Benita S Katzenellenbogen

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action
    William R Harrington
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Mol Endocrinol 20:491-502. 2006
  2. pmc The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization
    Yuechao Zhao
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine at Urbana Champaign, Urbana, IL 61801, USA
    Endocrinology 154:1349-60. 2013
  3. pmc Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: mutual restriction and competitive site selection
    Tze Howe Charn
    Department of Bioengineering, University of Illinois, Urbana, Illinois 61801, USA
    Mol Endocrinol 24:47-59. 2010
  4. pmc Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs)
    Karen J Kieser
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    J Med Chem 53:3320-9. 2010
  5. ncbi request reprint Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands
    Hai Bing Zhou
    Department of Chemistry, University of Illinois, Urbana, IL 61801, USA
    Chem Biol 14:659-69. 2007
  6. ncbi request reprint Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors
    Fabio Stossi
    Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Endocrinology 145:3473-86. 2004
  7. ncbi request reprint Synthesis and evaluation of estrogen receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif: estrogen antagonists of unusual structure
    Hai Bing Zhou
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    J Med Chem 48:7261-74. 2005
  8. pmc Phenethyl pyridines with non-polar internal substituents as selective ligands for estrogen receptor beta
    Michael Waibel
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, United States
    Eur J Med Chem 44:3560-70. 2009
  9. pmc Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation
    Joshua D Stender
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, IL 61801 3704, USA
    Mol Cell Biol 30:3943-55. 2010
  10. pmc Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding
    Edmund C Chang
    Department of Molecular, University of Illinois, Urbana, Illinois 61801 3704, USA
    Mol Endocrinol 22:1032-43. 2008

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action
    William R Harrington
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Mol Endocrinol 20:491-502. 2006
    ....
  2. pmc The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization
    Yuechao Zhao
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine at Urbana Champaign, Urbana, IL 61801, USA
    Endocrinology 154:1349-60. 2013
    ....
  3. pmc Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: mutual restriction and competitive site selection
    Tze Howe Charn
    Department of Bioengineering, University of Illinois, Urbana, Illinois 61801, USA
    Mol Endocrinol 24:47-59. 2010
    ....
  4. pmc Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs)
    Karen J Kieser
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    J Med Chem 53:3320-9. 2010
    ..Hence, the acrylic acid moiety of the ligand is crucial for SERD-like blockade of ER activities...
  5. ncbi request reprint Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands
    Hai Bing Zhou
    Department of Chemistry, University of Illinois, Urbana, IL 61801, USA
    Chem Biol 14:659-69. 2007
    ....
  6. ncbi request reprint Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors
    Fabio Stossi
    Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Endocrinology 145:3473-86. 2004
    ..These studies indicate both common as well as distinct target genes for these two ERs, and identify many novel genes not previously known to be under estrogen regulation...
  7. ncbi request reprint Synthesis and evaluation of estrogen receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif: estrogen antagonists of unusual structure
    Hai Bing Zhou
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    J Med Chem 48:7261-74. 2005
    ..These compounds, based on the bicyclo[2.2.1]core system, expand the structural diversity of ligands that can be antagonists for the estrogen receptors...
  8. pmc Phenethyl pyridines with non-polar internal substituents as selective ligands for estrogen receptor beta
    Michael Waibel
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, United States
    Eur J Med Chem 44:3560-70. 2009
    ..This study advances our understanding of compounds having ER-subtype selectivity and will help to direct efforts in developing novel ER ligands...
  9. pmc Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation
    Joshua D Stender
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, IL 61801 3704, USA
    Mol Cell Biol 30:3943-55. 2010
    ....
  10. pmc Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding
    Edmund C Chang
    Department of Molecular, University of Illinois, Urbana, Illinois 61801 3704, USA
    Mol Endocrinol 22:1032-43. 2008
    ....
  11. ncbi request reprint Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains
    Hai Bing Zhou
    Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA
    J Med Chem 50:399-403. 2007
    ....
  12. pmc Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors
    Zeynep Madak-Erdogan
    Department of Cell and Developmental Biology, University of Illinois, Urbana, Illinois 61801, USA
    Mol Endocrinol 22:2116-27. 2008
    ..This study thus highlights the importance of inputs from both nuclear and extranuclear ER signaling pathways in regulating patterns of gene expression in breast cancer cells...
