Jason H Karlawish

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Cognitive impairment and PD patients' capacity to consent to research
    Jason Karlawish
    University of Pennsylvania, Philadelphia, PA, USA
    Neurology 81:801-7. 2013
  2. pmc Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials
    Joshua D Grill
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, University of California, Los Angeles, 10911 Weyburn Avenue, Suite 200, Los Angeles, CA 90095, USA
    Alzheimers Res Ther 2:34. 2010
  3. doi request reprint Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease
    Jason Karlawish
    Center for Neuroscience and Society, Alzheimer s Disease Center, Center for Bioethics, Departments of Medicine and Medical Ethics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurology 77:1487-93. 2011
  4. ncbi request reprint The views of Alzheimer disease patients and their study partners on proxy consent for clinical trial enrollment
    Jason Karlawish
    Department of Medicine, Alzheimer s Disease Center, Leonard Davis Institute for Health Economics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 16:240-7. 2008
  5. pmc Interpreting the clinical significance of capacity scores for informed consent in Alzheimer disease clinical trials
    Jason Karlawish
    Department of Medicine, Alzheimer s Disease Center, Leonard Davis Institute for Health Economics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, School of Medicine, PA, USA
    Am J Geriatr Psychiatry 16:568-74. 2008
  6. doi request reprint Preference-based quality of life in patients with Alzheimer's disease
    Jason H Karlawish
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 4:193-202. 2008
  7. doi request reprint Caregivers' assessments of preference-based quality of life in Alzheimer's disease
    Jason H Karlawish
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 4:203-11. 2008
  8. pmc Older adults' attitudes toward enrollment of non-competent subjects participating in Alzheimer's research
    Jason Karlawish
    Institute on Aging, 3615 Chestnut St, Philadelphia, PA 19104, USA
    Am J Psychiatry 166:182-8. 2009
  9. pmc How redesigning AD clinical trials might increase study partners' willingness to participate
    Jason Karlawish
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurology 71:1883-8. 2008
  10. doi request reprint What Latino Puerto Ricans and non-Latinos say when they talk about Alzheimer's disease
    Jason Karlawish
    Division of Geriatrics, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 7:161-70. 2011

Detail Information

Publications43

  1. pmc Cognitive impairment and PD patients' capacity to consent to research
    Jason Karlawish
    University of Pennsylvania, Philadelphia, PA, USA
    Neurology 81:801-7. 2013
    ..To examine how cognitive impairment affects Parkinson disease (PD) patients' research consent capacity...
  2. pmc Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials
    Joshua D Grill
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, University of California, Los Angeles, 10911 Weyburn Avenue, Suite 200, Los Angeles, CA 90095, USA
    Alzheimers Res Ther 2:34. 2010
    ..We review the challenges to recruitment and retention in Alzheimer's disease clinical trials and present a framework to address them...
  3. doi request reprint Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease
    Jason Karlawish
    Center for Neuroscience and Society, Alzheimer s Disease Center, Center for Bioethics, Departments of Medicine and Medical Ethics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurology 77:1487-93. 2011
    ..Revisions are needed to laws, regulations, and professional practices governing driving, financial management and planning, and privacy and confidentiality...
  4. ncbi request reprint The views of Alzheimer disease patients and their study partners on proxy consent for clinical trial enrollment
    Jason Karlawish
    Department of Medicine, Alzheimer s Disease Center, Leonard Davis Institute for Health Economics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 16:240-7. 2008
    ..To examine the views of Alzheimer disease (AD) patients and their study partners on the ethics of proxy consent for clinical research...
  5. pmc Interpreting the clinical significance of capacity scores for informed consent in Alzheimer disease clinical trials
    Jason Karlawish
    Department of Medicine, Alzheimer s Disease Center, Leonard Davis Institute for Health Economics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, School of Medicine, PA, USA
    Am J Geriatr Psychiatry 16:568-74. 2008
    ..Among Alzheimer disease (AD) patients enrolled in a clinical trial, the authors assessed the ability of a standardized capacity assessment procedure to identify persons who are capable of giving their own informed consent...
  6. doi request reprint Preference-based quality of life in patients with Alzheimer's disease
    Jason H Karlawish
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 4:193-202. 2008
    ....
  7. doi request reprint Caregivers' assessments of preference-based quality of life in Alzheimer's disease
    Jason H Karlawish
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 4:203-11. 2008
    ....
