SUNIL D KAPILA

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants
    Tabassum Naqvi
    University of California, San Francisco, USA
    Arthritis Res Ther 7:R1-11. 2005
  2. pmc Relaxin and beta-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss
    Gihan Hashem
    Department of Orthodontics and Pediatric Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
    Arthritis Res Ther 8:R98. 2006
  3. pmc Matrix metalloproteinase induction by relaxin causes cartilage matrix degradation in target synovial joints
    Sunil Kapila
    Department of Orthodontics and Pediatric Dentistry, The University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Ann N Y Acad Sci 1160:322-8. 2009
  4. pmc Induction of MMP-1 (collagenase-1) by relaxin in fibrocartilaginous cells requires both the AP-1 and PEA-3 promoter sites
    S Kapila
    Department of Orthodontics and Pediatric Dentistry, The University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    Orthod Craniofac Res 12:178-86. 2009
  5. pmc The current status of cone beam computed tomography imaging in orthodontics
    S Kapila
    Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
    Dentomaxillofac Radiol 40:24-34. 2011

Collaborators

Detail Information

Publications5

  1. pmc Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants
    Tabassum Naqvi
    University of California, San Francisco, USA
    Arthritis Res Ther 7:R1-11. 2005
    ..These findings show for the first time that relaxin has degradative effects on non-reproductive synovial joint fibrocartilaginous tissue and provide evidence for a link between relaxin, MMPs, and matrix degradation...
  2. pmc Relaxin and beta-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss
    Gihan Hashem
    Department of Orthodontics and Pediatric Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
    Arthritis Res Ther 8:R98. 2006
    ..The findings suggest that this targeted modulation of matrix loss by hormones may contribute selectively to degeneration of specific synovial joints...
  3. pmc Matrix metalloproteinase induction by relaxin causes cartilage matrix degradation in target synovial joints
    Sunil Kapila
    Department of Orthodontics and Pediatric Dentistry, The University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Ann N Y Acad Sci 1160:322-8. 2009
    ..These findings suggest a novel model for targeted tissue turnover of cartilage of specific joints through hormone-mediated induction of select MMPs...
  4. pmc Induction of MMP-1 (collagenase-1) by relaxin in fibrocartilaginous cells requires both the AP-1 and PEA-3 promoter sites
    S Kapila
    Department of Orthodontics and Pediatric Dentistry, The University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    Orthod Craniofac Res 12:178-86. 2009
    ..CONCLUSION - These studies show that both the AP-1 and PEA-3 promoter sites are necessary for the induction of MMP-1 by relaxin in fibrocartilaginous cells...
  5. pmc The current status of cone beam computed tomography imaging in orthodontics
    S Kapila
    Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
    Dentomaxillofac Radiol 40:24-34. 2011
    ..The need to image other types of cases should be made on a case-by-case basis following an assessment of benefits vs risks of scanning in these situations...

Research Grants13

  1. Craniofacial Imaging in the 21st Century
    Sunil Kapila; Fiscal Year: 2002
    ..The meeting will be limited to 300 participants who have a background in imaging. This symposia series will provide momentum to discoveries that will be important to craniofacial sciences and patient care. ..
  2. MODULATION OF TMJ DEGRADATION BY RELAXIN AND ESTROGEN
    Sunil Kapila; Fiscal Year: 2004
    ..The Independent Scientist Award will be critical in achieving these goals. ..
  3. Fibronectin Fragment-Induced Osteolysis Mediated by MMPs
    Sunil Kapila; Fiscal Year: 2009
    ..These studies will provide a fundamental understanding of the basis for bone loss in periodontal disease and other osteolytic diseases. ..
  4. Hormone-Receptor-MMP Axis in Degenerative TMJ Diseases
    Sunil Kapila; Fiscal Year: 2007
    ....
  5. CRANIOFACIAL SKELETAL TISSUE ENGINEERING CONFERENCE
    Sunil Kapila; Fiscal Year: 2007
    ..The meeting will be limited to 250 participants who have a background in bioengineering. ..
  6. Hormone-Receptor-MMP Axis in Degenerative TMJ Diseases
    SUNIL D KAPILA; Fiscal Year: 2010
    ....