Mariana Kaplan

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus
    Dacheng Ding
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    J Immunol 177:5878-89. 2006
  2. pmc Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in autoimmune diseases
    Jason S Knight
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School Ann Arbor, MI, USA
    Front Immunol 3:380. 2012
  3. doi request reprint Mechanisms of premature atherosclerosis in rheumatoid arthritis and lupus
    J Michelle Kahlenberg
    Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 5680, USA
    Annu Rev Med 64:249-63. 2013
  4. pmc The liver is a common non-exocrine target in primary Sjögren's syndrome: a retrospective review
    Mariana J Kaplan
    Department of Internal Medicine, Division of Rheumatology, University of Michigan Health System, Ann Arbor, Michigan, USA
    BMC Gastroenterol 2:21. 2002
  5. pmc The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus
    J Michelle Kahlenberg
    Department of Internal Medicine, University of Michigan, nn Arbor, MI 48109 5680, USA
    Arthritis Res Ther 13:203. 2011
  6. pmc The role of aldosterone blockade in murine lupus nephritis
    Seetha U Monrad
    Division of Rheumatology, Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Arthritis Res Ther 10:R5. 2008
  7. pmc Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus
    Seetha U Monrad
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, 5520 MSRBI, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 10:R114. 2008
  8. doi request reprint Management of cardiovascular disease risk in chronic inflammatory disorders
    Mariana J Kaplan
    Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Nat Rev Rheumatol 5:208-17. 2009
  9. pmc Cardiometabolic risk in psoriasis: differential effects of biologic agents
    Mariana J Kaplan
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Vasc Health Risk Manag 4:1229-35. 2008
  10. doi request reprint Premature vascular damage in systemic lupus erythematosus: an imbalance of damage and repair?
    Mariana J Kaplan
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, University of Michigan Health System, Ann Arbor 48109 5680, USA
    Transl Res 154:61-9. 2009

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus
    Dacheng Ding
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    J Immunol 177:5878-89. 2006
    ..We conclude that myeloid DCs from SLE patients display significant changes in phenotype which promote aberrant T cell function and could contribute to the pathogenesis of SLE and organ damage...
  2. pmc Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in autoimmune diseases
    Jason S Knight
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School Ann Arbor, MI, USA
    Front Immunol 3:380. 2012
    ..Here, we review the autoimmune diseases linked to NETosis, with a focus on how modified proteins externalized on NETs may trigger loss of immune tolerance and promote organ damage...
  3. doi request reprint Mechanisms of premature atherosclerosis in rheumatoid arthritis and lupus
    J Michelle Kahlenberg
    Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 5680, USA
    Annu Rev Med 64:249-63. 2013
    ....
  4. pmc The liver is a common non-exocrine target in primary Sjögren's syndrome: a retrospective review
    Mariana J Kaplan
    Department of Internal Medicine, Division of Rheumatology, University of Michigan Health System, Ann Arbor, Michigan, USA
    BMC Gastroenterol 2:21. 2002
    ..We aimed to determine the prevalence of liver disease in patients with 1 degrees SS and to evaluate the association of this complication with other non-exocrine features and serologic markers of autoimmunity and systemic inflammation...
  5. pmc The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus
    J Michelle Kahlenberg
    Department of Internal Medicine, University of Michigan, nn Arbor, MI 48109 5680, USA
    Arthritis Res Ther 13:203. 2011
    ..The potential role of various cytokines, in particular type I interferons, in the development of accelerated atherosclerosis is examined. Potential therapeutic targets are discussed...
  6. pmc The role of aldosterone blockade in murine lupus nephritis
    Seetha U Monrad
    Division of Rheumatology, Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Arthritis Res Ther 10:R5. 2008
    ..The purpose of this study was to examine the effect of aldosterone receptor blockade on the immunopathogenesis and progression of nephritis in the (NZB x NZW) F1 murine lupus model...