  13. pmc Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta
    Michael Waibel
    Department of Chemistry, University of Illinois, 600 South Matthews Avenue, Urbana, IL 61801, United States
    Eur J Med Chem 44:3412-24. 2009
    ..These compounds should be useful probes for determining the physiological roles of ERbeta, and they might lead to the development of more selective and thus safer pharmaceuticals...
  14. ncbi request reprint Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity
    Varsha S Likhite
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    Mol Endocrinol 20:3120-32. 2006
    ....
  15. ncbi request reprint Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity
    Dennis R Compton
    Department of Chemistry and Department of Molecular and Integrative Physiology, University of Illinois, 600 South Matthews Avenue, Urbana, Illinois 61801, USA
    J Med Chem 47:5872-93. 2004
    ....
  16. pmc Differential estradiol and selective estrogen receptor modulator (SERM) regulation of Keratin 13 gene expression and its underlying mechanism in breast cancer cells
    Shubin Sheng
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801 3704, USA
    Mol Cell Endocrinol 296:1-9. 2008
    ....
  17. ncbi request reprint Isocoumarins as estrogen receptor beta selective ligands: Isomers of isoflavone phytoestrogens and their metabolites
    Meri De Angelis
    Department of Chemistry, University of Illinois, Urbana, 61801, USA
    Bioorg Med Chem 13:6529-42. 2005
    ..Two of the best compounds, which combine high transcriptional potency with an ERbeta selectivity greater than 1000, should prove to be excellent probes of ERbeta function in vivo...
  18. doi request reprint Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer
    Daniel H Barnett
    Department of Cell and Developmental Biology, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61801 3704, USA
    Cancer Res 68:3505-15. 2008
    ..Our findings highlight the crucial role of ER in the regulation of the CA12 gene, and provide insight into the transcriptional regulatory mechanism that accounts for the strong association of CA12 and ER in human breast cancers...
  19. pmc Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin complex involving the two receptors and the coregulator RIP140
    Zeynep Madak-Erdogan
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
    Toxicol Sci 125:401-11. 2012
    ....
  20. ncbi request reprint Molecular basis for the subtype discrimination of the estrogen receptor-beta-selective ligand, diarylpropionitrile
    Jun Sun
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
    Mol Endocrinol 17:247-58. 2003
    ..Our findings highlight that a limited number of critical interactions of DPN with the ERbeta ligand-binding pocket underlie its ER subtype-selective character...
  21. ncbi request reprint Therapeutic targeting in the estrogen receptor hormonal pathway
    Benita S Katzenellenbogen
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine, Urbana, IL, USA
    Semin Oncol 31:28-38. 2004
    ....
  22. ncbi request reprint Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression
    William R Harrington
    Department of Molecular and Integrative Physiology, University of Illinois, 407 S Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801 3704, USA
    Mol Cell Endocrinol 206:13-22. 2003
    ....
  23. pmc The estrogen-regulated transcription factor PITX1 coordinates gene-specific regulation by estrogen receptor-alpha in breast cancer cells
    Joshua D Stender
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801 3704, USA
    Mol Endocrinol 25:1699-709. 2011
    ..These studies identify PITX1 as a new ERα transcriptional target that acts as a repressor to coordinate and fine tune target-specific, ERα-mediated transcriptional activity in human breast cancer cells...
  24. ncbi request reprint Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells
    Edmund C Chang
    Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, 61801 3704, USA
    Endocrinology 147:4831-42. 2006
    ..Our observations suggest that the relative levels of ERbeta and ERalpha in breast cancers are likely to impact cell proliferation and the activities of diverse signaling pathways and their response to ER ligands and endocrine therapies...
  25. pmc Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1
    Fabio Stossi
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801 3704, USA
    Mol Cell Biol 29:1749-59. 2009
    ....
  26. pmc Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs
    Zeynep Madak-Erdogan
    University of Illinois, Department of Molecular and Integrative Physiology, 407 South Goodwin Ave, Urbana, IL 61801 3704, USA
    Mol Cell Biol 31:226-36. 2011
    ....
