M J Katovich

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Genetic targeting of the renin-angiotensin system for long-term control of hypertension
    Beverly L Metcalfe
    Department of Pharmacodynamics, University of Florida, College of Pharmacy, PO Box 100487, Gainesville, FL 32610 0487, USA
    Curr Hypertens Rep 4:25-31. 2002
  2. ncbi request reprint Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor
    Hongwei Li
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610 0274, USA
    Am J Physiol Heart Circ Physiol 292:H727-35. 2007
  3. ncbi request reprint Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension
    Michael J Katovich
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, PO Box 100487, Gainesville, FL 32610 0487, USA
    Exp Physiol 90:299-305. 2005
  4. ncbi request reprint Angiotensin-(1-7) as an antihypertensive, antifibrotic target
    Michael J Katovich
    Department of Pharmacodynamics, University of Florida, PO Box 100487, J Hillis Miller Health Science Center, Gainesville, FL 31610 0487, USA
    Curr Hypertens Rep 10:227-32. 2008
  5. pmc Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury
    Yanfei Qi
    Department of Pharmacodynamics, University of Florida, SW 1600 Archer Road, Gainesville, FL 32610, USA
    Exp Physiol 97:89-101. 2012
  6. ncbi request reprint Gene therapy attenuates the elevated blood pressure and glucose intolerance in an insulin-resistant model of hypertension
    M J Katovich
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610 0487, USA
    J Hypertens 19:1553-8. 2001
  7. ncbi request reprint Angiotensin II type 1 receptor antisense gene therapy prevents altered renal vascular calcium homeostasis in hypertension
    C H Gelband
    Department of Physiology, College of Medicine, University of Florida, Gainesville 32610, USA
    Hypertension 33:360-5. 1999
  8. ncbi request reprint The future of hypertension therapy: sense, antisense, or nonsense?
    A S Pachori
    Department of Pharmacodynamics Colleges of Pharmacy and Medicine, and University of Florida, McKnight Brain Institute, Gainesville, USA
    Hypertension 37:357-64. 2001
  9. ncbi request reprint Angiotensin I-converting enzyme antisense prevents altered renal vascular reactivity, but not high blood pressure, in spontaneously hypertensive rats
    C H Gelband
    Department of Physiology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Hypertension 35:209-13. 2000
  10. ncbi request reprint Gene therapy to control hypertension: current studies and future perspectives
    K W Sellers
    Department of Physiology, College of Medicine, University of Florida, Gainesville 32610, USA
    Am J Med Sci 322:1-6. 2001

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Genetic targeting of the renin-angiotensin system for long-term control of hypertension
    Beverly L Metcalfe
    Department of Pharmacodynamics, University of Florida, College of Pharmacy, PO Box 100487, Gainesville, FL 32610 0487, USA
    Curr Hypertens Rep 4:25-31. 2002
    ..We focus on our own research, which targets the use of antisense of the angiotensin type I receptor in various models of hypertension. Finally, we discuss the future of antisense technology in the treatment of human hypertension...
  2. ncbi request reprint Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor
    Hongwei Li
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610 0274, USA
    Am J Physiol Heart Circ Physiol 292:H727-35. 2007
    ..4, and -27.3 +/- 3.4 mmHg, respectively). These results provide support for a depressor role of AT(2)R and the proposal that combined AT(2)R agonist and ARB treatment may be an improved therapeutic strategy for controlling hypertension...
  3. ncbi request reprint Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension
    Michael J Katovich
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, PO Box 100487, Gainesville, FL 32610 0487, USA
    Exp Physiol 90:299-305. 2005
    ..This article will focus on angiotensin-converting enzyme 2 (ACE2) as a new, potential target of gene therapy for hypertensive disorders...
  4. ncbi request reprint Angiotensin-(1-7) as an antihypertensive, antifibrotic target
    Michael J Katovich
    Department of Pharmacodynamics, University of Florida, PO Box 100487, J Hillis Miller Health Science Center, Gainesville, FL 31610 0487, USA
    Curr Hypertens Rep 10:227-32. 2008
    ..Here, we review key studies investigating the blood pressure and tissue-protective roles of Ang-(1-7), and summarize potential genomic and pharmacologic therapeutic strategies previously advanced by our group and others...
