Sharon L Kardia

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Joint relationship between renal function and proteinuria on mortality of patients with type 2 diabetes: the Taichung Diabetes Study
    Cheng Chieh Lin
    Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
    Cardiovasc Diabetol 11:131. 2012
  2. pmc Identification of genes associated with complex traits by testing the genetic dissimilarity between individuals
    Yan V Sun
    Department of Epidemiology, School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    BMC Proc 5:S120. 2011
  3. pmc Genomics and public health: development of Web-based training tools for increasing genomic awareness
    Jennifer Bodzin
    Michigan Center for Genomics and Public Health, University of Michigan, School of Public Health, Ann Arbor, MI 48104 3028, USA
    Prev Chronic Dis 2:A25. 2005
  4. pmc Metabolic syndrome is associated with change in subclinical arterial stiffness: a community-based Taichung community health study
    Chia Ing Li
    School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
    BMC Public Health 11:808. 2011
  5. pmc The relationship of high sensitivity C-reactive protein to percent body fat mass, body mass index, waist-to-hip ratio, and waist circumference in a Taiwanese population
    Cheng Chieh Lin
    Department of Family Medicine, China Medical University and Hospital, Taichung, Taiwan
    BMC Public Health 10:579. 2010
  6. pmc Sex difference in the association of metabolic syndrome with high sensitivity C-reactive protein in a Taiwanese population
    Ming May Lai
    Department of Family Medicine, China Medical University and Hospital, Taichung, Taiwan
    BMC Public Health 10:429. 2010
  7. pmc Identification of correlated genetic variants jointly associated with rheumatoid arthritis using ridge regression
    Yan V Sun
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory, Ann Arbor, Michigan 48109, USA
    BMC Proc 3:S67. 2009
  8. pmc Classification of rheumatoid arthritis status with candidate gene and genome-wide single-nucleotide polymorphisms using random forests
    Yan V Sun
    Department of Epidemiology, School of Public Health, University of Michigan, 611 Church Street 244, Ann Arbor, Michigan 48104, USA
    BMC Proc 1:S62. 2007
  9. pmc Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA Study
    Jennifer A Smith
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    BMC Med Genomics 2:16. 2009
  10. pmc SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in African-Americans of the GENOA study
    Kristin J Meyers
    Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin, USA
    BMC Med Genet 11:160. 2010

Research Grants

  1. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2002
  2. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2003
  3. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2004
  4. GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS
    Sharon Kardia; Fiscal Year: 2004
  5. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2005
  6. Genomic Predictors of Arteriosclerosis in Hypertensives
    Sharon Kardia; Fiscal Year: 2007
  7. Genomic Predictors of Arteriosclerosis in Hypertensives
    Sharon Kardia; Fiscal Year: 2009

Detail Information

Publications80

  1. pmc Joint relationship between renal function and proteinuria on mortality of patients with type 2 diabetes: the Taichung Diabetes Study
    Cheng Chieh Lin
    Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
    Cardiovasc Diabetol 11:131. 2012
    ..In this study, we tested whether concomitant proteinuria increases the risk of mortality among patients with type 2 diabetes...
  2. pmc Identification of genes associated with complex traits by testing the genetic dissimilarity between individuals
    Yan V Sun
    Department of Epidemiology, School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    BMC Proc 5:S120. 2011
    ..05 as a threshold. These results suggest that the distance correlation method can be used to identify genotype-phenotype association when multiple rare genetic variants in a gene are involved...
  3. pmc Genomics and public health: development of Web-based training tools for increasing genomic awareness
    Jennifer Bodzin
    Michigan Center for Genomics and Public Health, University of Michigan, School of Public Health, Ann Arbor, MI 48104 3028, USA
    Prev Chronic Dis 2:A25. 2005
    ..This paper focuses on the processes and collaborative efforts by which these live presentations were developed and delivered as Web-based training sessions...
  4. pmc Metabolic syndrome is associated with change in subclinical arterial stiffness: a community-based Taichung community health study
    Chia Ing Li
    School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
    BMC Public Health 11:808. 2011
    ..The aim of this study was to evaluate the effect of MetS on arterial stiffness in a longitudinal study...