  7. pmc Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus
    Seetha U Monrad
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, 5520 MSRBI, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 10:R114. 2008
    ..The purpose of the present study was to characterize the phagocytic capacity and expression of receptors involved in pathogen recognition and self-nonself discrimination on myeloid dendritic cells from patients with lupus...
  8. doi request reprint Management of cardiovascular disease risk in chronic inflammatory disorders
    Mariana J Kaplan
    Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Nat Rev Rheumatol 5:208-17. 2009
    ....
  9. pmc Cardiometabolic risk in psoriasis: differential effects of biologic agents
    Mariana J Kaplan
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Vasc Health Risk Manag 4:1229-35. 2008
    ..Clearly, studies should focus on establishing the exact mechanisms that determine CV risk in psoriasis so that appropriate preventive strategies and treatment guidelines can be established...
  10. doi request reprint Premature vascular damage in systemic lupus erythematosus: an imbalance of damage and repair?
    Mariana J Kaplan
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, University of Michigan Health System, Ann Arbor 48109 5680, USA
    Transl Res 154:61-9. 2009
    ..This review summarizes some of the proposed mechanisms that may promote accelerated vascular damage in lupus and explores potential targets for cardiovascular risk prevention in this patient population...
  11. ncbi request reprint Premature vascular damage in systemic lupus erythematosus
    Mariana J Kaplan
    Division of Rheumatology, Department of Internal Medicine and Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 5680, USA
    Autoimmunity 42:580-6. 2009
    ..This review summarizes some of the proposed mechanisms that may promote accelerated vascular damage in lupus and explores potential targets for CV risk prevention in this patient population...
  12. pmc Neutrophils in the pathogenesis and manifestations of SLE
    Mariana J Kaplan
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Nat Rev Rheumatol 7:691-9. 2011
    ..This Review highlights the role of neutrophils in the pathogenesis of SLE, with a particular focus on the putative deleterious effects of LDGs and neutrophil extracellular trap formation...
  13. ncbi request reprint Systemic toxicity following administration of sirolimus (formerly rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesional lymphocytes
    M J Kaplan
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Arch Dermatol 135:553-7. 1999
    ..After 2 individuals with psoriasis developed a capillary leak syndrome following treatment with oral sirolimus lesional skin cells and activated peripheral blood cells were analyzed for induction of apoptosis...
  14. ncbi request reprint Leflunomide Aventis Pharma
    M J Kaplan
    University of Michigan Medical Center, Division of Rheumatology, Ann Arbor 48109 1065, USA
    Curr Opin Investig Drugs 2:222-30. 2001
    ..In 1996, leflunomide was designated as one of HMR's nine top-priority products, serving an unmet medical need and addressing a potential market in excess of US $500 million per year [221118]...
  15. ncbi request reprint Eculizumab (Alexion)
    Mariana Kaplan
    University of Michigan Medical Center, Division of Rheumatology, Ann Arbor 48109 1065, USA
    Curr Opin Investig Drugs 3:1017-23. 2002
    ....
  16. ncbi request reprint The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells
    Mariana J Kaplan
    Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, 5220 Medical Science Research Building I, Ann Arbor, MI 48109, USA
    J Immunol 169:6020-9. 2002
    ..We propose that this mechanism could provide a source of potentially antigenic material for the autoimmune response and interfere with normal clearing mechanisms...
  17. ncbi request reprint FK-778 Astellas
    Mariana J Kaplan
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Opin Investig Drugs 6:526-36. 2005
    ..Astellas, under license from sanofi-aventis, is developing the immunosuppressant compound FK-778 as a potential treatment for organ transplantation. By February 2005, phase II trials were ongoing both in the US and in Europe...
  18. ncbi request reprint Apoptosis in systemic lupus erythematosus
    Mariana J Kaplan
    University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Immunol 112:210-8. 2004
  19. ncbi request reprint Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells
    Mariana J Kaplan
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 172:3652-61. 2004
    ..Our results also suggest that aberrant perforin expression in CD4+ lupus T cells may contribute to monocyte killing...
