S E Kasner

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Clinical interpretation and use of stroke scales
    Scott E Kasner
    Comprehensive Stroke Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Lancet Neurol 5:603-12. 2006
  2. ncbi request reprint Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis
    Marc I Chimowitz
    Department of Neurology, School of Medicine, Emory University, Atlanta, USA
    N Engl J Med 352:1305-16. 2005
  3. doi request reprint Transcranial laser therapy and infarct volume
    Scott E Kasner
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Stroke 44:2025-7. 2013
  4. ncbi request reprint Emergency identification and treatment of acute ischemic stroke
    S E Kasner
    Department of Neurology, University of Texas Health Science Center, Houston, USA
    Ann Emerg Med 30:642-53. 1997
  5. pmc Echocardiography in patients with symptomatic intracranial stenosis
    Scott E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Stroke Cerebrovasc Dis 16:216-9. 2007
  6. ncbi request reprint Predictors of fatal brain edema in massive hemispheric ischemic stroke
    S E Kasner
    University of Pennsylvania, Department of Neurology, Philadelphia, PA, USA
    Stroke 32:2117-23. 2001
  7. doi request reprint Natural history of symptomatic intracranial arterial stenosis
    Scott E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Neuroimaging 19:20S-1S. 2009
  8. ncbi request reprint Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial
    Scott E Kasner
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Stroke 33:130-4. 2002
  9. ncbi request reprint Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis
    Scott E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Circulation 113:555-63. 2006
  10. pmc Who will participate in acute stroke trials?
    S E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, 3 West Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurology 72:1682-8. 2009

Research Grants

Detail Information

Publications80

  1. ncbi request reprint Clinical interpretation and use of stroke scales
    Scott E Kasner
    Comprehensive Stroke Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Lancet Neurol 5:603-12. 2006
    ..The SIS was designed to measure the patient's perspective on the effect of stroke. Familiarity with these scales could improve clinicians' interpretation of stroke research and their clinical decision-making...
  2. ncbi request reprint Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis
    Marc I Chimowitz
    Department of Neurology, School of Medicine, Emory University, Atlanta, USA
    N Engl J Med 352:1305-16. 2005
    ..Atherosclerotic intracranial arterial stenosis is an important cause of stroke. Warfarin is commonly used in preference to aspirin for this disorder, but these therapies have not been compared in a randomized trial...
  3. doi request reprint Transcranial laser therapy and infarct volume
    Scott E Kasner
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Stroke 44:2025-7. 2013
    ..Supportive proof of concept could be demonstrated if TLT reduces the volume of cortical infarction...
  4. ncbi request reprint Emergency identification and treatment of acute ischemic stroke
    S E Kasner
    Department of Neurology, University of Texas Health Science Center, Houston, USA
    Ann Emerg Med 30:642-53. 1997
    ..Finally, we discuss the delays that may occur in the emergency evaluation and management of acute ischemic stroke and suggest some methods to expedite the process...
  5. pmc Echocardiography in patients with symptomatic intracranial stenosis
    Scott E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Stroke Cerebrovasc Dis 16:216-9. 2007
    ..We evaluated the use of echocardiography in patients with transient ischemic attack (TIA) or stroke caused by stenosis of a major intracranial artery...
  6. ncbi request reprint Predictors of fatal brain edema in massive hemispheric ischemic stroke
    S E Kasner
    University of Pennsylvania, Department of Neurology, Philadelphia, PA, USA
    Stroke 32:2117-23. 2001
    ..Prior studies suggested that early nausea/vomiting and major hypodensity on baseline computed tomography (CT) were predictive of herniation...
  7. doi request reprint Natural history of symptomatic intracranial arterial stenosis
    Scott E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Neuroimaging 19:20S-1S. 2009
    ..Patients may also be at high risk if they had an initial stroke rather than TIA or if they have symptoms precipitated by hemodynamic maneuvers. The annual risk of subsequent stroke may exceed 20% in these high-risk groups...
