of reference electrode location on monopolar-derived multifocal electroretinograms in cynomolgus monkeysCharlene B Y Kim
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792 3220, USA
Doc Ophthalmol 111:113-25. 2005..K1 and K2.1 implicit times in males were longer than in females. Quadrant groupings revealed generally larger K1 and K2.1 amplitudes in nasal than in temporal retina... - Multifocal visual evoked potentials in the anesthetized non-human primateNathan A Maertz
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792-3220, USA
Curr Eye Res 31:885-93. 2006..Under the recording conditions described, mfVEPs are not contaminated by ERG activity. mfVEPs may be useful in animal models of diseases that differentially affect macular and peripheral visual field responsiveness... - Combined effects of H7 and pilocarpine on anterior segment physiology in monkey eyesBaohe Tian
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53705 3611, USA
Curr Eye Res 32:491-500. 2007.... - Surgical intervention and accommodative responses, I: centripetal ciliary body, capsule, and lens movements in rhesus monkeys of various agesMary Ann Croft
Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
Invest Ophthalmol Vis Sci 49:5484-94. 2008..To determine how surgically altering the normal relationship between the lens and the ciliary body in rhesus monkeys affects centripetal ciliary body and lens movement... - Effect of H-7 on secondary cataract after phacoemulsification in the live rabbit eyeBaohe Tian
Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, WI 53792 3220, USA
J Ocul Pharmacol Ther 26:533-9. 2010..This study is aimed to determine if the serine-threonine kinase inhibitor H-7 inhibits secondary cataract after phacoemulsification in the live rabbit eye... - Prostaglandin subtype-selective and non-selective IOP-lowering comparison in monkeysB Ann True Gabelt
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53705 2135, USA
J Ocul Pharmacol Ther 25:1-8. 2009..i.d. The combination of the FP, EP1, EP2, and EP3 agonists used in this study was sufficient to lower IOP by the same magnitude as PGF(2)alpha-ie, suggesting that combining PG-subtype agonists may be a potent antiglaucoma strategy... - Serial multifocal electroretinograms during long-term elevation and reduction of intraocular pressure in non-human primatesT Michael Nork
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave F4 336, Madison, WI 53792 3220, USA
Doc Ophthalmol 120:273-89. 2010..These results demonstrate species-specific changes in cone-driven retinal function during periods of elevated IOP. These IOP-related effects can occur in the absence of retinal ganglion cells and may be reversible... - The zonula, lens, and circumlental space in the normal iridectomized rhesus monkey eyeMary Ann Croft
Department of Ophthalmology and Visual Sciences, Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53792 3284, USA
Invest Ophthalmol Vis Sci 47:1087-95. 2006..To document zonular orientation and suspension of the lens during accommodation, and age-related changes of the circumlental space (CLS) at rest and during accommodation, in living iridectomized rhesus monkey eyes... - Accommodative ciliary body and lens function in rhesus monkeys, I: normal lens, zonule and ciliary process configuration in the iridectomized eyeMary Ann Croft
Department of Ophthalmology and Visual Sciences, Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53792 3284, USA
Invest Ophthalmol Vis Sci 47:1076-86. 2006..In the current study, these relationships were studied in rhesus monkeys, whose accommodative apparatus and age-related loss of accommodation are similar to those in humans... - Age-related changes in centripetal ciliary body movement relative to centripetal lens movement in monkeysMary Ann Croft
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792 3284, USA
Exp Eye Res 89:824-32. 2009..This, in turn, would allow enough zonular relaxation to achieve the magnitude of centripetal lens movement necessary for a given amplitude of accommodation... - Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeysBaohe Tian
Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Medical School, Madison, F4/328 CSC, 600 Highland Avenue Madison, WI 53792, USA
Exp Eye Res 80:215-25. 2005..The partial inhibitory effect of Caly-A on the Y-27632-induced increase in outflow facility may reflect the former partially inhibiting the latter's relaxation of cells in the TM... - Interspecies and gender differences in multifocal electroretinograms of cynomolgus and rhesus macaquesCharlene B Y Kim
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI, USA
Doc Ophthalmol 109:73-86. 2004..There also were gender-associated differences that varied across species. Thus, investigators should exercise caution when data from species or gender are combined... - Primate glaucoma modelsCarol A Rasmussen
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53792-3220, USA
J Glaucoma 14:311-4. 2005.... - Aqueous humor dynamics in monkeys after topical R-DOIB Ann T Gabelt
Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53792 3220, USA
Invest Ophthalmol Vis Sci 46:4691-6. 2005..To determine the effects of R-DOI, a selective 5-HT2 agonist, on intraocular pressure (IOP) and aqueous humor dynamics in monkeys... - Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segmentsB Ann True Gabelt
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792, USA
Exp Eye Res 82:935-44. 2006..This suggests that over-expression of the caldesmon gene in the TM may be an effective approach for the gene therapy of glaucoma... - Monkey organ-cultured anterior segments: technique and response to H-7Yujie Hu
Department of Ophthalmology and Visual Sciences, University of Wisconsin, 600 Highland Ave, Madison, WI 53792, USA
Exp Eye Res 82:1100-8. 2006..Thus, the monkey organ-cultured anterior segment system can be used to determine the effects of pharmacological and biological agents on trabecular outflow... - Accommodation and presbyopia: the ciliary neuromuscular viewMary Ann Croft
Department of Ophthalmology and Visual Sciences, University of Wisconsin, F4 328 CSC, 600 Highland Avenue, Madison, WI 53792, USA
