Raj Kapur

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Histopathologic delineation of the transition zone in short-segment Hirschsprung disease
    Raj P Kapur
    Department of Laboratories, Seattle Children s Hospital, Seattle, WA, USA
    Pediatr Dev Pathol 16:252-66. 2013
  2. doi request reprint Placental mesenchymal dysplasia and fetal renal-hepatic-pancreatic dysplasia: androgenetic-biparental mosaicism and pathogenesis of an autosomal recessive disorder
    Raj P Kapur
    Department of Laboratories, Seattle Children s Hospital, Seattle, WA, USA
    Pediatr Dev Pathol 16:191-200. 2013
  3. doi request reprint Transitional zone pull through: surgical pathology considerations
    Raj P Kapur
    Department of Laboratories, Seattle Children s Hospital, Seattle, WA 98115, USA
    Semin Pediatr Surg 21:291-301. 2012
  4. doi request reprint Calretinin immunohistochemistry versus acetylcholinesterase histochemistry in the evaluation of suction rectal biopsies for Hirschsprung Disease
    Raj P Kapur
    Department of Laboratories, Chidren s Hospital and Regional Medical Center, Seattle, WA, USA
    Pediatr Dev Pathol 12:6-15. 2009
  5. doi request reprint Normal and abnormal anatomy of the cerebellar vermis in midgestational human fetuses
    Raj P Kapur
    Department of Laboratories, Seattle Children s Hospital, Seattle, Washington 98105, USA
    Birth Defects Res A Clin Mol Teratol 85:700-9. 2009
  6. ncbi request reprint Multiple endocrine neoplasia type 2B and Hirschsprung's disease
    Raj P Kapur
    Department of Pathology, Children s Hospital and Regional Medical Center and University of Washington, Seattle, 91805, USA
    Clin Gastroenterol Hepatol 3:423-31. 2005
  7. doi request reprint Diffuse abnormal layering of small intestinal smooth muscle is present in patients with FLNA mutations and x-linked intestinal pseudo-obstruction
    Raj P Kapur
    Departments of Pathology, Seattle Children s Hospital, University of Washington, WA, USA
    Am J Surg Pathol 34:1528-43. 2010
  8. doi request reprint Gastrointestinal neuromuscular pathology in alpers disease
    Raj P Kapur
    Department of Laboratories, Seattle Children s Hospital, Seattle, WA, USA
    Am J Surg Pathol 35:714-22. 2011
  9. ncbi request reprint Achondrogenesis
    Raj P Kapur
    Department of Laboratories, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Pediatr Dev Pathol 10:253-5. 2007
  10. ncbi request reprint Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank
    Raj P Kapur
    Department of Pathology, Children s Hospital and Regional Medical Center, University of Washington, Seattle, Washington, USA
    J Bone Miner Res 19:1689-97. 2004