  8. ncbi request reprint Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial
    Scott E Kasner
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Stroke 33:130-4. 2002
    ..Elevated core body temperature (CBT), even if mild, may exacerbate neuronal injury and worsen outcome, whereas hypothermia is potentially neuroprotective. The antipyretic effects of acetaminophen were hypothesized to reduce CBT...
  9. ncbi request reprint Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis
    Scott E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Circulation 113:555-63. 2006
    ..A prespecified aim of WASID was to identify patients at highest risk for stroke in the territory of the stenotic artery who would be the target group for a subsequent trial comparing intracranial stenting with medical therapy...
  10. pmc Who will participate in acute stroke trials?
    S E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, 3 West Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurology 72:1682-8. 2009
    ..We aimed to identify factors associated with participation in clinical trials of novel therapeutic agents for acute stroke...
  11. ncbi request reprint Modified National Institutes of Health Stroke Scale can be estimated from medical records
    Scott E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Stroke 34:568-70. 2003
    ..We aimed to determine whether the mNIHSS could be accurately abstracted from medical records to facilitate retrospective research...
  12. ncbi request reprint Middle cerebral artery stenosis: stenting is one of the options: no
    Scott E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Stroke 38:1420-1. 2007
  13. doi request reprint Community views on neurologic emergency treatment trials
    Scott E Kasner
    Department of Neurology, University of Pennsylvania, 3400Spruce St, Philadelphia, PA 19104, USA
    Ann Emerg Med 57:346-354.e6. 2011
    ..We improve our understanding of the community consultation process for acute neurologic emergency trials conducted under the federal regulations for Exception From Informed Consent (EFIC) for emergency research...
  14. ncbi request reprint Dialysis disequilibrium: another reversible posterior leukoencephalopathy syndrome?
    Kevin N Sheth
    Department of Neurology, Comprehensive Stroke Center, University of Pennsylvania Medical Center, 3W Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Clin Neurol Neurosurg 105:249-52. 2003
    ..This case suggests that dialysis disequilibrium syndrome and RPLS may represent a spectrum of disorders in which the underlying mechanism is vasogenic edema...
  15. ncbi request reprint Ischemic stroke
    S E Kasner
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Neurol Clin 16:355-72. 1998
    ..The role of more traditional therapies, such as antiplatelet agents and anticoagulants, have been better defined through several recent major clinical trials...
  16. ncbi request reprint Warfarin vs aspirin for symptomatic intracranial stenosis: subgroup analyses from WASID
    S E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Neurology 67:1275-8. 2006
    ....
  17. ncbi request reprint Accuracy of initial stroke subtype diagnosis. a decision analysis
    S E Kasner
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cerebrovasc Dis 10:18-24. 2000
    ..Several candidate diagnostic tests might be useful for early determination of subtype, but there is no consensus on what level of accuracy is required to be useful in the selection of patients for subtype-specific studies or therapies...
  18. ncbi request reprint Stroke treatment-specific considerations
    S E Kasner
    Department of Neurology, Comprehensive Stroke Center, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Neurol Clin 18:399-417. 2000
    ....
  19. ncbi request reprint Reliability and validity of estimating the NIH stroke scale score from medical records
    S E Kasner
    Department of Neurology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Stroke 30:1534-7. 1999
    ..Recently, retrospective observational studies have estimated NIHSS scores from medical records for quantitative outcome analysis. The reliability and validity of estimation based on chart review has not been determined...
  20. ncbi request reprint Intravenous tissue plasminogen activator for acute ischemic stroke: feasibility, safety, and efficacy in the first year of clinical practice
    D Chiu
    Department of Neurology, University of Texas Houston Health Science Center, USA
    Stroke 29:18-22. 1998
    ..The feasibility, safety, and efficacy of intravenous tissue plasminogen activator (t-PA) for patients with acute ischemic stroke in clinical practice need to be assessed...