  27. ncbi request reprint Directed evolution of human estrogen receptor variants with significantly enhanced androgen specificity and affinity
    Zhilei Chen
    Center for Biophysics and Computational Biology and the Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 279:33855-64. 2004
    ....
  28. ncbi request reprint Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype
    Jonna Frasor
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
    Endocrinology 144:4562-74. 2003
    ..Our studies highlight the diverse gene networks and metabolic and cell regulatory pathways through which this hormone operates to achieve its widespread effects on breast cancer cells...
  29. ncbi request reprint Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome
    Jonna Frasor
    Department of Molecular and Integrative Physiology and Cell and Developmental Biology, University of Illinois and College of Medicine, Urbana, Illinois 61801 3704, USA
    Cancer Res 66:7334-40. 2006
    ..This may have a potential effect on the choice of tamoxifen versus aromatase inhibitors as adjuvant endocrine therapy...
  30. pmc Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA
    Sunghee Park
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Endocrinology 153:3982-94. 2012
    ....
  31. ncbi request reprint Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells
    Jonna Frasor
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine, 407 South Goodwin Avenue, Urbana, IL 61801, USA
    Cancer Res 64:1522-33. 2004
    ..Hence, gene expression profiling can discern fundamental differences among SERMs and provides insight into the distinct biologies of TOT, Ral, and ICI in breast cancer...
  32. pmc Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity
    Hai Bing Zhou
    Department of Chemistry, University of Illinois, Urbana, IL 61801, USA
    Bioorg Med Chem Lett 19:108-10. 2009
    ..This new analog retains the high ERalpha-selective binding affinity and antagonist potency of MPP...
  33. ncbi request reprint Indazole estrogens: highly selective ligands for the estrogen receptor beta
    Meri De Angelis
    Department of Chemistry, University of Illinois, 600 South Matthews Avenue, Urbana, Illinois 61801, USA
    J Med Chem 48:1132-44. 2005
    ..These findings also contribute to an evolving pharmacophore that characterizes certain nonsteroidal ligands having high ERbeta subtype affinity and potency selectivity...
  34. ncbi request reprint Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor
    Rajeev S Muthyala
    Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA
    J Med Chem 46:1589-602. 2003
    ..Some of the compounds show significant affinity selectivity in favor of ERbeta (4- to 5-fold), and in cell-based assays for transcriptional activity most are partial agonists on ERalpha and full antagonists on ERbeta...
  35. ncbi request reprint Estrogen-regulated gene networks in human breast cancer cells: involvement of E2F1 in the regulation of cell proliferation
    Joshua D Stender
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801 3704, USA
    Mol Endocrinol 21:2112-23. 2007
    ....
  36. pmc Post-transcriptional regulation of chemokine receptor CXCR4 by estrogen in HER2 overexpressing, estrogen receptor-positive breast cancer cells
    Surojeet Sengupta
    Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, IL 61801 3704, USA
    Breast Cancer Res Treat 117:243-51. 2009
    ..Thus, post-transcriptional regulation of CXCR4 by estrogens acting through ER via kinase pathways may play a critical role in determining the metastatic potential of breast cancer cells...
  37. ncbi request reprint Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta
    Rajeev S Muthyala
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA
    Bioorg Med Chem 12:1559-67. 2004
    ..The availability and the in vitro characterization of the equol enantiomers should enable their biological effects to be studied in detail...
  38. ncbi request reprint Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) alpha activity by ERbeta in the uterus
    Jonna Frasor
    Department of Molecular and Integrative Physiology, University of Illinois, 407 South Goodwin Avenue, Urbana, IL 61801 3704, USA
    Endocrinology 144:3159-66. 2003
    ..In addition, ERbeta can modulate ERalpha activity in a response-specific and dose-dependent manner...
  39. ncbi request reprint Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells
    William R Harrington
    Department of Molecular and Integrative Physiology, University of Illinois, Illinois 61801 3704, USA
    Endocrinology 147:3843-50. 2006
    ....
  40. ncbi request reprint Modulation of estrogen receptor activity by selective coregulators
    Paolo G V Martini
    Department of Molecular and Integrative Physiology, College of Medicine, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, IL 61801, USA
    J Steroid Biochem Mol Biol 85:117-22. 2003
    ..Analysis of the mechanisms underlying the activities of these two proteins highlights a new role for REA and PTalpha as activity-modulating proteins that confer receptor specificity...
