Thomas L Kash

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc The role of biogenic amine signaling in the bed nucleus of the stria terminals in alcohol abuse
    Thomas Louis Kash
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Alcohol 46:303-8. 2012
  2. pmc Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors
    Angela M Sparrow
    Department of Psychology, University of North Carolina, Chapel Hill, NC, USA
    Neuropsychopharmacology 37:1409-21. 2012
  3. pmc NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking
    Kristen E Pleil
    1 Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA 2 Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Nat Neurosci 18:545-52. 2015
  4. pmc Distinct extended amygdala circuits for divergent motivational states
    Joshua H Jennings
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nature 496:224-8. 2013
  5. pmc Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling
    Chia Li
    Curriculum in Neurobiology, School of Medicine, University of North Carolina Chapel Hill, NC 27599, USA
    Biol Psychiatry 71:725-32. 2012
  6. pmc Alcohol effects on synaptic transmission in periaqueductal gray dopamine neurons
    Chia Li
    Curriculum in Neurobiology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
    Alcohol 47:279-87. 2013
  7. pmc Neuropeptide regulation of signaling and behavior in the BNST
    Thomas L Kash
    Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USA
    Mol Cells 38:1-13. 2015
  8. pmc Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice
    Emily G Lowery-Gionta
    Department of Psychology, Bowles Center for Alcohol Studies, and Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    J Neurosci 32:3405-13. 2012
  9. pmc Functional alterations in the dorsal raphe nucleus following acute and chronic ethanol exposure
    Emily G Lowery-Gionta
    Laboratory of Molecular Neurophysiology, Department of Pharmacology, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Neuropsychopharmacology 40:590-600. 2015
  10. pmc A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior
    Eyal Vardy
    Department of Pharmacology and National Institute of Mental Health Psychoactive Drug Screening Program NIMH PDSP, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA
    Neuron 86:936-46. 2015

Collaborators

  • Jennifer A Rinker
  • Garret D Stuber
  • Juan Song
  • C J Malanga
  • Sheryl S Moy
  • Kristen E Pleil
  • Chia Li
  • Emily G Lowery-Gionta
  • Catherine A Marcinkiewcz
  • Hu Zhu
  • Todd E Thiele
  • Eyal Vardy
  • Christopher M Mazzone
  • Daniel J Urban
  • Bryan L Roth
  • Alberto J Lopez
  • Nora M McCall
  • Bradford B Lowell
  • Joshua H Jennings
  • Alice M Stamatakis
  • Angela M Sparrow
  • Montserrat Navarro
  • Ana M Jijon
  • Benjamin R Cox
  • Gretchen M Sprow
  • Joseph E Rittiner
  • Patrick M Giguère
  • Nicole A Crowley
  • Kathleen A Grant
  • Xi Ping Huang
  • Kate L White
  • J Elliott Robinson
  • David P Olson
  • Reid H J Olsen
  • Michael J Krashes
  • Philip D Mosier
  • Jeffrey F Diberto
  • Cayce E Dorrier
  • Flori M Sassano
  • Alexis M Kendra
  • Randall L Ung
  • Dennis R Sparta
  • Jose Pena
  • Linh Vong
  • Jose Peña Bravo
  • Alberto Lopez
  • Steven Busan
  • Nora McCall

Detail Information

Publications13

  1. pmc The role of biogenic amine signaling in the bed nucleus of the stria terminals in alcohol abuse
    Thomas Louis Kash
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Alcohol 46:303-8. 2012
    ....
  2. pmc Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors
    Angela M Sparrow
    Department of Psychology, University of North Carolina, Chapel Hill, NC, USA
    Neuropsychopharmacology 37:1409-21. 2012
    ..The current data suggest that Y1R agonists and Y2R antagonists may be useful for curbing and/or preventing binge drinking, protecting vulnerable individuals from progressing to the point of ethanol dependence...
  3. pmc NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking
    Kristen E Pleil
    1 Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA 2 Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Nat Neurosci 18:545-52. 2015
    ..Together, these data provide both a cellular locus and signaling framework for the development of new therapeutics for treatment of neuropsychiatric diseases, including alcohol use disorders...
  4. pmc Distinct extended amygdala circuits for divergent motivational states
    Joshua H Jennings
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nature 496:224-8. 2013
    ..These data demonstrate that functionally opposing BNST to VTA circuits regulate rewarding and aversive motivational states, and may serve as a crucial circuit node for bidirectionally normalizing maladaptive behaviours...
  5. pmc Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling
    Chia Li
    Curriculum in Neurobiology, School of Medicine, University of North Carolina Chapel Hill, NC 27599, USA
    Biol Psychiatry 71:725-32. 2012
    ..This suggests that KOR activation in this region may play a role in the regulation of emotional behaviors. To date, however, there has been no investigation of the ability of KOR to modulate synaptic transmission in the BNST...
  6. pmc Alcohol effects on synaptic transmission in periaqueductal gray dopamine neurons
    Chia Li
    Curriculum in Neurobiology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
    Alcohol 47:279-87. 2013
    ..These data add to a growing body of literature that points to alcohol having both region-dependent and cell-type dependent effects on function...
  7. pmc Neuropeptide regulation of signaling and behavior in the BNST
    Thomas L Kash
    Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USA
    Mol Cells 38:1-13. 2015
    ..The goal of this review is to explore the role of peptide signaling in one specific structure, the bed nucleus of the stria terminalis, that has proven to be a fertile ground for peptide action. ..
  8. pmc Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice
    Emily G Lowery-Gionta
    Department of Psychology, Bowles Center for Alcohol Studies, and Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    J Neurosci 32:3405-13. 2012
    ..We hypothesize that plastic changes in CRF signaling develop with repeated binge-like drinking episodes, contributing to the transition to dependence...
  9. pmc Functional alterations in the dorsal raphe nucleus following acute and chronic ethanol exposure
    Emily G Lowery-Gionta
    Laboratory of Molecular Neurophysiology, Department of Pharmacology, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Neuropsychopharmacology 40:590-600. 2015
    ....
  10. pmc A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior
    Eyal Vardy
    Department of Pharmacology and National Institute of Mental Health Psychoactive Drug Screening Program NIMH PDSP, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA
    Neuron 86:936-46. 2015
    ..The availability of DREADDs activated by different ligands provides enhanced opportunities for investigating diverse physiological systems using multiplexed chemogenetic actuators. ..
  11. pmc Ethanol induced adaptations in 5-HT2c receptor signaling in the bed nucleus of the stria terminalis: implications for anxiety during ethanol withdrawal
    Catherine A Marcinkiewcz
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropharmacology 89:157-67. 2015
    ..Taken together, these results suggest that CIE upregulates 5HT2c-R signaling in the vBNST, leading to increased excitability. This enhanced excitability of the vBNST may drive increased anxiety-like behavior during ethanol withdrawal...
  12. pmc Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory
    Hu Zhu
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Neuropsychopharmacology 39:1880-92. 2014
    ..Significantly, we found that selective inactivation of ventral but not dorsal glutamatergic hippocampal neurons suppressed the synaptic consolidation of contextual memory...
  13. pmc Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice
    Kristen E Pleil
    Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina Chapel Hill, 104 Manning Driv, Chapel Hill, NC 27599, USA
    Neuropharmacology 62:1777-86. 2012
    ....