Hrayr S Karagueuzian

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias
    Hrayr S Karagueuzian
    Cardiovascular Research Laboratory, Translational Arrhythmia Research Section, David Geffen School of Medicine at UCLA Los Angeles, CA, USA
    Front Physiol 4:19. 2013
  2. doi request reprint Cigarette smoke radioactivity and lung cancer risk
    Hrayr S Karagueuzian
    Translational Arrhythmia Research Section, Cardiovascular Research Laboratories, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, 675 Charles E Young Drive South, MRL 1630, Mail Code 176022, Los Angeles, CA 90095, USA
    Nicotine Tob Res 14:79-90. 2012
  3. pmc Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress
    Norishige Morita
    Translational Arrhythmia Research Laboratory and Cardiovascular Research Laboratory, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, USA
    Am J Physiol Heart Circ Physiol 297:H1594-605. 2009
  4. pmc Calcium transient dynamics and the mechanisms of ventricular vulnerability to single premature electrical stimulation in Langendorff-perfused rabbit ventricles
    Hideki Hayashi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Heart Rhythm 5:116-23. 2008
  5. ncbi request reprint High resolution mapping of the pulmonary vein and the vein of Marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure
    Yuji Okuyama
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    J Am Coll Cardiol 42:348-60. 2003
  6. ncbi request reprint Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction: implications for atrial fibrillation
    Yasushi Miyauchi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, Calif, USA
    Circulation 108:360-6. 2003
  7. pmc Virtual electrodes and the induction of fibrillation in Langendorff-perfused rabbit ventricles: the role of intracellular calcium
    Hideki Hayashi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Am J Physiol Heart Circ Physiol 295:H1422-8. 2008
  8. pmc Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts
    Norishige Morita
    Translational Arrhythmia Research Section, Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, 675 Charles E Young Dr South, MRL 3645 Mail Code 176022, Los Angeles, CA 90095, USA
    Am J Physiol Heart Circ Physiol 301:H180-91. 2011
  9. ncbi request reprint Thoracic vein ablation terminates chronic atrial fibrillation in dogs
    Angela M Park
    Division of Cardiology, Rm 5342, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048 1865, USA
    Am J Physiol Heart Circ Physiol 286:H2072-7. 2004
  10. pmc Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias
    Aneesh Bapat
    Translational Arrhythmia Research Section, University of California Los Angeles Cardiovascular Research Laboratory, USA
    Am J Physiol Heart Circ Physiol 302:H2331-40. 2012

Collaborators

Detail Information

Publications55

  1. pmc Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias
    Hrayr S Karagueuzian
    Cardiovascular Research Laboratory, Translational Arrhythmia Research Section, David Geffen School of Medicine at UCLA Los Angeles, CA, USA
    Front Physiol 4:19. 2013
    ..The findings imply that antifibrotic therapy, in addition to therapies designed to suppress EAD formation at the cellular level, may be synergistic in reducing the risk of sudden cardiac death...
  2. doi request reprint Cigarette smoke radioactivity and lung cancer risk
    Hrayr S Karagueuzian
    Translational Arrhythmia Research Section, Cardiovascular Research Laboratories, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, 675 Charles E Young Drive South, MRL 1630, Mail Code 176022, Los Angeles, CA 90095, USA
    Nicotine Tob Res 14:79-90. 2012
    ..To determine the tobacco industry's policy and action with respect to radioactive polonium 210 ((210)Po) in cigarette smoke and to assess the long-term risk of lung cancer caused by alpha particle deposits in the lungs of regular smokers...
  3. pmc Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress
    Norishige Morita
    Translational Arrhythmia Research Laboratory and Cardiovascular Research Laboratory, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, USA
    Am J Physiol Heart Circ Physiol 297:H1594-605. 2009
    ..We conclude that in aged ventricles exposed to oxidative stress, fibrosis facilitates the ability of cellular EADs to emerge and generate TA, VT, and VF at the tissue level...
