Research Topics
Species | Jason H KarlawishSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Detail Information
Publications
Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trialsJoshua D Grill
Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, University of California, Los Angeles, 10911 Weyburn Avenue, Suite 200, Los Angeles, CA 90095, USA
Alzheimers Res Ther 2:34. 2010..We review the challenges to recruitment and retention in Alzheimer's disease clinical trials and present a framework to address them...
Addressing the ethical, policy, and social challenges of preclinical Alzheimer diseaseJason Karlawish
Center for Neuroscience and Society, Alzheimer s Disease Center, Center for Bioethics, Departments of Medicine and Medical Ethics, University of Pennsylvania, Philadelphia, PA 19104, USA
Neurology 77:1487-93. 2011..Revisions are needed to laws, regulations, and professional practices governing driving, financial management and planning, and privacy and confidentiality...- The views of Alzheimer disease patients and their study partners on proxy consent for clinical trial enrollmentJason Karlawish
Department of Medicine, Alzheimer s Disease Center, Leonard Davis Institute for Health Economics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 16:240-7. 2008..To examine the views of Alzheimer disease (AD) patients and their study partners on the ethics of proxy consent for clinical research... - Interpreting the clinical significance of capacity scores for informed consent in Alzheimer disease clinical trialsJason Karlawish
Department of Medicine, Alzheimer s Disease Center, Leonard Davis Institute for Health Economics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, School of Medicine, PA, USA
Am J Geriatr Psychiatry 16:568-74. 2008..Among Alzheimer disease (AD) patients enrolled in a clinical trial, the authors assessed the ability of a standardized capacity assessment procedure to identify persons who are capable of giving their own informed consent... - Preference-based quality of life in patients with Alzheimer's diseaseJason H Karlawish
Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Alzheimers Dement 4:193-202. 2008.... - Caregivers' assessments of preference-based quality of life in Alzheimer's diseaseJason H Karlawish
Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Alzheimers Dement 4:203-11. 2008.... - How redesigning AD clinical trials might increase study partners' willingness to participateJason Karlawish
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Neurology 71:1883-8. 2008..We used conjoint analysis to identify how alterations in attributes of clinical trial design improve willingness to participate: risk, home visits, car service, or increased chance of receiving intervention... - Older adults' attitudes toward enrollment of non-competent subjects participating in Alzheimer's researchJason Karlawish
Institute on Aging, 3615 Chestnut St, Philadelphia, PA 19104, USA
Am J Psychiatry 166:182-8. 2009..The authors used hypothetical Alzheimer's disease studies that included either a blood draw or a blood draw and lumbar puncture to explore older persons' attitudes on this question... - What Latino Puerto Ricans and non-Latinos say when they talk about Alzheimer's diseaseJason Karlawish
Division of Geriatrics, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Alzheimers Dement 7:161-70. 2011..To discover whether Latino Puerto Rican and non-Latino communities differ in the words they use to talk about Alzheimer's disease (AD)... 
Identifying the barriers and challenges to voting by residents in nursing homes and assisted living settingsJason H T Karlawish
University of Pennsylvania Institute of Aging, Philadelphia, PA 19104, USA
J Aging Soc Policy 20:65-79. 2008....- Decisional capacity for research participation in individuals with mild cognitive impairmentAngela L Jefferson
Department of Neurology, Alzheimer s Disease Center, School of Medicine, University of Massachusetts at Boston, Boston, Massachusetts 02118, USA
J Am Geriatr Soc 56:1236-43. 2008..To assess decisional capacity performance and the neuropsychological correlates of such performance to better understand higher-level instrumental activities of daily living in individuals with mild cognitive impairment (MCI)... - Ethnoracial differences in the clinical characteristics of Alzheimer's disease at initial presentation at an urban Alzheimer's disease centerMelissa Gartenberg Livney
From the Penn Memory Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 19:430-9. 2011.... - Addressing the ethical, legal, and social issues raised by voting by persons with dementiaJason H Karlawish
Department of Medicine, Center for Bioethics, Institute on Aging, University of Pennsylvania, Philadelphia 19104, USA
JAMA 292:1345-50. 2004..In some instances, extrapolation from existing policies and research permits reasonable recommendations to guide policy and practice. However, in other instances, additional research is necessary... - Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementiaSteven E Arnold
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Alzheimers Dis 33:1089-95. 2013..Considered together with the increased prevalence and mortality of AD reported in Puerto Rico, these high rates may reflect hereditary risk concentrated in the island which warrants further study... - Design of comprehensive Alzheimer's disease centers to address unmet national needsJohn Q Trojanowski
Institute on Aging, Philadelphia, PA, USA
Alzheimers Dement 6:150-5. 2010..The intent of this position paper is to stimulate thinking and foster the development of other or alternative models for a systematic approach to the study of dementia and movement disorders... - Hospital protocols for the inpatient care of older adults: results from a statewide surveyMark D Neuman