  21. pmc Prior antiplatelet use does not affect hemorrhage growth or outcome after ICH
    L H Sansing
    Hospital of the University of Pennsylvania, 3400 Spruce Street, 3 W Gates, Philadelphia, PA 19104, USA
    Neurology 72:1397-402. 2009
    ..To examine whether antiplatelet medication use at onset of intracerebral hemorrhage (ICH) is associated with hemorrhage growth and outcome after spontaneous ICH using a large, prospectively collected database from a recent clinical trial...
  22. doi request reprint Anti-adrenergic medications and edema development after intracerebral hemorrhage
    L H Sansing
    Department of Neurology, University of Connecticut Health Center, 263 Farmington Avenue, MC 3401, Farmington, CT 06030, USA
    Neurocrit Care 14:395-400. 2011
    ..Medications that block adrenergic activation (e.g., beta-blockers and the alpha(2)-agonist, clonidine) may reduce the inflammatory response and therefore have secondary benefit after ICH...
  23. ncbi request reprint Early clinical and radiological predictors of fatal brain swelling in ischemic stroke
    D W Krieger
    Department of Neurology, Stroke Program, University of Texas at Houston, TX, USA
    Stroke 30:287-92. 1999
    ..Initial clinical, laboratory, and CT characteristics that may be used as selection criteria were analyzed to determine predictors of herniation and neurological death...
  24. ncbi request reprint Safety of air medical transportation after tissue plasminogen activator administration in acute ischemic stroke
    J A Chalela
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Stroke 30:2366-8. 1999
    ..The safety of AMT of patients with AIS after or during administration of tPA has not been examined...
  25. ncbi request reprint Safety of intra-arterial thrombolysis in the postoperative period
    J A Chalela
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Stroke 32:1365-9. 2001
    ..However, IAT may increase the risk of surgical bleeding. We sought to determine the safety of postoperative IAT...
  26. pmc Sex, aging, and preexisting cerebral ischemic disease in patients with aortic stenosis
    Ping Wang
    Department of Radiology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 90:1230-5. 2010
    ..We tested the hypotheses that increasing age, female sex, coronary artery disease, and the severity of AS are predictive of the severity of preexisting cerebral ischemic lesions...
  27. ncbi request reprint Practice parameter: recurrent stroke with patent foramen ovale and atrial septal aneurysm: report of the Quality Standards Subcommittee of the American Academy of Neurology
    S R Messe
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Neurology 62:1042-50. 2004
    ..2) To establish the optimal method of stroke prevention in this population of patients...
  28. ncbi request reprint Continuous arterial spin labeling perfusion magnetic resonance imaging findings in postpartum vasculopathy
    J A Chalela
    Department of Neurology, Hospital of the University of Pennsylvania, USA
    J Neuroimaging 11:444-6. 2001
    ..Although angiography often reveals diffuse arterial narrowing, the CBF values encountered in this study do not support a state of generalized or focal oligoemia. Vasomotor tone may change intermittently in patients with PPV...
  29. ncbi request reprint Noninvasive magnetic resonance imaging evaluation of cerebral blood flow with acetazolamide challenge in patients with cerebrovascular stenosis
    J A Detre
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Magn Reson Imaging 10:870-5. 1999
    ..J. Magn. Reson. Imaging 1999;10:870-875...
  30. ncbi request reprint Prediction of hospital disposition after thrombolysis for acute ischemic stroke using the National Institutes of Health Stroke Scale
    Daniel J Schlegel
    Comprehensive Stroke Center, Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, 3W Gates Building, Philadelphia, PA 19104, USA
    Arch Neurol 61:1061-4. 2004
    ..Early determination of discharge destination after acute stroke may promote earlier rehabilitation and reduce costs by shortening the duration of hospitalization...
  31. pmc Effect of body size on operative risk of carotid endarterectomy
    S R Messe
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Neurol Neurosurg Psychiatry 75:1759-61. 2004
    ..Both height and BSA confounded the effect of sex, implying that the generally smaller size of women may contribute to their increased risk. This finding should be validated in other large datasets...