  8. pmc Older adults' attitudes toward enrollment of non-competent subjects participating in Alzheimer's research
    Jason Karlawish
    Institute on Aging, 3615 Chestnut St, Philadelphia, PA 19104, USA
    Am J Psychiatry 166:182-8. 2009
    ..The authors used hypothetical Alzheimer's disease studies that included either a blood draw or a blood draw and lumbar puncture to explore older persons' attitudes on this question...
  9. pmc How redesigning AD clinical trials might increase study partners' willingness to participate
    Jason Karlawish
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurology 71:1883-8. 2008
    ..We used conjoint analysis to identify how alterations in attributes of clinical trial design improve willingness to participate: risk, home visits, car service, or increased chance of receiving intervention...
  10. doi request reprint What Latino Puerto Ricans and non-Latinos say when they talk about Alzheimer's disease
    Jason Karlawish
    Division of Geriatrics, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 7:161-70. 2011
    ..To discover whether Latino Puerto Rican and non-Latino communities differ in the words they use to talk about Alzheimer's disease (AD)...
  11. ncbi request reprint Identifying the barriers and challenges to voting by residents in nursing homes and assisted living settings
    Jason H T Karlawish
    University of Pennsylvania Institute of Aging, Philadelphia, PA 19104, USA
    J Aging Soc Policy 20:65-79. 2008
    ....
  12. pmc Decisional capacity for research participation in individuals with mild cognitive impairment
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, School of Medicine, University of Massachusetts at Boston, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 56:1236-43. 2008
    ..To assess decisional capacity performance and the neuropsychological correlates of such performance to better understand higher-level instrumental activities of daily living in individuals with mild cognitive impairment (MCI)...
  13. pmc Ethnoracial differences in the clinical characteristics of Alzheimer's disease at initial presentation at an urban Alzheimer's disease center
    Melissa Gartenberg Livney
    From the Penn Memory Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 19:430-9. 2011
    ....
  14. pmc Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementia
    Steven E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Alzheimers Dis 33:1089-95. 2013
    ..Considered together with the increased prevalence and mortality of AD reported in Puerto Rico, these high rates may reflect hereditary risk concentrated in the island which warrants further study...
  15. ncbi request reprint Addressing the ethical, legal, and social issues raised by voting by persons with dementia
    Jason H Karlawish
    Department of Medicine, Center for Bioethics, Institute on Aging, University of Pennsylvania, Philadelphia 19104, USA
    JAMA 292:1345-50. 2004
    ..In some instances, extrapolation from existing policies and research permits reasonable recommendations to guide policy and practice. However, in other instances, additional research is necessary...
  16. pmc A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research
    John Q Trojanowski
    Institute on Aging, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 8:564-73. 2012
    ..The "Ware-UPenn" program has been presented in this report as a useful prototype for partnerships between private philanthropy and academia in planning and developing programs to address a major national public health problem...
  17. doi request reprint Hospital protocols for the inpatient care of older adults: results from a statewide survey
    Mark D Neuman
    Robert Wood Johnson Foundation Clinical Scholars Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Geriatr Soc 58:1959-64. 2010
    ..To assess the prevalence of protocols or guidelines for selected domains of inpatient care for older adults; to explore associations between hospital characteristics and adoption of these guidelines or protocols...
  18. pmc Design of comprehensive Alzheimer's disease centers to address unmet national needs
    John Q Trojanowski
    Institute on Aging, Philadelphia, PA, USA
    Alzheimers Dement 6:150-5. 2010
    ..The intent of this position paper is to stimulate thinking and foster the development of other or alternative models for a systematic approach to the study of dementia and movement disorders...
  19. ncbi request reprint Improving the use of hospice services in nursing homes: a randomized controlled trial
    David Casarett
    Center for Health Equity Research and Promotion at the Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    JAMA 294:211-7. 2005
    ..Hospice care may improve the quality of end-of-life care for nursing home residents, but hospice is underutilized by this population, at least in part because physicians are not aware of their patients' preferences...
  20. ncbi request reprint Paying hypertension research subjects
    David Casarett
    Center for Health Equity Research and Promotion at the Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    J Gen Intern Med 17:650-2. 2002
    ..Cash payments are often used to compensate subjects who participate in research. However, ethicists have argued that these payments might constitute an undue inducement...
  21. ncbi request reprint How should clinicians discuss hospice for patients with dementia? Anticipating caregivers' preconceptions and meeting their information needs
    David Casarett
    Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania, USA
    Alzheimer Dis Assoc Disord 16:116-22. 2002
    ..In discussing hospice with AD caregivers, clinicians may want to emphasize selected features of hospice that are particularly important to caregivers...