  5. pmc The relationship of high sensitivity C-reactive protein to percent body fat mass, body mass index, waist-to-hip ratio, and waist circumference in a Taiwanese population
    Cheng Chieh Lin
    Department of Family Medicine, China Medical University and Hospital, Taichung, Taiwan
    BMC Public Health 10:579. 2010
    ..This study compared the association of percent body fat mass (%FM), body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) with hs-CRP in a Taiwanese population...
  6. pmc Sex difference in the association of metabolic syndrome with high sensitivity C-reactive protein in a Taiwanese population
    Ming May Lai
    Department of Family Medicine, China Medical University and Hospital, Taichung, Taiwan
    BMC Public Health 10:429. 2010
    ..Therefore, the aim of this study was to compare associations of high sensitivity C-creative protein (hs-CRP) with metabolic syndrome and its components between men and women...
  7. pmc Identification of correlated genetic variants jointly associated with rheumatoid arthritis using ridge regression
    Yan V Sun
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory, Ann Arbor, Michigan 48109, USA
    BMC Proc 3:S67. 2009
    ..This suggests that multivariable methods can be used to identify potentially relevant genetic variants in regions of interest that would be difficult to detect based on direct associations...
  8. pmc Classification of rheumatoid arthritis status with candidate gene and genome-wide single-nucleotide polymorphisms using random forests
    Yan V Sun
    Department of Epidemiology, School of Public Health, University of Michigan, 611 Church Street 244, Ann Arbor, Michigan 48104, USA
    BMC Proc 1:S62. 2007
    ..However, in a complete training-testing framework, replication of genetic predictors was less satisfactory; thus, further evaluation of existing methodology and development of new methods are warranted...
  9. pmc Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA Study
    Jennifer A Smith
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    BMC Med Genomics 2:16. 2009
    ....
  10. pmc SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in African-Americans of the GENOA study
    Kristin J Meyers
    Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin, USA
    BMC Med Genet 11:160. 2010
    ....
  11. pmc Software comparison for evaluating genomic copy number variation for Affymetrix 6.0 SNP array platform
    Jeanette E Eckel-Passow
    Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Bioinformatics 12:220. 2011
    ..0. We compared bias and variance in the locus-level copy number data, the concordance amongst regions of copy number gains/deletions and the false-positive rate amongst deleted segments...
  12. ncbi request reprint Linear dynamic features of ambulatory blood pressure in a population-based study
    Sharon L R Kardia
    Department of Epidemiology, University of Michigan, 611 Church Street 246, Ann Arbor, MI 48109 2029, USA
    Blood Press Monit 9:259-67. 2004
    ....
  13. ncbi request reprint Epistatic effects between two genes in the renin-angiotensin system and systolic blood pressure and coronary artery calcification
    Sharon L R Kardia
    Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104 3028, USA
    Med Sci Monit 12:CR150-8. 2006
    ..Since elevated blood pressure (BP) is an important predictor of CAC, genetic polymorphisms in the renin-angiotensin system and their interaction may play a role in explaining CAC quantity variation...
  14. pmc Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival
    Sharon L R Kardia
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory St, Ann Arbor, MI 48109 2029, USA
    BMC Med Genet 9:93. 2008
    ..The purpose of this study was to investigate possible synergistic effects of polymorphisms of these two intronless genes (ADRB1 and ADRA2C, respectively) on the risk of death/transplant in heart failure patients...
  15. ncbi request reprint The role of health education and behavior in public health genetics
    Sharon L R Kardia
    Department of Epidemiology, Public Health Genetics Program, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
    Health Educ Behav 32:583-8. 2005
    ..An introduction to the nine articles and two practice notes included in this special issue is also provided to draw attention to the crosscutting themes and issues presented...
  16. ncbi request reprint The relationship between risk factor levels and presence of coronary artery calcification is dependent on apolipoprotein E genotype
    S L Kardia
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Arterioscler Thromb Vasc Biol 19:427-35. 1999
    ..Thus, variation in the gene coding for ApoE may play a role in determining the contribution of established risk factors to risk of CAC...
