Research Topics
Genomes and Genes | Payal KapurSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Predictive biomarkers for response to therapy in advanced colorectal/rectal adenocarcinomaPayal Kapur
UT Southwestern Department of Pathology, 5323 Harry Hines Blvd, Dallas, TX 75390 9110, USA
Crit Rev Oncog 17:361-72. 2012..In this review, some of these novel markers are discussed for their potential use as pharmacogenetic predictors for specific therapy, drug toxicity, and disease outcome...- Pathologic quiz case: myxoid tibial lesion in a 31-year-old man. Low-grade myxofibrosarcomaPayal Kapur
Department of Pathology, The University of Texas Southwestern Medical Center, Dallas 75390-9073, USA
Arch Pathol Lab Med 128:e65-6. 2004 - Pathologic quiz case: paratesticular mass in a young man. Inflammatory myofibroblastic tumor of the paratestisPayal Kapur
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9073, USA
Arch Pathol Lab Med 128:589-90. 2004 
Tailoring treatment of rectal adenocarcinoma: immunohistochemistry for predictive biomarkersPayal Kapur
Department of Pathology, UT Southwestern Medical Center, Dallas, Texas 75390 9110, USA
Anticancer Drugs 22:362-70. 2011..In this report, we discuss the status of the markers currently available in an attempt to tailor specific targeted therapies for rectal cancer in the neoadjuvant setting...- Pathologic quiz case: laryngeal lesion in an elderly man. Verrucous carcinoma of the larynxPayal Kapur
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390, USA
Arch Pathol Lab Med 129:115-6. 2005 - Primary adenocarcinoma of the urinary bladder: value of cell cycle biomarkersPayal Kapur
Dept of Pathology, University of Texas Southwestern, 5323 Harry Hines Blvd, Dallas, TX 75390 9110, USA
Am J Clin Pathol 135:822-30. 2011..04). Stage, lymph node involvement, combined alterations of p27 and Ki-67, and combined alterations of all 5 biomarkers were associated with increased probability of disease recurrence and cancer-specific mortality (P < .05)... - Prognostic value of apoptotic markers in squamous cell carcinoma of the urinary bladderRamy Youssef
Departments of Urology Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
BJU Int 110:961-6. 2012..We found that apoptotic markers can improve prediction of oncological outcomes after RC for SCC and might potentially help in patient selection for adjunct therapies... - Bilharzial vs non-bilharzial related bladder cancer: pathological characteristics and value of cyclooxygenase-2 expressionRamy Youssef
Urology and Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
BJU Int 108:31-7. 2011..We also determined the clinico-pathological differences between BBC and NBBC... - BAP1 loss defines a new class of renal cell carcinomaSamuel Peña-Llopis
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Nat Genet 44:751-9. 2012..0005). Our results establish the foundation for an integrated pathological and molecular genetic classification of RCC, paving the way for subtype-specific treatments exploiting genetic vulnerabilities... - Fatty acid synthase expression in cutaneous melanocytic neoplasmsPayal Kapur
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9073, USA
Mod Pathol 18:1107-12. 2005..This may represent persistence of or regression to a fetal phenotype since normal fetal tissues are known to express high levels of fatty acid synthase... - Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumorsPayal Kapur
Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
Arch Pathol Lab Med 131:57-64. 2007..It has been suggested that a GCT be classified as atypical when 1 or 2 of these features are seen and as malignant when 3 or more of these are present. In our practice, we do not classify GCTs as malignant in the absence of metastasis... 