  41. ncbi request reprint Lipin1 regulation by estrogen in uterus and liver: implications for diabetes and fertility
    P Mangala Gowri
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Endocrinology 148:3685-93. 2007
    ..Estrogen regulation of lipin1 may provide a mechanistic link between estrogens, lipid metabolism, and lipid signaling...
  42. pmc Estrogen down-regulation of the corepressor N-CoR: mechanism and implications for estrogen derepression of N-CoR-regulated genes
    Jonna Frasor
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 102:13153-7. 2005
    ....
  43. ncbi request reprint Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97)
    Ramji R Rajendran
    Department of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 278:4628-38. 2003
    ..Our findings add to the growing evidence that RNA helicases can associate with nuclear receptors and function as coregulators to modulate receptor transcriptional activity...
  44. ncbi request reprint Estrogenic diazenes: heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes
    Usha Ghosh
    Department of Chemistry, University of Illinois, IL 61801, Urbana, USA
    Bioorg Med Chem 11:629-57. 2003
    ....
  45. ncbi request reprint DNA shuffling method for generating estrogen receptor alpha and beta chimeras in yeast
    Jun Sun
    University of Illinois, 407 South Goodwin Avenue, Urbana, IL 61801 3704, USA
    Biotechniques 34:278-80, 282, 284 passim. 2003
    ..This method should prove to be useful for generating chimeric gene products from parent templates that share relatively low sequence identity...
  46. ncbi request reprint Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter
    Fabio Stossi
    Department of Molecular and Integrative Physiology, Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Biol Chem 281:16272-8. 2006
    ....
  47. ncbi request reprint Distinctive actions of membrane-targeted versus nuclear localized estrogen receptors in breast cancer cells
    Deshanie Rai
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Mol Endocrinol 19:1606-17. 2005
    ..Hence, this study reveals distinct actions of the MT-ER vs. the WT-ER in effecting estrogen actions in breast cancer cells...
  48. pmc Alteration of large-scale chromatin structure by estrogen receptor
    Anne C Nye
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Mol Cell Biol 22:3437-49. 2002
    ..This work demonstrates that when tethered or recruited to DNA, ER possesses a novel large-scale chromatin unfolding activity...
  49. pmc Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo
    Seong Eun Park
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Ave, Urbana, IL 61801 3704, USA
    Mol Cell Biol 25:1989-99. 2005
    ..These studies demonstrate that REA is a significant modulator of estrogen responsiveness in vivo: it normally restrains estrogen actions, moderating ER stimulation and enhancing ER repression of E2-regulated genes...
  50. pmc Reversal of endocrine resistance in breast cancer: interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis
    Anna Bergamaschi
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine at Urbana Champaign, Urbana, IL 61801, USA
    Breast Cancer Res 13:R70. 2011
    ..Therefore, we now probe the role of 14-3-3ζ in endocrine resistance, and we examine the functional dimensions and molecular basis that underlie 14-3-3ζ activities...
  51. pmc Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice
    Sunghee Park
    Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Endocrinology 152:4336-49. 2011
    ..Our findings reveal that REA is essential for mammary gland development and has a gene dosage-dependent role in the regulation of stage-specific physiological functions of the mammary gland...
  52. ncbi request reprint Biomedicine. Defining the "S" in SERMs
    Benita S Katzenellenbogen
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine at Urbana Champaign, Urbana, IL 61801, USA
    Science 295:2380-1. 2002
  53. ncbi request reprint Estrogen receptor inducibility of the human Na+/H+ exchanger regulatory factor/ezrin-radixin-moesin binding protein 50 (NHE-RF/EBP50) gene involving multiple half-estrogen response elements
    Tracy R Ediger
    Department of Cell and Structural Biology, University of Illinois and College of Medicine, Urbana, Illinois 61801 3704, USA
    Mol Endocrinol 16:1828-39. 2002
    ..Our findings highlight a paradigm for gene regulation via numerous half-ERE sites that expands the range of modes by which DNA recognition sites mediate the actions of this nuclear receptor...