  4. pmc Calcium transient dynamics and the mechanisms of ventricular vulnerability to single premature electrical stimulation in Langendorff-perfused rabbit ventricles
    Hideki Hayashi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Heart Rhythm 5:116-23. 2008
    ..We hypothesize that Ca current-mediated slow-response action potentials (APs) play a key role in the propagation in the central common pathway (CCP) of the reentry...
  5. ncbi request reprint High resolution mapping of the pulmonary vein and the vein of Marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure
    Yuji Okuyama
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    J Am Coll Cardiol 42:348-60. 2003
    ..The study examined the activations in the pulmonary veins (PVs) and the vein of Marshall (VOM) during atrial fibrillation (AF) in dogs with congestive heart failure (CHF)...
  6. ncbi request reprint Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction: implications for atrial fibrillation
    Yasushi Miyauchi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, Calif, USA
    Circulation 108:360-6. 2003
    ..We hypothesized that chronic MI is associated with atrial electrical and neural remodeling that enhances AF vulnerability...
  7. pmc Virtual electrodes and the induction of fibrillation in Langendorff-perfused rabbit ventricles: the role of intracellular calcium
    Hideki Hayashi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Am J Physiol Heart Circ Physiol 295:H1422-8. 2008
    ..However, the inhibition of the sarcoplasmic reticulum function also reduced VFT, indicating that the [Ca(2+)](i) dynamics modulate, but are not essential, to ventricular vulnerability...
  8. pmc Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts
    Norishige Morita
    Translational Arrhythmia Research Section, Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, 675 Charles E Young Dr South, MRL 3645 Mail Code 176022, Los Angeles, CA 90095, USA
    Am J Physiol Heart Circ Physiol 301:H180-91. 2011
    ..05). We conclude that in aged fibrotic unlike in adult rat hearts, GI promotes EADs, triggered activity, and VF by activation of K(ATP) channels CaMKII and NCX...
  9. ncbi request reprint Thoracic vein ablation terminates chronic atrial fibrillation in dogs
    Angela M Park
    Division of Cardiology, Rm 5342, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048 1865, USA
    Am J Physiol Heart Circ Physiol 286:H2072-7. 2004
    ..We conclude that thoracic vein ablation converts canine sustained AF into sinus rhythm and prevents the reinduction of sustained AF. These findings suggest that thoracic veins are important in the maintenance of AF in dogs...
  10. pmc Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias
    Aneesh Bapat
    Translational Arrhythmia Research Section, University of California Los Angeles Cardiovascular Research Laboratory, USA
    Am J Physiol Heart Circ Physiol 302:H2331-40. 2012
    ....
  11. ncbi request reprint Effects of procainamide on electrical activity in thoracic veins and atria in canine model of sustained atrial fibrillation
    Chung Chuan Chou
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am J Physiol Heart Circ Physiol 286:H1936-45. 2004
    ..Second, FDs in the PV are more resistant to procainamide's action than FDs in the atria. Third, inherent PV ERP is important in determining the antifibrillatory efficacy of procainamide...
  12. ncbi request reprint Correlation between anatomy and electrical activation in canine pulmonary veins
    Akira Hamabe
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, Calif 90048, USA
    Circulation 107:1550-5. 2003
    ..The roles of complex muscle sleeve geometry and fiber orientation in the pulmonary veins (PVs) in wave-front propagation are poorly understood...
  13. ncbi request reprint Aging-related increase to inducible atrial fibrillation in the rat model
    Hideki Hayashi
    Department of Medicine, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Cardiovasc Electrophysiol 13:801-8. 2002
    ..We hypothesized that aged rats are suitable for study of aging-related AF and that partial atrial cellular uncoupling induced with heptanol in young rats mimics aging-related AF...
  14. ncbi request reprint The mechanisms of atrial fibrillation
    Peng Sheng Chen
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Cardiovasc Electrophysiol 17:S2-7. 2006
    ..Therefore, thoracic vein isolation is an important technique in AF control. We conclude that thoracic veins are important in the generation and maintenance of AF...