  32. ncbi request reprint Aphemia: an isolated disorder of articulation
    R J Fox
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Clin Neurol Neurosurg 103:123-6. 2001
    ..This case suggests that aphemia can occur as an isolated articulation deficit without language involvement or more widespread bulbar apraxia, and may be a severe form of apraxia of speech...
  33. pmc Predictors of outcome in childhood intracerebral hemorrhage: a prospective consecutive cohort study
    Lauren A Beslow
    Division of Neurology, 6th Floor, Wood Building, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Stroke 41:313-8. 2010
    ..The purposes of this study were to describe features of children with intracerebral hemorrhage (ICH) and to determine predictors of short-term outcome in a single-center prospective cohort study...
  34. ncbi request reprint CT-NIHSS mismatch does not correlate with MRI diffusion-perfusion mismatch
    Steven R Messe
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Stroke 38:2079-84. 2007
    ..However, MRI has limited availability in many hospitals. We investigated whether mismatch between the Alberta Stroke Program Early CT Score (ASPECTS) and the NIH Stroke Scale (NIHSS) correlates with MRI diffusion-perfusion mismatch...
  35. ncbi request reprint Teaching NeuroImage: subclavian steal syndrome
    Sashank Prasad
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurology 69:E1. 2007
  36. doi request reprint D-dimer, magnetic resonance imaging diffusion-weighted imaging, and ABCD2 score for transient ischemic attack risk stratification
    Brett L Cucchiara
    University of Pennsylvania, Philadelphia 19104, USA
    J Stroke Cerebrovasc Dis 18:367-73. 2009
    ..We sought to determine whether measurement of D-dimer (DD) would improve risk stratification after transient ischemic attack (TIA)...
  37. doi request reprint Lipoprotein-associated phospholipase A2 and C-reactive protein for risk-stratification of patients with TIA
    Brett L Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Stroke 40:2332-6. 2009
    ..Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a marker of unstable atherosclerotic plaque, and is predictive of both primary and secondary stroke in population-based studies...
  38. doi request reprint Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke: pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II Trials
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Stroke 40:3067-72. 2009
    ..A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies...
  39. ncbi request reprint Current management of symptomatic intracranial stenosis: medical versus endovascular therapy
    John B Weigele
    Interventional Neuroradiology Service, Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Curr Atheroscler Rep 9:296-304. 2007
    ..Antiplatelet agents are currently recommended as the primary treatment for symptomatic IAS, with endovascular therapy reserved for appropriate high-risk cases refractory to medical therapy...
  40. doi request reprint Prophylactic antiepileptic drug use is associated with poor outcome following ICH
    Steven R Messe
    Department of Neurology, University of Pennsylvania Medical Center, 3W Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurocrit Care 11:38-44. 2009
    ..Intracerebral hemorrhage (ICH) is associated with a risk of early seizure and guidelines recommend consideration of prophylactic antiepileptic drugs (AEDs) for some patients, although the utility is uncertain...
  41. pmc Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients
    Turgut Durduran
    Departments of Radiology, University of Pennsylvania, PA, USA
    Opt Express 17:3884-902. 2009
    ..Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere...
  42. doi request reprint Neurologic outcomes from high risk descending thoracic and thoracoabdominal aortic operations in the era of endovascular repair
    Steven R Messe
    Department of Neurology, Hospital of the University of Pennsylvania, University of Pennsylvania Medical Center, 3W Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurocrit Care 9:344-51. 2008
    ..However, there are limited data available on outcomes since the advent of thoracic endovascular aortic repair (TEVAR)...
  43. ncbi request reprint Increased cerebral blood flow after leukapheresis for acute myelogenous leukemia
    Margaret T Kasner
    Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Hematol 82:1110-2. 2007
    ..This is the first documentation that leukapheresis, in combination with hydroxyurea, improves cerebral hemodynamics in a patient with AML...
