Andrey L Karamyshev

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. Karamyshev A, Patrick A, Karamysheva Z, Griesemer D, Hudson H, Tjon Kon Sang S, et al. Inefficient SRP interaction with a nascent chain triggers a mRNA quality control pathway. Cell. 2014;156:146-57 pubmed publisher
    ..The results reveal a previously unappreciated general mechanism of translational quality control, in which specific mRNA degradation preemptively regulates aberrant protein production (RAPP). ..
  2. Nilsson I, Lara P, Hessa T, Johnson A, von Heijne G, Karamyshev A. The code for directing proteins for translocation across ER membrane: SRP cotranslationally recognizes specific features of a signal sequence. J Mol Biol. 2015;427:1191-201 pubmed publisher
    ..Thus, the hydrophobic core of the signal sequence is primarily responsible for its recognition and binding by SRP, while positive charges fine-tune the SRP-signal sequence affinity and targeting to the translocon. ..