PAUL LEON KAUFMAN

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension
    Kenneth S Kompass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Neurosci 9:93. 2008
  2. pmc Enhancing trabecular outflow by disrupting the actin cytoskeleton, increasing uveoscleral outflow with prostaglandins, and understanding the pathophysiology of presbyopia interrogating Mother Nature: asking why, asking how, recognizing the signs, followin
    Paul L Kaufman
    University of Wisconsin, School of Medicine and Public Health, Ophthalmology and Visual Sciences, 2870 University Ave, Suite 102, Madison, WI 53705, USA
    Exp Eye Res 86:3-17. 2008
  3. ncbi request reprint The effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyes
    Xuyang Liu
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI, USA
    Mol Vis 11:1112-21. 2005
  4. ncbi request reprint Aqueous humor dynamics and trabecular meshwork and anterior ciliary muscle morphologic changes with age in rhesus monkeys
    B Ann True Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Invest Ophthalmol Vis Sci 44:2118-25. 2003
  5. ncbi request reprint Adenovirus-mediated gene therapy using human p21WAF-1/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgery
    Todd W Perkins
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 1300 University Ave, Room 6640 MSC, Madison, WI 53706 1532, USA
    Arch Ophthalmol 120:941-9. 2002
  6. ncbi request reprint H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeys
    B Ann T Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53792, USA
    Invest Ophthalmol Vis Sci 45:2732-6. 2004
  7. pmc Identification of the active site in the heparin II domain of fibronectin that increases outflow facility in cultured monkey anterior segments
    Jose M Gonzalez
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Invest Ophthalmol Vis Sci 50:235-41. 2009
  8. pmc Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage
    Julie A Kiland
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
    Trans Am Ophthalmol Soc 107:146-58. 2009
  9. ncbi request reprint Aqueous humor dynamics in monkeys after topical 8-iso PGE(2)
    B Ann T Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792, USA
    Invest Ophthalmol Vis Sci 45:892-9. 2004
  10. pmc Heparin II domain of fibronectin mediates contractility through an alpha4beta1 co-signaling pathway
    Marie K Schwinn
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI 53706, USA
    Exp Cell Res 316:1500-12. 2010

Research Grants

  1. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2000
  2. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2005
  3. Aqueous humor dynamics studies in vivo and in vitro
    PAUL LEON KAUFMAN; Fiscal Year: 2010
  4. Workshops on Clinical and Basic Ophthalmology Research
    Paul Kaufman; Fiscal Year: 2004
  5. CILIARY MUSCLE AGING
    Paul Kaufman; Fiscal Year: 2004
  6. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2009
  7. Aqueous humor dynamics studies in vivo and in vitro
    Paul Kaufman; Fiscal Year: 2009
  8. ARVO Annual Meeting
    Paul Kaufman; Fiscal Year: 2006
  9. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 1980
  10. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 1993