  5. pmc Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury
    Yanfei Qi
    Department of Pharmacodynamics, University of Florida, SW 1600 Archer Road, Gainesville, FL 32610, USA
    Exp Physiol 97:89-101. 2012
    ....
  6. ncbi request reprint Gene therapy attenuates the elevated blood pressure and glucose intolerance in an insulin-resistant model of hypertension
    M J Katovich
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610 0487, USA
    J Hypertens 19:1553-8. 2001
    ..In the current study our aim was to test the hypothesis that intervention of the RAS with a gene therapy approach would be effective in preventing the development of hypertension and glucose intolerance in this animal model...
  7. ncbi request reprint Angiotensin II type 1 receptor antisense gene therapy prevents altered renal vascular calcium homeostasis in hypertension
    C H Gelband
    Department of Physiology, College of Medicine, University of Florida, Gainesville 32610, USA
    Hypertension 33:360-5. 1999
    ..These results are novel and demonstrate that viral-mediated delivery of AT1R-AS not only attenuates the development of hypertension on a long-term basis but prevents changes in renal vascular Ca2+ homeostasis associated with the disease...
  8. ncbi request reprint The future of hypertension therapy: sense, antisense, or nonsense?
    A S Pachori
    Department of Pharmacodynamics Colleges of Pharmacy and Medicine, and University of Florida, McKnight Brain Institute, Gainesville, USA
    Hypertension 37:357-64. 2001
    ..In addition, we will discuss the properties of an ideal vector for the systemic delivery of genes and the potential experimental hurdles that must be overcome to take this innovative approach to the next level of evaluation...
  9. ncbi request reprint Angiotensin I-converting enzyme antisense prevents altered renal vascular reactivity, but not high blood pressure, in spontaneously hypertensive rats
    C H Gelband
    Department of Physiology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Hypertension 35:209-13. 2000
    ..These results demonstrate that ACE-AS permanently prevents alterations in renal vascular pathophysiology in spite of the modest effect that ACE-AS had on high blood pressure in SHR...
  10. ncbi request reprint Gene therapy to control hypertension: current studies and future perspectives
    K W Sellers
    Department of Physiology, College of Medicine, University of Florida, Gainesville 32610, USA
    Am J Med Sci 322:1-6. 2001
    ..Finally, we discuss the future of this gene therapy approach in the reversal and long-term control of hypertension...
  11. ncbi request reprint Targeting of the renin-angiotensin system by antisense gene therapy: a possible strategy for the long-term control of hypertension
    M K Raizada
    Department of Physiology, College of Medicine, University of Florida, Gainesville 32610 0274, USA
    J Hypertens 18:353-62. 2000
    ....
  12. doi request reprint 17beta-Estradiol modulates local cardiac renin-angiotensin system to prevent cardiac remodeling in the DOCA-salt model of hypertension in rats
    V Shenoy
    Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610, USA
    Peptides 30:2309-15. 2009
    ..These findings suggest that physiologically relevant estrogen replacement therapy has blood pressure-independent cardioprotective effects, which are possibly mediated through modulation of the cardiac renin-angiotensin system...
  13. ncbi request reprint Current perspectives on the use of gene therapy for hypertension
    C H Gelband
    Department of Physiology, College of Medicine, University of Florida, Gainesville, FL 32610 0274, USA
    Circ Res 87:1118-22. 2000
    ....
  14. ncbi request reprint Genetic targeting for cardiovascular therapeutics: are we near the summit or just beginning the climb?
    S C Francis
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida Brain Institute, Gainesville, Florida 32610, USA
    Physiol Genomics 7:79-94. 2001
    ....
  15. ncbi request reprint Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats
    Matthew J Huentelman
    Department of Physiology and Functional Genomics, University of Florida, College of Medicine, PO Box 100274, Gainesville, FL 32610, USA
    Exp Physiol 90:783-90. 2005
    ..These observations demonstrate that ACE2 overexpression results in protective effects on angiotensin II-induced cardiac hypertrophy and fibrosis...
