Research Topics
Genomes and Genes
| Michael KarinSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV ResponseTomohisa Kato
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Mol Cell 12:829-39. 2003..Inhibition of this pathway prevents UV-induced IkappaBalpha degradation and increases UV-induced cell death. Thus, the p38-CK2-NF-kappaB axis is an important component of the mammalian UV response...- From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importanceMichael Karin
Department of Pharmacology, School of Medicine, University of California, San Diego, California 92093 0723, USA
IUBMB Life 57:283-95. 2005..Importantly, the JNKs have become prime targets for drug development in several important clinical areas, including: inflammation, diabetes, and cancer... 
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammationHiroyuki Takahashi
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, School of Medicine, La Jolla, CA 92093 0723, USA
Cancer Cell 17:89-97. 2010..Tumor promotion is due to induction of inflammation that results in enhanced pneumocyte proliferation and is abrogated by IKKbeta ablation in myeloid cells or inactivation of JNK1...- NF-kappaB as a critical link between inflammation and cancerMichael Karin
Department of Pharmacology and Pathology, Moores Cancer Canter, UCSD School of Medicine, La Jolla, California 92093 0723, USA
Cold Spring Harb Perspect Biol 1:a000141. 2009..Most importantly, through its ability to up-regulate the expression of tumor promoting cytokines, such as IL-6 or TNF-alpha, and survival genes, such as Bcl-X(L), NF-kappaB provides a critical link between inflammation and cancer... - Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokinesPing Hui Tseng
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA
Nat Immunol 11:70-5. 2010..Inhibition of degradative ubiquitination of TRAF3 prevented the expression of all proinflammatory cytokines without affecting the interferon response... - Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complexAtsushi Matsuzawa
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Science 321:663-8. 2008..This two-stage signaling mechanism may apply to other innate immune receptors, accounting for spatial and temporal separation of MAPK and IKK signaling... - IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesisShin Maeda
Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive MC 0723, La Jolla, California 92093, USA
Cell 121:977-90. 2005..IKKbeta, therefore, orchestrates inflammatory crosstalk between hepatocytes and hematopoietic-derived cells that promotes chemical hepatocarcinogenesis... - Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesisToshiharu Sakurai
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Cancer Cell 14:156-65. 2008..IL-1 alpha release by necrotic hepatocytes is therefore an important mediator of liver tumorigenesis... - I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone lossMaria Grazia Ruocco
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
J Exp Med 201:1677-87. 2005..IKKbeta also protects osteoclasts and their progenitors from tumor necrosis factor alpha-induced apoptosis, and its loss in hematopoietic cells prevents inflammation-induced bone loss... - IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancerSergei Grivennikov
Laboratory of Gene Regulation and Signal Transduction, UCSD School of Medicine, University of California San Diego, La Jolla, CA 92093 0723, USA
Cancer Cell 15:103-13. 2009..Thus, the NF-kappaB-IL-6-Stat3 cascade is an important regulator of the proliferation and survival of tumor-initiating IECs... - Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growthSergei I Grivennikov
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093 0723, USA
Nature 491:254-8. 2012..We propose that barrier deterioration induced by colorectal-cancer-initiating genetic lesions results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives tumour growth... - Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasisSunhwa Kim
Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
Nature 457:102-6. 2009..These results explain how advanced cancer cells usurp components of the host innate immune system, including bone-marrow-derived myeloid progenitors, to generate an inflammatory microenvironment hospitable for metastatic growth... - Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulatorsJin Mo Park
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
Immunity 23:319-29. 2005..Here we describe key roles for transcription factor CREB, a target for p38 signaling, and the plasminogen activator 2 (PAI-2) gene, a target for CREB, in maintenance of macrophage survival... - Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expressionEek Joong Park
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Cell 140:197-208. 2010..The chronic inflammatory response caused by obesity and enhanced production of IL-6 and TNF may also increase the risk of other cancers... - Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processingShin Maeda
