John C Kash

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus
    John C Kash
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195 8070, USA
    J Virol 78:9499-511. 2004
  2. pmc Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence
    John C Kash
    Department of Microbiology, School of Medicine, University of Washington, Box 358070, Seattle, Washington 98195 8070, USA
    J Virol 80:3009-20. 2006
  3. ncbi request reprint Hijacking of the host-cell response and translational control during influenza virus infection
    John C Kash
    Department of Microbiology, University of Washington School of Medicine, Box 358070, Seattle, WA 98195 8070, USA
    Virus Res 119:111-20. 2006
  4. pmc Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
    John C Kash
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nature 443:578-81. 2006
  5. ncbi request reprint Virus infection and the interferon response: a global view through functional genomics
    Marcus J Korth
    Department of Microbiology, Washington National Primate Research Center, University of Washington, Seattle, USA
    Methods Mol Med 116:37-55. 2005
  6. pmc Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis
    John C Kash
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Virol 76:10417-26. 2002
  7. pmc Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins
    Jeffrey O Langland
    School of Life Sciences, Faculty of Biomedicine and Biotechnology, Arizona State University, Tempe, AZ 85287 4501, USA
    J Virol 80:10083-95. 2006
  8. ncbi request reprint Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus
    Darwyn Kobasa
    Respiratory Viruses, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Nature 445:319-23. 2007

Collaborators

Detail Information

Publications8

  1. pmc Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus
    John C Kash
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195 8070, USA
    J Virol 78:9499-511. 2004
    ..These studies document clear differences in gene expression profiles that were correlated with pulmonary disease pathology induced by virulent and attenuated influenza virus infections...
  2. pmc Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence
    John C Kash
    Department of Microbiology, School of Medicine, University of Washington, Box 358070, Seattle, Washington 98195 8070, USA
    J Virol 80:3009-20. 2006
    ..Taken together, these studies showed a correlation between antagonism of type I IFN responses and filovirus virulence...
  3. ncbi request reprint Hijacking of the host-cell response and translational control during influenza virus infection
    John C Kash
    Department of Microbiology, University of Washington School of Medicine, Box 358070, Seattle, WA 98195 8070, USA
    Virus Res 119:111-20. 2006
    ....
  4. pmc Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
    John C Kash
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nature 443:578-81. 2006
    ..Moreover, understanding the contribution of host immune responses to virulent influenza virus infections is an important starting point for the identification of prognostic indicators and the development of novel antiviral therapies...
  5. ncbi request reprint Virus infection and the interferon response: a global view through functional genomics
    Marcus J Korth
    Department of Microbiology, Washington National Primate Research Center, University of Washington, Seattle, USA
    Methods Mol Med 116:37-55. 2005
    ....
  6. pmc Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis
    John C Kash
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Virol 76:10417-26. 2002
    ..Further, our data suggest GRSF-1 functions by selectively recruiting cellular and viral mRNAs containing 5' UTR GRSF-1 binding sites to polyribosomes, which is mediated through interactions with cellular proteins...
  7. pmc Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins
    Jeffrey O Langland
    School of Life Sciences, Faculty of Biomedicine and Biotechnology, Arizona State University, Tempe, AZ 85287 4501, USA
    J Virol 80:10083-95. 2006
    ..These data suggest that poxviruses actively inhibit cellular recognition of viral danger signals and the subsequent cellular response to the viral threat...
  8. ncbi request reprint Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus
    Darwyn Kobasa
    Respiratory Viruses, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Nature 445:319-23. 2007
    ..The ability of influenza viruses to modulate host immune responses, such as that demonstrated for the avian H5N1 influenza viruses, may be a feature shared by the virulent influenza viruses...