Collaborators

Detail Information

Publications41

  1. pmc Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension
    Kenneth S Kompass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Neurosci 9:93. 2008
    ..We used high-density oligonucleotide arrays to investigate whole genome transcriptional changes occurring at the optic nerve head during primate experimental glaucoma...
  2. pmc Enhancing trabecular outflow by disrupting the actin cytoskeleton, increasing uveoscleral outflow with prostaglandins, and understanding the pathophysiology of presbyopia interrogating Mother Nature: asking why, asking how, recognizing the signs, followin
    Paul L Kaufman
    University of Wisconsin, School of Medicine and Public Health, Ophthalmology and Visual Sciences, 2870 University Ave, Suite 102, Madison, WI 53705, USA
    Exp Eye Res 86:3-17. 2008
    ..5) Global collaborations such as those involved in these studies will be essential in the future, as science becomes "bigger"...
  3. ncbi request reprint The effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyes
    Xuyang Liu
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI, USA
    Mol Vis 11:1112-21. 2005
    ..To determine the effects of adenovirus-delivered exoenzyme C3 transferase (C3) gene expression on cultured human trabecular meshwork (HTM) cells and on outflow facility in organ cultured monkey anterior segments...
  4. ncbi request reprint Aqueous humor dynamics and trabecular meshwork and anterior ciliary muscle morphologic changes with age in rhesus monkeys
    B Ann True Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Invest Ophthalmol Vis Sci 44:2118-25. 2003
    ..To determine in rhesus monkeys the age-dependence of uveoscleral outflow (Fu) and morphology of the trabecular meshwork (TM) and anterior ciliary muscle (CM)...
  5. ncbi request reprint Adenovirus-mediated gene therapy using human p21WAF-1/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgery
    Todd W Perkins
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 1300 University Ave, Room 6640 MSC, Madison, WI 53706 1532, USA
    Arch Ophthalmol 120:941-9. 2002
    ..To determine if adenovirus-mediated p21(WAF-1/Cip-1) (p21) gene therapy can prevent fibroproliferation and wound healing in a rabbit model of glaucoma filtration surgery...
  6. ncbi request reprint H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeys
    B Ann T Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53792, USA
    Invest Ophthalmol Vis Sci 45:2732-6. 2004
    ..To determine whether H-7 can enhance outflow facility after trabecular meshwork obstruction by extracellular material that accumulates after long-term treatment of monkeys with the cholinesterase inhibitor echothiophate iodide (ECHO)...
  7. pmc Identification of the active site in the heparin II domain of fibronectin that increases outflow facility in cultured monkey anterior segments
    Jose M Gonzalez
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Invest Ophthalmol Vis Sci 50:235-41. 2009
    ..To determine the active site in the Heparin II (HepII) domain of fibronectin that regulates outflow facility in cultured anterior segments and disrupts the actin cytoskeleton in transformed human trabecular meshwork (TM-1) cells...
  8. pmc Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage
    Julie A Kiland
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
    Trans Am Ophthalmol Soc 107:146-58. 2009
    ....
  9. ncbi request reprint Aqueous humor dynamics in monkeys after topical 8-iso PGE(2)
    B Ann T Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792, USA
    Invest Ophthalmol Vis Sci 45:892-9. 2004
    ..To determine in normotensive cynomolgus monkeys, the effects of topical 8-iso prostaglandin (PG)E(2) on intraocular pressure (IOP), aqueous humor formation (AHF), uveoscleral outflow (Fu), and total and trabecular outflow facility...
  10. pmc Heparin II domain of fibronectin mediates contractility through an alpha4beta1 co-signaling pathway
    Marie K Schwinn
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI 53706, USA
    Exp Cell Res 316:1500-12. 2010
    ..This is the first time that the PPRARI sequence in the HepII domain has been shown to serve as a physiological alpha4beta1 ligand, suggesting that alpha4beta1 integrin may be a key regulator of tissue contractility...
  11. pmc Effects of latrunculin B on outflow facility, intraocular pressure, corneal thickness, and miotic and accommodative responses to pilocarpine in monkeys
    Mehmet Okka
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Trans Am Ophthalmol Soc 102:251-7; discussion 257-9. 2004
    ....
  12. pmc Surgical lowering of elevated intraocular pressure in monkeys prevents progression of glaucomatous disease
    Robert W Nickells
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA
    Exp Eye Res 84:729-36. 2007
    ....
  13. ncbi request reprint Effects of reference electrode location on monopolar-derived multifocal electroretinograms in cynomolgus monkeys
    Charlene B Y Kim
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792 3220, USA
    Doc Ophthalmol 111:113-25. 2005
    ..K1 and K2.1 implicit times in males were longer than in females. Quadrant groupings revealed generally larger K1 and K2.1 amplitudes in nasal than in temporal retina...
  14. ncbi request reprint Multifocal visual evoked potentials in the anesthetized non-human primate
    Nathan A Maertz
