Payal Kapur

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi BAP1 immunohistochemistry predicts outcomes in a multi-institutional cohort with clear cell renal cell carcinoma
    Payal Kapur
    Department of Pathology PK, University of Texas Southwestern Medical Center, Dallas, Texas Department of Urology PK, yl, VM, University of Texas Southwestern Medical Center, Dallas, Texas Department of Internal Medicine JB, University of Texas Southwestern Medical Center, Dallas, Texas Department of Developmental Biology JB, University of Texas Southwestern Medical Center, Dallas, Texas Simmons Cancer Center XJX, JB, University of Texas Southwestern Medical Center, Dallas, Texas Department of Urology, Penn State Milton S Hershey Medical Center JDR, Hershey, Pennsylvania Department of Pathology, University of Pittsburgh Medical Center MTT, Pittsburgh, Pennsylvania Department of Urology, University of Munich PN, AB, Munich, Germany Department of Urology, Paracelsus Klinik Golzheim, Dusseldorf, Germany PB Department of Urology, Central Hospital of Bolzano CS, Bolzano, Italy Department of Urology, Medical University of Vienna, Vienna General Hospital CS, SFS, Vienna, Bogot
    J Urol 191:603-10. 2014
  2. ncbi Predictive biomarkers for response to therapy in advanced colorectal/rectal adenocarcinoma
    Payal Kapur
    UT Southwestern Department of Pathology, 5323 Harry Hines Blvd, Dallas, TX 75390 9110, USA
    Crit Rev Oncog 17:361-72. 2012
  3. ncbi Pathologic quiz case: laryngeal lesion in an elderly man. Verrucous carcinoma of the larynx
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Arch Pathol Lab Med 129:115-6. 2005
  4. doi Tailoring treatment of rectal adenocarcinoma: immunohistochemistry for predictive biomarkers
    Payal Kapur
    Department of Pathology, UT Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    Anticancer Drugs 22:362-70. 2011
  5. ncbi Pathologic quiz case: myxoid tibial lesion in a 31-year-old man. Low-grade myxofibrosarcoma
    Payal Kapur
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas 75390 9073, USA
    Arch Pathol Lab Med 128:e65-6. 2004
  6. ncbi Pathologic quiz case: paratesticular mass in a young man. Inflammatory myofibroblastic tumor of the paratestis
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Arch Pathol Lab Med 128:589-90. 2004
  7. doi Primary adenocarcinoma of the urinary bladder: value of cell cycle biomarkers
    Payal Kapur
    Dept of Pathology, University of Texas Southwestern, 5323 Harry Hines Blvd, Dallas, TX 75390 9110, USA
    Am J Clin Pathol 135:822-30. 2011
  8. doi Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Lancet Oncol 14:159-67. 2013
  9. ncbi Prospective comparison of molecular signatures in urothelial cancer of the bladder and the upper urinary tract--is there evidence for discordant biology?
    Laura Maria Krabbe
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas Department of Urology, University of Muenster Medical Center, Muenster, Germany
    J Urol 191:926-31. 2014
  10. ncbi Ki67 is an independent predictor of oncological outcomes in patients with localized clear-cell renal cell carcinoma
    Bishoy A Gayed
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    BJU Int 113:668-73. 2014

Detail Information

Publications56

  1. doi BAP1 immunohistochemistry predicts outcomes in a multi-institutional cohort with clear cell renal cell carcinoma
    Payal Kapur
    Department of Pathology PK, University of Texas Southwestern Medical Center, Dallas, Texas Department of Urology PK, yl, VM, University of Texas Southwestern Medical Center, Dallas, Texas Department of Internal Medicine JB, University of Texas Southwestern Medical Center, Dallas, Texas Department of Developmental Biology JB, University of Texas Southwestern Medical Center, Dallas, Texas Simmons Cancer Center XJX, JB, University of Texas Southwestern Medical Center, Dallas, Texas Department of Urology, Penn State Milton S Hershey Medical Center JDR, Hershey, Pennsylvania Department of Pathology, University of Pittsburgh Medical Center MTT, Pittsburgh, Pennsylvania Department of Urology, University of Munich PN, AB, Munich, Germany Department of Urology, Paracelsus Klinik Golzheim, Dusseldorf, Germany PB Department of Urology, Central Hospital of Bolzano CS, Bolzano, Italy Department of Urology, Medical University of Vienna, Vienna General Hospital CS, SFS, Vienna, Bogot
    J Urol 191:603-10. 2014
    ..We investigated the clinicopathological significance and oncologic outcomes of BAP1 loss using a previously validated immunohistochemical assay...