Anti-respiratory syncytial virus (RSV) neutralizing antibody decreases lung inflammation, airway obstruction, and airway hyperresponsiveness in a murine RSV modelAsuncion Mejias
Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center at Dallas and Children s Medical Center of Dallas, Dallas, Texas 75390 9063, USA
Antimicrob Agents Chemother 48:1811-22. 2004..Studies to determine whether strategies aimed at preventing or reducing RSV replication could decrease the long-term morbidity associated with RSV infection in children should be considered...- Prognostic value of cyclooxygenase-2 expression in squamous cell carcinoma of the bladderRamy F Youssef
Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
J Urol 185:1112-7. 2011..We assessed the expression pattern of cyclooxygenase-2 in patients with squamous cell carcinoma of the bladder and determined whether cyclooxygenase-2 expression is associated with clinical outcomes after radical cystectomy... - A validated tumorgraft model reveals activity of dovitinib against renal cell carcinomaSharanya Sivanand
Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Sci Transl Med 4:137ra75. 2012..The routine incorporation of models recapitulating the molecular genetics and drug sensitivities of human tumors into preclinical programs has the potential to improve oncology drug development... - Microcystic adnexal carcinoma: an immunohistochemical reappraisalMai P Hoang
Department of Pathology, UMass Medical School, Worcester, MA, USA
Mod Pathol 21:178-85. 2008..Our experience indicates that microcystic adnexal carcinoma and desmoplastic trichoepithelioma have a similar immunohistochemical profile that is, CK15+ and BerEP4+/-; thus, additional studies are needed to separate these two entities... - Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberansMikhail Lisovsky
Department of Pathology, UMass Medical School, Worcester, MA, USA
Mod Pathol 21:31-8. 2008.... - Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 casesPushkar A Phadke
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Am J Surg Pathol 35:656-69. 2011..Although numerous mutations are detected in the samples, the diagnostic use of molecular analysis in this regard is limited... - Atypical and malignant hidradenomas: a histological and immunohistochemical studyRosalynn M Nazarian
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Mod Pathol 22:600-10. 2009..A tumor with Ki-67>11% and/or phosphorylated histone H3>0.7% would likely be a malignant rather than an atypical hidradenoma. The infrequent Her2/neu overexpression in hidradenocarcinoma suggests its limited therapeutic role... - Increased ratio of saturated to unsaturated C18 fatty acids in colonic adenocarcinoma: implications for cryotherapy and lipid raft functionDinesh Rakheja
Department of Pathology, MC 9073, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Med Hypotheses 65:1120-3. 2005..Dietary or therapeutic interventions targeting lipid rafts may thus be an option for cancer treatment... - Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validationPayal Kapur
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Lancet Oncol 14:159-67. 2013..The aim of this study was to investigate the clinicopathological significance of these molecular subtypes and to determine whether patients with BAP1-mutant and PBRM1-mutant tumours had different overall survival... - Tissue microarray constructs to predict a response to chemoradiation in rectal cancerSergio Huerta
Department of Surgery, University of Texas Southwestern Medical Center, United States
Dig Liver Dis 42:679-84. 2010..To identify, using tissue microarray (TMA), an immunohistochemical panel predictive of response to ionizing radiation (IR) in rectal cancer... - Respiratory syncytial virus induces pneumonia, cytokine response, airway obstruction, and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in miceHasan S Jafri
Department of Pediatrics, Division of Infectious Diseases, The University of Texas Southwestern Medical Center at Dallas, Texas, USA
J Infect Dis 189:1856-65. 2004..pneumonia and airway obstruction [AO]) and long-term complications (e.g., airway hyperresponsiveness [AHR]). We present a comprehensive evaluation of the acute and chronic phases of RSV respiratory tract infection, using a mouse model... - In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201Sergio Huerta
Department of Surgery, University of Texas Southwestern Medical Center Dallas VA Medical Center, Dallas, TX 75216, USA
Surgery 148:346-53. 2010..This study was undertaken to assess the radiosensitizing properties of the smac mimetic JP-1201 in radioresistant HT-29 colorectal cancer cells in vitro and established xenografts in SCID mice... - Congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker disease): ten-year experience at Dallas Children's Medical CenterPayal Kapur
Department of Pathology, Children s Medical Center Dallas, Texas, USA
J Am Acad Dermatol 56:290-4. 2007.... - Pediatric renal cell carcinomas with Xp11.2 rearrangements are immunoreactive for hMLH1 and hMSH2 proteinsDinesh Rakheja