  17. ncbi request reprint Family-centered approaches to understanding and preventing coronary heart disease
    Sharon L R Kardia
    Department of Epidemiology, University of Michigan, 109 Observatory Street, Room 3047, Ann Arbor, MI 48109 2029, USA
    Am J Prev Med 24:143-51. 2003
    ....
  18. ncbi request reprint Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populations
    Sharon L R Kardia
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Am J Hypertens 16:154-7. 2003
    ....
  19. pmc Interactions between the adducin 2 gene and antihypertensive drug therapies in determining blood pressure in people with hypertension
    Sharon L R Kardia
    Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
    BMC Med Genet 8:61. 2007
    ..Linkage analysis identified a region on chromosome 2 that was investigated using 70 single nucleotide polymorphisms (SNPs) typed in 7 positional candidate genes, including adducin 2 (ADD2)...
  20. ncbi request reprint Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks
    Kristin J Meyers
    Department of Epidemiology, University of Michigan, Ann Arbor, USA
    Hypertension 49:992-9. 2007
    ..We identified genetic variation that significantly influences left ventricular traits with replicable effects in a cohort of hypertensive, black siblings...
  21. ncbi request reprint Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors
    Guoan Chen
    Section of General Thoracic Surgery, Departments of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 8:2298-305. 2002
    ..The goal of this study was to identify potential protein markers in lung adenocarcinomas...
  22. pmc Evidence for consistent intragenic and intergenic interactions between SNP effects in the APOA1/C3/A4/A5 gene cluster
    Sara C Hamon
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Hum Hered 61:87-96. 2006
    ..Evaluate the consistency of the contribution of interactions between single nucleotide polymorphism (SNP) genotype effects to variation in measures of lipid metabolism across ethnic strata within gender...
  23. pmc Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families
    Donna K Arnett
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, RPHB 220E, 1530 3rd Ave South, Birmingham, AL 35294 0022, USA
    Circ Res 108:279-83. 2011
    ..Left ventricular (LV) mass and related phenotypes are heritable, important predictors of cardiovascular disease, particularly in hypertensive individuals...
  24. ncbi request reprint A model-based scan statistic for identifying extreme chromosomal regions of gene expression in human tumors
    Albert M Levin
    Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104 3028, USA
    Bioinformatics 21:2867-74. 2005
    ..However, currently available methods fail to account for variation in the distance between genes, gene density and genomic features (e.g. GC content) in identifying increased or decreased chromosomal regions of gene expression...
  25. pmc Comparison of the DNA methylation profiles of human peripheral blood cells and transformed B-lymphocytes
    Yan V Sun
    Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights 4629, Ann Arbor, MI 48109, USA
    Hum Genet 127:651-8. 2010
    ..While the majority of DNAm findings in PBC and TBL may be consistent, caution must be used when interpreting results because of the possibility of cell type-specific methylation modification...
  26. ncbi request reprint KGraph: a system for visualizing and evaluating complex genetic associations
    Reagan J Kelly
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
    Bioinformatics 23:249-51. 2007
    ..It emphasizes gene-environment and gene-gene interaction, both important components of any genetic system that are often overlooked in association frameworks...
  27. ncbi request reprint ChromoScan: a scan statistic application for identifying chromosomal regions in genomic studies
    Yan V Sun
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48104 3028, USA
    Bioinformatics 22:2945-7. 2006
    ..A Java graphic user interface (GUI) is provided to allow users to select appropriate data transformations and thresholds for defining the significant events...
  28. pmc A common copy number variation on chromosome 6 association with the gene expression level of endothelin 1 in transformed B lymphocytes from three racial groups
    Yan V Sun
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Mich 48109, USA
    Circ Cardiovasc Genet 2:483-8. 2009
    ....
  29. ncbi request reprint Genetic research on complex behaviors: an examination of attempts to identify genes for smoking
    Ovide F Pomerleau
    Nicotine Research Laboratory, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48105, USA
    Nicotine Tob Res 9:883-901. 2007
    ..These proceedings are excerpts based on the presentations at the conference...