  2. ncbi Predictive biomarkers for response to therapy in advanced colorectal/rectal adenocarcinoma
    Payal Kapur
    UT Southwestern Department of Pathology, 5323 Harry Hines Blvd, Dallas, TX 75390 9110, USA
    Crit Rev Oncog 17:361-72. 2012
    ..In this review, some of these novel markers are discussed for their potential use as pharmacogenetic predictors for specific therapy, drug toxicity, and disease outcome...
  3. ncbi Pathologic quiz case: laryngeal lesion in an elderly man. Verrucous carcinoma of the larynx
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Arch Pathol Lab Med 129:115-6. 2005
  4. doi Tailoring treatment of rectal adenocarcinoma: immunohistochemistry for predictive biomarkers
    Payal Kapur
    Department of Pathology, UT Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    Anticancer Drugs 22:362-70. 2011
    ..In this report, we discuss the status of the markers currently available in an attempt to tailor specific targeted therapies for rectal cancer in the neoadjuvant setting...
  5. ncbi Pathologic quiz case: myxoid tibial lesion in a 31-year-old man. Low-grade myxofibrosarcoma
    Payal Kapur
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas 75390 9073, USA
    Arch Pathol Lab Med 128:e65-6. 2004
  6. ncbi Pathologic quiz case: paratesticular mass in a young man. Inflammatory myofibroblastic tumor of the paratestis
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Arch Pathol Lab Med 128:589-90. 2004
  7. doi Primary adenocarcinoma of the urinary bladder: value of cell cycle biomarkers
    Payal Kapur
    Dept of Pathology, University of Texas Southwestern, 5323 Harry Hines Blvd, Dallas, TX 75390 9110, USA
    Am J Clin Pathol 135:822-30. 2011
    ..04). Stage, lymph node involvement, combined alterations of p27 and Ki-67, and combined alterations of all 5 biomarkers were associated with increased probability of disease recurrence and cancer-specific mortality (P < .05)...
  8. doi Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Lancet Oncol 14:159-67. 2013
    ..The aim of this study was to investigate the clinicopathological significance of these molecular subtypes and to determine whether patients with BAP1-mutant and PBRM1-mutant tumours had different overall survival...
  9. ncbi Prospective comparison of molecular signatures in urothelial cancer of the bladder and the upper urinary tract--is there evidence for discordant biology?
    Laura Maria Krabbe
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas Department of Urology, University of Muenster Medical Center, Muenster, Germany
    J Urol 191:926-31. 2014
    ..We prospectively evaluate molecular profiles of upper tract urothelial carcinoma and bladder cancer using a cell cycle biomarker panel...
  10. ncbi Ki67 is an independent predictor of oncological outcomes in patients with localized clear-cell renal cell carcinoma
    Bishoy A Gayed
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    BJU Int 113:668-73. 2014
    ..To validate the impact of Ki67 expression on oncological outcomes of patients treated for clinically localized clear-cell renal cell carcinoma (ccRCC)...
  11. pmc BAP1 loss defines a new class of renal cell carcinoma
    Samuel Peña-Llopis
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Genet 44:751-9. 2012
    ..0005). Our results establish the foundation for an integrated pathological and molecular genetic classification of RCC, paving the way for subtype-specific treatments exploiting genetic vulnerabilities...