Department of Pathology, Children s Medical Center and University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Pediatr Dev Pathol 8:615-20. 2005..Our study demonstrates that inactivation of the DNA mismatch repair genes hMLH1 and hMSH2 does not appear to play a role in the tumorigenesis of pediatric renal cell carcinomas with Xp11.2 rearrangements... - Immunohistochemical expression of neural cell adhesion molecule in Wilms tumors, nephrogenic rests, and fetal and postnatal renal corticesPayal Kapur
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Pediatr Dev Pathol 14:16-9. 2011..It is not known if these persistent NCAM-positive interstitial cells might give rise to adult Wilms tumors and cases of pediatric Wilms tumors not associated with nephrogenic rests... - Central role for PELP1 in nonandrogenic activation of the androgen receptor in prostate cancerLin Yang
Department of Urology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9110, USA
Mol Endocrinol 26:550-61. 2012..These data suggest a novel mechanism of AR activation in the absence of androgens in PCa cells. Our data indicate that disruption of the complex between AR and PELP1 may be a viable therapeutic strategy in advanced PCa... - Extrahepatic biliary atresia demonstrates abnormal persistence of HES1 protein in neonatal biliary epithelium: an immunohistochemical studyDinesh Rakheja
Department of Pathology, Children's Medical Center and University of Texas Southwestern Medical Center, Dallas, USA
Pediatr Dev Pathol 9:98-102. 2006..Further studies should be performed to evaluate the role of HES1 immunohistochemistry as a diagnostic tool in extrahepatic biliary atresia... - Primary mucinous adenocarcinoma of the thymus: a case report and review of the literaturePayal Kapur
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9073, USA
Arch Pathol Lab Med 130:201-4. 2006..Morphologic and immunophenotypic similarities to mucinous adenocarcinomas of the gastrointestinal tract can pose diagnostic challenges for surgical pathologists, especially in small biopsy specimens... - Microsatellite instability among individuals of Hispanic origin with colorectal cancerSamir Gupta
Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8887, USA
Cancer 116:4965-72. 2010.... - DAB2IP regulates autophagy in prostate cancer in response to combined treatment of radiation and a DNA-PKcs inhibitorLan Yu
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9187, USA
Neoplasia 14:1203-12. 2012..Taken together, NU7441 is a potent radiosensitizer in aggressive PCa cells and DAB2IP plays a critical role in enhancing PCa cell death after combined treatment with NU7441 and radiation... - Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumorsIsaac Marin-Valencia
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
NMR Biomed 25:1177-86. 2012..Taken together, these data demonstrate that (13) C-labeled glucose can be used in orthotopic mouse models to study tumor metabolism in vivo and to ascertain new metabolic targets for cancer diagnosis and therapy... - Indications and recommended approach for surgical intervention of metastatic disease to the gallbladderZarrish S Khan
Department of Surgery, UT Southwestern Medical Center, Harry Hines Blvd, Dallas, 75219, USA
World J Surg Oncol 8:80. 2010.... - Papillary thyroid carcinoma shows elevated levels of 2-hydroxyglutarateDinesh Rakheja
Department of Pathology, Children s Medical Center, Dallas, TX, USA
Tumour Biol 32:325-33. 2011..Further studies should clarify if elevated 2-hydroxyglutarate in PTC may be useful as cancer biomarker and evaluate the role of 2-hydroxyglutarate in cancer biology... - Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinomaBlanka Kucejova
Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Mol Cancer Res 9:1255-65. 2011..Understanding how ccRCCs become refractory to REDD1-induced mTORC1 inhibition should shed light into the development of ccRCC and may aid in patient selection for molecular-targeted therapies... - Pathologic quiz case: a woman with right facial nerve paralysis. Endolymphatic sac tumor associated with von Hippel-Lindau diseaseDinesh Rakheja
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Tex 75390-9073, USA
Arch Pathol Lab Med 127:1387-8. 2003 - Characterization of inflammation in syphilitic villitis and in villitis of unknown etiologyPayal Kapur
Department of Pathology, The University of Texas Southwestern Medical School, Dallas, TX, USA
Pediatr Dev Pathol 7:453-8; discussion 421. 2004..These data indicate that the immune response in both syphilitic villitis and VUE is similar, raising the possibility of a similar immunopathogenetic pathway... - Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysisPayal Kapur
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9073, USA
Mod Pathol 18:197-204. 2005..The adult lesions were significantly more likely to be intradermal and to display dermal fibroplasia, but were histologically similar to their pediatric counterparts in all other respects... - Expression of cell cycle-related molecular markers in patients treated with radical cystectomy for squamous cell carcinoma of the bladderRamy F Youssef
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
Hum Pathol 42:347-55. 2011..Only p53 had a prognostic role in patients treated with radical cystectomy for SCC. Our findings support the need for further evaluation of molecular markers and their signaling pathways in SCC...