  22. ncbi request reprint Emotion-discrimination deficits in mild Alzheimer disease
    Christian G Kohler
    Department of Psychiatry, Univ of Pennsylvania, Philadelphia, PA, USA
    Am J Geriatr Psychiatry 13:926-33. 2005
    ..Mild Alzheimer disease (AD) preferentially affects temporal lobe regions, which represent important structures in memory and emotional processes. This study investigated emotion discrimination in people with mild AD, versus Caretakers...
  23. ncbi request reprint Are hospices ready to participate in palliative care research? Results of a national survey
    David J Casarett
    Philadelphia Veterans Affairs Medical Center and Division of Geriatric Medicine, Department of Medicine, Center for Bioethics and the Leonard Davis Institute of Health Economics, University of Pennsylvania, 19104, USA
    J Palliat Med 5:397-406. 2002
    ..However, it is not known whether hospices are prepared to participate in research, nor is it known what barriers may prevent hospices from becoming involved in research...
  24. ncbi request reprint Voting by older adults with cognitive impairments
    Jason Karlawish
    Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Penna, USA
    LDI Issue Brief 13:1-4. 2008
    ..At what point does someone lose the capacity to vote, and who decides? What kinds of assistance should these voters get, and who should provide it? And how can the voting rights of residents in long-term care facilities be protected?..
  25. pmc Association between cognition and function in patients with Parkinson disease with and without dementia
    Emily Rosenthal
    Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Mov Disord 25:1170-6. 2010
    ..87 vs. 0.75, P = 0.0008). Cognition is associated with impairment in ADL function, even in nondemented patients with PD. However, sensitive cognitive assessment measures may be needed to identify these functionally relevant impairments...
  26. pmc Differences in depression symptoms in patients with Alzheimer's and Parkinson's diseases: evidence from the 15-item Geriatric Depression Scale (GDS-15)
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Int J Geriatr Psychiatry 22:1025-30. 2007
    ..Depression occurs frequently in patients with both Alzheimer's disease (AD) and Parkinson's disease (PD), but there has been little comparison of depression symptoms in the two populations...
  27. pmc Characterization of activities of daily living in individuals with mild cognitive impairment
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Am J Geriatr Psychiatry 16:375-83. 2008
    ....
  28. ncbi request reprint Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations
    Mark S Forman
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Neuropathol Exp Neurol 65:571-81. 2006
    ..Our findings are consistent with the hypothesis that the pathology associated with VCP gene mutations is the result of impairment of ubiquitin-based degradation pathways...
  29. pmc Frontotemporal dementia: clinicopathological correlations
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 59:952-62. 2006
    ..This study assessed whether specific clinical features predict the underlying pathology...
  30. pmc Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit
    Mary D Naylor
    Institute on Aging, University of Pennsylvania, Philadelphia, USA
    Alzheimers Dement 8:445-52. 2012
    ..The workgroups shared, discussed, and compiled an integrated set of priorities, recommendations, and action plans, which are presented in this article...
  31. pmc Self-reported distress after cognitive testing in patients with Alzheimer's disease
    James M Lai
    University of Pennsylvania Institute on Aging, 3615 Chestnut Street, Philadelphia, PA 19104, USA
    J Gerontol A Biol Sci Med Sci 63:855-9. 2008
    ..It is also unknown whether this level of distress is at all related to specific patient factors, test performance, or awareness of test performance...
  32. doi request reprint The relationship between short-term mortality and quality of care for hip fracture: a meta-analysis of clinical pathways for hip fracture
    Mark D Neuman
    Robert Wood Johnson Foundation Clinical Scholars Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Geriatr Soc 57:2046-54. 2009
    ..To assess the association between use of clinical pathways for hip fracture and changes in the rates of five inpatient complications and short-term mortality...
  33. ncbi request reprint Assessing the capacity to make everyday decisions: a guide for clinicians and an agenda for future research
    James M Lai
    Department of Medicine, Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, New Haven, CT 06504, USA
    Am J Geriatr Psychiatry 15:101-11. 2007
    ..Future research should develop and validate methods to identify patients with impaired capacity to make everyday decisions. These data will supplement functional, cognitive, and medical assessments...
  34. doi request reprint How should we use age to ration health care? Lessons from the case of kidney transplantation
    PETER P REESE
    Renal Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Geriatr Soc 58:1980-6. 2010
    ..This article argues that attempts to use HTA for healthcare rationing are likely to disadvantage older patients. Guiding principles to help ensure that resources such as kidneys are justly allocated across the life span are proposed...
