DAN KAUFMAN

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase
    J L Gori
    Gene Therapy Program, Department of Genetics, Cell Biology and Development, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Gene Ther 17:238-49. 2010
  2. ncbi request reprint Functional endothelial cells derived from rhesus monkey embryonic stem cells
    Dan S Kaufman
    Wisconsin Priamte Research Center, Laboratory of Developmental Biology and Department of Anatamy, University of Wisconsin, Madison, USA
    Blood 103:1325-32. 2004
  3. pmc Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells
    Dan S Kaufman
    Department of Medicine and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 114:3513-23. 2009
  4. pmc Reduced-intensity conditioning followed by related allografts in hematologic malignancies: long-term outcomes most successful in indolent and aggressive non-Hodgkin lymphomas
    Erica D Warlick
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 17:1025-32. 2011
  5. pmc Reduced-intensity allogeneic transplant in patients older than 55 years: unrelated umbilical cord blood is safe and effective for patients without a matched related donor
    Navneet S Majhail
    Blood and Marrow Transplant Program, Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:282-9. 2008
  6. pmc Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome
    Michael B Tomblyn
    Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Oncol 27:3634-41. 2009
  7. ncbi request reprint Synergistic use of adult and embryonic stem cells to study human hematopoiesis
    Colin H Martin
    University of Minnesota, Stem Cell Institute, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Curr Opin Biotechnol 16:510-5. 2005
  8. ncbi request reprint Use of human embryonic stem cells to understand hematopoiesis and hematopoietic stem cell niche
    Mohammad Saiful Islam
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    Curr Stem Cell Res Ther 5:245-50. 2010
  9. ncbi request reprint Cytokine requirements differ for stroma and embryoid body-mediated hematopoiesis from human embryonic stem cells
    Xinghui Tian
    Stem Cell Institute and Dept of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Hematol 32:1000-9. 2004
  10. pmc Differences in lymphocyte developmental potential between human embryonic stem cell and umbilical cord blood-derived hematopoietic progenitor cells
    Colin H Martin
    Stem Cell Institute, Department of Medicine, University of Minnesota, Minneapolis, USA
    Blood 112:2730-7. 2008

