ROLF KARLSTROM

Summary

Affiliation: University of Massachusetts
Country: USA

Publications

  1. pmc A laser pointer driven microheater for precise local heating and conditional gene regulation in vivo. Microheater driven gene regulation in zebrafish
    Mike Placinta
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    BMC Dev Biol 9:73. 2009
  2. pmc Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning
    R O Karlstrom
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016 USA
    Genes Dev 13:388-93. 1999
  3. ncbi request reprint Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
    Rolf O Karlstrom
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Development 130:1549-64. 2003
  4. ncbi request reprint Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling
    Oksana V Tyurina
    Department of Biology, University of Massachusetts, Amherst, MA 01003 9297, USA
    Dev Biol 277:537-56. 2005
  5. doi request reprint A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary
    Christine A Devine
    Department of Biology, University of Massachusetts, Amherst, MA, USA
    Dev Biol 326:143-54. 2009
  6. ncbi request reprint Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain
    Michael J F Barresi
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Development 132:3643-56. 2005
  7. pmc Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube
    Burcu Guner
    Biology Department, University of Massachusetts, Amherst, MA 01003 9297, USA
    Gene Expr Patterns 7:596-605. 2007
  8. ncbi request reprint Multiple roles for Hedgehog signaling in zebrafish pituitary development
    Jennifer L Sbrogna
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Dev Biol 254:19-35. 2003
  9. pmc Graded hedgehog and fibroblast growth factor signaling independently regulate pituitary cell fates and help establish the pars distalis and pars intermedia of the zebrafish adenohypophysis
    Burcu Guner
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Endocrinology 149:4435-51. 2008
  10. pmc Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos
    Sadie A Bergeron
    Department of Biology, University of Massachusetts, Amherst, MA 01003 9297, USA
    Genomics 91:165-77. 2008

Research Grants

Collaborators

  • Alexander Schier
  • W S Talbot
  • Hiroshi Sasaki
  • JHUMKU DUTT KOHTZ
  • Miguel L Allende
  • Sabrina Toro
  • Hiroyuki Takeda
  • D W Raible
  • Atsushi Kawakami
  • Stephan C F Neuhauss
  • Burcu Guner
  • Oksana V Tyurina
  • Jennifer L Sbrogna
  • Meng Chieh Shen
  • Jeanne E Thomas
  • Anandita Seth
  • Jianchi Feng
  • Michael J F Barresi
  • James Culverwell
  • Christine A Devine
  • Mike Placinta
  • Zhaohui Wang
  • Sadie A Bergeron
  • Veronica Palma
  • Gustavo A Cerda
  • Gary Vanderlaan
  • Kohshin Sekimizu
  • Josette M Ungos
  • Philip J diIorio
  • Honor Glenn
  • Christine Brown
  • Christos Valavanis
  • Marc Achermann
  • Jing Xia Liu
  • Marcey Osgood
  • Lawrence M Schwartz
  • A Tuba Ozacar
  • Shawn M Burgess
  • Rosario Villegas
  • Luis A Milla
  • Zoltan M Varga
  • Mitchell Walkowicz
  • Jens M Rick
  • Lara D Hutson
  • Chi Bin Chien
  • Evgenya Popova
  • Anand Chandrasekhar
  • Noriyuki Nishioka
  • Hae Young Lee
  • Theresa Larson
  • Bryan White
  • Larry G Moss
  • Jennifer B Moss