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792 3220, USA
    Curr Eye Res 31:885-93. 2006
    ..To evaluate monkey multifocal visual evoked cortical potentials (mfVEPs) recorded from central and peripheral fields for reliability and isolation from electroretinographic (ERG) activity...
  15. ncbi request reprint Combined effects of H7 and pilocarpine on anterior segment physiology in monkey eyes
    Baohe Tian
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53705 3611, USA
    Curr Eye Res 32:491-500. 2007
    ....
  16. pmc Surgical intervention and accommodative responses, I: centripetal ciliary body, capsule, and lens movements in rhesus monkeys of various ages
    Mary Ann Croft
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
    Invest Ophthalmol Vis Sci 49:5484-94. 2008
    ..To determine how surgically altering the normal relationship between the lens and the ciliary body in rhesus monkeys affects centripetal ciliary body and lens movement...
  17. pmc Effect of H-7 on secondary cataract after phacoemulsification in the live rabbit eye
    Baohe Tian
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, WI 53792 3220, USA
    J Ocul Pharmacol Ther 26:533-9. 2010
    ..This study is aimed to determine if the serine-threonine kinase inhibitor H-7 inhibits secondary cataract after phacoemulsification in the live rabbit eye...
  18. pmc Prostaglandin subtype-selective and non-selective IOP-lowering comparison in monkeys
    B Ann True Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53705 2135, USA
    J Ocul Pharmacol Ther 25:1-8. 2009
    ..i.d. The combination of the FP, EP1, EP2, and EP3 agonists used in this study was sufficient to lower IOP by the same magnitude as PGF(2)alpha-ie, suggesting that combining PG-subtype agonists may be a potent antiglaucoma strategy...
  19. pmc Serial multifocal electroretinograms during long-term elevation and reduction of intraocular pressure in non-human primates
    T Michael Nork
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave F4 336, Madison, WI 53792 3220, USA
    Doc Ophthalmol 120:273-89. 2010
    ..These results demonstrate species-specific changes in cone-driven retinal function during periods of elevated IOP. These IOP-related effects can occur in the absence of retinal ganglion cells and may be reversible...
  20. ncbi request reprint The zonula, lens, and circumlental space in the normal iridectomized rhesus monkey eye
    Mary Ann Croft
    Department of Ophthalmology and Visual Sciences, Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53792 3284, USA
    Invest Ophthalmol Vis Sci 47:1087-95. 2006
    ..To document zonular orientation and suspension of the lens during accommodation, and age-related changes of the circumlental space (CLS) at rest and during accommodation, in living iridectomized rhesus monkey eyes...
  21. ncbi request reprint Accommodative ciliary body and lens function in rhesus monkeys, I: normal lens, zonule and ciliary process configuration in the iridectomized eye
    Mary Ann Croft
    Department of Ophthalmology and Visual Sciences, Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53792 3284, USA
    Invest Ophthalmol Vis Sci 47:1076-86. 2006
    ..In the current study, these relationships were studied in rhesus monkeys, whose accommodative apparatus and age-related loss of accommodation are similar to those in humans...
  22. pmc Age-related changes in centripetal ciliary body movement relative to centripetal lens movement in monkeys
    Mary Ann Croft
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792 3284, USA
    Exp Eye Res 89:824-32. 2009
    ..This, in turn, would allow enough zonular relaxation to achieve the magnitude of centripetal lens movement necessary for a given amplitude of accommodation...
  23. ncbi request reprint Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys
    Baohe Tian
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Medical School, Madison, F4 328 CSC, 600 Highland Avenue Madison, WI 53792, USA
    Exp Eye Res 80:215-25. 2005
    ..The partial inhibitory effect of Caly-A on the Y-27632-induced increase in outflow facility may reflect the former partially inhibiting the latter's relaxation of cells in the TM...
  24. ncbi request reprint Interspecies and gender differences in multifocal electroretinograms of cynomolgus and rhesus macaques
    Charlene B Y Kim
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI, USA
    Doc Ophthalmol 109:73-86. 2004
    ..There also were gender-associated differences that varied across species. Thus, investigators should exercise caution when data from species or gender are combined...
  25. ncbi request reprint Primate glaucoma models
    Carol A Rasmussen
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53792 3220, USA
    J Glaucoma 14:311-4. 2005
    ....
  26. ncbi request reprint Aqueous humor dynamics in monkeys after topical R-DOI
    B Ann T Gabelt
    Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53792 3220, USA
    Invest Ophthalmol Vis Sci 46:4691-6. 2005
    ..To determine the effects of R-DOI, a selective 5-HT2 agonist, on intraocular pressure (IOP) and aqueous humor dynamics in monkeys...
  27. ncbi request reprint Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments
    B Ann True Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792, USA
    Exp Eye Res 82:935-44. 2006
    ..This suggests that over-expression of the caldesmon gene in the TM may be an effective approach for the gene therapy of glaucoma...