  44. ncbi request reprint Fatal subacute cytomegalovirus encephalitis associated with hypogammaglobulinemia and thymoma
    Brett L Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Mayo Clin Proc 78:223-7. 2003
    ..The possibility of a cytomegalovirus infection should be considered early in the evaluation of patients with Good syndrome if appropriate clinical symptoms are present...
  45. ncbi request reprint PFO management: neurologists vs cardiologists
    Steven R Messe
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Neurology 65:172-3. 2005
  46. ncbi request reprint Pseudo-subarachnoid hemorrhage: report of three cases and review of the literature
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Neurocrit Care 1:371-4. 2004
    ..In contrast to prior reports, all three of our patients had a favorable outcome...
  47. ncbi request reprint Carotid dissection causing occipital lobe infarction
    Brett L Cucchiara
    Comprehensive Stroke Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Neurology 65:1408. 2005
  48. ncbi request reprint Early impairment in consciousness predicts mortality after hemispheric ischemic stroke
    Brett L Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, USA
    Crit Care Med 32:241-5. 2004
    ..Early predictors of poor outcome after acute ischemic stroke may be useful in selecting patients for potentially beneficial but high-risk interventions...
  49. ncbi request reprint Is the ABCD score useful for risk stratification of patients with acute transient ischemic attack?
    Brett L Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Stroke 37:1710-4. 2006
    ..This score incorporates age (A), blood pressure (B), clinical features (C), and duration (D) of TIA. A score <4 reportedly indicates minimal short-term stroke risk. We evaluated this scoring system in an independent population...
  50. ncbi request reprint Carotid artery diameter in men and women and the relation to body and neck size
    Jaroslaw Krejza
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Stroke 37:1103-5. 2006
    ..To explore relationships among gender, body size, neck size, and the diameters of the common carotid artery (CCA) and internal carotid artery (ICA)...
  51. doi request reprint Cervical carotid artery dissection is associated with styloid process length
    J M Raser
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Neurology 77:2061-6. 2011
    ..To investigate whether cervical carotid artery dissection (CCAD) is associated with anatomic characteristics of the styloid process of the temporal bone...
  52. ncbi request reprint Altered hemodynamics and regional cerebral blood flow in patients with hemodynamically significant stenoses
    Anne C Roc
    Center for Functional Neuroimaging, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Stroke 37:382-7. 2006
    ..Because cerebrovascular disease may result in altered CBF, we assessed the temporal dynamics and magnitude of the BOLD response in patients with major arterial stenoses...
  53. doi request reprint Blood pressure management in acute stroke
    M T Mullen
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    J Hum Hypertens 23:559-69. 2009
    ..We review the current literature, published guidelines, and emerging research on this important topic. Additionally, the treatment algorithm which we employ is discussed...
  54. ncbi request reprint Neuroprotection for ischaemic stroke: an unattainable goal?
    D S Liebeskind
    Comprehensive Stroke Center and Department of Neurology, University of Pennsylvania, Philadelphia 19104 4283, USA
    CNS Drugs 15:165-74. 2001
    ..The future of neuroprotection for stroke remains bright in spite of previous disappointments...
  55. ncbi request reprint MRI identification of early white matter injury in anoxic-ischemic encephalopathy
    J A Chalela
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 56:481-5. 2001
    ..The authors describe the MRI findings in seven patients with AIE who demonstrate early preferential involvement of the white matter...
  56. ncbi request reprint Safety and efficacy of thrombolytic therapy in postoperative cerebral infarctions
    Michael T Mullen
    Department of Neurology, University of Pennsylvania, Medical Center, 3 West Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurol Clin 24:783-93. 2006
    ..In these patients, and in patients who present greater than 6 hours but less than 8 hours after their stroke, mechanical thrombolysis/embolectomy may emerge as the only viable treatment option...
  57. pmc The safety and efficacy of thrombolysis for strokes after cardiac catheterization
    Pooja Khatri
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
    J Am Coll Cardiol 51:906-11. 2008
    ..The purpose of this study was to systematically compare clinical outcomes of patients treated with thrombolysis with those without treatment in a multi-year, multicenter cohort of strokes after cardiac catheterization...