Collaborators

Detail Information

Publications33

  1. pmc In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase
    J L Gori
    Gene Therapy Program, Department of Genetics, Cell Biology and Development, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Gene Ther 17:238-49. 2010
    ..These results demonstrate that MTX treatment supports selective, long-term engraftment of Tyr22-DHFR cells in vivo, and provides a novel approach for combined human cell and gene therapy...
  2. ncbi request reprint Functional endothelial cells derived from rhesus monkey embryonic stem cells
    Dan S Kaufman
    Wisconsin Priamte Research Center, Laboratory of Developmental Biology and Department of Anatamy, University of Wisconsin, Madison, USA
    Blood 103:1325-32. 2004
    ..RESDECs provide a novel means to examine the mechanisms of endothelial cell development, and may open up new therapeutic strategies...
  3. pmc Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells
    Dan S Kaufman
    Department of Medicine and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 114:3513-23. 2009
    ..This review outlines the current status of hematopoietic cell development and what obstacles must be surmounted to bring hematopoietic cell therapies from human PSCs from "bench to bedside."..
  4. pmc Reduced-intensity conditioning followed by related allografts in hematologic malignancies: long-term outcomes most successful in indolent and aggressive non-Hodgkin lymphomas
    Erica D Warlick
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 17:1025-32. 2011
    ....
  5. pmc Reduced-intensity allogeneic transplant in patients older than 55 years: unrelated umbilical cord blood is safe and effective for patients without a matched related donor
    Navneet S Majhail
    Blood and Marrow Transplant Program, Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:282-9. 2008
    ..A careful review of existing comorbidities is necessary when considering older patients for HCT...
  6. pmc Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome
    Michael B Tomblyn
    Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Oncol 27:3634-41. 2009
    ..Analysis of hematopoietic cell transplantation (HCT) for high-risk or recurrent acute lymphoblastic leukemia (ALL) using different donor sources is confounded by variable conditioning and supportive care...
  7. ncbi request reprint Synergistic use of adult and embryonic stem cells to study human hematopoiesis
    Colin H Martin
    University of Minnesota, Stem Cell Institute, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Curr Opin Biotechnol 16:510-5. 2005
    ..Eventually, the long history of basic and clinical research with adult hematopoietic cell transplantation could translate to establish human ESCs as a suitable alternative starting cell source for clinical hematopoietic reconstitution...
  8. ncbi request reprint Use of human embryonic stem cells to understand hematopoiesis and hematopoietic stem cell niche
    Mohammad Saiful Islam
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    Curr Stem Cell Res Ther 5:245-50. 2010
    ..This review discusses recent status of hematopoietic development from the hESCs and highlights the possibility of developing HSC niche using hESC-derived niche components...
  9. ncbi request reprint Cytokine requirements differ for stroma and embryoid body-mediated hematopoiesis from human embryonic stem cells
    Xinghui Tian
    Stem Cell Institute and Dept of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Hematol 32:1000-9. 2004
    ..Here, we better characterize cell-bound and secreted factors that support this hematopoietic development...
  10. pmc Differences in lymphocyte developmental potential between human embryonic stem cell and umbilical cord blood-derived hematopoietic progenitor cells
    Colin H Martin
    Stem Cell Institute, Department of Medicine, University of Minnesota, Minneapolis, USA
    Blood 112:2730-7. 2008
    ..Therefore, hESCs can be more readily supported to differentiate into certain cell types than others, findings that have important implications for derivation of defined lineage-committed populations from hESCs...
  11. doi request reprint Differentiation of embryonic stem cells towards hematopoietic cells: progress and pitfalls
    Xinghui Tian
    Department of Medicine, Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Curr Opin Hematol 15:312-8. 2008
    ..Strategies to produce defined blood cell populations can be used to better understand normal and abnormal hematopoiesis, as well as potentially improve the generation of hematopoietic cells with therapeutic potential...
  12. pmc Human embryonic stem cell-derived vascular progenitor cells capable of endothelial and smooth muscle cell function
    Katherine L Hill
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, Minn 55455, USA
    Exp Hematol 38:246-257.e1. 2010
    ..These studies better define the developmental origin and reveal the relationship between these two cell types, as well as provide a more complete biological characterization...
  13. pmc Pluripotent stem cell-derived natural killer cells for cancer therapy
    David A Knorr
    Department of Medicine and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Transl Res 156:147-54. 2010
    ..This review will focus on the application of hESC-derived NK cells with currently used and novel therapeutics for clinical trials, barriers to translation, and future applications through genetic engineering approaches...
  14. ncbi request reprint Defined conditions for development of functional hepatic cells from human embryonic stem cells
    Robert E Schwartz
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Stem Cells Dev 14:643-55. 2005
    ..These hES cell-derived hepatocytes will serve as a resource to understand normal human hepatocyte development and for applications such as cell replacement therapies and screening of pharmacologic drugs...
  15. ncbi request reprint Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity
    Petter S Woll
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 175:5095-103. 2005
    ..These cells may also provide a source for innovative cellular immune therapies...
  16. ncbi request reprint Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation
    C M Cameron
    Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA
    Biotechnol Bioeng 94:938-48. 2006
    ....
  17. ncbi request reprint Nonhuman primate embryonic stem cells as a preclinical model for hematopoietic and vascular repair
    Peiman Hematti
    Department of Medicine, Section of Hematology Bone Marrow Transplant, University of Wisconsin Comprehensive Cancer Center and Wisconsin National Primate Research Center, Madison, Wis, USA
    Exp Hematol 33:980-6. 2005
    ..Therefore, additional research on nonhuman primate ES cells, in addition to work on mouse and human ES cells, is greatly needed to facilitate clinical translation of new stem cell treatments...
  18. ncbi request reprint Donor cell leukemia: insight into cancer stem cells and the stem cell niche
    Catherine M Flynn
    Stem Cell Institute and Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 109:2688-92. 2007
