Fekadu Kassie

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Dimethylaminoparthenolide, a water soluble parthenolide, suppresses lung tumorigenesis through down-regulating the STAT3 signaling pathway
    Jung M Song
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Curr Cancer Drug Targets 14:59-69. 2014
  2. doi request reprint Lipopolysaccharide enhances mouse lung tumorigenesis: a model for inflammation-driven lung cancer
    T Melkamu
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455 Email
    Vet Pathol 50:895-902. 2013
  3. pmc Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination
    Fekadu Kassie
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Carcinogenesis 31:1634-41. 2010
  4. pmc Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice
    Fekadu Kassie
    Masonic Cancer Center, Mayo Mail Code 806, Minneapolis, MN 55455, USA
    Carcinogenesis 31:239-45. 2010
  5. pmc Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol
    Fekadu Kassie
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Prev Res (Phila) 1:568-76. 2008
  6. pmc Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice
    Fekadu Kassie
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Prev Res (Phila) 1:285-97. 2008
  7. doi request reprint Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice
    Fekadu Kassie
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, MN 55455, USA
    Carcinogenesis 29:610-9. 2008
  8. pmc Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N'-nitrosonornicotine
    Yanbin Lao
    Department of Medicinal Chemistry, and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:246-56. 2007
  9. ncbi request reprint Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels
    Fekadu Kassie
    Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 67:6502-11. 2007
  10. ncbi request reprint Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice
    Thomas E Johnson
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Chin Med 39:727-42. 2011

Research Grants

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Dimethylaminoparthenolide, a water soluble parthenolide, suppresses lung tumorigenesis through down-regulating the STAT3 signaling pathway
    Jung M Song
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Curr Cancer Drug Targets 14:59-69. 2014
    ....
  2. doi request reprint Lipopolysaccharide enhances mouse lung tumorigenesis: a model for inflammation-driven lung cancer
    T Melkamu
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455 Email
    Vet Pathol 50:895-902. 2013
    ....
  3. pmc Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination
    Fekadu Kassie
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Carcinogenesis 31:1634-41. 2010
    ..In conclusion, our studies demonstrated the promise of combinations of PEITC-NAC, I3C/DIM and MI for the chemoprevention of lung carcinogenesis in current and former smokers...
  4. pmc Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice
    Fekadu Kassie
    Masonic Cancer Center, Mayo Mail Code 806, Minneapolis, MN 55455, USA
    Carcinogenesis 31:239-45. 2010
    ..Our data show that I3C and MI inhibit lung carcinoma and provide a basis for future evaluation of these compounds in clinical trials as chemopreventive agents for current and former smokers...
  5. pmc Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol
    Fekadu Kassie
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Prev Res (Phila) 1:568-76. 2008
    ....
  6. pmc Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice
    Fekadu Kassie
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Prev Res (Phila) 1:285-97. 2008
    ....
  7. doi request reprint Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice
    Fekadu Kassie
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, MN 55455, USA
    Carcinogenesis 29:610-9. 2008
    ..These proteins may have utility for development of candidate lung cancer biomarkers and as targets of chemopreventive/chemotherapeutic agents...
  8. pmc Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N'-nitrosonornicotine
    Yanbin Lao
    Department of Medicinal Chemistry, and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:246-56. 2007
    ....
  9. ncbi request reprint Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels
    Fekadu Kassie
    Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 67:6502-11. 2007
    ....
  10. ncbi request reprint Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice
    Thomas E Johnson
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Chin Med 39:727-42. 2011
    ..Specifically, kava treatment showed no effect on liver integrity indicator enzymes or liver weight, indicating that kava may be potentially safe for long-term chemopreventive application...
  11. pmc Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice
    Abaineh Dagne
    Masonic Cancer Center, College of Veterinary Medicine, and School of Public Health, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minnesota, MN 55455, USA
    Carcinogenesis 32:561-7. 2011
    ..Taken together, our findings showed that mixtures of I3C and silibinin are more potent than the individual compounds for the chemoprevention of lung cancer in A/J mice...
  12. pmc Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis
    Xuemin Qian
    Masonic Cancer Center, University of Minnesota, MN 55455, USA
    Cancer Lett 311:57-65. 2011
    ..Mechanistic studies in A549 lung adenocarcinoma cells indicated that the lung cancer preventive effects of I3C are mediated, at least in part, via modulation of the receptor tyrosine kinase/PI3K/Akt signaling pathway...
  13. pmc Chemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice
    Xuemin Qian
    Department of Veterinary Clinical Sciences Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Carcinogenesis 34:841-9. 2013
    ....
  14. ncbi request reprint Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol
    Tamene Melkamu
    College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Carcinogenesis 31:252-8. 2010
    ..Therefore, miRNAs and their target genes are promising biomarkers for the diagnosis of lung cancer and efficacy of chemopreventive/chemotherapeutic agents...
  15. pmc Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis
    Sharon E Murphy
    Department of Biochemistry Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Prev Res (Phila) 4:1752-60. 2011
    ..These negative findings in a commonly used model of human lung carcinogenesis should lead us to question the interpretation of the many in vitro studies that find that nicotine stimulates cancer cell growth...
  16. doi request reprint Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice
    Thomas E Johnson
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Prev Res (Phila) 1:430-8. 2008
    ..Although not rigorously evaluated in this study, our preliminary data were not suggestive of hepatotoxicity. Based on these results, further studies are warranted to explore the chemopreventive potential and safety of kava...
  17. pmc Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street South East, Minneapolis, Minnesota 55455, USA
    Nat Rev Cancer 9:476-88. 2009
    ..It seems likely that logically constructed mixtures of these agents, developed from the ground up, will be necessary for the prevention of lung carcinogenesis...
  18. pmc (S)-N'-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in rats
    Silvia Balbo
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 34:2178-83. 2013
    ....
  19. pmc Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase
    Delshanee Kotandeniya
    Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Biochemistry 52:4075-88. 2013
    ....
  20. doi request reprint DNA adducts in aldehyde dehydrogenase-positive lung stem cells of A/J mice treated with the tobacco specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
    Silvia Balbo
    The Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, United States
    Chem Res Toxicol 26:511-3. 2013
    ..This is the first example of detection of carcinogen-DNA adducts in lung stem cells, supporting the hypothesis of their role in lung carcinogenesis. ..
  21. pmc Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Yanbin Lao
    Department of Medicinal Chemistry, and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:235-45. 2007
    ....

Research Grants2

  1. Lung carcinogenesis: Chemoprevention by Indole-3-carbinol
    Fekadu Kassie; Fiscal Year: 2009
    ..Proving the hypothesis that indole-3-carbinol (I3C) inhibits lung tumorigenesis in A/J mouse model provides a solid platform for clinical trials of I3C as a chemopreventive agent against lung cancer. ..
  2. Lung carcinogenesis: Chemoprevention by Indole-3-carbinol
    Fekadu Kassie; Fiscal Year: 2010
    ..Proving the hypothesis that indole-3-carbinol (I3C) inhibits lung tumorigenesis in A/J mouse model provides a solid platform for clinical trials of I3C as a chemopreventive agent against lung cancer. ..