  58. ncbi request reprint Distinguishing ischemic stroke from the stroke-like lesions of MELAS using apparent diffusion coefficient mapping
    Stephen J Kolb
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Neurol Sci 216:11-5. 2003
    ..We conclude that conventional MRI when used with diffusion-weighted MR imaging may be invaluable in detecting mitochondrial-related CNS dysfunction...
  59. ncbi request reprint Bow hunter's syndrome caused by accessory cervical ossification: posterolateral decompression and the use of intraoperative Doppler ultrasonography
    Robert G Whitmore
    Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Surg Neurol 67:169-71. 2007
    ..Bow hunter's syndrome refers to symptomatic vertebrobasilar insufficiency provoked by physiologic head rotation...
  60. ncbi request reprint Use of statins in CNS disorders
    B Cucchiara
    Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neurol Sci 187:81-9. 2001
    ..These actions of statins might have potential uses in other neurological disorders such as Alzheimer's disease and certain types of brain tumors...
  61. pmc Lack of hemispheric dominance for consciousness in acute ischaemic stroke
    B Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Neurol Neurosurg Psychiatry 74:889-92. 2003
    ..Previous reports have suggested left hemispheric dominance for maintaining consciousness, although there is controversy over this claim...
  62. ncbi request reprint Automated CT segmentation and analysis for acute middle cerebral artery stroke
    J A Maldjian
    Departments of Radiology, Hospital of the University of Pennsylvania, Philadelphia, USA
    AJNR Am J Neuroradiol 22:1050-5. 2001
    ..This approach can be extended to other brain regions and vascular territories and may aid in the interpretation of CT scans in cases of hyperacute stroke...
  63. ncbi request reprint Adverse neurologic events associated with rebound hypertension after using short-acting nifedipine in childhood hypertension
    M B Leonard
    Department of Pediatrics, The Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Emerg Care 17:435-7. 2001
    ..We describe two children with neurologic events caused by rebound hypertension following SA-NIF use...
  64. pmc ABC/XYZ estimates intracerebral hemorrhage volume as a percent of total brain volume in children
    Lauren A Beslow
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Stroke 41:691-4. 2010
    ..We aimed to determine whether easily performed approximations of intracerebral hemorrhage and brain volume can accurately and reliably stratify intracerebral hemorrhage by size...
  65. ncbi request reprint Utility of the NIH Stroke Scale as a predictor of hospital disposition
    Daniel Schlegel
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Stroke 34:134-7. 2003
    ..The NIH Stroke Scale (NIHSS) is an attractive candidate predictor of disposition because it is widely used, is easily learned, and can be performed rapidly on admission...
  66. ncbi request reprint Ischemic strokes after cardiac catheterization: opportune thrombolysis candidates?
    Pooja Khatri
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
    Arch Neurol 63:817-21. 2006
    ..Whether thrombolysis is safe and efficacious remains to be determined, but the existing evidence seems favorable for individual circumstances...
  67. ncbi request reprint Reversible cerebral vasoconstriction syndrome associated with subarachnoid hemorrhage
    Brian L Edlow
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Neurocrit Care 7:203-10. 2007
    ..Reversible cerebral vasoconstriction syndrome (RCVS) is a rare vasculopathy of unknown etiology. Ischemic stroke and intracerebral hemorrhage are well-documented sequelae, but subarachnoid hemorrhage is an uncommon complication of RCVS...
  68. pmc Cerebrovascular thromboprophylaxis in mice by erythrocyte-coupled tissue-type plasminogen activator
    Kristina Danielyan
    Pharmacology Department, Universityof Pennsylvania, Philadelphia, PA 19104 6068, USA
    Circulation 118:1442-9. 2008
    ..To evaluate the utility of this new approach for preventing cerebrovascular thrombosis, we examined the effect of RBC/tPA in animal models of cerebrovascular thromboembolism and ischemia...