Research Grants

Collaborators

Detail Information

Publications41

  1. doi request reprint Histopathologic delineation of the transition zone in short-segment Hirschsprung disease
    Raj P Kapur
    Department of Laboratories, Seattle Children s Hospital, Seattle, WA, USA
    Pediatr Dev Pathol 16:252-66. 2013
    ....
  2. doi request reprint Placental mesenchymal dysplasia and fetal renal-hepatic-pancreatic dysplasia: androgenetic-biparental mosaicism and pathogenesis of an autosomal recessive disorder
    Raj P Kapur
    Department of Laboratories, Seattle Children s Hospital, Seattle, WA, USA
    Pediatr Dev Pathol 16:191-200. 2013
    ..Nonetheless, the fetal phenotype and laser capture data support the model of a paternally transmitted autosomal recessive disorder, which occurred because of ABM...
  3. doi request reprint Transitional zone pull through: surgical pathology considerations
    Raj P Kapur
    Department of Laboratories, Seattle Children s Hospital, Seattle, WA 98115, USA
    Semin Pediatr Surg 21:291-301. 2012
    ..Well-controlled studies to correlate proximal margin histology, especially subtle anatomic or immunohistochemical changes, with postoperative outcome are needed...
  4. doi request reprint Calretinin immunohistochemistry versus acetylcholinesterase histochemistry in the evaluation of suction rectal biopsies for Hirschsprung Disease
    Raj P Kapur
    Department of Laboratories, Chidren s Hospital and Regional Medical Center, Seattle, WA, USA
    Pediatr Dev Pathol 12:6-15. 2009
    ..Calretinin IHC appears to be a reasonable, and potentially superior, alternative to AChE as an adjunctive diagnostic method for evaluating suction rectal biopsies for HSCR...
  5. doi request reprint Normal and abnormal anatomy of the cerebellar vermis in midgestational human fetuses
    Raj P Kapur
    Department of Laboratories, Seattle Children s Hospital, Seattle, Washington 98105, USA
    Birth Defects Res A Clin Mol Teratol 85:700-9. 2009
    ....
  6. ncbi request reprint Multiple endocrine neoplasia type 2B and Hirschsprung's disease
    Raj P Kapur
    Department of Pathology, Children s Hospital and Regional Medical Center and University of Washington, Seattle, 91805, USA
    Clin Gastroenterol Hepatol 3:423-31. 2005
    ..In this review, the molecular genetics of the 2 conditions are discussed, and the clinical implications of existing data and future studies are summarized...
  7. doi request reprint Diffuse abnormal layering of small intestinal smooth muscle is present in patients with FLNA mutations and x-linked intestinal pseudo-obstruction
    Raj P Kapur
    Departments of Pathology, Seattle Children s Hospital, University of Washington, WA, USA
    Am J Surg Pathol 34:1528-43. 2010
    ....
  8. doi request reprint Gastrointestinal neuromuscular pathology in alpers disease
    Raj P Kapur
    Department of Laboratories, Seattle Children s Hospital, Seattle, WA, USA
    Am J Surg Pathol 35:714-22. 2011
    ..Recognition of these distinctive light microscopic findings, in an appropriate clinical setting, should prompt the evaluation of an underlying primary mitochondriopathy...
  9. ncbi request reprint Achondrogenesis
    Raj P Kapur
    Department of Laboratories, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Pediatr Dev Pathol 10:253-5. 2007
    ..The changes reported differ from matrix alterations observed in achondrogenesis types IB or II and provide insight into the phenotypic and genotypic differences within this group of skeletal dysplasias...
  10. ncbi request reprint Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank
    Raj P Kapur
    Department of Pathology, Children s Hospital and Regional Medical Center, University of Washington, Seattle, Washington, USA
    J Bone Miner Res 19:1689-97. 2004
    ..The phenotype, including a block in RANKL-dependent osteoclast differentiation and lymph node agenesis, copies that of Rank(-/-) mice, which have been produced by targeted recombination...
  11. ncbi request reprint Hox11L1 expression by precursors of enteric smooth muscle: an alternative explanation for megacecum in HOX11L1-/- mice
    Raj P Kapur
    Department of Pathology, Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Pediatr Dev Pathol 8:148-61. 2005
    ....
  12. doi request reprint Architectural malformation of the muscularis propria as a cause for intestinal pseudo-obstruction: two cases and a review of the literature
    Raj P Kapur
    Department of Laboratories, Children s Hospital and Regional Medical Center, Seattle, WA, USA
    Pediatr Dev Pathol 12:156-64. 2009
    ..The 2nd patient, an infant with multiple malformations, had diffuse abnormal layering of his small intestine. The rare reports of other individuals with similar pathological findings are discussed...
  13. doi request reprint Practical pathology and genetics of Hirschsprung's disease
    Raj P Kapur
    Department of Laboratories, Seattle Children s Hospital, University of Washington, Seattle, Washington 98115, USA
    Semin Pediatr Surg 18:212-23. 2009
    ..Many HSCR-susceptibility genes have been identified, but mutational analysis has limited practical value unless family history or clinical findings suggest syndromic HSCR...
