Affiliation: University of Florida
- Overview of large database analysis in renal transplantationBruce Kaplan
Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
Am J Transplant 3:1052-6. 2003..We hope to present both a guide to investigators who are first embarking on large-scale database analysis and also to present a fair view of the utility and limitations of a potentially very useful research tool in renal transplantation...
- Access to quality: evaluation of the allocation of deceased donor kidneys for transplantationJesse D Schold
Department of Medicine, University of Florida, Gainesville, Florida 32610 0224, USA
J Am Soc Nephrol 16:3121-7. 2005..The extent to which these disparities are in line with broad policies of equity and potentially modifiable will have to be examined in the context of allocation policy...
- ABO incompatible renal transplantation in an HIV-seropositive patientMaya Campara
Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL, USA
Transplantation 86:176-8. 2008..Antibody-mediated rejection was not observed on biopsy. The patient reached a serum creatinine nadir of 2.0 mg/dL on postoperative day 20, which has now been maintained for 170 days. His current CD4 count was 410 cells/microL...
- Factors associated with long-term renal allograft survivalBruce Kaplan
Division of Nephrology, Shands University Hospital, University of Florida, Gainesville, Florida 32610 0224, USA
Ther Drug Monit 24:36-9. 2002....
- Randomized calcineurin inhibitor cross over study to measure the pharmacokinetics of co-administered enteric-coated mycophenolate sodiumBruce Kaplan
Division of Nephrology, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0224, USA
Clin Transplant 19:551-8. 2005..These observations should be taken into consideration when switching from one calcineurin inhibitor to another, but the final dosage should be based on both this pharmacokinetic data and the clinical situation...
- Long-term graft survival with neoral and tacrolimus: a paired kidney analysisBruce Kaplan
Department of Medicine, University of Florida, Gainesville, Florida 32610, USA
J Am Soc Nephrol 14:2980-4. 2003..Renal function was superior in the patients receiving initial tacrolimus therapy; however, slope of 1/Cr did not differ between the agents...
- Poor predictive value of serum creatinine for renal allograft lossBruce Kaplan
University of Florida College of Medicine, Gainesville, FL, USA
Am J Transplant 3:1560-5. 2003..While renal function is a strong risk factor and highly correlated with graft failure, the utility of renal function as a predictive tool for graft loss is limited...
- Effect of sirolimus withdrawal in patients with deteriorating renal functionBruce Kaplan
University of Florida, Gainesville, FL 32610 0224, USA
Am J Transplant 4:1709-12. 2004..This strategy may be particularly useful in those patients where CNI withdrawal is considered to be of high immunologic or metabolic risk...
- Sirolimus in combination with tacrolimus is associated with worse renal allograft survival compared to mycophenolate mofetil combined with tacrolimusHerwig Ulf Meier-Kriesche
Department of Medicine, University of Florida College of Medicine, Florida, USA
Am J Transplant 5:2273-80. 2005..These results have to be interpreted in the context of the inherent limitations of any retrospective database analysis and evaluated in context with data from prospective clinical trials...
- Mycophenolate mofetil versus azathioprine therapy is associated with a significant protection against long-term renal allograft function deteriorationHerwig Ulf Meier-Kriesche
Department of Internal Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0224, USA
Transplantation 75:1341-6. 2003....
- Sirolimus with neoral versus mycophenolate mofetil with neoral is associated with decreased renal allograft survivalHerwig Ulf Meier-Kriesche
Department of Internal Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
Am J Transplant 4:2058-66. 2004..Outcomes regarding alternative strategies of Rapa utilization with reduced CsA, with alternative agents or with no calcineurin inhibitor cannot be extrapolated from these data...
- The impact of mycophenolate mofetil on long-term outcomes in kidney transplantationTitte R Srinivas
Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL 32610, USA
Transplantation 80:S211-20. 2005..In coming years, these benefits will require reevaluation in the context of the growing use of novel protocols combining MMF with tacrolimus or sirolimus...
