Research Topics
Species | Mariana KaplanSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosusDacheng Ding
Department of Internal Medicine, Division of Rheumatology, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
J Immunol 177:5878-89. 2006..We conclude that myeloid DCs from SLE patients display significant changes in phenotype which promote aberrant T cell function and could contribute to the pathogenesis of SLE and organ damage...
Mechanisms of premature atherosclerosis in rheumatoid arthritis and lupusJ Michelle Kahlenberg
Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 5680 email
Annu Rev Med 64:249-63. 2013....
The liver is a common non-exocrine target in primary Sjögren's syndrome: a retrospective reviewMariana J Kaplan
Department of Internal Medicine, Division of Rheumatology, University of Michigan Health System, Ann Arbor, Michigan, USA
BMC Gastroenterol 2:21. 2002..Its presence correlates with systemic disease. We consider that this complication should be routinely sought in patients with 1 degrees SS, especially when a positive anti-ENA or evidence of systemic inflammation is found...- The interplay of inflammation and cardiovascular disease in systemic lupus erythematosusJ Michelle Kahlenberg
Department of Internal Medicine, University of Michigan, nn Arbor, MI 48109 5680, USA
Arthritis Res Ther 13:203. 2011..The potential role of various cytokines, in particular type I interferons, in the development of accelerated atherosclerosis is examined. Potential therapeutic targets are discussed... - The role of aldosterone blockade in murine lupus nephritisSeetha U Monrad
Division of Rheumatology, Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Arthritis Res Ther 10:R5. 2008..The purpose of this study was to examine the effect of aldosterone receptor blockade on the immunopathogenesis and progression of nephritis in the (NZB x NZW) F1 murine lupus model... - Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosusSeetha U Monrad
Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, 5520 MSRBI, Ann Arbor, MI 48109, USA
Arthritis Res Ther 10:R114. 2008..The purpose of the present study was to characterize the phagocytic capacity and expression of receptors involved in pathogen recognition and self-nonself discrimination on myeloid dendritic cells from patients with lupus... - Management of cardiovascular disease risk in chronic inflammatory disordersMariana J Kaplan
Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Nat Rev Rheumatol 5:208-17. 2009.... - Cardiometabolic risk in psoriasis: differential effects of biologic agentsMariana J Kaplan
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Vasc Health Risk Manag 4:1229-35. 2008..Clearly, studies should focus on establishing the exact mechanisms that determine CV risk in psoriasis so that appropriate preventive strategies and treatment guidelines can be established... - Premature vascular damage in systemic lupus erythematosus: an imbalance of damage and repair?Mariana J Kaplan
Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, University of Michigan Health System, Ann Arbor 48109 5680, USA
Transl Res 154:61-9. 2009..This review summarizes some of the proposed mechanisms that may promote accelerated vascular damage in lupus and explores potential targets for cardiovascular risk prevention in this patient population... - Premature vascular damage in systemic lupus erythematosusMariana J Kaplan
Division of Rheumatology, Department of Internal Medicine and Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 5680, USA
Autoimmunity 42:580-6. 2009..This review summarizes some of the proposed mechanisms that may promote accelerated vascular damage in lupus and explores potential targets for CV risk prevention in this patient population... - Neutrophils in the pathogenesis and manifestations of SLEMariana J Kaplan
Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
Nat Rev Rheumatol 7:691-9. 2011..This Review highlights the role of neutrophils in the pathogenesis of SLE, with a particular focus on the putative deleterious effects of LDGs and neutrophil extracellular trap formation... - Systemic toxicity following administration of sirolimus (formerly rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesional lymphocytesM J Kaplan
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
Arch Dermatol 135:553-7. 1999..After 2 individuals with psoriasis developed a capillary leak syndrome following treatment with oral sirolimus lesional skin cells and activated peripheral blood cells were analyzed for induction of apoptosis... - FK-778 AstellasMariana J Kaplan
Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA
Curr Opin Investig Drugs 6:526-36. 2005..Astellas, under license from sanofi-aventis, is developing the immunosuppressant compound FK-778 as a potential treatment for organ transplantation. By February 2005, phase II trials were ongoing both in the US and in Europe... - Leflunomide Aventis PharmaM J Kaplan
University of Michigan Medical Center, Division of Rheumatology, Ann Arbor 48109 1065, USA
Curr Opin Investig Drugs 2:222-30. 2001..In 1996, leflunomide was designated as one of HMR's nine top-priority products, serving an unmet medical need and addressing a potential market in excess of US $500 million per year [221118]... - Eculizumab (Alexion)Mariana Kaplan
University of Michigan Medical Center, Division of Rheumatology, Ann Arbor 48109 1065, USA
Curr Opin Investig Drugs 3:1017-23. 2002.... - The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cellsMariana J Kaplan
Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, 5220 Medical Science Research Building I, Ann Arbor, MI 48109, USA
J Immunol 169:6020-9. 2002..We propose that this mechanism could provide a source of potentially antigenic material for the autoimmune response and interfere with normal clearing mechanisms... - Apoptosis in systemic lupus erythematosusMariana J Kaplan
University of Michigan Medical School, Ann Arbor, MI 48109, USA
Clin Immunol 112:210-8. 2004 - Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cellsMariana J Kaplan
Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 172:3652-61. 2004..Our results also suggest that aberrant perforin expression in CD4+ lupus T cells may contribute to monocyte killing... - Plasminogen activator inhibitor-1 is associated with impaired endothelial function in women with systemic lupus erythematosusEmily C Somers
Division of Rheumatology, University of Michigan Health System, 1150 W Medical Center Dr, 5520 MSRB 1, Ann Arbor, MI 48109 0680, USA
Ann N Y Acad Sci 1051:271-80. 2005..Given the high incidence of cardiovascular disease in SLE, further investigation of the role of subclinical markers of CVD is needed... - New evidence for vascular disease in patients with early rheumatoid arthritisMariana J Kaplan
Department of Internal Medicine, Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI 408109, USA
Lancet 361:1068-9. 2003 - Cardiovascular complications of rheumatoid arthritis: assessment, prevention, and treatmentMariana J Kaplan
Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, 5520 MSRBI, Box 5680, Ann Arbor, MI 48109, USA
Rheum Dis Clin North Am 36:405-26. 2010..This review highlights recent investigations on the assessment, prevention, and treatment of cardiovascular disease in RA... - The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefactionSeth G Thacker
Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 185:4457-69. 2010..Our study introduces a novel putative pathway by which type I IFNs may interfere with vascular repair in SLE through repression of IL-1-dependent pathways. This could promote atherosclerosis and loss of renal function in this disease... - Increased asymmetric dimethylarginine and endothelin 1 levels in secondary Raynaud's phenomenon: implications for vascular dysfunction and progression of diseaseSanjay Rajagopalan
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0273, USA
Arthritis Rheum 48:1992-2000. 2003..To compare microvascular and macrovascular functions in a cohort of patients with primary and secondary Raynaud's phenomenon (RP) who were matched for demographic, risk factor, and severity profiles... - Effects of cilostazol in patients with Raynaud's syndromeSanjay Rajagopalan
Division of Cardiology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
Am J Cardiol 92:1310-5. 2003..018). Cilostazol increased conduit vessel diameter in patients with primary and secondary RS, with a favorable impact on conduit vessel responsiveness to cold in patients with primary RS without affecting microvascular flow or symptoms... - Cardiovascular disease in rheumatoid arthritisMariana J Kaplan
Division of Rheumatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0680, USA
Curr Opin Rheumatol 18:289-97. 2006..The purpose of this review is to discuss recent advances in our understanding of the pathogenesis, prevalence, treatment, and prevention of accelerated atherosclerotic disease in rheumatoid arthritis... - Do tumor-necrosis-factor inhibitors prevent first cardiovascular events in patients with rheumatoid arthritis?Mariana J Kaplan
Division of Rheumatology, University of Michigan Medical School, Ann Arbor, 48109 0680, USA