  12. doi Prospective analysis of Ki-67 as an independent predictor of oncologic outcomes in patients with high grade upper tract urothelial carcinoma
    Laura Maria Krabbe
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas Department of Urology, University of Muenster Medical Center, Muenster, Germany
    J Urol 191:28-34. 2014
    ..We determined the association of the proliferation marker Ki-67 with pathological parameters and oncologic outcomes in patients with high grade upper tract urothelial carcinoma...
  13. ncbi Prognostic value of apoptotic markers in squamous cell carcinoma of the urinary bladder
    Ramy Youssef
    Departments of Urology Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
    BJU Int 110:961-6. 2012
    ..We found that apoptotic markers can improve prediction of oncological outcomes after RC for SCC and might potentially help in patient selection for adjunct therapies...
  14. doi Bilharzial vs non-bilharzial related bladder cancer: pathological characteristics and value of cyclooxygenase-2 expression
    Ramy Youssef
    Urology and Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    BJU Int 108:31-7. 2011
    ..We also determined the clinico-pathological differences between BBC and NBBC...
  15. doi Prognostic role of cell cycle and proliferative biomarkers in patients with clear cell renal cell carcinoma
    Bishoy A Gayed
    Departments of Urology and Pathology PK, University of Texas Southwestern Medical Center, Dallas, Texas
    J Urol 190:1662-7. 2013
    ..In this proof of principle study we systematically evaluate the association of aberrant expression of cell cycle regulators and proliferative markers and their effect on oncologic outcomes of patients with clear cell renal carcinoma...
  16. ncbi Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors
    Payal Kapur
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Arch Pathol Lab Med 131:57-64. 2007
    ..It has been suggested that a GCT be classified as atypical when 1 or 2 of these features are seen and as malignant when 3 or more of these are present. In our practice, we do not classify GCTs as malignant in the absence of metastasis...
  17. ncbi Fatty acid synthase expression in cutaneous melanocytic neoplasms
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Mod Pathol 18:1107-12. 2005
    ..This may represent persistence of or regression to a fetal phenotype since normal fetal tissues are known to express high levels of fatty acid synthase...
  18. doi Prospective evaluation of a preoperative biomarker panel for prediction of upstaging at radical cystectomy
    Shahrokh F Shariat
    Department of Urology, Medical University of Vienna, Vienna General Hospital, Vienna, Austria
    BJU Int 113:70-6. 2014
    ....
  19. pmc Anti-respiratory syncytial virus (RSV) neutralizing antibody decreases lung inflammation, airway obstruction, and airway hyperresponsiveness in a murine RSV model
    Asuncion Mejias
    Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center at Dallas and Children s Medical Center of Dallas, Dallas, Texas 75390 9063, USA
    Antimicrob Agents Chemother 48:1811-22. 2004
    ..Studies to determine whether strategies aimed at preventing or reducing RSV replication could decrease the long-term morbidity associated with RSV infection in children should be considered...
  20. ncbi DOC-2/DAB2 Interacting Protein Status in High-Risk Prostate Cancer Correlates With Outcome for Patients Treated With Radiation Therapy
    Corbin Jacobs
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas
    Int J Radiat Oncol Biol Phys 89:729-35. 2014
    ..This pilot study investigates the role of DOC-2/DAB2 Interacting Protein (DAB2IP) and enhancer of zeste homolog 2 (EZH2) as prognostic biomarkers in high-risk prostate cancer patients receiving definitive radiation therapy...
  21. doi GATA-3 immunohistochemistry in the differential diagnosis of adenocarcinoma of the urinary bladder
    Carla L Ellis
    Department of Pathology, The Johns Hopkins Hospital and School of Medicine, Baltimore, MD Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX
    Am J Surg Pathol 37:1756-60. 2013
    ..GATA-3 is rarely positive in bladder adenocarcinomas that lack signet ring features and in SRCs displaying extracellular mucin production...
