George A Kassavetis

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Reconfiguring the connectivity of a multiprotein complex: fusions of yeast TATA-binding protein with Brf1, and the function of transcription factor IIIB
    George A Kassavetis
    Division of Biological Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    Proc Natl Acad Sci U S A 102:15406-11. 2005
  2. ncbi request reprint Nhp6 is a transcriptional initiation fidelity factor for RNA polymerase III transcription in vitro and in vivo
    George A Kassavetis
    Division of Biological Sciences and Center for Molecular Genetics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    J Biol Chem 281:7445-51. 2006
  3. ncbi request reprint Mapping the principal interaction site of the Brf1 and Bdp1 subunits of Saccharomyces cerevisiae TFIIIB
    George A Kassavetis
    Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 281:14321-9. 2006
  4. pmc Essential roles of Bdp1, a subunit of RNA polymerase III initiation factor TFIIIB, in transcription and tRNA processing
    Akira Ishiguro
    Division of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    Mol Cell Biol 22:3264-75. 2002
  5. pmc A common site on TBP for transcription by RNA polymerases II and III
    Oliver Schroder
    Division of Biological Sciences, Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    EMBO J 22:5115-24. 2003
  6. ncbi request reprint The role of transcription initiation factor IIIB subunits in promoter opening probed by photochemical cross-linking
    George A Kassavetis
    Division of Biological Sciences and the Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 278:17912-7. 2003
  7. ncbi request reprint A gene-specific effect of an internal deletion in the Bdp1 subunit of the RNA polymerase III transcription initiation factor TFIIIB
    Akira Ishiguro
    Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    FEBS Lett 548:33-6. 2003
  8. pmc Absolute gene occupancies by RNA polymerase III, TFIIIB, and TFIIIC in Saccharomyces cerevisiae
    Elisabetta Soragni
    Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 283:26568-76. 2008
  9. pmc The C53/C37 subcomplex of RNA polymerase III lies near the active site and participates in promoter opening
    George A Kassavetis
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 285:2695-706. 2010
  10. ncbi request reprint Mutational and functional analysis of a segment of the sigma family bacteriophage T4 late promoter recognition protein gp55
    Kevin Wong
    Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 278:7073-80. 2003