  16. ncbi request reprint Effect of acute and chronic losartan treatment on glucose tolerance and insulin sensitivity in fructose-fed rats
    S N Iyer
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Am J Hypertens 9:662-8. 1996
    ..These results strongly suggest that the renin-angiotensin system modulates the insulin resistance, hypertension, and cardiac hypertrophy in fructose-treated rats...
  17. ncbi request reprint Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7)
    Justin L Grobe
    Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610 0487, USA
    Am J Physiol Heart Circ Physiol 292:H736-42. 2007
    ....
  18. pmc The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension
    Vinayak Shenoy
    Department of Pharmacodynamics, University of Florida, Gainesville, Florida, USA
    Am J Respir Crit Care Med 182:1065-72. 2010
    ..The recent discovery of a counterregulatory axis of the renin angiotensin system composed of ACE2/Ang-(1-7)/Mas has led us to examine the role of this vasoprotective axis on such disorders...
  19. ncbi request reprint Fructose feeding in rats is not associated with sodium retention
    S N Iyer
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Am J Hypertens 9:1018-23. 1996
    ..The results of these two in vivo studies are the first to document that elevation of blood pressure in fructose-fed rats does not occur directly via sodium retention or an increase in fluid volume...
  20. ncbi request reprint Gene therapy for cardiovascular disorders: is there a future?
    B L Metcalfe
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville 32610, USA
    Ann N Y Acad Sci 953:31-42. 2001
    ..Finally, we will discuss the future of gene therapy and other new technologies that may further advance this field of therapeutics...
  21. ncbi request reprint Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate
    M O James
    Departments of Medicinal Chemistry and Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610 0485, USA
    Drug Metab Dispos 26:1134-43. 1998
    ....
  22. ncbi request reprint ACE2: A novel therapeutic target for cardiovascular diseases
    Shant Der Sarkissian
    Department of Physiology and Functional Genomics, College of Medicine, and the McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Prog Biophys Mol Biol 91:163-98. 2006
    ....
  23. ncbi request reprint ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts
    Justin L Grobe
    Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610, USA
    Clin Sci (Lond) 113:357-64. 2007
    ..We conclude that ACE2 expression, limited to cardiac fibroblasts, may represent a novel paradigm for in vivo therapy following acute ischaemia...
  24. pmc Involvement of the brain (pro)renin receptor in cardiovascular homeostasis
    Zhiying Shan
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610, USA
    Circ Res 107:934-8. 2010
    ..Despite overwhelming evidence of the importance of brain renin-angiotensin system (RAS), the very existence of intrinsic brain RAS remains controversial...
  25. ncbi request reprint Elevated blood pressure in normotensive rats produced by 'knockdown' of the angiotensin type 2 receptor
    Hongwei Wang
    College of Pharmacy, Box 100487 JHMHC, University of Florida, Gainesville, FL 32610, USA
    Exp Physiol 89:313-22. 2004
    ..The actions of the AT(2) receptors appear to be antagonistic to the cardiovascular actions of the AT(1) receptors, whereas AT(1) and AT(2) receptors appear to act synergistically in the regulation of water intake...
  26. doi request reprint Selective tropism of the recombinant adeno-associated virus 9 serotype for rat cardiac tissue
    Yanfei Qi
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610 0487, USA
    J Gene Med 12:22-34. 2010
    ..Cardiac gene transfer may serve as a novel therapeutic approach for heart disease. Numerous serotypes of recombinant adeno-associated virus (rAAV) have been identified with variable tropisms to cardiac tissue...
  27. ncbi request reprint Body fluid distribution in rats with cold-induced hypertension
    Z Sun
    Department of Physiology, College of Medicine, University of Florida, Gainesville 32610, USA
    Physiol Behav 65:879-84. 1999
    ..The results also imply that exposure to cold induces a dehydration in rats...