  15. ncbi request reprint Heterogeneous pulmonary vein myocardial cell repolarization implications for reentry and triggered activity
    Yasushi Miyauchi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Heart Rhythm 2:1339-45. 2005
    ..However, systematic single-cell microelectrode recordings from different regions in intact PV-atrial tissues are lacking...
  16. ncbi request reprint Intracellular calcium and vulnerability to fibrillation and defibrillation in Langendorff-perfused rabbit ventricles
    Gyo Seung Hwang
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Circulation 114:2595-603. 2006
    ..The role of intracellular calcium (Ca(i)) in defibrillation and vulnerability is unclear...
  17. ncbi request reprint Age-related sensitivity to nicotine for inducible atrial tachycardia and atrial fibrillation
    Hideki Hayashi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90048, USA
    Am J Physiol Heart Circ Physiol 285:H2091-8. 2003
    ..Nicotine, at concentrations found in the blood of smokers (30-85 ng/ml), exerts biphasic effects on inducible AT/AF in young rats and suppresses it in the old rats by causing high degrees of interatrial conduction block...
  18. ncbi request reprint Demonstration of electrical and anatomic connections between Marshall bundles and left atrium in dogs: implications on the generation of P waves on surface electrocardiogram
    Chikaya Omichi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048 1865, USA
    J Cardiovasc Electrophysiol 13:1283-91. 2002
    ..The muscle bundles within the ligament of Marshall (LOM) are electrically active. The importance of these muscle bundles (Marshall bundle [MB]) to atrial activation and the generation of the ECG P wave is unclear...
  19. ncbi request reprint Nonreentrant focal activations in pulmonary veins in canine model of sustained atrial fibrillation
    Shengmei Zhou
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048 1865, USA
    Am J Physiol Heart Circ Physiol 283:H1244-52. 2002
    ..No reentrant wavefronts were demonstrated in the PVs. We conclude that nonreentrant focal activations are present in the PVs in a canine model of pacing-induced sustained AF...
  20. pmc Superiority of biphasic over monophasic defibrillation shocks is attributable to less intracellular calcium transient heterogeneity
    Gyo Seung Hwang
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    J Am Coll Cardiol 52:828-35. 2008
    ..The purpose of this study was to test the hypothesis that superiority of biphasic waveform (BW) over monophasic waveform (MW) defibrillation shocks is attributable to less intracellular calcium (Ca(i)) transient heterogeneity...
  21. ncbi request reprint Chronic nicotine in hearts with healed ventricular myocardial infarction promotes atrial flutter that resembles typical human atrial flutter
    Mizuho Miyauchi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Am J Physiol Heart Circ Physiol 288:H2878-86. 2005
    ..Chronic nicotine in hearts with MI promotes AFL that closely resembles typical human AFL. Increased atrial interstitial fibrosis and flattened electrical restitution are important substrates for the AFL...
  22. ncbi request reprint Nerve sprouting induced by radiofrequency catheter ablation in dogs
    Yuji Okuyama
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Heart Rhythm 1:712-7. 2004
    ..The purpose of this study was to test the hypothesis that radiofrequency (RF) catheter ablation results in cardiac nerve sprouting...
  23. ncbi request reprint Intracellular Ca dynamics in ventricular fibrillation
    Chikaya Omichi
    Division of Cardiology, Cedars Sinai Medical Center and Center for Health Sciences, University of California Los Angeles Cardiovascular Research Laboratory, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 1760, USA
    Am J Physiol Heart Circ Physiol 286:H1836-44. 2004
    ..Cai is closely associated with Vm closely during pacing and VT but not during VF. These findings suggest that during VF, non-voltage-gated Cai release events occur and may influence wavebreak by altering Vm and APD locally...