    ..In this article, we discuss the possible pathogenesis of DCL, its association with stem cells, and its likely dependence on a less-supportive stem cell niche...
  19. ncbi request reprint Hematopoietic engraftment of human embryonic stem cell-derived cells is regulated by recipient innate immunity
    Xinghui Tian
    Stem Cell Institute, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Stem Cells 24:1370-80. 2006
    ..These results demonstrate that SCID-repopulating cells, a close surrogate for hematopoietic stem cells, can be derived from hESCs. Moreover, both adaptive and innate immune effector cells may be barriers to engraftment of these cells...
  20. pmc Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms
    Zhenya Ni
    Department of Medicine, University of Minnesota, 420 Delaware St SE, MMC 480, Minneapolis, MN 55455, USA
    J Virol 85:43-50. 2011
    ..Our results establish the potential to utilize hESC- and iPSC-derived NK cells to better understand anti-HIV-1 immunity and provide a novel cellular immunotherapeutic approach to treat HIV/AIDS...
  21. ncbi request reprint Mouse and human embryonic stem cell models of hematopoiesis: past, present, and future
    Dong Chen
    University of Wisconsin, University of Wisconsin Hospital and Clinics, Madison, WI, USA
    Biotechniques 35:1253-61. 2003
    ..Eventually, research on human ES cells may provide an alternative source of HSCs and other blood products for hematopoietic cell transplantation or other cellular therapies...
  22. ncbi request reprint Efficient transfection of embryonic and adult stem cells
    Uma Lakshmipathy
    Stem Cell Institute, Hematology, Oncology and Transplantation Division, University of Minnesota, Minneapolis 55455, USA
    Stem Cells 22:531-43. 2004
    ..The high levels of transfection achieved by nucleofection will enable its use as a rapid screening tool to evaluate the effect of ectopically expressed transcription factors on tissue-specific differentiation of stem cells...
  23. pmc Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells
    Xinghui Tian
    Department of Medicine and Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Stem Cells 27:2675-85. 2009
    ..Although transplanted hESC-derived CD34(+) cells are well-suited for revascularization therapies, additional measures are needed to provide higher levels of long-term hematopoietic engraftment...
  24. pmc Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity
    Petter S Woll
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 113:6094-101. 2009
    ..These studies demonstrate that hESCs provide an important model to study human lymphocyte development and may serve as a novel source for antitumor immunotherapy...
  25. doi request reprint Hematopoietic differentiation of human embryonic stem cells by cocultivation with stromal layers
    Katherine L Hill
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    Curr Protoc Stem Cell Biol . 2008
    ..These methods will allow efficient and reproducible development of hematopoietic progenitor cells, as well as potentially mature hematopoietic cells that are suitable for subsequent in vitro and in vivo studies...
  26. doi request reprint Activation of hypoxic response in human embryonic stem cell-derived embryoid bodies
    C M Cameron
    Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Exp Biol Med (Maywood) 233:1044-57. 2008
    ..Therefore, although hypoxia effectively stimulates hypoxic responsive genes, this single variable was not sufficient to improve development of hemato-endothelial cells from hESCs...
  27. ncbi request reprint Hematopoietic development of human embryonic stem cells in culture
    Xinghui Tian
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Methods Mol Med 105:425-36. 2005
    ..Better understanding of basic human hematopoiesis through the study of human ES cells will likely have future therapeutic benefits...
  28. doi request reprint Hematopoietic development of human embryonic stem cells in culture
    Xinghui Tian
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Methods Mol Biol 430:119-33. 2008
    ..Subsequent to this early differentiation step, distinct progenitor cell populations can be derived, sorted, and utilized for further lineage-specific developmental studies...
  29. ncbi request reprint Hematopoietic development of human embryonic stem cells in culture
    Xinghui Tian
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, USA
    Methods Mol Biol 290:149-62. 2005
    ..Better understanding of basic human hematopoiesis through the study of human ES cells will likely have future therapeutic benefits...
  30. pmc Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells
    Petter S Woll
    Stem Cell Institute and Department of Medicine, University of Minnesota, Translational Research Facility, 2001 6th St SE, Minneapolis, MN 55455, USA
    Blood 111:122-31. 2008
    ..These studies effectively demonstrate the importance of canonical Wnt signaling to mediate development of early hematoendothelial progenitors during human development...
  31. pmc Derivation of normal macrophages from human embryonic stem (hES) cells for applications in HIV gene therapy
    Joseph S Anderson
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    Retrovirology 3:24. 2006
    ....
  32. ncbi request reprint Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development
    Caihong Qiu
    Einstein Center for Human Embryonic Stem Cell Research, Department of Medicine, Division of Hematology and Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Exp Hematol 33:1450-8. 2005
    ..To find a human cell line that could support differentiation of human embryonic stem cells (hESCs) into hematopoietic cells. To determine in detail the expression profiles of the beta-like globin genes in hESC-derived erythroid cells...
  33. doi request reprint Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells
    Tapan K Bera
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Stem Cells Dev 17:325-32. 2008
    ..There is no detectable POTE gene expression in fetal tissues (ages 16-36 weeks). The POTE paralogs that are expressed in ES cells may have a specific function during lineage-specific differentiation of ES cells...

Research Grants8

  1. In Vivo Potential of Human ES Cell-Derived Blood Cells
    DAN KAUFMAN; Fiscal Year: 2004
    ..abstract_text> ..
  2. Hematopoietic precursor development from human ES cells
    DAN KAUFMAN; Fiscal Year: 2006
    ..These cells may also be used as a new source for transfusion medicine. ..
  3. Hematopoietic Precursor Development from Human Embryonic Stem (ES) Cells
    DAN KAUFMAN; Fiscal Year: 2007
    ..These cells may also be used as a new source for transfusion medicine. ..
  4. Hematopoietic Precursor Development from Human Embryonic Stem (ES) Cells
    DAN KAUFMAN; Fiscal Year: 2009
    ..These cells may also be used as a new source for transfusion medicine. ..
  5. Hematopoietic Precursor Development from Human Embryonic Stem (ES) Cells
    Dan S Kaufman; Fiscal Year: 2010
    ..These cells may also be used as a new source for transfusion medicine. ..
  6. Hematopoietic Precursor Development from Human Embryonic Stem (ES) Cells
    DAN KAUFMAN; Fiscal Year: 2009
    ..These cells may also be used as a new source for transfusion medicine. ..