  28. ncbi request reprint Monkey organ-cultured anterior segments: technique and response to H-7
    Yujie Hu
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, 600 Highland Ave, Madison, WI 53792, USA
    Exp Eye Res 82:1100-8. 2006
    ..Thus, the monkey organ-cultured anterior segment system can be used to determine the effects of pharmacological and biological agents on trabecular outflow...
  29. ncbi request reprint Accommodation and presbyopia: the ciliary neuromuscular view
    Mary Ann Croft
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, F4 328 CSC, 600 Highland Avenue, Madison, WI 53792, USA
    Ophthalmol Clin North Am 19:13-24, v. 2006
    ..Even if loss of ciliary muscle mobility is not causally related to presbyopia, it may limit the performance of putatively accommodating intraocular lenses now being developed by academic and industrial groups...
  30. pmc Aqueous humor dynamics in monkeys in response to the kappa opioid agonist bremazocine
    Carol A Rasmussen
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
    Trans Am Ophthalmol Soc 105:225-38; discussion 238-9. 2007
    ..To determine the effects of the kappa opioid agonist, bremazocine (BRE), on intraocular pressure (IOP) and aqueous humor dynamics in normotensive cynomolgus monkeys...
  31. pmc Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathways
    Mark S Filla
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Invest Ophthalmol Vis Sci 50:5723-31. 2009
    ..CLANs form in glaucomatous and steroid-treated TM cells, which may contribute to reducing outflow facility through the TM...
  32. ncbi request reprint Effect of heparin II domain of fibronectin on aqueous outflow in cultured anterior segments of human eyes
    Amy J Santas
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Invest Ophthalmol Vis Sci 44:4796-804. 2003
    ..To determine whether an integrin/syndecan-binding domain of fibronectin, called the heparin II (Hep II) domain, affects outflow facility in the human eye...
  33. pmc Beta1 and beta3 integrins cooperate to induce syndecan-4-containing cross-linked actin networks in human trabecular meshwork cells
    Mark S Filla
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53706, USA
    Invest Ophthalmol Vis Sci 47:1956-67. 2006
    ..CLANs have been observed in steroid-treated and glaucomatous TM cells and have been suggested to contribute to decreased outflow facility by altering the contractility of the TM...
  34. pmc The role of the actomyosin system in regulating trabecular fluid outflow
    Baohe Tian
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792 3220, USA
    Exp Eye Res 88:713-7. 2009
    ..In this review, we discuss the mechanisms underlying these and similar effects on trabecular outflow resistance in living animals and/or in cultured ocular anterior segments from enucleated animal or human eyes...
  35. ncbi request reprint Changes in aqueous humor dynamics with age and glaucoma
    B Ann True Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, F4 340 CSC, 600 Highland Avenue, Madison, WI 53792 3220, USA
    Prog Retin Eye Res 24:612-37. 2005
    ..Future research to identify additional factors and clarify their roles in these processes could lead to alternative therapies for age and glaucoma related changes in the eye...
  36. ncbi request reprint Comparison of the Ahmed Glaucoma Valve, the Krupin Eye Valve with Disk, and the double-plate Molteno implant
    Daniel P Taglia
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53705 3631, USA
    J Glaucoma 11:347-53. 2002
    ..To compare the efficacy of the nonvalved double-plate Molteno implant with two valved implants, the Krupin Eye Valve with Disc and the Ahmed Glaucoma Valve, in the treatment of recalcitrant glaucoma...
  37. ncbi request reprint In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin
    Mark S Filla
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Invest Ophthalmol Vis Sci 43:151-61. 2002
    ..To determine whether trabecular meshwork-inducible glucocorticoid response/myocilin (TIGR/MYOC) protein associates with the extracellular matrix (ECM) of human trabecular meshwork (HTM) cells...
  38. ncbi request reprint Distribution of syndecans 1-4 within the anterior segment of the human eye: expression of a variant syndecan-3 and matrix-associated syndecan-2
    Mark S Filla
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
    Exp Eye Res 79:61-74. 2004
    ..Western blots supported this idea and showed syndecan-2 ectodomains in lysates from anterior segments...
  39. pmc Effect of daily prolonged ketamine anesthesia on intraocular pressure in monkeys
    Theodora J Bunch
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53705 2135, USA
    Curr Eye Res 33:946-53. 2008
    ....
  40. ncbi request reprint Transformation of human trabecular meshwork cells with SV40 TAg alters promoter utilization
    Xuyang Liu
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA
    Curr Eye Res 25:347-53. 2002
    ..To compare promoter usage in primary differentiated and SV40 TAg transformed human trabecular meshwork cells (HTM and TM1 cells)...
  41. ncbi request reprint Ocular drug delivery: molecules, cells, and genes
    Xuyang Liu
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53705 3611, USA
    Can J Ophthalmol 42:447-54. 2007
    ..The advantages and limitations of these delivery and therapeutic methods are also discussed...