  28. ncbi request reprint Gene therapy in cardiovascular disease. Current status
    S C Francis
    Department of Physiology, College of Medicine, University of Florida Brain Institute, Gainesville, Florida, USA
    Am J Pharmacogenomics 1:55-66. 2001
    ..Continued technologic advances in vector systems and promising results in human and animal gene transfer studies make the use of gene therapy a promising strategy for the treatment of cardiovascular disorders...
  29. ncbi request reprint Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension
    Justin L Grobe
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Heart Circ Physiol 290:H2417-23. 2006
    ..These results indicate that angiotensin-(1-7) selectively prevents cardiac fibrosis independent of blood pressure or cardiac hypertrophy in the DOCA-salt model of hypertension...
  30. ncbi request reprint Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer
    Beverly L Metcalfe
    Department of Physiology College of Medicine and the Evelyn F and William L McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Hypertension 43:1233-8. 2004
    ..Our data indicate that AT2R overexpression attenuates cardiac hypertrophy in the SHR. This beneficial outcome was observed despite the existence of elevated BP...
  31. ncbi request reprint Angiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension
    Beverly L Falcon
    Department of Physiology and Functional Genomics, College of Medicine and the Evelyn F and William L McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    Physiol Genomics 19:255-61. 2004
    ..Thus our observations indicate that long-term expression of the AT2R in the heart attenuates cardiac hypertrophy and fibrosis in a nongenetic rat model of hypertension...
  32. doi request reprint Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology
    Shant Der Sarkissian
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Hypertension 51:712-8. 2008
    ....
  33. doi request reprint Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents
    Jose A Hernandez Prada
    McKnight Brain Institute and Department of Physiology, College of Medicine, University of Florida, Gainesville, USA
    Hypertension 51:1312-7. 2008
    ..We conclude that structure-based screening can help identify compounds that activate ACE2, decrease blood pressure, and reverse tissue remodeling. Administration of ACE2 activators may be a valid strategy for antihypertensive therapy...
  34. ncbi request reprint Perinatal dietary NaCl level: effect on angiotensin-induced thermal and dipsogenic responses in adult rats
    M J Katovich
    Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610, USA
    Physiol Behav 72:621-7. 2001
    ..Thus, dietary salt level may have opposite effects on Ang II effects on adult thermoregulation, depending on the age at the exposure...
  35. ncbi request reprint Alterations in aortic vascular reactivity to angiotensin 1-7 in 17-beta-estradiol-treated female SD rats
    Justin L Grobe
    Department of Pharmacodynamics, University of Florida College of Pharmacy, JHMHSC, PO Box 100487, Gainesville, FL 32610, USA
    Regul Pept 133:62-7. 2006
    ..These findings are in contrast to recent work showing potentiated responses to Ang 1-7 in mesenteric arteries from estrogen-manipulated rats, and may suggest a regional specificity in estradiol-mediated changes in the RAS...
  36. ncbi request reprint Cloning and characterization of a secreted form of angiotensin-converting enzyme 2
    Matthew J Huentelman
    Department of Physiology and Functional Genomics, College of Medicine, UF McKnight Brain Institute, University of Florida, 1600 SW Archer Road, P O Box 100274, Gainesville, FL 32610 0255, USA
    Regul Pept 122:61-7. 2004
    ..Collectively, these results set the stage for the use of these vectors to investigate the consequences of ACE2 over-expression in the pathogenesis of hypertension...
  37. ncbi request reprint Large-scale production of retroviral vectors for systemic gene delivery
    Matthew J Huentelman
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    Methods Enzymol 346:562-73. 2002
  38. doi request reprint Angiotensin type 2 receptor-mediated apoptosis of human prostate cancer cells
    Hongwei Li
    Department of Physiology and Functional Genomics, College of Medicine, Box 100274, 1600 Southwest Archer Road, University of Florida, Gainesville, FL 32610 0274, USA
    Mol Cancer Ther 8:3255-65. 2009
    ....
  39. pmc Brain microglial cytokines in neurogenic hypertension
    Peng Shi
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610, USA
    Hypertension 56:297-303. 2010
    ..These data have significant implications on the development of innovative therapeutic strategies for the control of neurogenic hypertension...