  24. ncbi request reprint Spontaneous atrial fibrillation initiated by triggered activity near the pulmonary veins in aged rats subjected to glycolytic inhibition
    Norihiko Ono
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Am J Physiol Heart Circ Physiol 292:H639-48. 2007
    ..We conclude that GI interacts with the aged and fibrotic atria to amplify Ca(i)(2+) handling abnormalities that facilitate EAD-mediated triggered activity and AF...
  25. ncbi request reprint Catheter ablation of ventricular fibrillation in rabbit ventricles treated with beta-blockers
    Hui Nam Pak
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California Los Angeles, Calif 90048, USA
    Circulation 108:3149-56. 2003
    ..We hypothesize that beta-adrenergic receptor blockade converts multiple-wavelet VF to focal-source VF and that this focal source is located near the papillary muscle (PM)...
  26. ncbi request reprint Action potential duration restitution and ventricular fibrillation due to rapid focal excitation
    Moshe Swissa
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am J Physiol Heart Circ Physiol 282:H1915-23. 2002
    ..In this model of focal source VF, the VT-to-VF transition occurred due to a wave break outside the aconitine site, and drugs that flattened the APD restitution slope converted VF to VT despite continuous activation from aconitine site...
  27. ncbi request reprint Induction of atrial fibrillation and nerve sprouting by prolonged left atrial pacing in dogs
    Akira Hamabe
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Pacing Clin Electrophysiol 26:2247-52. 2003
    ..The nerves were inhomogeneously distributed. LA epicardial pacing induced sustained AF much faster than RA endocardial pacing and rapid electrical stimulation can induce inhomogeneous nerve sprouting near the pacing site...
  28. pmc Bi-stable wave propagation and early afterdepolarization-mediated cardiac arrhythmias
    Marvin G Chang
    Department of Medicine Cardiology, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
    Heart Rhythm 9:115-22. 2012
    ..However, it has not been shown whether the same tissue can exhibit both the I(Na)-mediated and the I(Ca,L)-mediated conduction...
  29. ncbi request reprint Left stellate ganglion and vagal nerve activity and cardiac arrhythmias in ambulatory dogs with pacing-induced congestive heart failure
    Masahiro Ogawa
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    J Am Coll Cardiol 50:335-43. 2007
    ..The purpose of this study was to determine the patterns of autonomic nerve activity in congestive heart failure (CHF)...
  30. ncbi request reprint Increased vulnerability to inducible atrial fibrillation caused by partial cellular uncoupling with heptanol
    Toshihiko Ohara
    Division of Cardiology, Cedars Sinai Research Institute, Department of Medicine, University of California of Los Angeles School of Medicine, Los Angeles, California 90048, USA
    Am J Physiol Heart Circ Physiol 283:H1116-22. 2002
    ..The effects of heptanol were reversible. We conclude that partial cellular uncoupling by heptanol without changing atrial active membrane properties promotes wavebreak, reentry, and AF during rapid pacing...
  31. ncbi request reprint A tale of two fibrillations
    Peng Sheng Chen
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, Calif, USA
    Circulation 108:2298-303. 2003
  32. pmc Mechanisms of recurrent ventricular fibrillation in a rabbit model of pacing-induced heart failure
    Masahiro Ogawa
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Heart Rhythm 6:784-92. 2009
    ..Successful defibrillation may be followed by recurrent spontaneous ventricular fibrillation (VF). The mechanisms of postshock spontaneous VF are unclear...
  33. pmc Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve
    Zhilin Qu
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cardiovasc Res 99:6-15. 2013
    ..We also summarize different mechanisms of phase-3 EADs. Based on the dynamical theory, we discuss the roles of each of the major ionic currents in the genesis of EADs, and potential therapeutic targets. ..
  34. ncbi request reprint Low-affinity nerve growth factor receptor p75NTR immunoreactivity in the myocardium with sympathetic hyperinnervation
    Shengmei Zhou
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    J Cardiovasc Electrophysiol 15:430-7. 2004
    ..The aim of this study was to determine the density and location of TrkA and p75NTR in canine ventricles with sympathetic hyperinnervation...