  30. ncbi request reprint Genome-wide linkage analysis for smoking-related regions, with replication in two ethnically diverse populations
    Ovide F Pomerleau
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Nicotine Tob Res 9:955-8. 2007
    ..Fine mapping may well provide useful new information about genetic factors underlying nicotine dependence...
  31. pmc The genetic architecture of fasting plasma triglyceride response to fenofibrate treatment
    Jennifer A Smith
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Eur J Hum Genet 16:603-13. 2008
    ..These results yield insight into the complex biology of fenofibrate response, which can be used to target fenofibrate therapy to individuals who are most likely to benefit from the drug...
  32. pmc Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design
    Yan V Sun
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genet Epidemiol 32:350-60. 2008
    ..This study illustrates how machine learning methods can be used in sibships to identify important, replicable predictors of subclinical coronary atherosclerosis...
  33. pmc Identification of epistatic effects using a protein-protein interaction database
    Yan V Sun
    Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights No 4605, Ann Arbor, MI 48109, USA
    Hum Mol Genet 19:4345-52. 2010
    ..This study demonstrates that using PPI data can assist in targeting statistical hypothesis testing to biological plausible epistatic interaction that reflects molecular mechanisms...
  34. ncbi request reprint Research and practice opportunities at the intersection of health education, health behavior, and genomics
    Catharine Wang
    Department of Health Behavior and Health Education, and Michigan Center for Genomics and Public Health School of Public Health, University of Michigan, Ann Arbor, USA
    Health Educ Behav 32:686-701. 2005
    ..This analysis has identified the need to consider potential application efforts in genomics and HBHE from an ecological perspective, with an emphasis on multiple levels of intervention and analysis...
  35. ncbi request reprint Gene-expression profiles predict survival of patients with lung adenocarcinoma
    David G Beer
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Nat Med 8:816-24. 2002
    ..The identification of a set of genes that predict survival in early-stage lung adenocarcinoma allows delineation of a high-risk group that may benefit from adjuvant therapy...
  36. ncbi request reprint Heterogeneity in phenotypes based on smoking status in the Great Lakes Smoker Sibling Registry
    Cynthia S Pomerleau
    Nicotine Research Laboratory, Behavioral Medicine Program, Department of Psychiatry, University of Michigan, 475 Market Place, Suite L, Ann Arbor, MI 48108, USA
    Addict Behav 29:1851-5. 2004
    ....
  37. ncbi request reprint Dynamic relationships between the genome and exposures to environments as causes of common human diseases
    Charles F Sing
    Departments of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    World Rev Nutr Diet 93:77-91. 2004
  38. pmc Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework
    Kerby A Shedden
    Department of Statistics, University of Michigan, Ann Arbor, MI 48109 1027, USA
    Am J Pathol 163:1985-95. 2003
    ..Our findings suggest that accurate and robust cancer diagnosis from gene expression profiles can be achieved by mimicking the classification strategies routinely used by surgical pathologists...
  39. ncbi request reprint Genes, environment, and cardiovascular disease
    Charles F Sing
    Department of Human Genetics, University of Michigan, 1241 E Catherine St, 5928 Buhl Bldg, Ann Arbor, MI 48109 0618, USA
    Arterioscler Thromb Vasc Biol 23:1190-6. 2003
    ..We make recommendations for what needs to be done to cope with these complexities...
  40. ncbi request reprint Differences in accuracy of offspring assessment based on parental smoking status
    Cynthia S Pomerleau
    Nicotine Research Laboratory, Department of Psychiatry, University of Michigan, 475 Market Place, Ste L, Ann Arbor, MI 48108, USA
    Addict Behav 30:437-41. 2005
    ..Overall, these results support the utility of proxy reports of parental smoking phenotype by adult informants when self-report is unavailable...