- Long-term renal allograft survival: have we made significant progress or is it time to rethink our analytic and therapeutic strategies?Herwig Ulf Meier-Kriesche
Department of Medicine, University of Florida, Gainesville, FL, USA
Am J Transplant 4:1289-95. 2004..Redirection of attention from early endpoints towards the process of long-term graft loss may be necessary to sustain early gains in the long term...
- Mycophenolate mofetil vs azathioprine in a large population of elderly renal transplant patientsHerwig Ulf Meier-Kriesche
Division of Internal Medicine, University of Florida College of Medicine, Gainesville, FL, USA
Nephrol Dial Transplant 19:2864-9. 2004..Previous studies reported a higher risk of death due to infection in elderly recipients treated with MMF-based immunosuppression...
- Death after graft loss: an important late study endpoint in kidney transplantationBruce Kaplan
University of Florida, College of Medicine, Division of Nephrology, 1600 SW Archer Road, Gainesville, FL 32610 0224, USA
Am J Transplant 2:970-4. 2002....
- Renal allograft survival in patients with oxalosisDiane M Cibrik
Department of Medicine, University of Michigan Health System, Ann Arbor, USA
Transplantation 74:707-10. 2002....
- Kidneys from deceased donors: maximizing the value of a scarce resourceHerwig Ulf Meier-Kriesche
Department of Medicine, University of Florida, Gainesville, FL, USA
Am J Transplant 5:1725-30. 2005..5 billion dollars...
- Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent eraHerwig Ulf Meier-Kriesche
University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
Am J Transplant 4:378-83. 2004..However, the etiology of this concerning trend for worse death censored graft survival in recent years will warrant further investigation...
- The relationship between diabetes and infectious hospitalizations in renal transplant recipientsM Cecilia Lansang
Division of Endocrinology, University of Florida, Gainesville, USA
Diabetes Care 29:1659-60. 2006
- Are we frozen in time? Analysis of the utilization and efficacy of pulsatile perfusion in renal transplantationJesse D Schold
Department of Medicine, University of Florida, Gainesville, FL, USA
Am J Transplant 5:1681-8. 2005..Additional evidence of improvement in graft survival, particularly in more recent years, provides further encouraging evidence for the use of PP...
- Decreased renal function is a strong risk factor for cardiovascular death after renal transplantationHerwig Ulf Meier-Kriesche
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224
Transplantation 75:1291-5. 2003..The purpose of this study was to investigate if renal function has a significant role in determining the risk for cardiovascular death in renal-allograft recipients...
- The broad spectrum of quality in deceased donor kidneysJesse D Schold
University of Florida, Gainesville, FL, USA
Am J Transplant 5:757-65. 2005....
- Interaction between donor and recipient age in determining the risk of chronic renal allograft failureHerwig Ulf Meier-Kriesche
Department of Medicine, The University of Michigan, Ann Arbor, Michigan, USA
J Am Geriatr Soc 50:14-7. 2002..To investigate the interaction between donor and recipient age, we analyzed 40,289 primary solitary Caucasian adult renal transplants registered at the United States Renal Data System (USRDS) from 1988 to 1997...
- Dendritic cell deficiency associated with development of BK viremia and nephropathy in renal transplant recipientsKarl L Womer
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Transplantation 89:115-23. 2010..In a previous univariate analysis, we demonstrated a peripheral blood DC (PBDC) deficiency in patients with biopsy-proven BKVN, raising the possibility that reduction in DC predisposed to BK reactivation...
- Renal allograft survival in transplant recipients with focal segmental glomerulosclerosisDiane M Cibrik
Department of Medicine, University of Michigan, Ann Arbor, MI, USA
Am J Transplant 3:64-7. 2003..Zero mismatch LRD kidney transplants are not a risk factor for graft loss in FSGS patients but are associated with significantly better death-censored graft survival as compared to CAD 6-antigen match or mismatched donations...