  22. doi Lymphovascular invasion in clear cell renal cell carcinoma--association with disease-free and cancer-specific survival
    Michael Belsante
    Department of Urology, UT Southwestern Medical Center, Dallas, TX
    Urol Oncol 32:30.e23-8. 2014
    ..The objective is to evaluate the effect of lymphovascular invasion (LVI) on disease-free survival (DFS) and cancer-specific survival (CSS) in patients with clinically localized clear cell renal cell carcinoma (ccRCC)...
  23. doi Surgical management of the distal ureter during radical nephroureterectomy is an independent predictor of oncological outcomes: results of a current series and a review of the literature
    Laura Maria Krabbe
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX Department of Urology, University of Muenster Medical Center, Muenster, Germany
    Urol Oncol 32:54.e19-26. 2014
    ..To evaluate the effect of distal ureter management on oncological outcomes in patients with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma...
  24. pmc DAB2IP regulates autophagy in prostate cancer in response to combined treatment of radiation and a DNA-PKcs inhibitor
    Lan Yu
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9187, USA
    Neoplasia 14:1203-12. 2012
    ..Taken together, NU7441 is a potent radiosensitizer in aggressive PCa cells and DAB2IP plays a critical role in enhancing PCa cell death after combined treatment with NU7441 and radiation...
  25. doi Prognostic value of cyclooxygenase-2 expression in squamous cell carcinoma of the bladder
    Ramy F Youssef
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    J Urol 185:1112-7. 2011
    ..We assessed the expression pattern of cyclooxygenase-2 in patients with squamous cell carcinoma of the bladder and determined whether cyclooxygenase-2 expression is associated with clinical outcomes after radical cystectomy...
  26. pmc A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma
    Sharanya Sivanand
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Sci Transl Med 4:137ra75. 2012
    ..The routine incorporation of models recapitulating the molecular genetics and drug sensitivities of human tumors into preclinical programs has the potential to improve oncology drug development...
  27. ncbi Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans
    Mikhail Lisovsky
    Department of Pathology, UMass Medical School, Worcester, MA, USA
    Mod Pathol 21:31-8. 2008
    ....
  28. ncbi Microcystic adnexal carcinoma: an immunohistochemical reappraisal
    Mai P Hoang
    Department of Pathology, UMass Medical School, Worcester, MA, USA
    Mod Pathol 21:178-85. 2008
    ..Our experience indicates that microcystic adnexal carcinoma and desmoplastic trichoepithelioma have a similar immunohistochemical profile that is, CK15+ and BerEP4+/-; thus, additional studies are needed to separate these two entities...
  29. doi Comparative analysis of oncologic outcomes of partial ureterectomy vs radical nephroureterectomy in upper tract urothelial carcinoma
    Aditya Bagrodia
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
    Urology 81:972-7. 2013
    ..To compare oncologic outcomes in an international cohort of patients who underwent either partial ureterectomy (PU) or radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC)...
  30. doi Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern Medical Center and North Texas VA Health Care System, Dallas, Texas 75216, USA
    Surgery 154:143-51. 2013
    ..Molecular factors that dictate tumor response to ionizing radiation in rectal cancer are not well described...
  31. ncbi Increased ratio of saturated to unsaturated C18 fatty acids in colonic adenocarcinoma: implications for cryotherapy and lipid raft function
    Dinesh Rakheja
    Department of Pathology, MC 9073, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Med Hypotheses 65:1120-3. 2005
    ..Dietary or therapeutic interventions targeting lipid rafts may thus be an option for cancer treatment...
  32. doi Atypical and malignant hidradenomas: a histological and immunohistochemical study
    Rosalynn M Nazarian
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 22:600-10. 2009
    ..A tumor with Ki-67>11% and/or phosphorylated histone H3>0.7% would likely be a malignant rather than an atypical hidradenoma. The infrequent Her2/neu overexpression in hidradenocarcinoma suggests its limited therapeutic role...
  33. doi Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases
    Pushkar A Phadke
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:656-69. 2011
    ..Although numerous mutations are detected in the samples, the diagnostic use of molecular analysis in this regard is limited...