  14. ncbi request reprint The influence of Hox genes and three intercellular signalling pathways on enteric neuromuscular development
    R P Kapur
    Department of Pathology, Children s Hospital and Regional Medical Center, Seattle, USA
    Neurogastroenterol Motil 16:8-13. 2004
    ..These signals affect enteric neural precursors as they colonize the gut, and perturbations of these molecules are associated with various types of intestinal neuropathology...
  15. pmc Recurrent reciprocal genomic rearrangements of 17q12 are associated with renal disease, diabetes, and epilepsy
    Heather C Mefford
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 81:1057-69. 2007
    ..We also identified the reciprocal duplication, which appears to be enriched in samples from patients with epilepsy. We describe the first example of a recurrent genomic disorder associated with diabetes...
  16. pmc Amelioration of enteric neuropathology in a mouse model of Niemann-Pick C by Npc1 expression in enteric glia
    Raj Kapur
    Department of Laboratories, Children s Hospital and Regional Medical Center, Seattle, Washington, USA
    J Neurosci Res 87:2994-3001. 2009
    ....
  17. ncbi request reprint Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts
    R P Kapur
    Department of Pathology, Children s Hospital, Seattle, Washington, USA
    Development 121:3787-95. 1995
    ..Instead, intercellular interactions downstream of the endothelin receptor-B mediate complete colonization of the skin and gut by neural crest cells...
  18. ncbi request reprint Early death of neural crest cells is responsible for total enteric aganglionosis in Sox10(Dom)/Sox10(Dom) mouse embryos
    R P Kapur
    Department of Pathology, University of Washington Medical Center, 1959 NE Pacific Street, Box 357470, Seattle, WA 98195, USA
    Pediatr Dev Pathol 2:559-69. 1999
    ..Instead, excessive cell death occurs in mutant neural crest cells early in their migratory pathway. Comparison with other models suggests that genetic heterogeneity of aganglionosis correlates with different pathogenetic mechanisms...
  19. ncbi request reprint Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice
    J Rice
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Dev Dyn 217:120-32. 2000
    ..dev dyn 2000;217:120-132...
  20. ncbi request reprint Neuropathology of paediatric chronic intestinal pseudo-obstruction and related animal models
    R P Kapur
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Pathol 194:277-88. 2001
    ..Information gleaned from studies of these animals is likely to change diagnostic and therapeutic approaches to paediatric CIP and related conditions...
  21. ncbi request reprint Association of cloacal anomalies, caudal duplication, and twinning
    Joseph R Siebert
    Department of Laboratories A 6901, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Pediatr Dev Pathol 8:339-54. 2005
    ....
  22. ncbi request reprint Hydrocephalus and intestinal aganglionosis: is L1CAM a modifier gene in Hirschsprung disease?
    Melissa A Parisi
    Division of Genetics and Development, Department of Pediatrics, University of Washington and Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
    Am J Med Genet 108:51-6. 2002
    ....
  23. ncbi request reprint Neuronal dysplasia: a controversial pathological correlate of intestinal pseudo-obstruction
    Raj P Kapur
    Department of Laboratories, Children s Hospital and Regional Medical Center, University of Washington, Seattle, Washington 98105, USA
    Am J Med Genet A 122:287-93. 2003
    ..Possible genetic and developmental bases for IND are also discussed...
  24. ncbi request reprint Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1-/- mice
    Melissa A Parisi
    Department of Pediatrics, University of Washington School of Medicine, Children s Hospital and Regional Medical Center, 4800 Sand Point Way NW, Seattle, WA 98105, USA
    Gastroenterology 125:1428-40. 2003
    ..We investigated the regulation of Hox11L1 and factors that influence the penetrance of pseudo-obstruction in Hox11L1-null mice...
  25. pmc Visceral neuropathy and intestinal pseudo-obstruction in a murine model of a nuclear inclusion disease
    Christine M Clarke
    Department of Laboratories, Children s Hospital and Regional Medical Center, Seattle, Washington, USA
    Gastroenterology 133:1971-8. 2007
    ..The enteric neuropathology of PrP-SCA7-92Q mice was investigated after observing that they develop signs of intestinal pseudo-obstruction...
  26. ncbi request reprint Five cases of caudal regression with an aberrant abdominal umbilical artery: Further support for a caudal regression-sirenomelia spectrum
    Sara M Duesterhoeft
    Department of Laboratories, Children s Hospital and Regional Medical Center, Seattle, Washington, USA
    Am J Med Genet A 143:3175-84. 2007
    ....
  27. ncbi request reprint Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction
    Melissa A Parisi
    Department of Pediatrics, Children s Hospital and Regional Medical Center and University of Washington, Seattle, WA 98105, USA
    J Pediatr Surg 40:1760-5. 2005
    ..We hypothesized that fmc is a mutant allele of the rat Hox11L1 gene and tested this hypothesis by direct sequencing...