  35. ncbi request reprint The dynamics of cardiac fibrillation
    James N Weiss
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1760, USA
    Circulation 112:1232-40. 2005
    ..As global properties, rather than local electrophysiological characteristics, dynamic factors represent an attractive target for novel therapies to prevent ventricular fibrillation...
  36. ncbi request reprint Downregulation of immunodetectable atrial connexin40 in a canine model of chronic left ventricular myocardial infarction: implications to atrial fibrillation
    Keiko Ohara
    Division of Cardiology, Cedars Sinai Research Institute, Los Angeles, CA 90048, USA
    J Cardiovasc Pharmacol Ther 7:89-94. 2002
    ..Since atrial connexin40 has a rapid turnover rate and may cause atrial fibrillation, we hypothesized that chronic left ventricular myocardial infarction downregulates atrial Connexin40 and increases atrial fibrillation vulnerability...
  37. ncbi request reprint Electrical current-induced atrial and pulmonary vein action potential duration shortening and repetitive activity
    Yasushi Miyauchi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Am J Physiol Heart Circ Physiol 287:H178-86. 2004
    ....
  38. ncbi request reprint Effects of cytochalasin D on electrical restitution and the dynamics of ventricular fibrillation in isolated rabbit heart
    Hideki Hayashi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, and David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Cardiovasc Electrophysiol 14:1077-84. 2003
    ..Cytochalasin D in Rabbit Ventricle...
  39. ncbi request reprint Long-term subthreshold electrical stimulation of the left stellate ganglion and a canine model of sudden cardiac death
    Moshe Swissa
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    J Am Coll Cardiol 43:858-64. 2004
    ..We sought to develop a high-yield canine model of sudden cardiac death (SCD)...
  40. ncbi request reprint On the mechanism of the probabilistic nature of ventricular defibrillation threshold
    Masaaki Yashima
    Division of Cardiology, Cedars Sinai Medical Center, Department of Medicine, School of Medicine, University of California, Los Angeles 90048, USA
    Am J Physiol Heart Circ Physiol 284:H249-55. 2003
    ..We conclude that the probabilistic nature of the DFT is related to the amount of myocardium in its VP...
  41. ncbi request reprint Effects of Na(+) channel and cell coupling abnormalities on vulnerability to reentry: a simulation study
    Zhilin Qu
    Department of Medicine, Cedars Sinai Research Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Am J Physiol Heart Circ Physiol 286:H1310-21. 2004
    ..In remodeled hearts with altered Na(+) channel properties and cellular uncoupling, dynamic instabilities arising from electrical restitution exert important influences on the VW for reentry...
  42. pmc Early afterdepolarizations and cardiac arrhythmias
    James N Weiss
    UCLA Cardiovascular Research Laboratory, Departments of Medicine Cardiology, Physiology and Integrative Biology and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Heart Rhythm 7:1891-9. 2010
    ....
  43. pmc Dynamics of early afterdepolarization-mediated triggered activity in cardiac monolayers
    Marvin G Chang
    Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biophys J 102:2706-14. 2012
    ....
  44. doi request reprint Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine
    Norishige Morita
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Am Coll Cardiol 57:366-75. 2011
    ..The purpose of this study was to test the hypothesis that the late Na current blocker ranolazine suppresses re-entrant and multifocal ventricular fibrillation (VF)...
  45. ncbi request reprint The role of approximate entropy in predicting ventricular defibrillation threshold
    Ali Hamzei
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center and UCLA School of Medicine, Los Angeles, CA 90048, USA
    J Cardiovasc Pharmacol Ther 7:45-52. 2002
    ..The role of myocardial tissue mass on ventricular defibrillation threshold (DFT) is unclear. We hypothesized that changes in tissue mass modulate DFT by changing ventricular fibrillation (VF) wavefront regularity (entropy)...
