Ana Kasirer-Friede

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1
    Stefanie Kliche
    Institute of Immunology, Otto von Guericke University, 39120 Magdeburg, Germany
    Mol Cell Biol 26:7130-44. 2006
  2. ncbi ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla 92093 0726, USA
    Blood 109:1018-25. 2007
  3. ncbi Role for ADAP in shear flow-induced platelet mechanotransduction
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    Blood 115:2274-82. 2010
  4. ncbi Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3
    Ana Kasirer-Friede
    Departments of Cell Biology and Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:11949-56. 2002
  5. ncbi Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors
    Ana Kasirer-Friede
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 103:3403-11. 2004
  6. ncbi PTP-1B is an essential positive regulator of platelet integrin signaling
    Elena Garcia Arias-Salgado
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 170:837-45. 2005
  7. ncbi Microfluidic devices for studies of shear-dependent platelet adhesion
    Edgar Gutierrez
    Department of Physics, University of California San Diego, La Jolla, CA 92093, USA
    Lab Chip 8:1486-95. 2008
  8. ncbi Platelet integrins and immunoreceptors
    Ana Kasirer-Friede
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0726, USA
    Immunol Rev 218:247-64. 2007

Detail Information

Publications8

  1. ncbi The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1
    Stefanie Kliche
    Institute of Immunology, Otto von Guericke University, 39120 Magdeburg, Germany
    Mol Cell Biol 26:7130-44. 2006
    ..However, it appears as if the ADAP/SKAP55 module can exert its signaling function outside of the classical raft fraction of the cell membrane...
  2. ncbi ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla 92093 0726, USA
    Blood 109:1018-25. 2007
    ..These studies establish ADAP as a component of inside-out signaling pathways that couple GP Ib-IX-V and other platelet agonist receptors to alphaIIbbeta3 activation...
  3. ncbi Role for ADAP in shear flow-induced platelet mechanotransduction
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    Blood 115:2274-82. 2010
    ..These results establish that ADAP is an essential component of alphaIIbbeta3-mediated platelet mechanotransduction that promotes F-actin assembly and enables platelet spreading and thrombus stabilization under fluid shear stress...
  4. ncbi Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3
    Ana Kasirer-Friede
    Departments of Cell Biology and Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:11949-56. 2002
    ..By extrapolation, GP Ib-IX clustering in platelets may promote thrombus formation...
  5. ncbi Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors
    Ana Kasirer-Friede
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 103:3403-11. 2004
    ..These data establish that GP Ib-IX-V itself can signal to activate alpha IIb beta 3, through sequential actions of Src kinases, Ca(2+) oscillations, and PI 3-kinase/PKC...
  6. ncbi PTP-1B is an essential positive regulator of platelet integrin signaling
    Elena Garcia Arias-Salgado
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 170:837-45. 2005
    ..Thus, PTP-1B is an essential positive regulator of the initiation of outside-in alphaIIbbeta3 signaling in platelets...
  7. ncbi Microfluidic devices for studies of shear-dependent platelet adhesion
    Edgar Gutierrez
    Department of Physics, University of California San Diego, La Jolla, CA 92093, USA
    Lab Chip 8:1486-95. 2008
    ..Because of small sample volumes required, the devices could be employed in research with genetically-modified model organisms and for adhesion tests in clinical settings with blood from neonates...
  8. ncbi Platelet integrins and immunoreceptors
    Ana Kasirer-Friede
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0726, USA
    Immunol Rev 218:247-64. 2007
    ....