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Science 307:734-8. 2005..These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion... - Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activationGuobin He
Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Cancer Cell 17:286-97. 2010..Hepatocyte-specific STAT3 ablation prevented HCC development. The negative crosstalk between NF-kappaB and STAT3, which is also evident in human HCC, is a critical regulator of liver cancer development and progression... - Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitorJohn L Stebbins
Infectious and Inflammatory Disease Center, Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
J Med Chem 54:6206-14. 2011..Finally, compound 19 successfully inhibits JNK in a variety of cell-based experiments, as well as in vivo where it is shown to protect against Jo-2 induced liver damage and improve glucose tolerance in diabetic mice... - Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activationMonica Guma
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
J Exp Med 208:1889-900. 2011..Inflammation is driven by massive TNF production, which requires additional activation of p38 and extracellular-signal-regulated kinase mitogen-activated protein kinases (MAPKs)... - Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like diseaseThomas Enzler
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Immunity 25:403-15. 2006..Thus, both classical and alternative NF-kappaB signaling are important for development of lupus-like disease associated with BAFF overproduction. The same mechanisms may be involved in the pathogenesis of human SLE... - Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activationToshiharu Sakurai
Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093 0723, USA
Proc Natl Acad Sci U S A 103:10544-51. 2006.... - Targeted deletion of hepatocyte Ikkbeta confers growth advantagesKatherine S Koch
Hepatocyte Growth Control and Stem Cell Laboratory, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0636, La Jolla, CA 92093 0636, USA
Biochem Biophys Res Commun 380:349-54. 2009..Increased HCC development in Ikkbeta(Delta hep) mice may also be caused by growth advantages of surviving Ikkbeta-deleted hepatocytes... - Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody productionEwen Gallagher
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, California 92093 0723, USA
Nat Immunol 8:57-63. 2007..Our data emphasize that MEKK1 is an essential component of signaling cascades needed for thymus-dependent antigen-induced B cell proliferation and antibody production... - Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substratesGiovanni Solinas
Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive, MC 0723, La Jolla, CA 92093 0723, USA
Proc Natl Acad Sci U S A 103:16454-9. 2006..This mechanism may account for the induction of central insulin resistance by free fatty acids... - Sestrin as a feedback inhibitor of TOR that prevents age-related pathologiesJun Hee Lee
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego UCSD, La Jolla, CA 92093 0723, USA
Science 327:1223-8. 2010.... - IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalphaShin Maeda
Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA
Immunity 19:725-37. 2003..Thus, the antiapoptotic function of IKKbeta, which is most critical in situations that involve cell-bound TNFalpha, is mediated partially through attenuation of JNK activity... - Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injurySungwon Chae
Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
J Immunol 177:1214-20. 2006..difficile toxin A exposure that is mediated, at least in part, through promoting epithelial cell survival by abrogating epithelial cell apoptosis... - Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonistsJin Mo Park
Laboratory of Gene Regulation and Signal Transduction, Dept of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
J Exp Med 200:1647-55. 2004..We also provide genetic evidence that ALO is required for induction of macrophage apoptosis in response to infection with live B. anthracis and that other CDC family members share the ability to activate TLR4... - Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expressionMonica Guma
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Proc Natl Acad Sci U S A 106:8760-5. 2009..These results strongly suggest that JNK1 plays a key role in retinal neoangiogenesis and that it represents a new pharmacological target for treatment of diseases where excessive neoangiogenesis is the underlying pathology... - Opposing functions of IKKbeta during acute and chronic intestinal inflammationLars Eckmann
Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 105:15058-63. 2008..Our findings caution against the therapeutic use of IKKbeta/NF-kappaB inhibitors in acute inflammatory settings dominated by cell loss and ulceration... - Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancerSergei I Grivennikov
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA
Cytokine Growth Factor Rev 21:11-9. 2010..In addition to explaining the molecular pathogenesis of cancer, these interactions also offer opportunities for the design of new therapeutic interventions... 
Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progressionThomas Enzler
Moores Cancer Center, Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA
Blood 114:4469-76. 2009....- A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptideLi Chung Hsu
Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 105:7803-8. 2008..Thus, NOD2 plays a key role in the B. anthracis-induced inflammatory response by being a critical mediator of IL-1beta secretion... - Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakageSyed Raza Ali
Laboratory of Signal Transduction, Department of Pharmacology, University of California, San Diego, La Jolla, California, USA
Immunity 35:34-44. 2011..Prevention of cell death or ATP release through constitutive p38 or AKT activation interfered with inflammasome activation and IL-1β production, thereby compromising antimicrobial immunity... - Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epitheliumDavid H Broide
Department of Medicine, Laboratory of Gene Regulation and Signal Transduction, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 102:17723-8. 2005..Overall, these studies show an important role for NF-kappaB regulated genes in airway epithelium in allergen-induced airway remodeling, including peribronchial fibrosis and mucus production... - Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational changeEwen Gallagher
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Proc Natl Acad Sci U S A 103:1717-22. 2006.... - B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemiaWeizhou Zhang
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 107:18956-60. 2010.... - Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liverChristoph H Osterreicher
Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 108:308-13. 2011..These findings suggest that FSP1 is a marker of a specific subset of inflammatory macrophages in liver injury, fibrosis, and cancer... - IKK-beta links inflammation to obesity-induced insulin resistanceMelek C Arkan
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Nat Med 11:191-8. 2005..We suggest that inhibition of IKK-beta, especially in myeloid cells, may be used to treat insulin resistance... - Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimersGiuseppina Bonizzi
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
EMBO J 23:4202-10. 2004..This site links induction of organogenic chemokines and other important regulatory molecules to activation of the alternative pathway... - Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regressionJun-Li Luo
Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cancer Cell 6:297-305. 2004..The latter response is TNFalpha-independent, but depends on another member of the TNF superfamily, TRAIL, whose receptor is induced in NF-kappaB-deficient cancer cells... - Inflammation and colon cancerJanos Terzic
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, La Jolla, California, USA
Gastroenterology 138:2101-2114.e5. 2010..These mechanisms, as well as new approaches to prevention and therapy, are discussed in this review... - Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosisAnjuli M Timmer
Department of Pediatrics, Biomedical Sciences Graduate Program, Laboratory of Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 284:862-71. 2009..We conclude that accelerated, caspase-dependent macrophage apoptosis induced by the pore-forming cytolysin SLO contributes to GAS immune evasion and virulence... - IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cellsYixue Cao
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Proc Natl Acad Sci U S A 104:15852-7. 2007..IKKalpha may represent a novel and specific target for treatment of ErbB2-positive breast cancer... - A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approachesEkihiro Seki
Department of Medicine, University of California, La Jolla, CA, USA
Gastroenterology 143:307-20. 2012..We review the functions and pathways of JNK in liver physiology and pathology and discuss findings from preclinical studies with JNK inhibitors... - Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activationRyan G Holzer
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Cell 147:173-84. 2011..Consumption of a diabetogenic high-fat diet causes the partitioning and activation of c-Src within detergent insoluble membrane subdomains of murine adipocytes... - Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing MaspinJun Li Luo
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
Nature 446:690-4. 2007..We propose that tumour-infiltrating RANKL-expressing cells lead to nuclear IKKalpha activation and inhibition of Maspin transcription, thereby promoting the metastatic phenotype... - Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase ItchMin Gao
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Science 306:271-5. 2004..This pathway modulates cytokine production by effector T cells... - IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiationPascal Descargues
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Proc Natl Acad Sci U S A 105:2487-92. 2008..We suggest that a TGFbeta-Smad2/3-IKKalpha axis is a critical Smad4-independent regulator of keratinocyte proliferation and differentiation... - Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatasesHideaki Kamata
Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cell 120:649-61. 2005..Antioxidant treatment also prevents TNFalpha-mediated fulminant liver failure without affecting liver regeneration... - NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activationPetr Hruz
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 106:12873-8. 2009.... - IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancerPascal Descargues
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, Cancer Center, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0723, USA
EMBO J 27:2639-47. 2008..Although these are not the only functions of nuclear IKKalpha, this multifunctional protein is a key regulator of keratinocyte and epidermal differentiation and a critical suppressor of skin cancer... - Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulationHelena Shaked
Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 109:14007-12. 2012..The results suggest that persistent NF-κB activation in IEC may accelerate loss of heterozygocity by enhancing nitrosative DNA damage... - Anthrax lethal factor and edema factor act on conserved targets in DrosophilaAnnabel Guichard
Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, 92093 0349, USA
Proc Natl Acad Sci U S A 103:3244-9. 2006.... - NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alphaJordi Rius
Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
Nature 453:807-11. 2008..IKK-beta is also essential for HIF-1alpha accumulation in macrophages experiencing a bacterial infection. Hence, IKK-beta is an important physiological contributor to the hypoxic response, linking it to innate immunity and inflammation... - Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6Hans Hacker
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Nature 439:204-7. 2006.... - The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosisShujuan Chen
Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
J Biol Chem 278:19526-33. 2003..These results confirm that the Ah receptor plays a critical role in B[a]P-7,8-dihydrodiol-induced apoptosis while p38 MAP kinase links the actions of an electrophilic metabolite like BPDE-2 to the regulation of programmed cell death... - Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signalsDavid M Mills
Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 104:6359-64. 2007..Thus, the NIK-IKKalpha-p52 axis is not as linear and exclusive as previous studies suggest, and IKKalpha possesses critical NF-kappaB-independent functions in B cells... - Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in DrosophilaJin Mo Park
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, 92093-0636, USA
Genes Dev 18:584-94. 2004..Because the IKK-NF-kappa B module also negatively regulates JNK activation in mammals, thereby controlling inflammation-induced apoptosis, the regulatory cross-talk between the JNK and NF-kappa B pathways appears to be broadly conserved... - The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4Li Chung Hsu
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0636, USA
Nature 428:341-5. 2004..The pro-apoptotic actions of PKR are mediated both through inhibition of protein synthesis and activation of interferon response factor 3... - B-cell-derived lymphotoxin promotes castration-resistant prostate cancerMassimo Ammirante
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
Nature 464:302-5. 2010.... - IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epitheliumLaurence J Egan
Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 101:2452-7. 2004..Selective preactivation of NF-kappaB through IKKbeta in intestinal epithelial cells could provide a therapeutic modality that allows higher doses of radiation to be tolerated during cancer radiotherapy... - JNK-1 deficiency limits macrophage-mediated antigen-induced arthritisMonica Guma
Department of Medicine, University of California at San Diego, La Jolla, California 92093 0663, USA
Arthritis Rheum 63:1603-12. 2011..To elucidate the nonredundant roles of JNK-1 and JNK-2 in antigen-induced arthritis (AIA)... - IKK beta is required for peripheral B cell survival and proliferationZhi Wei Li
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
J Immunol 170:4630-7. 2003..Thus, IKKbeta provides a requisite role in B cell activation and maintenance and thus is a key determinant of humoral immunity... - JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritisMonica Guma
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, Division of Rheumatology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 107:22122-7. 2010..Hence, JNK1 controls mast cell degranulation and FcγR-triggered IL-1β production, in addition to regulating cytokine and matrix metalloproteinase biosynthesis, and is an attractive therapeutic target in inflammatory arthritis... - From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odysseyVladislav Temkin
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA, USA
Immunol Rev 220:8-21. 2007..These molecular mechanisms may be involved in neoplastic, autoimmune, neurodegenerative, inflammatory, and metabolic diseases...