Research Topics
| DAN KAUFMANSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Functional endothelial cells derived from rhesus monkey embryonic stem cellsDan S Kaufman
Wisconsin Priamte Research Center, Laboratory of Developmental Biology and Department of Anatamy, University of Wisconsin, Madison, USA
Blood 103:1325-32. 2004..RESDECs provide a novel means to examine the mechanisms of endothelial cell development, and may open up new therapeutic strategies...
Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cellsDan S Kaufman
Department of Medicine and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
Blood 114:3513-23. 2009..This review outlines the current status of hematopoietic cell development and what obstacles must be surmounted to bring hematopoietic cell therapies from human PSCs from "bench to bedside."..
Reduced-intensity conditioning followed by related allografts in hematologic malignancies: long-term outcomes most successful in indolent and aggressive non-Hodgkin lymphomasErica D Warlick
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Biol Blood Marrow Transplant 17:1025-32. 2011....- Reduced-intensity allogeneic transplant in patients older than 55 years: unrelated umbilical cord blood is safe and effective for patients without a matched related donorNavneet S Majhail
Blood and Marrow Transplant Program, Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 14:282-9. 2008..A careful review of existing comorbidities is necessary when considering older patients for HCT... - Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcomeMichael B Tomblyn
Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
J Clin Oncol 27:3634-41. 2009..Analysis of hematopoietic cell transplantation (HCT) for high-risk or recurrent acute lymphoblastic leukemia (ALL) using different donor sources is confounded by variable conditioning and supportive care... - Cytokine requirements differ for stroma and embryoid body-mediated hematopoiesis from human embryonic stem cellsXinghui Tian
Stem Cell Institute and Dept. of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Exp Hematol 32:1000-9. 2004..Moreover, the method used to promote differentiation of ES cells may alter the cytokines or growth factors required to isolate specific cell types... - Synergistic use of adult and embryonic stem cells to study human hematopoiesisColin H Martin
University of Minnesota, Stem Cell Institute, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Curr Opin Biotechnol 16:510-5. 2005..Eventually, the long history of basic and clinical research with adult hematopoietic cell transplantation could translate to establish human ESCs as a suitable alternative starting cell source for clinical hematopoietic reconstitution... - Use of human embryonic stem cells to understand hematopoiesis and hematopoietic stem cell nicheMohammad Saiful Islam
Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
Curr Stem Cell Res Ther 5:245-50. 2010..This review discusses recent status of hematopoietic development from the hESCs and highlights the possibility of developing HSC niche using hESC-derived niche components... - Differentiation of embryonic stem cells towards hematopoietic cells: progress and pitfallsXinghui Tian
Department of Medicine, Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA
Curr Opin Hematol 15:312-8. 2008..Strategies to produce defined blood cell populations can be used to better understand normal and abnormal hematopoiesis, as well as potentially improve the generation of hematopoietic cells with therapeutic potential... - Human embryonic stem cell-derived vascular progenitor cells capable of endothelial and smooth muscle cell functionKatherine L Hill
Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, Minn 55455, USA
Exp Hematol 38:246-257.e1. 2010..These studies better define the developmental origin and reveal the relationship between these two cell types, as well as provide a more complete biological characterization... - Differences in lymphocyte developmental potential between human embryonic stem cell and umbilical cord blood-derived hematopoietic progenitor cellsColin H Martin
Stem Cell Institute, Department of Medicine, University of Minnesota, Minneapolis, USA
Blood 112:2730-7. 2008..Therefore, hESCs can be more readily supported to differentiate into certain cell types than others, findings that have important implications for derivation of defined lineage-committed populations from hESCs... - Defined conditions for development of functional hepatic cells from human embryonic stem cellsRobert E Schwartz
Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Stem Cells Dev 14:643-55. 2005..These hES cell-derived hepatocytes will serve as a resource to understand normal human hepatocyte development and for applications such as cell replacement therapies and screening of pharmacologic drugs... - Pluripotent stem cell-derived natural killer cells for cancer therapyDavid A Knorr
Department of Medicine and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
Transl Res 156:147-54. 2010..This review will focus on the application of hESC-derived NK cells with currently used and novel therapeutics for clinical trials, barriers to translation, and future applications through genetic engineering approaches... - Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activityPetter S Woll
Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 175:5095-103. 2005..These cells may also provide a source for innovative cellular immune therapies... - Hematopoietic engraftment of human embryonic stem cell-derived cells is regulated by recipient innate immunityXinghui Tian
Stem Cell Institute, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
Stem Cells 24:1370-80. 2006..These results demonstrate that SCID-repopulating cells, a close surrogate for hematopoietic stem cells, can be derived from hESCs. Moreover, both adaptive and innate immune effector cells may be barriers to engraftment of these cells... - Nonhuman primate embryonic stem cells as a preclinical model for hematopoietic and vascular repairPeiman Hematti
Department of Medicine, Section of Hematology/Bone Marrow Transplant, University of Wisconsin Comprehensive Cancer Center and Wisconsin National Primate Research Center, Madison, Wis, USA