  28. ncbi request reprint Inhibition of protein kinase A in murine enteric neurons causes lethal intestinal pseudo-obstruction
    Douglas G Howe
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7750, USA
    J Neurobiol 66:256-72. 2006
    ....
  29. ncbi request reprint Holoprosencephaly and limb reduction defects: a consideration of Steinfeld syndrome and related conditions
    Joseph R Siebert
    Department of Laboratories, Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
    Am J Med Genet A 134:381-92. 2005
    ..The phenotypic heterogeneity inherent in these patients continues to complicate diagnosis, which will hopefully be simplified by continuing delineation at morphologic and especially genetic levels...
  30. pmc Critical proinflammatory and anti-inflammatory functions of different subsets of CD1d-restricted natural killer T cells during Trypanosoma cruzi infection
    Malcolm S Duthie
    IDRI, 1124 Columbia St, Ste 600, Seattle, WA 98104, USA
    Infect Immun 73:181-92. 2005
    ..Strikingly, most Jalpha18(-/-) mice die. Thus, in response to the same infection, vNKT cells appear to augment a robust proinflammatory response, whereas the iNKT cells dampen this response, possibly by regulating vNKT cells...
  31. ncbi request reprint Does bcl2 immunostaining really help with pathological evaluation of intestinal pseudo-obstruction?
    Raj P Kapur
    Am J Surg Pathol 30:1059; author reply 1059-62. 2006
  32. ncbi request reprint Can we stop looking? Immunohistochemistry and the diagnosis of Hirschsprung disease
    Raj P Kapur
    Am J Clin Pathol 126:9-12. 2006
  33. ncbi request reprint A report of dizygous monochorionic twins
    Vivienne L Souter
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, USA
    N Engl J Med 349:154-8. 2003
  34. ncbi request reprint Cytokine polymorphisms and histologic expression in autopsy studies: contribution of TNF-alpha and TGF-beta 1 to the pathogenesis of autoimmune-associated congenital heart block
    Robert M Clancy
    Hospital for Joint Diseases, New York University School of Medicine, Department of Rheumatology, New York, NY 10003, USA
    J Immunol 171:3253-61. 2003
    ..This profibrosing cytokine and its secretion/activation circuitry may provide a novel direction for evaluating fetal factors in the development of a robust animal model of CHB as well as therapeutic strategies in humans...
  35. ncbi request reprint A case of true hermaphroditism reveals an unusual mechanism of twinning
    Vivienne L Souter
    Department of Obstetrics and Gynecology, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
    Hum Genet 121:179-85. 2007
    ..The twins are chimeric and share a single genetic contribution from their mother but have two genetic contributions from their father thus supporting the existence of a third, previously unreported type of twinning...
  36. ncbi request reprint Genetic disruption of dopamine production results in pituitary adenomas and severe prolactinemia
    Thomas S Hnasko
    Graduate Program in Neurobiology and Behavior, Children s Hospital and Regional Medical Center, University of Washington, Seattle, WA 98195, USA
    Neuroendocrinology 86:48-57. 2007
    ..Dopamine release from tuberoinfundibular dopamine neurons into the median eminence activates dopamine-D2 receptors in the pituitary gland where it inhibits lactotroph function...
  37. ncbi request reprint Rulers rule: present and future applications of cerebellar morphometry
    Joseph R Siebert
    Department of Laboratories, Children s Hospital and Regional Medical Center, Seattle, WA, USA
    Pediatr Dev Pathol 5:422-4. 2002
  38. pmc Both CD1d antigen presentation and interleukin-12 are required to activate natural killer T cells during Trypanosoma cruzi infection
    Malcolm S Duthie
    Infectious Disease Research Institute, 1124 Columbia St, Suite 600, Seattle, WA 98104, USA
    Infect Immun 73:1890-4. 2005
    ..The required IL-12 arises independently of MyD88. The data support a model of normal NKT-cell activation that requires IL-12 and TCR stimulation...
  39. ncbi request reprint Hepatic mesenchymal hamartoma: a disorder of imprinting
    Robyn C Reed
    Department of Laboratories, Seattle Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Pediatr Dev Pathol 11:264-5. 2008
  40. ncbi request reprint Characterization of developing bowel transplanted from transgenic erythropoietin receptor-deficient mouse embryos
    Marcella Mascher-Denen
    Department of Pediatrics, University of Washington, WA 98195, USA
    Neonatology 93:56-63. 2008
    ..Transgenic mice with absent Epo function are embryonic lethal, so it is not known whether Epo function is required for bowel development...
  41. pmc Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy
    Shane E Kruse
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell Metab 7:312-20. 2008
    ..Nonetheless, total oxygen consumption and muscle ATP and phosphocreatine concentrations measured in vivo were within normal parameters...

Research Grants5

  1. SACRAL CREST CELLS AND ENTERIC NEURODEVELOPMENT
    Raj Kapur; Fiscal Year: 2005
    ..The results of this study will further our understanding of normal enteric neurodevelopment and congenital disorders of intestinal motility. ..