  20. ncbi request reprint Plasminogen activator inhibitor-1 is associated with impaired endothelial function in women with systemic lupus erythematosus
    Emily C Somers
    Division of Rheumatology, University of Michigan Health System, 1150 W Medical Center Dr, 5520 MSRB 1, Ann Arbor, MI 48109 0680, USA
    Ann N Y Acad Sci 1051:271-80. 2005
    ..Given the high incidence of cardiovascular disease in SLE, further investigation of the role of subclinical markers of CVD is needed...
  21. ncbi request reprint New evidence for vascular disease in patients with early rheumatoid arthritis
    Mariana J Kaplan
    Department of Internal Medicine, Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI 408109, USA
    Lancet 361:1068-9. 2003
  22. pmc Cardiovascular complications of rheumatoid arthritis: assessment, prevention, and treatment
    Mariana J Kaplan
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, 5520 MSRBI, Box 5680, Ann Arbor, MI 48109, USA
    Rheum Dis Clin North Am 36:405-26. 2010
    ..This review highlights recent investigations on the assessment, prevention, and treatment of cardiovascular disease in RA...
  23. pmc The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction
    Seth G Thacker
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 185:4457-69. 2010
    ..Our study introduces a novel putative pathway by which type I IFNs may interfere with vascular repair in SLE through repression of IL-1-dependent pathways. This could promote atherosclerosis and loss of renal function in this disease...
  24. ncbi request reprint Increased asymmetric dimethylarginine and endothelin 1 levels in secondary Raynaud's phenomenon: implications for vascular dysfunction and progression of disease
    Sanjay Rajagopalan
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0273, USA
    Arthritis Rheum 48:1992-2000. 2003
    ..To compare microvascular and macrovascular functions in a cohort of patients with primary and secondary Raynaud's phenomenon (RP) who were matched for demographic, risk factor, and severity profiles...
  25. ncbi request reprint Effects of cilostazol in patients with Raynaud's syndrome
    Sanjay Rajagopalan
    Division of Cardiology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Am J Cardiol 92:1310-5. 2003
    ..018). Cilostazol increased conduit vessel diameter in patients with primary and secondary RS, with a favorable impact on conduit vessel responsiveness to cold in patients with primary RS without affecting microvascular flow or symptoms...
  26. ncbi request reprint Do tumor-necrosis-factor inhibitors prevent first cardiovascular events in patients with rheumatoid arthritis?
    Mariana J Kaplan
    Division of Rheumatology, University of Michigan Medical School, Ann Arbor, 48109 0680, USA
    Nat Clin Pract Rheumatol 1:74-5. 2005
  27. ncbi request reprint Cardiovascular disease in rheumatoid arthritis
    Mariana J Kaplan
    Division of Rheumatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0680, USA
    Curr Opin Rheumatol 18:289-97. 2006
    ..The purpose of this review is to discuss recent advances in our understanding of the pathogenesis, prevalence, treatment, and prevention of accelerated atherosclerotic disease in rheumatoid arthritis...
  28. pmc The peroxisome proliferator-activated receptor gamma agonist pioglitazone improves cardiometabolic risk and renal inflammation in murine lupus
    Wenpu Zhao
    Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 183:2729-40. 2009
    ..These results indicate that peroxisome proliferator-activated receptor gamma agonists could serve as important tools in the prevention of premature cardiovascular disease and organ damage in SLE...
  29. ncbi request reprint Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosus
    Michael F Denny
    Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, USA
    J Immunol 176:2095-104. 2006
    ..This study suggests that mechanisms that induce scavenger cell apoptosis, such as death induced by autoreactive cytotoxic T cells observed in SLE, could play a pathogenic role and contribute to the severity of the disease...
  30. pmc Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cells
    Dhiman Basu
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 183:3481-7. 2009
    ..These results indicate that aberrant T cell KIR expression may contribute to IFN overproduction and macrophage killing in human lupus, and they suggest that Abs to inhibitory KIR may be a treatment for this disease...
  31. ncbi request reprint Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity
    Sanjay Rajagopalan
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 0680, USA
    Blood 103:3677-83. 2004
    ..Heightened endothelial apoptosis may represent an important mechanism for development of atherothrombosis in SLE...