  34. pmc Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer
    Shan Wang
    Eugene McDermott Center for Human Growth and Development, Departments of Urology, Pathology, and Phamacology, Simmons Comprehensive Cancer Center, and Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390
    Proc Natl Acad Sci U S A 111:4251-6. 2014
    ..Thus, we identified USP9X as a potential therapeutic target in prostate cancer cells and established WP1130 as a lead compound for the development of ERG-depleting drugs. ..
  35. ncbi Pediatric renal cell carcinomas with Xp11.2 rearrangements are immunoreactive for hMLH1 and hMSH2 proteins
    Dinesh Rakheja
    Department of Pathology, Children s Medical Center and University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Pediatr Dev Pathol 8:615-20. 2005
    ..Our study demonstrates that inactivation of the DNA mismatch repair genes hMLH1 and hMSH2 does not appear to play a role in the tumorigenesis of pediatric renal cell carcinomas with Xp11.2 rearrangements...
  36. pmc Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors
    Isaac Marin-Valencia
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 25:1177-86. 2012
    ..Taken together, these data demonstrate that (13) C-labeled glucose can be used in orthotopic mouse models to study tumor metabolism in vivo and to ascertain new metabolic targets for cancer diagnosis and therapy...
  37. doi Cumulative number of altered biomarkers in mammalian target of rapamycin pathway is an independent predictor of outcome in patients with clear cell renal cell carcinoma
    Oussama M Darwish
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
    Urology 81:581-6. 2013
    ..To evaluate the association of the altered expression of the mammalian target of rapamycin (mTOR) pathway components with oncologic outcomes in patients with nonmetastatic clear cell renal cell carcinoma (ccRCC)...
  38. ncbi Respiratory syncytial virus induces pneumonia, cytokine response, airway obstruction, and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in mice
    Hasan S Jafri
    Department of Pediatrics, Division of Infectious Diseases, The University of Texas Southwestern Medical Center at Dallas, Texas, USA
    J Infect Dis 189:1856-65. 2004
    ..pneumonia and airway obstruction [AO]) and long-term complications (e.g., airway hyperresponsiveness [AHR]). We present a comprehensive evaluation of the acute and chronic phases of RSV respiratory tract infection, using a mouse model...
  39. doi Tissue microarray constructs to predict a response to chemoradiation in rectal cancer
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern Medical Center, United States
    Dig Liver Dis 42:679-84. 2010
    ..To identify, using tissue microarray (TMA), an immunohistochemical panel predictive of response to ionizing radiation (IR) in rectal cancer...
  40. ncbi Phospho-mTOR is not upregulated in metastatic SDHB paragangliomas
    Hans K Ghayee
    Department of Internal Medicine, VA North Texas Health Care System, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Eur J Clin Invest 43:970-7. 2013
    ..Treatment for patients with metastatic tumours is lacking. As new PCC/PGL susceptibility genes are discovered that are associated with the mTOR pathway, treatment targets focusing on this pathway are being intensively explored...
  41. doi In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern Medical Center Dallas VA Medical Center, Dallas, TX 75216, USA
    Surgery 148:346-53. 2010
    ..This study was undertaken to assess the radiosensitizing properties of the smac mimetic JP-1201 in radioresistant HT-29 colorectal cancer cells in vitro and established xenografts in SCID mice...
  42. ncbi Congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker disease): ten-year experience at Dallas Children's Medical Center
    Payal Kapur
    Department of Pathology, Children s Medical Center Dallas, Texas, USA
    J Am Acad Dermatol 56:290-4. 2007
    ....
  43. doi Immunohistochemical expression of neural cell adhesion molecule in Wilms tumors, nephrogenic rests, and fetal and postnatal renal cortices
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Pediatr Dev Pathol 14:16-9. 2011
    ..It is not known if these persistent NCAM-positive interstitial cells might give rise to adult Wilms tumors and cases of pediatric Wilms tumors not associated with nephrogenic rests...
