L M Katz
Affiliation: University of North Carolina
- Low-dose Carbicarb improves cerebral outcome after asphyxial cardiac arrest in ratsLaurence M Katz
Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Ann Emerg Med 39:359-65. 2002....
- Infrared imaging of trauma patients for detection of acute compartment syndrome of the legLaurence M Katz
University of North Carolina at Chapel Hill, Department of Emergency Medicine, Chapel Hill, North Carolina 27599, USA
Crit Care Med 36:1756-61. 2008..We hypothesized that development of compartment syndrome is associated with a reduction in surface temperature in the involved leg and that the temperature reduction can be detected by infrared imaging...
- Independence of brain and trunk temperature during hypothermic preconditioning in ratsLaurence M Katz
University of North Carolina School of Medicine, Department of Emergency Medicine, CB 7594, Neurosciences Hospital Ground Floor, 101 Manning Drive, Chapel Hill, NC 27599, USA
J Neurosci Methods 179:179-83. 2009..Hypothermic preconditioning is rapid cooling and warming to induce tolerance to ischemia. The purpose of the study was to examine differences in brain and trunk temperature during hypothermic preconditioning...
- Regulated hypothermia reduces brain oxidative stress after hypoxic-ischemiaLaurence M Katz
Carolina Resuscitation Research Group, Department of Emergency Medicine, University of North Carolina School of Medicine, Neurosciences Hospital, Ground Floor, CB 7594 101 Manning Drive, Chapel Hill, NC 27517, USA
Brain Res 1017:85-91. 2004..Malondialdehyde (MDA) levels in the brain were measured during reperfusion to quantitate oxidative stress...
- Nitroglycerin attenuates vasoconstriction of HBOC-201 during hemorrhagic shock resuscitationLaurence M Katz
Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States
Resuscitation 81:481-7. 2010..The purpose of this study was to determine if co-administration of a weak NO donor, intravenous nitroglycerin (NTG), with HBOC-201 during resuscitation from hemorrhagic shock could safely attenuate HBOC-201 vasoconstriction...
- HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injuryLaurence M Katz
Department of Emergency Medicine, School of Medicine, University of North Carolina, Neurosciences Hospital Ground Floor, 101 Manning Drive, CB 7594, Chapel Hill, NC 27599, USA
Resuscitation 54:77-87. 2002..This hypothesis was tested in a large animal model that simulated blunt abdominal trauma with major organ injury...
- Neurotensin analog NT69L induces rapid and prolonged hypothermia after hypoxic ischemiaL M Katz
Department of Emergency Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
Acad Emerg Med 8:1115-21. 2001..To determine whether the neurotensin analog NT69L, administered systemically, could induce mild brain hypothermia after asphyxial cardiac arrest (ACA) in rats...
- Regulation of caspases and XIAP in the brain after asphyxial cardiac arrest in ratsL M Katz
Department of Emergency Medicine, University of North Carolina at Chapel Hill, Neurosciences Hospital, Chapel Hill, NC 27599, USA
Neuroreport 12:3751-4. 2001..We conclude that hypoxic-ischemia increases caspases-1 and-3, and XIAP expression. Treatment with zVAD significantly decreases caspase and XIAP expression in these brain regions and improves neurological outcome...
- Selective aortic arch perfusion with hemoglobin-based oxygen carrier-201 for resuscitation from exsanguinating cardiac arrest in swineJ E Manning
Department of Emergency Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7594, USA
Crit Care Med 29:2067-74. 2001..This study evaluated the acute cardiovascular and metabolic effects of SAAP with HBOC-201 in an exsanguination model of cardiac arrest...
- Cardiopulmonary and cerebral resuscitationJ E Manning
Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, USA
Crit Care Clin 16:659-79. 2000..The allocation of such resources to provide intensive resuscitation and post-resuscitation support will need to be addressed from medical and societal viewpoints...
- Neurotensin-induced hypothermia improves neurologic outcome after hypoxic-ischemiaLaurence M Katz
University of North Carolina School of Medicine, Chapel Hill, NC, USA
Crit Care Med 32:806-10. 2004..We hypothesize that NT77 would be more effective for improving neurologic outcome than external cooling of the same duration...
- Exercise and the aging mind: buffing the baby boomer's body and brainBonita L Marks
Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, NC 27599 8700, USA
Phys Sportsmed 37:119-25. 2009..This study argues that "what is good for the heart is good for the brain," although more research is needed to determine the optimal exercise prescription for brain health and successful cognitive aging...
- Infrared thermography: a rapid, portable, and accurate technique to detect experimental pneumothoraxPreston B Rich
Department of Surgery, School of Medicine, Medical Wing D Room 186, CB 7228, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7228 USA
J Surg Res 120:163-70. 2004..Infrared thermography (IRT), a compact and portable technology, has become highly sensitive. We hypothesized that IRT could detect Ptx by identifying associated changes in skin temperature...
- Feasibility of external cranial cooling during out-of-hospital cardiac arrestClifton W Callaway
Department of Emergency Medicine, University of Pittsburgh, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
Resuscitation 52:159-65. 2002..However, most cardiac arrest victims are spontaneously mildly hypothermic and preventing rewarming may provide some of the desired benefits of cerebral hypothermia...
- Aerobic fitness and obesity: relationship to cerebral white matter integrity in the brain of active and sedentary older adultsB L Marks
Department of Exercise and Sport Science, Fetzer Gym, Campus Box 8700, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 8700, USA
Br J Sports Med 45:1208-15. 2011..This study examined hemispheric and segment specific relationships between VO(2) peak, OR and cerebral white-matter (CWM) integrity in the cingulum brain region in healthy older adults...
- The effect of exercise on the cerebral vasculature of healthy aged subjects as visualized by MR angiographyE Bullitt
Department of Surgery, University of North Carolina, Chapel Hill, NC, USA
AJNR Am J Neuroradiol 30:1857-63. 2009..The purpose of this blinded study was to compare high-activity and low-activity healthy elderly volunteers for differences in the cerebrovasculature as calculated from vessels extracted from noninvasive MR angiograms (MRAs)...
- Spectral analysis of heart rate variability and pulmonary responses to topical applications of 2% aminophylline-based thigh creamB L Marks
Department of Physical Education, Exercise and Sport Science, University of North Carolina, Chapel Hill 27599 8700, USA
Int J Obes Relat Metab Disord 23:198-202. 1999..Noninvasive assessment of the immediate and delayed cardiopulmonary response to a 2% aminophylline-based topical thigh reducing cream...
- Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivationAmi P Raval
Department of Neurology and Neuroscience Program, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Florida 33101, USA
J Cereb Blood Flow Metab 25:730-41. 2005..Our results support the deleterious role of deltaPKC in reperfusion injury. We propose that early cytochrome c release and caspase 3 activation promote deltaPKC translocation/cleavage...
- Mild cardiopulmonary arrest promotes synaptic dysfunction in rat hippocampusKunjan R Dave
Department of Neurology and Neuroscience, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Miami, FL 33101, USA
Brain Res 1024:89-96. 2004..These data suggest that synaptic dysfunction occurs before and without overt histopathology. We suggest that the synaptic dysfunction precedes and may be an early marker for delayed neuronal cell death in the hippocampus after CA...