Robert Wood Johnson Foundation Clinical Scholars Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Am Geriatr Soc 58:1959-64. 2010..To assess the prevalence of protocols or guidelines for selected domains of inpatient care for older adults; to explore associations between hospital characteristics and adoption of these guidelines or protocols... - Association between cognition and function in patients with Parkinson disease with and without dementiaEmily Rosenthal
Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
Mov Disord 25:1170-6. 2010..87 vs. 0.75, P = 0.0008). Cognition is associated with impairment in ADL function, even in nondemented patients with PD. However, sensitive cognitive assessment measures may be needed to identify these functionally relevant impairments... - Emotion-discrimination deficits in mild Alzheimer diseaseChristian G Kohler
Department of Psychiatry, Univ of Pennsylvania, Philadelphia, PA, USA
Am J Geriatr Psychiatry 13:926-33. 2005..Mild Alzheimer disease (AD) preferentially affects temporal lobe regions, which represent important structures in memory and emotional processes. This study investigated emotion discrimination in people with mild AD, versus Caretakers... - Paying hypertension research subjectsDavid Casarett
Center for Health Equity Research and Promotion at the Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
J Gen Intern Med 17:650-2. 2002..Cash payments are often used to compensate subjects who participate in research. However, ethicists have argued that these payments might constitute an undue inducement... - Improving the use of hospice services in nursing homes: a randomized controlled trialDavid Casarett
Center for Health Equity Research and Promotion at the Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
JAMA 294:211-7. 2005..Hospice care may improve the quality of end-of-life care for nursing home residents, but hospice is underutilized by this population, at least in part because physicians are not aware of their patients' preferences... - Are hospices ready to participate in palliative care research? Results of a national surveyDavid J Casarett
Philadelphia Veterans Affairs Medical Center and Division of Geriatric Medicine, Department of Medicine, Center for Bioethics and the Leonard Davis Institute of Health Economics, University of Pennsylvania, 19104, USA
J Palliat Med 5:397-406. 2002..However, it is not known whether hospices are prepared to participate in research, nor is it known what barriers may prevent hospices from becoming involved in research... - How should clinicians discuss hospice for patients with dementia? Anticipating caregivers' preconceptions and meeting their information needsDavid Casarett
Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania, USA
Alzheimer Dis Assoc Disord 16:116-22. 2002..In discussing hospice with AD caregivers, clinicians may want to emphasize selected features of hospice that are particularly important to caregivers... - Voting by older adults with cognitive impairmentsJason Karlawish
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Penna, USA
LDI Issue Brief 13:1-4. 2008..At what point does someone lose the capacity to vote, and who decides? What kinds of assistance should these voters get, and who should provide it? And how can the voting rights of residents in long-term care facilities be protected?.. - Differences in depression symptoms in patients with Alzheimer's and Parkinson's diseases: evidence from the 15-item Geriatric Depression Scale (GDS-15)Daniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Int J Geriatr Psychiatry 22:1025-30. 2007..Depression occurs frequently in patients with both Alzheimer's disease (AD) and Parkinson's disease (PD), but there has been little comparison of depression symptoms in the two populations... - Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational SummitMary D Naylor
Institute on Aging, University of Pennsylvania, Philadelphia, USA
Alzheimers Dement 8:445-52. 2012..The workgroups shared, discussed, and compiled an integrated set of priorities, recommendations, and action plans, which are presented in this article... - A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary researchJohn Q Trojanowski
Institute on Aging, University of Pennsylvania, Philadelphia, PA, USA
Alzheimers Dement 8:564-73. 2012..The "Ware-UPenn" program has been presented in this report as a useful prototype for partnerships between private philanthropy and academia in planning and developing programs to address a major national public health problem... - The relationship between short-term mortality and quality of care for hip fracture: a meta-analysis of clinical pathways for hip fractureMark D Neuman
Robert Wood Johnson Foundation Clinical Scholars Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Am Geriatr Soc 57:2046-54. 2009..To assess the association between use of clinical pathways for hip fracture and changes in the rates of five inpatient complications and short-term mortality... - Self-reported distress after cognitive testing in patients with Alzheimer's diseaseJames M Lai
University of Pennsylvania Institute on Aging, 3615 Chestnut Street, Philadelphia, PA 19104, USA
J Gerontol A Biol Sci Med Sci 63:855-9. 2008..It is also unknown whether this level of distress is at all related to specific patient factors, test performance, or awareness of test performance... - Assessing the capacity to make everyday decisions: a guide for clinicians and an agenda for future researchJames M Lai
Department of Medicine, Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, New Haven, CT 06504, USA
Am J Geriatr Psychiatry 15:101-11. 2007..Future research should develop and validate methods to identify patients with impaired capacity to make everyday decisions. These data will supplement functional, cognitive, and medical assessments... - Characterization of activities of daily living in individuals with mild cognitive impairmentAngela L Jefferson
Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Boston, MA 02118 2526, USA
Am J Geriatr Psychiatry 16:375-83. 2008.... - Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutationsMark S Forman
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Neuropathol Exp Neurol 65:571-81. 2006..Our findings are consistent with the hypothesis that the pathology associated with VCP gene mutations is the result of impairment of ubiquitin-based degradation pathways... - Frontotemporal dementia: clinicopathological correlationsMark S Forman
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
Ann Neurol 59:952-62. 2006.... - Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measuresSean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Clin Epidemiol 60:911-8. 2007..A prior study suggested that antidepressants might increase the risk of hospitalization for pneumonia in the elderly. This study sought to confirm or refute this hypothesis... - How should we use age to ration health care? Lessons from the case of kidney transplantationPETER P REESE
Renal Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Am Geriatr Soc 58:1980-6. 2010..This article argues that attempts to use HTA for healthcare rationing are likely to disadvantage older patients. Guiding principles to help ensure that resources such as kidneys are justly allocated across the life span are proposed... - Trends in the prevalence and mortality of cognitive impairment in the United States: is there evidence of a compression of cognitive morbidity?Kenneth M Langa
Division of General Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA
Alzheimers Dement 4:134-44. 2008..To assess the impact of these multiple trends, we compared the prevalence and 2-year mortality of cognitive impairment (CI) consistent with dementia in the United States in 1993 to 1995 and 2002 to 2004... - Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairmentWilliam T Hu
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Acta Neuropathol 119:669-78. 2010..In summary, our targeted proteomic screen revealed novel CSF biomarkers that can improve the distinction between AD and non-AD cases by established biomarkers alone... - Prevalence and factors associated with use of placebo control groups in randomized controlled trials in psoriasis: a cross-sectional studyKenneth A Katz
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Am Acad Dermatol 55:814-22. 2006..The findings suggest that ethical and scientific issues related to choice of control group in psoriasis trials are interpreted markedly differently depending on trial location and funding source... - Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's diseaseWilliam T Hu
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
Acta Neuropathol 120:385-99. 2010.... - Obtaining informed consent for cancer pain research: do patients with advanced cancer and patients with chronic pain have different concerns?David Casarett
Center for Health Equity Research and Promotion, Philadelphia, PA, USA
J Pain Symptom Manage 24:506-16. 2002..Although chronic pain patients' willingness to enroll in research was related to pain severity and a desire for better pain management, cancer patients' willingness to enroll was not... - Measuring decision-making capacity in cognitively impaired individualsJason Karlawish
Department of Medicine, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neurosignals 16:91-8. 2008..The results illustrate the clinical phenotype of the patient who retains the capacity to consent. They also suggest that measures of capacity can improve how researchers measure the benefits of cognitive enhancements and stage dementia... - Everyday decision-making ability in older persons with cognitive impairmentJames M Lai
Department of Internal Medicine, Section of Geriatric Medicine, Yale University, New Haven, CT, USA
Am J Geriatr Psychiatry 16:693-6. 2008..To demonstrate the reliability and validity of the Assessment of Capacity for Everyday Decision-Making (ACED), an instrument to evaluate everyday decision-making... - The capacity to vote of persons with Alzheimer's diseasePaul S Appelbaum
Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
Am J Psychiatry 162:2094-100. 2005..This article explores how persons with Alzheimer's disease perform on these criteria...
Research Grants
- COMMUNITY EQUIPOISE AND THE ETHICS OF CLINICAL RESEARCHJason Karlawish; Fiscal Year: 2002..Karlawish advanced training in bioethics scholarship. Other sponsors include experts in clinical trial design, Alzheimers Disease research and empirical research in research ethics. ..
- Parkinsons disease and research consent capacityJason Karlawish; Fiscal Year: 2009..This project will understand the impact of cognitive as well as neuropsychiatric impairments on a patient's ability to make a research enrollment decision. ..
- Consent Methods and Participation in Geriatric Clinical ResearchJason Karlawish; Fiscal Year: 2009..These results will assist researchers and proxies in conducting subject-centered informed consent discussions. ..
- Consent Methods and Participation in Geriatric Clinical ResearchJason Karlawish; Fiscal Year: 2007..These results will assist researchers and proxies in conducting subject-centered informed consent discussions. ..
- Improving informed consent in Alzheimer disease researchJason Karlawish; Fiscal Year: 2006..The results will also begin to elucidate how experts make judgments of competency. ..
- Parkinsons disease and research consent capacityJason H Karlawish; Fiscal Year: 2010..This project will understand the impact of cognitive as well as neuropsychiatric impairments on a patient's ability to make a research enrollment decision. ..