- Overcoming barriers to long-term graft survivalBruce Kaplan
Department of Medicine, University of Illinois College of Medicine, Chicago, IL 60612 7315, USA
Am J Kidney Dis 47:S52-64. 2006....
- Kidney transplantation halts cardiovascular disease progression in patients with end-stage renal diseaseHerwig Ulf Meier-Kriesche
Kidney Transplant Program, Division of Nephrology, University of Florida College of Medicine, 1600 SW Archer Rd, Rm CG 98, Gainesville, FL, USA
Am J Transplant 4:1662-8. 2004..The data presented in this paper thus suggest that the development or progression of these lesions could be ameliorated by restoring renal function with a transplant...
- Improvement in hypercalcemia with cinacalcet after kidney transplantationTitte R Srinivas
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
Clin J Am Soc Nephrol 1:323-6. 2006..10). Graft function remained stable. Cinacalcet lowers SCa and raises SP in the short term in patients with persistent post-Tx hyperparathyroidism; long-term bone effects and persistent hyperparathyroidism merit further study...
- Long-term use of mycophenolate mofetil is associated with a reduction in the incidence and risk of late rejectionHerwig Ulf Meier-Kriesche
Department of Internal Medicine, University of Florida, USA
Am J Transplant 3:68-73. 2003..30, p < 0.001). Further study is indicated to determine the optimal duration of MMF therapy after renal allograft transplantation...
- Pharmacokinetic principles of immunosuppressive drugsTitte R Srinivas
Department of Medicine, University of Florida, Gainesville, Florida, USA
Am J Transplant 5:207-17. 2005..In addition, we hope this review will help in understanding some of the basic drug interactions encountered in transplant practice...
- Why hasn't eliminating acute rejection improved graft survival?JogiRaju Tantravahi
Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida 32601 0224, USA
Annu Rev Med 58:369-85. 2007....
- Mycophenolate mofetil in solid-organ transplantationTitte R Srinivas
Division of Nephrology, Hypertension and Transplantation, University of Florida, 1600 SW Archer Road, Box 100224, Gainesville, FL 32610 0224, USA
Expert Opin Pharmacother 4:2325-45. 2003....
- Waiting time on dialysis as the strongest modifiable risk factor for renal transplant outcomes: a paired donor kidney analysisHerwig Ulf Meier-Kriesche
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, USA
Transplantation 74:1377-81. 2002....
- Immunosuppressive strategies to improve outcomes of kidney transplantationIgnatius Y Tang
Transplantation Medicine, Section of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Semin Nephrol 27:377-92. 2007..We discuss the impact of various immunosuppressive regimens on the outcome measures of kidney transplantation: acute rejection episodes, allograft survival, and renal function...
- Association of antibody induction with short- and long-term cause-specific mortality in renal transplant recipientsHerwig Ulf Meier-Kriesche
Division of Nephrology, University of Florida, Gainesville, Florida 32610 0224, USA
J Am Soc Nephrol 13:769-72. 2002..In addition, ABI was associated with a significant risk for long-term malignancy-related death. The risk of ABI should be taken in context with potential benefits of this therapy...
- The effects of renal transplantation on peripheral blood dendritic cellsKarl L Womer
Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA
Clin Transplant 19:659-67. 2005..Furthermore, PBDC monitoring may represent a novel strategy to predict important outcomes such as acute rejection, long-term graft loss and infectious complications...
- The impact of body mass index on renal transplant outcomes: a significant independent risk factor for graft failure and patient deathHerwig Ulf Meier-Kriesche
Division of Nephrology, University of Florida, Shands Hospital, 1600 SW Archer Rd, Rm CG 98, Gainesville FL 32610 0224, USA
Transplantation 73:70-4. 2002..To investigate this hypothesis we retrospectively analyzed 51,927 primary, adult renal transplants registered in the USRDS...