  46. ncbi request reprint Simultaneous biatrial computerized mapping during permanent atrial fibrillation in patients with organic heart disease
    Tsu Juey Wu
    Department of Medicine, Cedars Sinai Medical Center and UCLA School of Medicine, Los Angeles, CA 90048, USA
    J Cardiovasc Electrophysiol 13:571-7. 2002
    ..Activation patterns during permanent atrial fibrillation (AF) in patients with organic heart diseases are unclear...
  47. pmc Serum transforming growth factor-beta1 as a risk stratifier of sudden cardiac death
    Ali A Sovari
    Translational Arrhythmia Research Laboratory, Cardiovascular Research Laboratory, Division of Cardiology Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States
    Med Hypotheses 71:262-5. 2008
    ..In the present hypothesis we suggest that monitoring the serum levels of TGF-beta1 may be a cost-effective risk stratifier to identify patients at high risk of sudden cardiac death caused by VT and VF...
  48. pmc Spontaneous ventricular fibrillation in right ventricular failure secondary to chronic pulmonary hypertension
    Soban Umar
    Department of Anesthesiology, UCLA School of Medicine, BH 160CHS, 650 Charles Young Dr, Los Angeles, CA 90095 7115, USA
    Circ Arrhythm Electrophysiol 5:181-90. 2012
    ..We test the hypothesis that PH promotes spontaneous ventricular fibrillation (VF) during a critical post-PH onset period characterized by a sudden increase in mortality...
  49. doi request reprint Apocynin: a potent NADPH oxidase inhibitor for the management of atrial fibrillation
    Ali A Sovari
    Translational Arrhythmia Research Laboratory, Cardiovascular Research Laboratory, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Redox Rep 13:242-5. 2008
    ..Atrial fibrillation is known to be initiated by the interaction of these multiple factors...
  50. ncbi request reprint Thoracic veins and the mechanisms of non-paroxysmal atrial fibrillation
    Peng Sheng Chen
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center and UCLA School of Medicine, Los Angeles, CA, USA
    Cardiovasc Res 54:295-301. 2002
    ..The purpose of this article is to review the importance of thoracic veins in the maintenance of sustained (non-paroxysmal) atrial fibrillation (AF)...
  51. ncbi request reprint Sildenafil-nitric oxide donor combination promotes ventricular tachyarrhythmias in the swine right ventricle
    Moshe Swissa
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles 90048, USA
    Am J Physiol Heart Circ Physiol 282:H1787-92. 2002
    ..We conclude that a sildenafil (2 microg/ml) and NO donor combination increases VT/VF vulnerability in the normal RV by a mechanism compatible with the restitution hypothesis...
  52. ncbi request reprint Torsade de pointes and sudden death induced by thiopental and isoflurane anesthesia in dogs with cardiac electrical remodeling
    Shengmei Zhou
    The Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, and UCLA, Los Angeles, CA, USA
    J Cardiovasc Pharmacol Ther 7:39-43. 2002
    ..Many anesthetic agents are known to have cardiac effects. The effects of pentobarbital, thiopental and isoflurane on dogs with electrical remodeling are lacking...
  53. pmc Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity
    Sabine Groenke
    Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e81633. 2013
    ..Recurring Ca sparks were present in all KO SAN cells, suggesting that Ca cycling persists but is uncoupled from the sarcolemma. We conclude that NCX1 is required for normal pacemaker activity in murine SAN. ..
  54. ncbi request reprint Electrical restitution and cardiac fibrillation
    James N Weiss
    Department of Medicine, UCLA School of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90095 1760, USA
    J Cardiovasc Electrophysiol 13:292-5. 2002
    ..Developing therapies that favorably alter these cardiac electrical restitution properties are a promising new approach to preventing fibrillation...
  55. pmc Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts
    Arash Pezhouman
    Translational Arrhythmia Research Section, UCLA Cardiovascular Research Laboratory, Department of Medicine Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California
    Heart Rhythm 11:492-501. 2014
    ..Enhanced late inward Na current (INa-L) modulates action potential duration (APD) and plays a key role in the genesis of early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs) and triggered activity...