  41. ncbi request reprint Family history of stroke among Mexican-American and non-Hispanic white patients with stroke and TIA: implications for the feasibility and design of stroke genetics research
    Lynda D Lisabeth
    Stroke Program, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Neuroepidemiology 24:96-102. 2005
    ..9%; 95% CI: 0.1-3.8). Since MAs are more likely to have living siblings with stroke compared with NHWs, MAs may be a more feasible population for family stroke studies than predominantly white populations...
  42. pmc Protein profiles associated with survival in lung adenocarcinoma
    Guoan Chen
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:13537-42. 2003
    ..These studies identify new prognostic biomarkers and indicate that protein expression profiles can predict the outcome of patients with early-stage lung cancer...
  43. ncbi request reprint Discordant protein and mRNA expression in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 1:304-13. 2002
    ..Using a quantitative analysis of mRNA and protein expression within the same lung adenocarcinomas, we showed that only a subset of the proteins exhibited a significant correlation with mRNA abundance...
  44. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    ..These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney...
  45. ncbi request reprint A scan statistic for identifying chromosomal patterns of SNP association
    Yan V Sun
    Department of Epidemiology, University of Michigan, 611 Church Street, Ann Arbor, MI 48104, USA
    Genet Epidemiol 30:627-35. 2006
    ..The scan statistic developed here can be used to make gene-based or region-based SNP inferences about disease association...
  46. ncbi request reprint Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas
    Donald R Schwartz
    Department of Pathology, College of Literature Science and the Arts, University of Michigan, Ann Arbor, Michigan 48109 0638, USA
    Cancer Res 63:2913-22. 2003
    ....
  47. ncbi request reprint Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas
    Donald R Schwartz
    Departments of Pathology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4722-9. 2002
    ..Moreover, these studies provide a foundation for the development of new type-specific diagnostic strategies and treatments for ovarian cancer...
  48. ncbi request reprint Association of parental smoking history with nicotine dependence, smoking rate, and psychological cofactors in adult smokers
    Sharon L R Kardia
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Addict Behav 28:1447-52. 2003
    ..These findings suggest that family history of smoking may be a key determinant of interindividual variation in smoking behavior, nicotine dependence, and psychological cofactors among smokers...
  49. ncbi request reprint Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 2:107-16. 2003
    ....
  50. ncbi request reprint Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3
    Liisa Koivukoski
    Department of Endocrinology, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Hum Mol Genet 13:2325-32. 2004
    ..We conclude that modest or non-significant linkage on chromosomes 3p14.1-q12.3 and 2p12-q22.1 in each individual study translates into genome-wide significant or highly suggestive linkages to HT and DBP in our GSMA analysis...
  51. pmc A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure
    Stephen B Liggett
    Department of Internal Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, Ohio 45267, USA
    Nat Med 14:510-7. 2008
    ....
  52. ncbi request reprint Ethnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study
    John G O'Meara
    Department of Pharmacy Services, Mayo Clinic and Foundation, Rochester, Minn, USA
    Arch Intern Med 164:1313-8. 2004
    ..Two ethnically different, community-based samples of hypertensive adults were evaluated to determine the prevalence of dyslipidemia and how often dyslipidemia is drug-treated and controlled by such treatment...
  53. ncbi request reprint Multivariate linkage analysis of blood pressure and body mass index
    Stephen T Turner
    Division of Hypertension and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Genet Epidemiol 27:64-73. 2004
    ....
  54. ncbi request reprint Ethnic differences in peripheral arterial disease in the NHLBI Genetic Epidemiology Network of Arteriopathy (GENOA) study
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA
    Vasc Med 8:237-42. 2003
    ..Identifying additional 'novel' risk factors that account for the ethnic differences in PAD is an important next step towards understanding why such differences exist and developing more effective strategies to reduce the burden of PAD...
  55. ncbi request reprint Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure
    Kersten M Small
    Division of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati 45267 0564, USA
    N Engl J Med 347:1135-42. 2002
    ..We hypothesized that this combination of receptor variants, which results in increased synaptic norepinephrine release and enhanced receptor function at the myocyte, would predispose persons to heart failure...