Detail Information

Publications18

  1. pmc Reconfiguring the connectivity of a multiprotein complex: fusions of yeast TATA-binding protein with Brf1, and the function of transcription factor IIIB
    George A Kassavetis
    Division of Biological Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    Proc Natl Acad Sci U S A 102:15406-11. 2005
    ..The Brf1-TBP triple fusion protein also effectively replaces Brf1 function in vivo as the intact protein, creating a TBP paralogue in yeast that is privatized for pol III transcription...
  2. ncbi request reprint Nhp6 is a transcriptional initiation fidelity factor for RNA polymerase III transcription in vitro and in vivo
    George A Kassavetis
    Division of Biological Sciences and Center for Molecular Genetics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    J Biol Chem 281:7445-51. 2006
    ..Analyses of unprocessed tRNAs from yeast lacking Nhp6a and its closely related paralogue Nhp6b demonstrate that Nhp6 is required for transcriptional initiation fidelity of some but not all tRNA genes, in vivo...
  3. ncbi request reprint Mapping the principal interaction site of the Brf1 and Bdp1 subunits of Saccharomyces cerevisiae TFIIIB
    George A Kassavetis
    Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 281:14321-9. 2006
    ....
  4. pmc Essential roles of Bdp1, a subunit of RNA polymerase III initiation factor TFIIIB, in transcription and tRNA processing
    Akira Ishiguro
    Division of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    Mol Cell Biol 22:3264-75. 2002
    ..Physical interaction of RNase P with Bdp1 was demonstrated by coimmunoprecipitation and pull-down assays...
  5. pmc A common site on TBP for transcription by RNA polymerases II and III
    Oliver Schroder
    Division of Biological Sciences, Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    EMBO J 22:5115-24. 2003
    ....
  6. ncbi request reprint The role of transcription initiation factor IIIB subunits in promoter opening probed by photochemical cross-linking
    George A Kassavetis
    Division of Biological Sciences and the Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 278:17912-7. 2003
    ..In contrast, promoter opening-defective TFIIIB mutants generate significant changes of cross-linking of polymerase subunits. The weight of this evidence argues in favor of an indirect mode of action of TFIIIB in promoter opening...
  7. ncbi request reprint A gene-specific effect of an internal deletion in the Bdp1 subunit of the RNA polymerase III transcription initiation factor TFIIIB
    Akira Ishiguro
    Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    FEBS Lett 548:33-6. 2003
    ..It is shown that TFIIIC-dependent assembly of TFIIIB on the RPR1 promoter is specifically sensitive to this Bdp1 deletion, leading to gene-specifically defective single-round and multiple-round transcription...
  8. pmc Absolute gene occupancies by RNA polymerase III, TFIIIB, and TFIIIC in Saccharomyces cerevisiae
    Elisabetta Soragni
    Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 283:26568-76. 2008
    ....
  9. pmc The C53/C37 subcomplex of RNA polymerase III lies near the active site and participates in promoter opening
    George A Kassavetis
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 285:2695-706. 2010
    ....
  10. ncbi request reprint Mutational and functional analysis of a segment of the sigma family bacteriophage T4 late promoter recognition protein gp55
    Kevin Wong
    Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 278:7073-80. 2003
    ..2 and the recently determined structures of the Thermus thermophilus and Thermus aquaticus sigma(70)-RNA polymerase holoenzymes...
  11. pmc Effects of DNA strand breaks on transcription by RNA polymerase III: insights into the role of TFIIIB and the polarity of promoter opening
    George A Kassavetis
    Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA or
    EMBO J 21:5508-15. 2002
    ....
  12. ncbi request reprint Transcription: adjusting to adversity by regulating RNA polymerase
    E Peter Geiduschek
    Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Curr Biol 16:R849-51. 2006
    ....
  13. pmc A single-stranded promoter for RNA polymerase III
    Oliver Schroder
    Division of Biological Sciences and Center for Molecular Genetics, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    Proc Natl Acad Sci U S A 100:934-9. 2003
    ....
  14. pmc Human TFIID binds to core promoter DNA in a reorganized structural state
    Michael A Cianfrocco
    Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 152:120-31. 2013
    ..The existence of two structurally and functionally distinct forms of TFIID suggests that the different conformers may serve as specific targets for the action of regulatory factors...
  15. pmc Marking the start site of RNA polymerase III transcription: the role of constraint, compaction and continuity of the transcribed DNA strand
    Anne Grove
    Division of Biology and Center for Molecular Genetics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    EMBO J 21:704-14. 2002
    ..Breaks in the non-transcribed strand generate only minor effects on transcription. A structure-based model interprets these observations and explains how the transcribed strand is used to locate the transcriptional start site...
  16. pmc Transcription of the T4 late genes
    E Peter Geiduschek
    Division of Biological Sciences, Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093 0634, USA
    Virol J 7:288. 2010
    ..The emphasis of this account is on the sites and mechanisms of actions of these three proteins, and on their roles in the formation of transcription-ready open T4 late promoter complexes...
  17. ncbi request reprint Crystal structure of a transcription factor IIIB core interface ternary complex
    Z Sean Juo
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520 8114, USA
    Nature 422:534-9. 2003
    ..The structure reveals the core interface for assembly of TFIIIB and demonstrates how the loosely packed Brf1 domain achieves remarkable binding specificity with the convex and lateral surfaces of TBP...
  18. pmc High-level activation of transcription of the yeast U6 snRNA gene in chromatin by the basal RNA polymerase III transcription factor TFIIIC
    Sushma Shivaswamy
    Centre for Cellular and Molecular Biology, Tarnaka, Hyderabad 500007, India
    Mol Cell Biol 24:3596-606. 2004
    ..Our results suggest that TFIIIC, which is a basal transcription factor of pol III, also plays a direct role in remodeling chromatin on the SNR6 gene...