Ophthalmol Clin North Am 19:13-24, v. 2006..Even if loss of ciliary muscle mobility is not causally related to presbyopia, it may limit the performance of putatively accommodating intraocular lenses now being developed by academic and industrial groups... - Aqueous humor dynamics in monkeys in response to the kappa opioid agonist bremazocineCarol A Rasmussen
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
Trans Am Ophthalmol Soc 105:225-38; discussion 238-9. 2007..To determine the effects of the kappa opioid agonist, bremazocine (BRE), on intraocular pressure (IOP) and aqueous humor dynamics in normotensive cynomolgus monkeys... - Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathwaysMark S Filla
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
Invest Ophthalmol Vis Sci 50:5723-31. 2009..CLANs form in glaucomatous and steroid-treated TM cells, which may contribute to reducing outflow facility through the TM... - Effect of heparin II domain of fibronectin on aqueous outflow in cultured anterior segments of human eyesAmy J Santas
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
Invest Ophthalmol Vis Sci 44:4796-804. 2003..This suggests that fibronectin-mediated interactions may have a role in modulating aqueous hydrodynamics. Such interactions may represent avenues of novel therapeutic interventions for glaucoma... - Beta1 and beta3 integrins cooperate to induce syndecan-4-containing cross-linked actin networks in human trabecular meshwork cellsMark S Filla
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53706, USA
Invest Ophthalmol Vis Sci 47:1956-67. 2006.... - The role of the actomyosin system in regulating trabecular fluid outflowBaohe Tian
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792 3220, USA
Exp Eye Res 88:713-7. 2009..In this review, we discuss the mechanisms underlying these and similar effects on trabecular outflow resistance in living animals and/or in cultured ocular anterior segments from enucleated animal or human eyes... - Changes in aqueous humor dynamics with age and glaucomaPaul L Kaufman
Department of Ophthalmology and Visual Sciences, University of Wisconsin, F4/340 CSC, 600 Highland Avenue, Madison, WI 53792-3220, USA
Prog Retin Eye Res 24:612-37. 2005..Future research to identify additional factors and clarify their roles in these processes could lead to alternative therapies for age and glaucoma related changes in the eye... - Comparison of the Ahmed Glaucoma Valve, the Krupin Eye Valve with Disk, and the double-plate Molteno implantDaniel P Taglia
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53705-3631, USA
J Glaucoma 11:347-53. 2002..The findings suggest that the Ahmed implant is less likely to create problems leading to reoperations or visual acuity loss than the Molteno or Krupin implants... - In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectinMark S Filla
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
Invest Ophthalmol Vis Sci 43:151-61. 2002..To determine whether trabecular meshwork-inducible glucocorticoid response/myocilin (TIGR/MYOC) protein associates with the extracellular matrix (ECM) of human trabecular meshwork (HTM) cells... - Distribution of syndecans 1-4 within the anterior segment of the human eye: expression of a variant syndecan-3 and matrix-associated syndecan-2Mark S Filla
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
Exp Eye Res 79:61-74. 2004..Western blots supported this idea and showed syndecan-2 ectodomains in lysates from anterior segments... - Effect of daily prolonged ketamine anesthesia on intraocular pressure in monkeysTheodora J Bunch
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53705 2135, USA
Curr Eye Res 33:946-53. 2008.... - Transformation of human trabecular meshwork cells with SV40 TAg alters promoter utilizationXuyang Liu
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA
Curr Eye Res 25:347-53. 2002.... - Ocular drug delivery: molecules, cells, and genesXuyang Liu
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53705 3611, USA
Can J Ophthalmol 42:447-54. 2007..The advantages and limitations of these delivery and therapeutic methods are also discussed...
Research Grants
- ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGYPaul Kaufman; Fiscal Year: 2000..Cholinergic/adrenergic receptor subtypes will be identified, quantified and localized by ligand binding, autoradiography and in situ hybridization in untouched eyes and following the various perturbations. ..
- ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGYPaul Kaufman; Fiscal Year: 2005..Structural parameters in the meshwork and ciliary muscle/processes of intact eyes will be evaluated by light/electron microscopy, immunohistochemistry and quantitative morphometry. ..
- Aqueous humor dynamics studies in vivo and in vitroPAUL LEON KAUFMAN; Fiscal Year: 2010....
- Workshops on Clinical and Basic Ophthalmology ResearchPaul Kaufman; Fiscal Year: 2004..Based on these visits and discussions, collaborative research projects are expected to emerge. A list of broad topics or sub-fields could be identified as thrust areas. ..
- CILIARY MUSCLE AGINGPaul Kaufman; Fiscal Year: 2004..These studies will generate new information about the pathophysiology of presbyopia. ..
- ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGYPaul Kaufman; Fiscal Year: 2009..Such knowledge will contribute to the development of new antiglaucoma drugs and perhaps to understanding the underlying biochemical, physiological, and morphological basis of the human open angle glaucomas. ..
- Aqueous humor dynamics studies in vivo and in vitroPaul Kaufman; Fiscal Year: 2009....
- ARVO Annual MeetingPaul Kaufman; Fiscal Year: 2006..The dates for the next five ARVO Annual Meetings are: May 5 - 10, 2002; May 4 - 9, 2003; April 25 - May 30, 2004; May 1 - 6, 2005; April 30 - May 3, 2006 ..
- ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGYPaul Kaufman; Fiscal Year: 1980....
- ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGYPaul Kaufman; Fiscal Year: 1993..These studies may enhance our knowledge of the pathophysiology of human glaucoma and its therapy and contribute to new pharmacological approaches to glaucoma treatment...
- ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGYPaul Kaufman; Fiscal Year: 1990....