Ana Kasirer-Friede

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1
    Stefanie Kliche
    Institute of Immunology, Otto von Guericke University, 39120 Magdeburg, Germany
    Mol Cell Biol 26:7130-44. 2006
  2. pmc Role for ADAP in shear flow-induced platelet mechanotransduction
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    Blood 115:2274-82. 2010
  3. pmc ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla 92093 0726, USA
    Blood 109:1018-25. 2007
  4. ncbi request reprint Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3
    Ana Kasirer-Friede
    Departments of Cell Biology and Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:11949-56. 2002
  5. ncbi request reprint Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors
    Ana Kasirer-Friede
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 103:3403-11. 2004
  6. pmc PTP-1B is an essential positive regulator of platelet integrin signaling
    Elena Garcia Arias-Salgado
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 170:837-45. 2005
  7. pmc Microfluidic devices for studies of shear-dependent platelet adhesion
    Edgar Gutierrez
    Department of Physics, University of California San Diego, La Jolla, CA 92093, USA
    Lab Chip 8:1486-95. 2008
  8. ncbi request reprint ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding
    Ana Kasirer-Friede
    Hematology Oncology Division, Department of Medicine, University of California, San Diego, La Jolla, CA
    Blood 123:3156-65. 2014
  9. doi request reprint The mechanism of kindlin-mediated activation of integrin αIIbβ3
    Feng Ye
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Curr Biol 23:2288-95. 2013
  10. ncbi request reprint Platelet integrins and immunoreceptors
    Ana Kasirer-Friede
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0726, USA
    Immunol Rev 218:247-64. 2007

Detail Information

Publications10

  1. pmc The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1
    Stefanie Kliche
    Institute of Immunology, Otto von Guericke University, 39120 Magdeburg, Germany
    Mol Cell Biol 26:7130-44. 2006
    ..However, it appears as if the ADAP/SKAP55 module can exert its signaling function outside of the classical raft fraction of the cell membrane...
  2. pmc Role for ADAP in shear flow-induced platelet mechanotransduction
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    Blood 115:2274-82. 2010
    ..These results establish that ADAP is an essential component of alphaIIbbeta3-mediated platelet mechanotransduction that promotes F-actin assembly and enables platelet spreading and thrombus stabilization under fluid shear stress...
  3. pmc ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla 92093 0726, USA
    Blood 109:1018-25. 2007
    ..These studies establish ADAP as a component of inside-out signaling pathways that couple GP Ib-IX-V and other platelet agonist receptors to alphaIIbbeta3 activation...
  4. ncbi request reprint Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3
    Ana Kasirer-Friede
    Departments of Cell Biology and Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:11949-56. 2002
    ..By extrapolation, GP Ib-IX clustering in platelets may promote thrombus formation...
  5. ncbi request reprint Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors
    Ana Kasirer-Friede
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 103:3403-11. 2004
    ..These data establish that GP Ib-IX-V itself can signal to activate alpha IIb beta 3, through sequential actions of Src kinases, Ca(2+) oscillations, and PI 3-kinase/PKC...
  6. pmc PTP-1B is an essential positive regulator of platelet integrin signaling
    Elena Garcia Arias-Salgado
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 170:837-45. 2005
    ..Thus, PTP-1B is an essential positive regulator of the initiation of outside-in alphaIIbbeta3 signaling in platelets...
  7. pmc Microfluidic devices for studies of shear-dependent platelet adhesion
    Edgar Gutierrez
    Department of Physics, University of California San Diego, La Jolla, CA 92093, USA
    Lab Chip 8:1486-95. 2008
    ..Because of small sample volumes required, the devices could be employed in research with genetically-modified model organisms and for adhesion tests in clinical settings with blood from neonates...
  8. ncbi request reprint ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding
    Ana Kasirer-Friede
    Hematology Oncology Division, Department of Medicine, University of California, San Diego, La Jolla, CA
    Blood 123:3156-65. 2014
    ..Thus, ADAP uniquely promotes activation of and irreversible fibrinogen binding to platelet αIIbβ3 through interactions with talin and kindlin-3. ..
  9. doi request reprint The mechanism of kindlin-mediated activation of integrin αIIbβ3
    Feng Ye
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Curr Biol 23:2288-95. 2013
    ..Thus, in contrast to talins, kindlins have little primary effect on integrin αIIbβ3 affinity for monovalent ligands and increase multivalent ligand binding by promoting the clustering of talin-activated integrins...
  10. ncbi request reprint Platelet integrins and immunoreceptors
    Ana Kasirer-Friede
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0726, USA
    Immunol Rev 218:247-64. 2007
    ....