  40. pmc Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer
    Yoriko Yamazato
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, PO Box 100274, Gainesville, FL 32610 0274, USA
    Hypertension 54:365-71. 2009
    ....
  41. pmc Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension
    Anderson J Ferreira
    Department of Physiology and Functional Genomics, College of Medicine, Gainesville, FL 32610, USA
    Am J Respir Crit Care Med 179:1048-54. 2009
    ....
  42. ncbi request reprint Endothelial-independent prevention of high blood pressure in L-NAME-treated rats by angiotensin II type I receptor antisense gene therapy
    Phyllis Y Reaves
    Department of Physiology and Functional Genomics, Colleges of Medicine and Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Exp Physiol 88:467-73. 2003
    ..However, endothelial dysfunction could not be prevented with the antisense therapy. These observations demonstrate that attenuation of endothelial dysfunction is not a prerequisite for the antihypertensive effects of AT(1)R-AS treatment...
  43. ncbi request reprint Decrease in hypothalamic gamma adducin in rat models of hypertension
    Hong Yang
    Department of Physiology and Functional Genomics, University of Florida McKnight Brain Institute, Gainesville, FL 32610, USA
    Hypertension 43:324-8. 2004
    ..This chronic incubation with Ang II resulted in a 60% decrease in the neuronal gamma-adducin. Taken together, these observations strengthen our hypothesis that a decrease in hypothalamic gamma-adducin is linked to hypertension...
  44. ncbi request reprint Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo
    Jason E Coleman
    Department of Neuroscience, University of Florida McKnight Brain Institute and College of Medicine, Gainesville, FL 32610 0255, USA
    Physiol Genomics 12:221-8. 2003
    ..The method is reproducible and can be scaled up to facilitate the use of these vectors in animal studies...
  45. pmc Lentivirus-mediated overexpression of angiotensin-(1-7) attenuated ischaemia-induced cardiac pathophysiology
    Yanfei Qi
    Department of Pharmadocynamics, University of Florida, SW 1600 Archer Road, Gainesville, FL 32610, USA
    Exp Physiol 96:863-74. 2011
    ..The protective effects of Ang-(1-7) appear to be mediated, at least in part, through modulation of the cardiac renin-angiotensin system and cytokine production...
  46. pmc ACE2 activation promotes antithrombotic activity
    Rodrigo A Fraga-Silva
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610, United States of America
    Mol Med 16:210-5. 2010
    ..Furthermore, ACE2 activation attenuates thrombus formation and reduces platelet attachment to vessels. These results suggest that ACE2 could be a novel target for the treatment of thrombogenic diseases...
  47. ncbi request reprint Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats
    Anaya Mitra
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, USA
    Physiol Behav 89:221-5. 2006
    ....
  48. ncbi request reprint Hypertension-linked decrease in the expression of brain gamma-adducin
    Hong Yang
    Department of Physiology and Functional Genomics, College of Medicine and University of Florida McKnight Brain Institute, Gainesville, Fla 32610, USA
    Circ Res 91:633-9. 2002
    ..These observations support our hypothesis that a decrease in gamma-adducin expression in cardioregulatory-relevant brain areas is linked to hypertension possibly by regulating the release of neurotransmitters...
  49. pmc Macrophage migration inhibitory factor in hypothalamic paraventricular nucleus neurons decreases blood pressure in spontaneously hypertensive rats
    Hongwei Li
    Dept of Physiology and Functional Genomics, College of Medicine, 1600 SW Archer Rd, University of Florida, Gainesville, FL 32610 0274, USA
    FASEB J 22:3175-85. 2008
    ..Collectively, these findings suggest that a lack of MIF expression within PVN neurons contributes to the development of hypertension and cardiac hypertrophy in SHRs...
  50. ncbi request reprint Blood pressure-independent attenuation of cardiac hypertrophy by AT(1)R-AS gene therapy
    Alok S Pachori
    Hypertension Center, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hypertension 39:969-75. 2002
    ..Collectively, these results provide further proof of the concept and indicate that antisense gene therapy could successfully target the local tissues' renin-angiotensin system to produce beneficial cardiovascular outcomes...