Research Grants43

  1. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2000
    ..Cholinergic/adrenergic receptor subtypes will be identified, quantified and localized by ligand binding, autoradiography and in situ hybridization in untouched eyes and following the various perturbations. ..
  2. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2005
    ..Structural parameters in the meshwork and ciliary muscle/processes of intact eyes will be evaluated by light/electron microscopy, immunohistochemistry and quantitative morphometry. ..
  3. Aqueous humor dynamics studies in vivo and in vitro
    PAUL LEON KAUFMAN; Fiscal Year: 2010
    ....
  4. Workshops on Clinical and Basic Ophthalmology Research
    Paul Kaufman; Fiscal Year: 2004
    ..Based on these visits and discussions, collaborative research projects are expected to emerge. A list of broad topics or sub-fields could be identified as thrust areas. ..
  5. CILIARY MUSCLE AGING
    Paul Kaufman; Fiscal Year: 2004
    ..These studies will generate new information about the pathophysiology of presbyopia. ..
  6. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2009
    ..Such knowledge will contribute to the development of new antiglaucoma drugs and perhaps to understanding the underlying biochemical, physiological, and morphological basis of the human open angle glaucomas. ..
  7. Aqueous humor dynamics studies in vivo and in vitro
    Paul Kaufman; Fiscal Year: 2009
    ....
  8. ARVO Annual Meeting
    Paul Kaufman; Fiscal Year: 2006
    ..The dates for the next five ARVO Annual Meetings are: May 5 - 10, 2002; May 4 - 9, 2003; April 25 - May 30, 2004; May 1 - 6, 2005; April 30 - May 3, 2006 ..
  9. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 1980
    ....
  10. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 1993
    ..These studies may enhance our knowledge of the pathophysiology of human glaucoma and its therapy and contribute to new pharmacological approaches to glaucoma treatment...
  11. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 1990
    ....