Nat Clin Pract Rheumatol 1:74-5. 2005 - Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosusMichael F Denny
Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, USA
J Immunol 176:2095-104. 2006..This study suggests that mechanisms that induce scavenger cell apoptosis, such as death induced by autoreactive cytotoxic T cells observed in SLE, could play a pathogenic role and contribute to the severity of the disease... - The peroxisome proliferator-activated receptor gamma agonist pioglitazone improves cardiometabolic risk and renal inflammation in murine lupusWenpu Zhao
Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 183:2729-40. 2009..These results indicate that peroxisome proliferator-activated receptor gamma agonists could serve as important tools in the prevention of premature cardiovascular disease and organ damage in SLE... - Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cellsDhiman Basu
Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 183:3481-7. 2009..These results indicate that aberrant T cell KIR expression may contribute to IFN overproduction and macrophage killing in human lupus, and they suggest that Abs to inhibitory KIR may be a treatment for this disease... - A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNsMichael F Denny
Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 184:3284-97. 2010..They may play an important dual role in premature cardiovascular disease development in systemic lupus erythematosus by simultaneously mediating enhanced vascular damage and inhibiting vascular repair... - Endothelial damage and autoimmune diseasesMariana J Kaplan
Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
Autoimmunity 42:561-2. 2009..In addition, this issue explores recent advances in the understanding of how abnormalities in angiogenesis present in autoimmune diseases may lead to tissue damage and/or to premature vascular disease... - Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensitySanjay Rajagopalan
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109-0680, USA
Blood 103:3677-83. 2004..Heightened endothelial apoptosis may represent an important mechanism for development of atherothrombosis in SLE... - Dendritic cells and the immunopathogenesis of systemic lupus erythematosusSeetha Monrad
Division of Rheumatology, University of Michigan, 5520 MSRBI, Box 0680, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
Immunol Res 37:135-45. 2007..How medications used to treat SLE and other autoimmune conditions may exert effects on DCs is also explored... - Interleukin 17 as a novel predictor of vascular function in rheumatoid arthritisWendy Marder
University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Ann Rheum Dis 70:1550-5. 2011..While interleukin 17 (IL-17) is considered pathogenic in RA, its role in determining vascular dysfunction in this disease has not been systematically assessed... - Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosisMichael F Denny
Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Blood 110:2907-15. 2007..SLE is characterized by an imbalance between endothelial cell damage and repair triggered by type I IFNs, which might promote accelerated atherosclerosis... - Abetimus sodium for renal flare in systemic lupus erythematosus: results of a randomized, controlled phase III trialMario H Cardiel
Hospital General Dr Miguel Silva, Morelia, Michoacan, Mexico
Arthritis Rheum 58:2470-80. 2008....
Research Grants
- The role of dendritic cell-T cell interactions in the p*Mariana Kaplan; Fiscal Year: 2006..These could lead into the development of novel therapeutic interventions designed to reverse these abnormalities and abrogate or block the onset and/or severity of this disease. ..
- Mechanisms of T-cell induced-APC cytotoxicity in lupusMariana Kaplan; Fiscal Year: 2006..The sponsor and the institution are committed to contributing protected time, career development and resources to the applicant. ..
- PPAR-y agonists, RA and cardiovascular diseaseMariana Kaplan; Fiscal Year: 2007..This study will also shed further light on the biology of endothelial cell injury in RA. ..
- PPAR-y agonists, RA and cardiovascular diseaseMariana Kaplan; Fiscal Year: 2009..This study will also shed further light on the biology of endothelial cell injury in RA. ..
- PPAR-y agonists, RA and cardiovascular diseaseMariana J Kaplan; Fiscal Year: 2010..This study will also shed further light on the biology of endothelial cell injury in RA. ..
- Abnormal vascular repair in lupus: a link to premature atherosclerosisMariana J Kaplan; Fiscal Year: 2010....