- Evaluation of drug interaction software to identify alerts for transplant medicationsWendy D Smith
Shands Hospital, University of Florida, Gainesville, FL, USA
Ann Pharmacother 39:45-50. 2005..A CPOE system with incomplete or inaccurate drug information will fail to identify clinically important drug interactions and, therefore, fail to reduce preventable adverse drug events (pADEs)...
- 2008 Update from the Collaborative Islet Transplant RegistryRodolfo Alejandro
The Diabetes Research Institute, University of Miami Leonard M Miller School of Medicine, Miami, FL, USA
Transplantation 86:1783-8. 2008....
- The time is now: formation of true transplant centersR J Howard
Department of Surgery, University of Florida School of Medicine, Gainesville, FL, USA
Am J Transplant 8:2225-9. 2008....
- Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulationGreg Simon
Department of Pathology, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA
Diabetes 57:405-14. 2008....
- Cyclosporine microemulsion and tacrolimus are associated with decreased chronic allograft failure and improved long-term graft survival as compared with sandimmuneHerwig Ulf Meier-Kriesche
University of Michigan Health System, Department of Internal Medicine, Nephrology, Ann Arbor 48109 0364, USA
Am J Transplant 2:100-4. 2002..This association is independent of the use of MMF or changes in era...
- The role of ABO-incompatible living donors in kidney transplantation: state of the artJames Thielke
Department of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Semin Nephrol 27:408-13. 2007..The present article reviews the history, outcomes, and current issues in kidney transplantation with ABO-incompatible living donors in adult and pediatric recipients...
- Exposure-response relationships for everolimus in de novo kidney transplantation: defining a therapeutic rangeJohn M Kovarik
Novartis Pharmaceuticals, Basel, Switzerland
Transplantation 73:920-5. 2002..Exposure, safety, and efficacy data from the two everolimus randomized, double-blind phase 3 trials were evaluated to identify a therapeutic concentration range applicable in de novo kidney transplantation...
- Therapeutic monitoring of mycophenolate mofetilHyunyoung Jeong
Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL 60612, USA
Clin J Am Soc Nephrol 2:184-91. 2007
- A randomized trial of a home-based educational approach to increase live donor kidney transplantation: effects in blacks and whitesJames R Rodrigue
The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Kidney Dis 51:663-70. 2008..We assessed the differential effectiveness in blacks and whites of a home-based (HB) LDKT educational approach...
- Patients' willingness to talk to others about living kidney donationJames R Rodrigue
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Prog Transplant 18:25-31. 2008..Living donor kidney transplantation has several advantages for patients with end-stage renal disease. However, many patients are reluctant to pursue this treatment option, preferring instead to wait for a deceased donor organ...
- The practical utility of an economic analysis of calcineurin withdrawal following renal transplantationBruce Kaplan
J Am Soc Nephrol 19:1627-8. 2008
- Mycophenolic acid trough level monitoring in solid organ transplant recipients treated with mycophenolate mofetil: association with clinical outcomeBruce Kaplan
UIC Multiorgan Transplant Center, University of Illinois, Chicago, IL 60612, USA
Curr Med Res Opin 22:2355-64. 2006..Predose trough samples of MPA are considered most convenient and economic, thereby allowing an increased use of TDM in the transplant setting. However, the added value of TDM for MMF therapy is still under debate...
- Therapeutic drug monitoring of mycophenolate mofetil in transplantationTeun van Gelder
Department of Hospital Pharmacy, Clinical Pharmacology Unit, Erasmus Medical Center, Rotterdam, The Netherlands
Ther Drug Monit 28:145-54. 2006..The value of TDM in the general transplant population will be assessed from large, ongoing, randomized studies...