  69. doi request reprint Who will consent to emergency treatment trials for subarachnoid hemorrhage?
    Angela Del Giudice
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Acad Emerg Med 16:309-15. 2009
    ....
  70. doi request reprint Consensus conference on intracranial atherosclerotic disease: rationale, methodology, and results
    Adnan I Qureshi
    Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neuroimaging 19:1S-10S. 2009
    ..The proceedings of the consensus conference provide a template for standardizing management of patients with ICAD and determining research priorities...
  71. ncbi request reprint Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey
    David Tanne
    Stroke Unit, Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Circulation 105:1679-85. 2002
    ..Our aim was to identify, in a large cohort of patients, readily available baseline factors that are associated with thrombolysis-related ICH...
  72. ncbi request reprint Effect of arundic acid on serum S-100beta in ischemic stroke
    L Creed Pettigrew
    Stroke Program, Sanders Brown Center on Aging, and Department of Neurology, 101 Sanders Brown Building, University of Kentucky Medical Center, Lexington, KY 40536 0230, USA
    J Neurol Sci 251:57-61. 2006
    ..Our results showing correlation between S-100beta and NIHSS indicate that this protein is a clinically relevant marker of neurological deficit in acute stroke...
  73. ncbi request reprint Safety and tolerability of arundic acid in acute ischemic stroke
    L Creed Pettigrew
    Stroke Program, Sanders Brown Center on Aging, and Department of Neurology, 101 Sanders Brown Building, University of Kentucky Medical Center, Lexington, KY 40536 0230, USA
    J Neurol Sci 251:50-6. 2006
    ..023 vs. placebo), 7 (p=0.002), 10 (p=0.003), and 40 (p=0.018). A dose of 8 mg/kg/h AA produced a favorable trend in reduction of NIHSS that should be confirmed in a future clinical trial...
  74. ncbi request reprint Treatment of intracranial arterial stenosis
    Robert A Taylor
    Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1077, USA
    Expert Rev Neurother 6:1685-94. 2006
    ..Current treatment recommendations include antiplatelet agents, with consideration for angioplasty alone or angioplasty and stenting in cases refractory to medical therapy...
  75. ncbi request reprint Danger of treatment protocols
    Brett Cucchiara
    Stroke 34:e19. 2003
  76. ncbi request reprint Racial differences in the prevalence of cardiac sources of embolism in subjects with unexplained stroke or transient ischemic attack evaluated by transesophageal echocardiography
    Jorge R Kizer
    Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    Am J Cardiol 90:395-400. 2002
    ....
  77. ncbi request reprint Computed tomographic parameters predicting fatal outcome in large middle cerebral artery infarction
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Cerebrovasc Dis 16:230-5. 2003
    ..As yet there are few guidelines to aid the selection of patients for aggressive interventional therapies, such as decompression hemicraniectomy and/or hypothermia...
  78. ncbi request reprint Editorial comment--More than one way to lyse a clot
    Scott E Kasner
    Stroke 35:911-2. 2004
  79. ncbi request reprint Folate and the risk of stroke: fortify first and ask questions later?
    Scott E Kasner
    Stroke 33:1188-9. 2002
  80. ncbi request reprint Stroke associated with Barth syndrome
    Beau M Ances
    Departments of Neuroscience and Radiology, University of California at San Diego, San Diego, CA, USA
    J Child Neurol 21:805-7. 2006
    ..This case suggests that cardiovascular complications can be observed in patients with Barth syndrome. Stroke prevention measures, including the use of antithrombotic agents, might be warranted...

Research Grants1

  1. EARLY DETERMINATION OF STROKE SUBTYPE: CT ANGIOGRAPHY
    Scott Kasner; Fiscal Year: 2003
    ..This approach will, for the first time, formally evaluate CTA as a tool for early stroke diagnosis and selection of patients with specific stroke mechanisms for specific mechanism-directed stroke therapies. ..