LAWRENCE KARNISKI

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Mutations in the diastrophic dysplasia sulfate transporter (DTDST) gene: correlation between sulfate transport activity and chondrodysplasia phenotype
    L P Karniski
    Laboratory of Epithelial Transport, Department of Internal Medicine, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Hum Mol Genet 10:1485-90. 2001
  2. ncbi Functional expression and cellular distribution of diastrophic dysplasia sulfate transporter (DTDST) gene mutations in HEK cells
    Lawrence P Karniski
    Laboratory of Epithelial Transport, Department of Internal Medicine, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Hum Mol Genet 13:2165-71. 2004
  3. ncbi Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein
    Lawrence P Karniski
    Department of Internal Medicine, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Renal Physiol 283:F952-6. 2002
  4. ncbi Regulation of anion exchanger Slc26a6 by protein kinase C
    Hatim A Hassan
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Cell Physiol 292:C1485-92. 2007
  5. ncbi A compound heterozygote harboring novel and recurrent DTDST mutations with intermediate phenotype between atelosteogenesis type II and diastrophic dysplasia
    Koichi Maeda
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, Shirokanedai, Tokyo, Japan
    Am J Med Genet A 140:1143-7. 2006
  6. pmc The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct
    Nikolay Shcheynikov
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Physiol 586:3813-24. 2008

Research Grants

  1. FUNCTIONAL AND MOLECULAR CHARACTERIZATION OF PENDRIN
    LAWRENCE KARNISKI; Fiscal Year: 2004

Collaborators

Detail Information

Publications6

  1. ncbi Mutations in the diastrophic dysplasia sulfate transporter (DTDST) gene: correlation between sulfate transport activity and chondrodysplasia phenotype
    L P Karniski
    Laboratory of Epithelial Transport, Department of Internal Medicine, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Hum Mol Genet 10:1485-90. 2001
    ....
  2. ncbi Functional expression and cellular distribution of diastrophic dysplasia sulfate transporter (DTDST) gene mutations in HEK cells
    Lawrence P Karniski
    Laboratory of Epithelial Transport, Department of Internal Medicine, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Hum Mol Genet 13:2165-71. 2004
    ..In contrast to previous studies in Xenopus laevis oocytes, we find a strong correlation between the severity of the phenotype and the level of residual transport function in mammalian cells...
  3. ncbi Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein
    Lawrence P Karniski
    Department of Internal Medicine, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Renal Physiol 283:F952-6. 2002
    ..These studies demonstrate that pendrin is not responsible for formate-dependent NaCl reabsorption in the proximal tubule...
  4. ncbi Regulation of anion exchanger Slc26a6 by protein kinase C
    Hatim A Hassan
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Cell Physiol 292:C1485-92. 2007
    ..We conclude that multiple modes of anion exchange mediated by Slc26a6 are negatively regulated by PKC-delta activation...
  5. ncbi A compound heterozygote harboring novel and recurrent DTDST mutations with intermediate phenotype between atelosteogenesis type II and diastrophic dysplasia
    Koichi Maeda
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, Shirokanedai, Tokyo, Japan
    Am J Med Genet A 140:1143-7. 2006
    ..G663R is a loss-of-function mutation. Our case supports the previously described correlation between the severity of the phenotype and the putative level of residual transport function...
  6. pmc The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct
    Nikolay Shcheynikov
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Physiol 586:3813-24. 2008
    ....

Research Grants4

  1. FUNCTIONAL AND MOLECULAR CHARACTERIZATION OF PENDRIN
    LAWRENCE KARNISKI; Fiscal Year: 2004
    ..This work is a first step towards understanding the physiologic role of pendrin and determining how defects in pendrin lead to the clinical manifestations of Pendred syndrome. ..