- Renal transplantation: a half century of success and the long road aheadBruce Kaplan
J Am Soc Nephrol 15:3270-1. 2004
- Renal transplantations performed using non-heart-beating organ donors: going back to the future?Steven M Rudich
Division of Transplant Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
Transplantation 74:1715-20. 2002..The purpose of this study was to analyze renal transplant outcomes using this source of cadaveric (CAD) organs and compare the results with heart-beating organ sources...
- Pharmacokinetics of an everolimus-cyclosporine immunosuppressive regimen over the first 6 months after kidney transplantationJohn M Kovarik
Novartis Pharmaceuticals, Basel, Switzerland 4002
Am J Transplant 3:606-13. 2003..Weight-adjusted dosing (mg/kg) does not appear warranted. Black patients may have lower bioavailability and/or higher clearance of everolimus compared with white patients...
- Assessing long-term nephron loss: is it time to kick the CAN grading system?Philip F Halloran
Am J Transplant 4:1729-30. 2004
- Treating tobacco use and dependence in kidney transplant recipients: development and implementation of a programShawna L Ehlers
Mayo Clinic, Rochester, Minn, USA
Prog Transplant 16:33-7. 2006..The purpose of this article is to describe one institution's experience in implementing the clinical practice guideline for treating tobacco use and dependence within a kidney and pancreas transplant program...
- The expectancies of living kidney donors: do they differ as a function of relational status and gender?James R Rodrigue
The Transplant Center, Department of Psychiatry, Beth Israel Deaconess Medical Center, 110 Francis Street, LMOB Suite 7, Boston, MA 02215, USA
Nephrol Dial Transplant 21:1682-8. 2006..Also, women continue to represent more than half of all the living kidney donors. This study examined whether donor expectancies varied as a function of relational status or gender...
- Transplant immunosuppressive drug trials on trialJohn J Curtis
Am J Transplant 4:671-2. 2004
- Measuring the expectations of kidney donors: initial psychometric properties of the Living Donation Expectancies QuestionnaireJames R Rodrigue
The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Transplantation 85:1230-4. 2008..0001), Personal Growth (P<0.01), Quid Pro Quo (P<0.0001), and Health Consequences (P<0.0001) expectations. The LDEQ has promise in evaluating donor candidates' expectations...
- A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradationMichael R Olson
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 278:44758-68. 2003....
- Response to "Sustained improvement of renal graft function for two years in hypertensive renal transplant recipients treated with nifedipine as compared with lisinopril"Titte R Srinivas
Transplantation 74:139; author reply 139-40. 2002
- Electrolyte imbalances in pediatric living related small bowel transplantationUlf H Beier
Division of Pediatric Nephrology, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL 60612, USA
Transplantation 85:217-23. 2008..We investigated the pattern of electrolyte disturbances with regard to enteral malabsorption, renal compensation, and the influence of immunosuppression...
- The financial burden of transplantation: a single-center survey of liver and kidney transplant recipientsJames R Rodrigue
The Transplant Center and the Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Transplantation 84:295-300. 2007..These findings highlight the potential financial impact of transplantation on patients and families, and they have implications for assisting patients in managing out-of-pocket expenses after transplantation...
- Patient-reported outcomes for open versus laparoscopic living donor nephrectomyJames R Rodrigue
Beth Israel Deaconess Medical Center, Boston, Mass, USA
Prog Transplant 16:162-9. 2006..Rates of living kidney donation have increased dramatically in recent years, in large part because of improved surgical techniques such as laparoscopic nephrectomy...
- Do report cards influence hospital choice? The case of kidney transplantationDavid H Howard
Department of Health Policy and Management, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Inquiry 43:150-9. 2006..We find some evidence that report cards influence younger and college-educated patients, but, overall, report cards do not affect demand...
- Successful rescue of refractory, severe antibody mediated rejection with splenectomyBruce Kaplan
Division of Transplant Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Transplantation 83:99-100. 2007..Splenectomy may play a role in the treatment of AMR refractory to ST...