Alexander S Kauffman

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Sexual differentiation and the Kiss1 system: hormonal and developmental considerations
    Alexander S Kauffman
    Department of Physiology and Biophysics, Health Sciences Building, Box 357290, University of Washington, Seattle, WA 98195, United States
    Peptides 30:83-93. 2009
  2. ncbi The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 27:8826-35. 2007
  3. ncbi Gonadotropin-releasing hormone-II messenger ribonucleic acid and protein content in the mammalian brain are modulated by food intake
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 147:5069-77. 2006
  4. pmc Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge
    Jessica L Robertson
    Departments of Biology, University of Washington, Seattle, Washington 98195, USA
    Endocrinology 150:3664-71. 2009
  5. ncbi Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, 1229 Jordan Hall, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Horm Behav 48:141-51. 2005
  6. ncbi Sexual differentiation of Kiss1 gene expression in the brain of the rat
    Alexander S Kauffman
    Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, Washington 98195 7290, USA
    Endocrinology 148:1774-83. 2007
  7. ncbi Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction
    Alexander S Kauffman
    Department of Physiology, University of Washington, Seattle, WA 98195, USA
    Trends Neurosci 30:504-11. 2007
  8. ncbi A critical role for the evolutionarily conserved gonadotropin-releasing hormone II: mediation of energy status and female sexual behavior
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 145:3639-46. 2004
  9. ncbi Increased heat loss affects hibernation in golden-mantled ground squirrels
    Alexander S Kauffman
    Dept of Biochemistry and Molecular Genetics, Jordan Hall, Rm 1229, 1300 Jefferson Park Ave, Univ of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Regul Integr Comp Physiol 287:R167-73. 2004
  10. ncbi The evolutionarily conserved gonadotropin-releasing hormone II modifies food intake
    Alexander S Kauffman
    University of Virginia Medical School, P O Box 800733, Jordan Hall, Room 1229, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Endocrinology 145:686-91. 2004

Research Grants

Detail Information

Publications14

  1. pmc Sexual differentiation and the Kiss1 system: hormonal and developmental considerations
    Alexander S Kauffman
    Department of Physiology and Biophysics, Health Sciences Building, Box 357290, University of Washington, Seattle, WA 98195, United States
    Peptides 30:83-93. 2009
    ..This review discusses the recent data, and their implications, regarding the bi-directional relationship between the Kiss1 system and the process of sexual differentiation...
  2. ncbi The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 27:8826-35. 2007
    ..However, GPR54 is necessary for proper male-like development of several sexually dimorphic traits, likely by regulating GnRH-mediated androgen secretion during "critical windows" in perinatal development...
  3. ncbi Gonadotropin-releasing hormone-II messenger ribonucleic acid and protein content in the mammalian brain are modulated by food intake
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 147:5069-77. 2006
    ..We postulate that this highly conserved neuropeptide functions similarly in other mammals, including humans, to fine-tune reproductive efforts with periods of sufficient energy resources...
  4. pmc Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge
    Jessica L Robertson
    Departments of Biology, University of Washington, Seattle, Washington 98195, USA
    Endocrinology 150:3664-71. 2009
    ..Collectively, these findings suggest that the LH surge is controlled by AVPV Kiss1 neurons whose activity is gated by SCN signals in an E(2)-dependent manner...
  5. ncbi Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, 1229 Jordan Hall, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Horm Behav 48:141-51. 2005
    ..Furthermore, our sexual behavior and locomotor findings suggest species-specific differences in the mechanism and/or location of GALP action in the brains of rats and mice...
  6. ncbi Sexual differentiation of Kiss1 gene expression in the brain of the rat
    Alexander S Kauffman
    Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, Washington 98195 7290, USA
    Endocrinology 148:1774-83. 2007
    ..Our findings suggest that sex differences in kisspeptin signaling from the AVPV subserve the cellular mechanisms controlling the sexually differentiated GnRH/LH surge...
  7. ncbi Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction
    Alexander S Kauffman
    Department of Physiology, University of Washington, Seattle, WA 98195, USA
    Trends Neurosci 30:504-11. 2007
    ....
  8. ncbi A critical role for the evolutionarily conserved gonadotropin-releasing hormone II: mediation of energy status and female sexual behavior
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 145:3639-46. 2004
    ..We speculate that GnRH-II acts via its own receptor as a regulatory signal in mammals to ensure that reproduction is synchronized with energetically favorable conditions...
  9. ncbi Increased heat loss affects hibernation in golden-mantled ground squirrels
    Alexander S Kauffman
    Dept of Biochemistry and Molecular Genetics, Jordan Hall, Rm 1229, 1300 Jefferson Park Ave, Univ of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Regul Integr Comp Physiol 287:R167-73. 2004
    ..This prolongs the hibernation season by several weeks, thereby eliminating the debilitating consequences associated with premature emergence from hibernation...
  10. ncbi The evolutionarily conserved gonadotropin-releasing hormone II modifies food intake
    Alexander S Kauffman
    University of Virginia Medical School, P O Box 800733, Jordan Hall, Room 1229, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Endocrinology 145:686-91. 2004
    ..We conclude that, in addition to its permissive role in regulating reproduction, GnRH II may also modulate food intake in mammals. Because GnRH II is present in primate brain, it may also serve a similar function in humans...
  11. ncbi Huddling, locomotor, and nest-building behaviors of furred and furless Siberian hamsters
    Alexander S Kauffman
    Department of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720, USA
    Physiol Behav 79:247-56. 2003
    ..Huddling and nest-building behaviors each ameliorate energetic challenges posed by absence of fur; animals that concurrently employ several modes of thermoregulation realize substantial energy savings in the cold...
  12. ncbi Feeding schedule controls circadian timing of daily torpor in SCN-ablated Siberian hamsters
    Matthew J Paul
    Department of Psychology, University of California at Berkeley, 94720 1650, USA
    J Biol Rhythms 19:226-37. 2004
    ....
  13. ncbi Reduced leptin concentrations are permissive for display of torpor in Siberian hamsters
    David A Freeman
    Dept of Psychology, Box 1650, Univ of California, Berkeley, CA 94720 1650, USA
    Am J Physiol Regul Integr Comp Physiol 287:R97-R103. 2004
    ..It is proposed that drastically reduced leptin concentrations provide a "starvation signal" to an as yet unidentified central mechanism mediating torpor initiation...
  14. ncbi Testicular recrudescence in intermediate day lengths reflects loss of photoperiodic memory in Siberian hamsters
    Alexander S Kauffman
    Department of Integrative Biology, University of California, Berkeley 94720, USA
    J Biol Rhythms 17:345-52. 2002
    ....

Research Grants3

  1. Neuroendocrine control of feeding and reproduction
    ALEXANDER KAUFFMAN; Fiscal Year: 2005
    ..Determine the neural sites of action for GnRH II in the regulation of behavior; 3.) Determine how energetic status affects GnRH II peptide and type-2 GnRH receptor content in the brain. ..
  2. Role of Kiss1 neurons in the seasonal and circadian control of reproduction
    ALEXANDER KAUFFMAN; Fiscal Year: 2007
    ....