Detail Information

Publications19

  1. pmc A laser pointer driven microheater for precise local heating and conditional gene regulation in vivo. Microheater driven gene regulation in zebrafish
    Mike Placinta
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    BMC Dev Biol 9:73. 2009
    ..Local heating allows for spatial control of hsp-promoter-driven transgenes, but methods for local heating are cumbersome and variably effective...
  2. pmc Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning
    R O Karlstrom
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016 USA
    Genes Dev 13:388-93. 1999
    ..These findings reveal that truncated zebrafish Gli2 proteins interfere with Hh signaling necessary for differentiation and axon guidance in the ventral forebrain...
  3. ncbi request reprint Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
    Rolf O Karlstrom
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Development 130:1549-64. 2003
    ..These results reveal divergent requirements for Gli1 and Gli2 in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 has minor roles as a repressor or activator of Hh targets...
  4. ncbi request reprint Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling
    Oksana V Tyurina
    Department of Biology, University of Massachusetts, Amherst, MA 01003 9297, USA
    Dev Biol 277:537-56. 2005
    ..These results reveal a conserved role for Gli3 in vertebrate development and uncover novel regional functions and regulatory interactions among gli genes...
  5. doi request reprint A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary
    Christine A Devine
    Department of Biology, University of Massachusetts, Amherst, MA, USA
    Dev Biol 326:143-54. 2009
    ..Given the link between Hh signaling and pituitary adenomas in humans, our data suggest misregulation of Gli function may contribute to these common pituitary tumors...
  6. ncbi request reprint Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain
    Michael J F Barresi
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Development 132:3643-56. 2005
    ..This analysis shows that Hh signaling helps to pattern the expression of Slit guidance molecules that then help to regulate glial cell position and axon guidance across the midline of the forebrain...
  7. pmc Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube
    Burcu Guner
    Biology Department, University of Massachusetts, Amherst, MA 01003 9297, USA
    Gene Expr Patterns 7:596-605. 2007
    ....
  8. ncbi request reprint Multiple roles for Hedgehog signaling in zebrafish pituitary development
    Jennifer L Sbrogna
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Dev Biol 254:19-35. 2003
    ....
  9. pmc Graded hedgehog and fibroblast growth factor signaling independently regulate pituitary cell fates and help establish the pars distalis and pars intermedia of the zebrafish adenohypophysis
    Burcu Guner
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Endocrinology 149:4435-51. 2008
    ..These data suggest that there are distinct origins and signaling requirements for the PD and PI...
  10. pmc Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos
    Sadie A Bergeron
    Department of Biology, University of Massachusetts, Amherst, MA 01003 9297, USA
    Genomics 91:165-77. 2008
    ..We thus provide a comprehensive survey of Hh/Gli-regulated genes during embryogenesis and we identify new Hh-regulated genes that may be targets of misregulation during tumorigenesis...
  11. ncbi request reprint Making the connection: retinal axon guidance in the zebrafish
    James Culverwell
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Semin Cell Dev Biol 13:497-506. 2002
    ..The combination of zebrafish genetic and embryological approaches promises to greatly increase our understanding of how multiple guidance mechanisms establish the complex neural interconnectivity of the vertebrate brain...
  12. doi request reprint Regulation of muscle differentiation and survival by Acheron
    Zhaohui Wang
    Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
    Mech Dev 126:700-9. 2009
    ..These results display a crucial evolutionarily conserved role for Achn in myogenesis and suggest that it plays key roles in the processes of differentiation and self-renewal...
  13. ncbi request reprint belladonna/(Ihx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain
    Anandita Seth
    Biology Department, University of Massachusetts, Amherst, MA 01003 9297, USA
    Development 133:725-35. 2006
    ..Our analysis reveals new roles for Ihx2 in midline axon guidance, forebrain patterning and eye morphogenesis...
  14. ncbi request reprint Electroporation of DNA, RNA, and morpholinos into zebrafish embryos
    Gustavo A Cerda
    Millennium Nucleus in Developmental Biology and Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Methods 39:207-11. 2006
    ..This is the first report that describes the electroporation of three different molecules into embryonic and larval zebrafish cells...
  15. ncbi request reprint Sonic hedgehog is required early in pancreatic islet development
    Philip J diIorio
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Dev Biol 244:75-84. 2002
    ..The early action of Shh may be part of a more general process allowing neuroendocrine cells to originate in nonneuroectodermally derived tissues...
  16. ncbi request reprint Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids
    Jianchi Feng
    Program in Neurobiology and Department of Pediatrics, Children s Memorial Institute for Education and Research and The Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
    Development 131:4357-70. 2004
    ....
  17. ncbi request reprint The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling
    Kohshin Sekimizu
    Department of Biological Science, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 131:2521-32. 2004
    ..Taken together, our studies show that Igu/Dzip1 functions as a permissive factor that is required for the proper regulation of Hh target genes in response to Hh signals...
  18. ncbi request reprint Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons
    Josette M Ungos
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195 7420 USA
    Development 130:5351-62. 2003
    ..These results suggest that Hh signaling may normally promote DRG development by regulating expression of ngn1 in DRG precursors...
  19. pmc Gli function is essential for motor neuron induction in zebrafish
    Gary Vanderlaan
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    Dev Biol 282:550-70. 2005
    ..These observations demonstrate that Gli activator function (encoded by gli1, gli2, and gli3) is essential for motor neuron induction and Hh-regulated gene expression in zebrafish...

Research Grants11

  1. Hh signaling in the zebrafish forebrain and pituitary
    ROLF KARLSTROM; Fiscal Year: 2007
    ..Ultimately, this zebrafish research promises to contribute to our understanding of human birth defects affecting the pituitary and may shed light on tumorigenesis caused by mis-regulation of Hh signaling postnatally. ..
  2. SIGNALING CELL SPECIFICATION FOREBRAIN
    ROLF KARLSTROM; Fiscal Year: 2005
    ..The combination of these two approaches is well suited to the study of molecular signaling pathways that regulate cell fate decisions and promises to provide insights not readily attainable in other vertebrate systems. ..
  3. Molecular Control of Pituitary Development and Tumorigenesis
    Rolf O Karlstrom; Fiscal Year: 2010
    ..Comment [MB1]: I assume that stat is in the US? I would insert US here, given that you are applying for PHS money. ..