  35. pmc Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Epidemiol 60:911-8. 2007
    ..A prior study suggested that antidepressants might increase the risk of hospitalization for pneumonia in the elderly. This study sought to confirm or refute this hypothesis...
  36. pmc Trends in the prevalence and mortality of cognitive impairment in the United States: is there evidence of a compression of cognitive morbidity?
    Kenneth M Langa
    Division of General Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA
    Alzheimers Dement 4:134-44. 2008
    ..To assess the impact of these multiple trends, we compared the prevalence and 2-year mortality of cognitive impairment (CI) consistent with dementia in the United States in 1993 to 1995 and 2002 to 2004...
  37. pmc Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 119:669-78. 2010
    ..In summary, our targeted proteomic screen revealed novel CSF biomarkers that can improve the distinction between AD and non-AD cases by established biomarkers alone...
  38. ncbi request reprint Prevalence and factors associated with use of placebo control groups in randomized controlled trials in psoriasis: a cross-sectional study
    Kenneth A Katz
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Am Acad Dermatol 55:814-22. 2006
    ..The ethics and science of using placebo control groups in clinical trials have been widely debated. Few studies, however, have examined factors associated with choice of control group...
  39. ncbi request reprint Obtaining informed consent for cancer pain research: do patients with advanced cancer and patients with chronic pain have different concerns?
    David Casarett
    Center for Health Equity Research and Promotion, Philadelphia, PA, USA
    J Pain Symptom Manage 24:506-16. 2002
    ..Although chronic pain patients' willingness to enroll in research was related to pain severity and a desire for better pain management, cancer patients' willingness to enroll was not...
  40. pmc Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease
    William T Hu
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Acta Neuropathol 120:385-99. 2010
    ....
  41. pmc Measuring decision-making capacity in cognitively impaired individuals
    Jason Karlawish
    Department of Medicine, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurosignals 16:91-8. 2008
    ..The results illustrate the clinical phenotype of the patient who retains the capacity to consent. They also suggest that measures of capacity can improve how researchers measure the benefits of cognitive enhancements and stage dementia...
  42. pmc Everyday decision-making ability in older persons with cognitive impairment
    James M Lai
    Department of Internal Medicine, Section of Geriatric Medicine, Yale University, New Haven, CT, USA
    Am J Geriatr Psychiatry 16:693-6. 2008
    ..To demonstrate the reliability and validity of the Assessment of Capacity for Everyday Decision-Making (ACED), an instrument to evaluate everyday decision-making...
  43. ncbi request reprint The capacity to vote of persons with Alzheimer's disease
    Paul S Appelbaum
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Psychiatry 162:2094-100. 2005
    ..This article explores how persons with Alzheimer's disease perform on these criteria...

Research Grants10

  1. COMMUNITY EQUIPOISE AND THE ETHICS OF CLINICAL RESEARCH
    Jason Karlawish; Fiscal Year: 2002
    ..Karlawish advanced training in bioethics scholarship. Other sponsors include experts in clinical trial design, Alzheimers Disease research and empirical research in research ethics. ..
  2. Parkinsons disease and research consent capacity
    Jason Karlawish; Fiscal Year: 2009
    ..This project will understand the impact of cognitive as well as neuropsychiatric impairments on a patient's ability to make a research enrollment decision. ..
  3. Consent Methods and Participation in Geriatric Clinical Research
    Jason Karlawish; Fiscal Year: 2009
    ..These results will assist researchers and proxies in conducting subject-centered informed consent discussions. ..
  4. Consent Methods and Participation in Geriatric Clinical Research
    Jason Karlawish; Fiscal Year: 2007
    ..These results will assist researchers and proxies in conducting subject-centered informed consent discussions. ..
  5. Improving informed consent in Alzheimer disease research
    Jason Karlawish; Fiscal Year: 2006
    ..The results will also begin to elucidate how experts make judgments of competency. ..
  6. Understanding attitudes about research advance planning
    Jason Karlawish; Fiscal Year: 2006
    ..These results will assist researchers and proxies in conducting subject-centered informed consent discussions. ..
  7. Improving informed consent in Alzheimer disease research
    Jason Karlawish; Fiscal Year: 2005
    ..The results will also begin to elucidate how experts make judgments of competency. ..
  8. Improving informed consent in Alzheimer disease research
    Jason Karlawish; Fiscal Year: 2004
    ..The results will also begin to elucidate how experts make judgments of competency. ..
  9. Parkinsons disease and research consent capacity
    Jason H Karlawish; Fiscal Year: 2010
    ..This project will understand the impact of cognitive as well as neuropsychiatric impairments on a patient's ability to make a research enrollment decision. ..