  56. ncbi request reprint Familial aggregation of hypertension treatment and control in the Genetic Epidemiology Network of Arteriopathy (GENOA) study
    Paul R Daniels
    Division of Hypertension and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Med 116:676-81. 2004
    ..To assess if the treatment and control of hypertension aggregates in families...
  57. ncbi request reprint A meta-analysis of genome-wide linkage scans for hypertension: the National Heart, Lung and Blood Institute Family Blood Pressure Program
    Michael A Province
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hypertens 16:144-7. 2003
    ..The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives)...
  58. ncbi request reprint Risk of lung cancer among white and black relatives of individuals with early-onset lung cancer
    Michele L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University, Detroit, Mich, USA
    JAMA 293:3036-42. 2005
    ..Family studies of early-onset lung cancer patients offer a unique opportunity to evaluate lifetime risk of lung cancer in relatives...
  59. ncbi request reprint Evaluating the context-dependent effect of family history of stroke in a genome scan for hypertension
    Alanna C Morrison
    Human Genetics Center, University of Texas, Houston Health Science Center, 1200 Herman Pressler, Ste 453 E, Houston, TX 77030, USA
    Stroke 34:1170-5. 2003
    ..Hypertension is an important risk factor for stroke, and the 2 diseases may share susceptibility genes in common. We sought to identify genomic regions influencing susceptibility to both hypertension and stroke...
  60. ncbi request reprint Low-density lipoprotein particle size and coronary atherosclerosis in subjects belonging to hypertensive sibships
    Iftikhar J Kullo
    Divisions of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Hypertens 17:845-51. 2004
    ..Whether LDL particle size is associated with the extent of coronary atherosclerosis in hypertensive sibships is unknown...
  61. ncbi request reprint A novel quantitative trait locus on chromosome 1 with pleiotropic effects on HDL-cholesterol and LDL particle size in hypertensive sibships
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Hypertens 18:1084-90. 2005
    ..We performed univariate and bivariate linkage analyses to identify genomic regions that influence levels of these traits and exert pleiotropic effects on the traits in hypertensive sibships...
  62. pmc Contribution of regulatory and structural variations in APOE to predicting dyslipidemia
    Jari H Stengård
    National Public Health Institute, Helsinki, Finland
    J Lipid Res 47:318-28. 2006
    ..Our study suggests that both regulatory and structural variations should be considered when evaluating the utility of APOE for predicting dyslipidemia in the population at large...
  63. ncbi request reprint Association of plasma homocysteine with coronary artery calcification in different categories of coronary heart disease risk
    Ifirkhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 81:177-82. 2006
    ..To Investigate the association of plasma homocystelne with coronary artery calcification (CAC) in strata based on 10-year risk of coronary heart disease (CHD) in a cohort enriched in persons with hypertension...
  64. ncbi request reprint A comparison of serum creatinine-based methods for identifying chronic kidney disease in hypertensive individuals and their siblings
    Andrew D Rule
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Hypertens 19:608-14. 2006
    ..This study compared kidney disease as defined by reduced eGFR, elevated serum creatinine, or elevated urinary albumin-to-creatinine ratio (ACR)...
  65. ncbi request reprint Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Genet 119:624-33. 2006
    ..Excess obesity among Native Americans compared to whites is not consistent with a simple genetic explanation...
  66. ncbi request reprint Novel genomic loci influencing plasma homocysteine levels
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn 55905, USA
    Stroke 37:1703-9. 2006
    ..We performed linkage analyses to identify genomic regions that influence homocysteine levels in blacks and non-Hispanic whites...
  67. ncbi request reprint Influence of genomic loci on measures of chronic kidney disease in hypertensive sibships
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester MN 55905, USA
    J Am Soc Nephrol 17:2048-55. 2006
    ..62, at 85 cM from pter; P = 0.00023). These findings support the utility of genetic linkage analyses for identification of novel risk factors that influence measures of chronic kidney disease, particularly among black individuals...
  68. ncbi request reprint Genomic loci with pleiotropic effects on coronary artery calcification
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Atherosclerosis 185:340-6. 2006
    ..Inasmuch as the chromosome 9 and 17 regions were not detected in the univariate linkage analysis for CAC, multivariate linkage analyses of CAC and genetically correlated risk factors may help localize genes for coronary atherosclerosis...