  32. pmc A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs
    Michael F Denny
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 184:3284-97. 2010
    ..They may play an important dual role in premature cardiovascular disease development in systemic lupus erythematosus by simultaneously mediating enhanced vascular damage and inhibiting vascular repair...
  33. ncbi request reprint Endothelial damage and autoimmune diseases
    Mariana J Kaplan
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Autoimmunity 42:561-2. 2009
    ..In addition, this issue explores recent advances in the understanding of how abnormalities in angiogenesis present in autoimmune diseases may lead to tissue damage and/or to premature vascular disease...
  34. ncbi request reprint Sera from patients with type 2 diabetes and neuropathy induce autophagy and colocalization with mitochondria in SY5Y cells
    Roberto Towns
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0108, USA
    Autophagy 1:163-70. 2005
    ..Stimulation of autophagy by an autoantibody-mediated pathway can provide a critical link between the immune system and the loss of function and eventual demise of neuronal tissue in type 2 diabetes...
  35. ncbi request reprint Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus
    Qianjin Lu
    Cancer Center and Geriatric Center, University of Michigan, Ann Arbor, MI 48109, USA
    Arthritis Rheum 46:1282-91. 2002
    ..The present study investigated the nature of the methylation change that affects LFA-1 expression in vitro and in human lupus...
  36. ncbi request reprint Dendritic cells and the immunopathogenesis of systemic lupus erythematosus
    Seetha Monrad
    Division of Rheumatology, University of Michigan, 5520 MSRBI, Box 0680, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Immunol Res 37:135-45. 2007
    ..How medications used to treat SLE and other autoimmune conditions may exert effects on DCs is also explored...
  37. pmc Interleukin 17 as a novel predictor of vascular function in rheumatoid arthritis
    Wendy Marder
    University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Ann Rheum Dis 70:1550-5. 2011
    ..While interleukin 17 (IL-17) is considered pathogenic in RA, its role in determining vascular dysfunction in this disease has not been systematically assessed...
  38. pmc Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis
    Michael F Denny
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Blood 110:2907-15. 2007
    ..SLE is characterized by an imbalance between endothelial cell damage and repair triggered by type I IFNs, which might promote accelerated atherosclerosis...
  39. ncbi request reprint Abetimus sodium for renal flare in systemic lupus erythematosus: results of a randomized, controlled phase III trial
    Mario H Cardiel
    Hospital General Dr Miguel Silva, Morelia, Michoacan, Mexico
    Arthritis Rheum 58:2470-80. 2008
    ....

Research Grants8

  1. The role of dendritic cell-T cell interactions in the p*
    Mariana Kaplan; Fiscal Year: 2006
    ..These could lead into the development of novel therapeutic interventions designed to reverse these abnormalities and abrogate or block the onset and/or severity of this disease. ..
  2. Mechanisms of T-cell induced-APC cytotoxicity in lupus
    Mariana Kaplan; Fiscal Year: 2006
    ..The sponsor and the institution are committed to contributing protected time, career development and resources to the applicant. ..
  3. PPAR-y agonists, RA and cardiovascular disease
    Mariana Kaplan; Fiscal Year: 2007
    ..This study will also shed further light on the biology of endothelial cell injury in RA. ..
  4. PPAR-y agonists, RA and cardiovascular disease
    Mariana Kaplan; Fiscal Year: 2009
    ..This study will also shed further light on the biology of endothelial cell injury in RA. ..
  5. Abnormal vascular repair in lupus: a link to premature atherosclerosis
    Mariana Kaplan; Fiscal Year: 2009
    ....
  6. PPAR-y agonists, RA and cardiovascular disease
    Mariana J Kaplan; Fiscal Year: 2010
    ..This study will also shed further light on the biology of endothelial cell injury in RA. ..
  7. Abnormal vascular repair in lupus: a link to premature atherosclerosis
    Mariana J Kaplan; Fiscal Year: 2010
    ....