Exp Hematol 33:980-6. 2005..Therefore, additional research on nonhuman primate ES cells, in addition to work on mouse and human ES cells, is greatly needed to facilitate clinical translation of new stem cell treatments... - Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivationC M Cameron
Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA
Biotechnol Bioeng 94:938-48. 2006.... - Donor cell leukemia: insight into cancer stem cells and the stem cell nicheCatherine M Flynn
Stem Cell Institute and Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Blood 109:2688-92. 2007..In this article, we discuss the possible pathogenesis of DCL, its association with stem cells, and its likely dependence on a less-supportive stem cell niche... - Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanismsZhenya Ni
Department of Medicine, University of Minnesota, 420 Delaware St SE, MMC 480, Minneapolis, MN 55455, USA
J Virol 85:43-50. 2011..Our results establish the potential to utilize hESC- and iPSC-derived NK cells to better understand anti-HIV-1 immunity and provide a novel cellular immunotherapeutic approach to treat HIV/AIDS... - Mouse and human embryonic stem cell models of hematopoiesis: past, present, and futureDong Chen
University of Wisconsin, University of Wisconsin Hospital and Clinics, Madison, WI, USA
Biotechniques 35:1253-61. 2003..Eventually, research on human ES cells may provide an alternative source of HSCs and other blood products for hematopoietic cell transplantation or other cellular therapies... - Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activityPetter S Woll
Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Blood 113:6094-101. 2009..These studies demonstrate that hESCs provide an important model to study human lymphocyte development and may serve as a novel source for antitumor immunotherapy... - Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cellsXinghui Tian
Department of Medicine and Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA
Stem Cells 27:2675-85. 2009..Although transplanted hESC-derived CD34(+) cells are well-suited for revascularization therapies, additional measures are needed to provide higher levels of long-term hematopoietic engraftment... - Hematopoietic differentiation of human embryonic stem cells by cocultivation with stromal layersKatherine L Hill
Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Curr Protoc Stem Cell Biol . 2008..These methods will allow efficient and reproducible development of hematopoietic progenitor cells, as well as potentially mature hematopoietic cells that are suitable for subsequent in vitro and in vivo studies... - Activation of hypoxic response in human embryonic stem cell-derived embryoid bodiesC M Cameron
Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, USA
Exp Biol Med (Maywood) 233:1044-57. 2008..Therefore, although hypoxia effectively stimulates hypoxic responsive genes, this single variable was not sufficient to improve development of hemato-endothelial cells from hESCs... - Hematopoietic development of human embryonic stem cells in cultureXinghui Tian
Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Methods Mol Biol 430:119-33. 2008..Subsequent to this early differentiation step, distinct progenitor cell populations can be derived, sorted, and utilized for further lineage-specific developmental studies... - Efficient transfection of embryonic and adult stem cellsUma Lakshmipathy
Stem Cell Institute, Hematology, Oncology and Transplantation Division, University of Minnesota, Minneapolis 55455, USA
Stem Cells 22:531-43. 2004..The high levels of transfection achieved by nucleofection will enable its use as a rapid screening tool to evaluate the effect of ectopically expressed transcription factors on tissue-specific differentiation of stem cells... - Wnt signaling promotes hematoendothelial cell development from human embryonic stem cellsPetter S Woll
Stem Cell Institute and Department of Medicine, University of Minnesota, Translational Research Facility, 2001 6th St SE, Minneapolis, MN 55455, USA
Blood 111:122-31. 2008..These studies effectively demonstrate the importance of canonical Wnt signaling to mediate development of early hematoendothelial progenitors during human development... - Hematopoietic development of human embryonic stem cells in cultureXinghui Tian
Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Methods Mol Med 105:425-36. 2005..Better understanding of basic human hematopoiesis through the study of human ES cells will likely have future therapeutic benefits... - Hematopoietic development of human embryonic stem cells in cultureXinghui Tian
Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, USA
Methods Mol Biol 290:149-62. 2005..Better understanding of basic human hematopoiesis through the study of human ES cells will likely have future therapeutic benefits... - Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cellsTapan K Bera
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Stem Cells Dev 17:325-32. 2008..There is no detectable POTE gene expression in fetal tissues (ages 16-36 weeks). The POTE paralogs that are expressed in ES cells may have a specific function during lineage-specific differentiation of ES cells... - Derivation of normal macrophages from human embryonic stem (hES) cells for applications in HIV gene therapyJoseph S Anderson
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
Retrovirology 3:24. 2006.... - Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in developmentCaihong Qiu
Einstein Center for Human Embryonic Stem Cell Research, Department of Medicine, Division of Hematology and Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
Exp Hematol 33:1450-8. 2005..This experimental system will be useful for studying the regulation of globin gene expression during early human hematopoiesis...
Research Grants
- In Vivo Potential of Human ES Cell-Derived Blood CellsDAN KAUFMAN; Fiscal Year: 2004..abstract_text> ..
- Hematopoietic Precursor Development from Human Embryonic Stem (ES) CellsDan S Kaufman; Fiscal Year: 2010..These cells may also be used as a new source for transfusion medicine. ..
- Hematopoietic Precursor Development from Human Embryonic Stem (ES) CellsDAN KAUFMAN; Fiscal Year: 2009..These cells may also be used as a new source for transfusion medicine. ..