  69. ncbi request reprint Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury
    Myriam Fornage
    Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St, Room 530 G, Houston, TX 77030, USA
    Hum Genet 120:671-80. 2007
    ..They provide the basis for further investigation of the role of these genes in susceptibility and/or progression to clinical disease...
  70. ncbi request reprint Genomic susceptibility loci for brain atrophy in hypertensive sibships from the GENOA study
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Hypertension 45:793-8. 2005
    ....
  71. ncbi request reprint Pleiotropic genetic effects contribute to the correlation between HDL cholesterol, triglycerides, and LDL particle size in hypertensive sibships
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Am J Hypertens 18:99-103. 2005
    ..We investigated heritability of these three lipid traits and the extent to which shared effects of genes (pleiotropy) contribute to the additive genetic variation in each trait in hypertensive sibships...
  72. ncbi request reprint Hidden Markov model for defining genomic changes in lung cancer using gene expression data
    Chiang Ching Huang
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 4402, USA
    OMICS 10:276-88. 2006
    ..Our proposed method provides a valuable tool to accurately pinpoint regions of abnormal expression for further investigation...
  73. pmc Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Hum Genet 76:268-75. 2005
    ..S. population. Implications of this genetic structure for case-control association studies are discussed...
  74. pmc Association of polymorphisms in NOS3 with the ankle-brachial index in hypertensive adults
    Iftikhar J Kullo
    Divisions of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Atherosclerosis 196:905-12. 2008
    ..These findings motivate further investigation of the role of NOS3 variants in determining susceptibility to peripheral arterial disease...
  75. ncbi request reprint A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure
    Stephen B Liggett
    Department of Medicine, Cardiopulmonary Genomics Program, University of Maryland, Baltimore, MD, USA
    Hum Mol Genet 16:2740-50. 2007
    ..Thus, the GNAQ -694/-695 promoter polymorphism alters transcription factor binding, increases promoter activity and adversely affects outcome in human heart failure...
  76. pmc Multiple genes for essential-hypertension susceptibility on chromosome 1q
    YEN PEI CHRISTY CHANG
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 80:253-64. 2007
    ..Because the associated alleles in these genes are relatively common (frequency >5%), these three genes are important contributors to elevated BP in the population at large...
  77. ncbi request reprint A genome-wide linkage scan for ankle-brachial index in African American and non-Hispanic white subjects participating in the GENOA study
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA
    Atherosclerosis 187:433-8. 2006
    ..In conclusion, ABI is a modestly heritable trait in AA and NHW hypertensive sibships. Quantitative trait linkage analyses identified several chromosomal regions that may harbor genes influencing ABI...
  78. ncbi request reprint 5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study
    Samir N P Kelada
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Hum Mol Genet 15:3055-62. 2006
    ..66 (95% CI: 1.73-18.53). Thus, allelic variants in SLC6A3, which affect gene expression, are associated with PD in this population and may interact with occupational pesticide exposure to increase PD risk...
  79. ncbi request reprint Genetic and social environment interactions and their impact on health policy
    Perry W Payne
    Department of Health Policy, George Washington University, Washington, DC, USA
    J Am Acad Orthop Surg 15:S95-8. 2007
    ..The importance of this gene-social environment paradigm is evident in current and proposed health policies, and future research likely will spur further questions related to various areas of public policy...

Research Grants8

  1. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2002
    ..abstract_text> ..
  2. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2003
    ..abstract_text> ..
  3. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2004
    ..abstract_text> ..
  4. GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS
    Sharon Kardia; Fiscal Year: 2004
    ..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
  5. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2005
    ..abstract_text> ..
  6. Genomic Predictors of Arteriosclerosis in Hypertensives
    Sharon Kardia; Fiscal Year: 2007
    ..End of Abstract) ..
  7. Genomic Predictors of Arteriosclerosis in Hypertensives
    Sharon Kardia; Fiscal Year: 2009
    ..End of Abstract) ..