  44. pmc Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma
    Blanka Kucejova
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cancer Res 9:1255-65. 2011
    ..Understanding how ccRCCs become refractory to REDD1-induced mTORC1 inhibition should shed light into the development of ccRCC and may aid in patient selection for molecular-targeted therapies...
  45. pmc Indications and recommended approach for surgical intervention of metastatic disease to the gallbladder
    Zarrish S Khan
    Department of Surgery, UT Southwestern Medical Center, Harry Hines Blvd, Dallas, 75219, USA
    World J Surg Oncol 8:80. 2010
    ....
  46. doi Expression of cell cycle-related molecular markers in patients treated with radical cystectomy for squamous cell carcinoma of the bladder
    Ramy F Youssef
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
    Hum Pathol 42:347-55. 2011
    ..Only p53 had a prognostic role in patients treated with radical cystectomy for SCC. Our findings support the need for further evaluation of molecular markers and their signaling pathways in SCC...
  47. doi Central role for PELP1 in nonandrogenic activation of the androgen receptor in prostate cancer
    Lin Yang
    Department of Urology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9110, USA
    Mol Endocrinol 26:550-61. 2012
    ..These data suggest a novel mechanism of AR activation in the absence of androgens in PCa cells. Our data indicate that disruption of the complex between AR and PELP1 may be a viable therapeutic strategy in advanced PCa...
  48. ncbi Extrahepatic biliary atresia demonstrates abnormal persistence of HES1 protein in neonatal biliary epithelium: an immunohistochemical study
    Dinesh Rakheja
    Department of Pathology, Children s Medical Center and University of Texas Southwestern Medical Center, Dallas, USA
    Pediatr Dev Pathol 9:98-102. 2006
    ..Further studies should be performed to evaluate the role of HES1 immunohistochemistry as a diagnostic tool in extrahepatic biliary atresia...
  49. ncbi Primary mucinous adenocarcinoma of the thymus: a case report and review of the literature
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Arch Pathol Lab Med 130:201-4. 2006
    ..Morphologic and immunophenotypic similarities to mucinous adenocarcinomas of the gastrointestinal tract can pose diagnostic challenges for surgical pathologists, especially in small biopsy specimens...
  50. pmc A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer
    Kai Hsiung Chang
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell 154:1074-84. 2013
    ..We suggest that 3βHSD1 is a valid target for the treatment of CRPC. ..
  51. pmc Microsatellite instability among individuals of Hispanic origin with colorectal cancer
    Samir Gupta
    Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8887, USA
    Cancer 116:4965-72. 2010
    ....
  52. ncbi Pathologic quiz case: a woman with right facial nerve paralysis. Endolymphatic sac tumor associated with von Hippel-Lindau disease
    Dinesh Rakheja
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Tex 75390 9073, USA
    Arch Pathol Lab Med 127:1387-8. 2003
  53. doi Papillary thyroid carcinoma shows elevated levels of 2-hydroxyglutarate
    Dinesh Rakheja
    Department of Pathology, Children s Medical Center, Dallas, TX, USA
    Tumour Biol 32:325-33. 2011
    ..Further studies should clarify if elevated 2-hydroxyglutarate in PTC may be useful as cancer biomarker and evaluate the role of 2-hydroxyglutarate in cancer biology...
  54. ncbi Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis
    Payal Kapur
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Mod Pathol 18:197-204. 2005
    ..The adult lesions were significantly more likely to be intradermal and to display dermal fibroplasia, but were histologically similar to their pediatric counterparts in all other respects...
  55. ncbi Characterization of inflammation in syphilitic villitis and in villitis of unknown etiology
    Payal Kapur
    Department of Pathology, The University of Texas Southwestern Medical School, Dallas, TX, USA
    Pediatr Dev Pathol 7:453-8; discussion 421. 2004
    ..These data indicate that the immune response in both syphilitic villitis and VUE is similar, raising the possibility of a similar immunopathogenetic pathway...